HypertensionDynamic and IsNCT07448818
Dynamic and Isometric Strength Training in Older Adults With Hypertension
A study testing Dynamic Strength Training and Isometric Strength Training in people with Hypertension and Elderly (People Aged 65 or More), run by Raphael Mendes Ritti Dias at 1 site in Brazil.
Trial summary
This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Read more about this study
- Who is it for?
- Ages 60 years and older
- Conditions the study is for
- Hypertension, Elderly (People Aged 65 or More)
- What is being tested?
- Dynamic Strength Training and Isometric Strength Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteBrazil
- Study dates
- 1 Mar 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosis of arterial hypertension and currently taking antihypertensive medication
- Age 60 years or older
- Resting blood pressure below 160/95 mmHg
- No high cardiovascular risk according to the American College of Sports Medicine criteria (for participants with type 2 diabetes, glycemic control with fasting glucose <100 mg/dL and postprandial glucose <140 mg/dL)
- Not participating in a structured exercise program for more than three months
- No cognitive or functional limitations that prevent participation in the exercise program
Who cannot join
- Presence of acute illnesses, such as influenza, sinusitis, gastroenteritis, urinary tract infection, fever, inflammatory processes, or any clinical condition requiring rest or that may compromise safety during assessments or training.
- Decompensated clinical conditions, including: Blood pressure spikes, Chest pain, Uncontrolled arrhythmias, Shortness of breath at rest, Asthma exacerbations, Decompensated diabetes mellitus, characterized by Persistently elevated blood glucose levels (fasting glucose > 180 mg/dL or postprandial glucose > 250 mg/dL)
- Irregular use of medication
- Any unstable clinical condition or condition that represents additional risk for the practice of physical exercise.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Dynamic Strength Training and Isometric Strength Training on Cardiovascular Health Indicators, Mental Health, and Neuromuscular Fitness in Older Adults With Hypertension: A Feasibility Study
This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Participants will be randomly assigned to one of the two training modalities and will complete supervised exercise sessions throughout the intervention period. The study will provide preliminary evidence regarding the safety, acceptability, and potential impact of each training modality on health outcomes in this population.
- Conditions
- Hypertension, Elderly (People Aged 65 or More)
- Being tested
- Dynamic Strength Training, Isometric Strength Training, No supervised intervention Control
- Keywords
- Hypertension, Strength training, Resistance training, Cardiovascular health, blood pressure, old age
- Medical subject headings
- Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Dynamic Strength TrainingBehavioural
The experimental group will perform dynamic strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group movements, initially 2 sets of 15 repetitions (Borg 4-6), progressing to 3 sets of 10 repetitions (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for ~30 minutes at moderate intensity.
Isometric Strength TrainingBehavioural
The experimental group will perform isometric strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group contractions, initially 2 sets of 60 seconds (Borg 4-6), progressing to 3 sets of 40 seconds (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for ~30 minutes at moderate intensity.
No supervised intervention ControlBehavioural
This group serves as a control and will not perform any structured exercise program.
| Study group | Role | What they receive |
|---|---|---|
| Dynamic Strength Training | Active comparator | The subjects randomized to this group will perform two supervised dynamic strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes. Receives: Behavioral: Dynamic Strength Training |
| Isometric Strength Training | Experimental | The subjects randomized to this group will perform two supervised isometric strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes. Receives: Behavioral: Isometric Strength Training |
| Control | Other | No supervised training will be provided. Participants in this group will not receive any exercise intervention during the 6-week study period, but they will be stimulated to be active. Receives: Behavioral: No supervised intervention Control |
What is being measured
The primary outcome is the main question the study is designed to answer.
Recruitment rate
Proportion of enrolled participants relative to the total number of eligible individuals contacted. Reported as a percentage.
Measured: Baseline and 6 weeks
Adherence to training sessions
Percentage of completed training sessions relative to the total number of planned sessions over the 6-week intervention period.
Measured: During 6 weeks
Retention rate
Proportion of participants who complete the full 6-week intervention
Measured: During 6 weeks
Fidelity to exercise protocol
Percentage of exercises performed according to the prescribed protocol parameters, including load, repetitions, and time under tension.
Measured: Duiring 6 weeks
Acceptability of the intervention
Acceptability assessed through a structured satisfaction questionnaire, scored from 0 to 10, administered at the end of the 6-week intervention
Measured: During 6 weeks
Occurrence of adverse events
Number of intervention-related adverse events, classified as mild, moderate, or severe
Measured: During 6 weeks
Secondary outcomes (17)
Change from baseline in Clinical resting blood pressure at 6 weeks
Systolic and diastolic blood pressure measured with automatic device (HEM-742, Omron Healthcare, Japan) in seated position, average of last two of three readings, in millimeters of mercury.
Measured: Baseline and 6 weeks
Change from baseline in Home blood pressure monitoring at 6 weeks
Seven-day home monitoring with automatic device (Omron Healthcare, Japan), two readings morning and evening in duplicate; average of valid readings, in millimeters of mercury
Measured: Baseline and 6 weeks
Change from baseline in Flow-mediated dilation at 6 weeks
Brachial and femoral artery vasodilation assessed by ultrasonography with spectral Doppler (Cannon Xario, Japan); calculated as percentage change from baseline
Measured: Baseline and 6 weeks
Change from baseline in Standard deviation of normal R-R intervals at 6 weeks
Standard deviation of normal R-R intervals will be assessed using the Polar V800 heart rate monitor (Polar Electro, Finland) and expressed in milliseconds (ms).
Measured: Baseline and 6 weeks
Change from baseline in Arterial stiffness at 6 weeks
Carotid-femoral pulse wave velocity measured by applanation tonometry (SphygmoCor, AtCor Medical, Australia), calculated as distance/time in meters per second
Measured: Baseline and 6 weeks
Change from baseline in Depressive symptoms at 6 weeks
Geriatric Depression Scale (GDS-15), 15 items, scored 0-15, higher score = worse symptoms
Measured: Baseline and 6 weeks
Change from baseline in Anxiety symptoms at 6 weeks
Generalized Anxiety Disorder questionnaire (GAD-7), 7 items, scored 0-21, higher score = worse symptoms
Measured: Baseline and 6 weeks
Change from baseline in Six-Minute Walk Test distance at 6 weeks
Distance walked in meters during the six-minute walk test performed in a 30-meter corridor.
Measured: Baseline and 6 weeks
Change from baseline in Root mean square of successive differences between R-R intervals at 6 weeks
Root mean square of successive differences between R-R intervals will be measured using the Polar V800 heart rate monitor (Polar Electro, Finland) and expressed in milliseconds (ms).
Measured: Baseline to 6 weeks
Change from baseline in Proportion of successive R-R intervals differing by more than 50 milliseconds at 6 weeks
Proportion of successive R-R intervals differing by more than 50 milliseconds will be measured using the Polar V800 heart rate monitor (Polar Electro, Finland) and expressed in milliseconds (ms).
Measured: Baseline to 6 weeks.
Change from baseline in Low-frequency spectral power at 6 weeks
Low-frequency spectral power will be assessed using the Polar V800 (Polar Electro, Finland) and expressed in ms².
Measured: Baseline to 6 weeks.
Change from baseline in high-frequency power at 6 weeks
high-frequency power High-frequency component measured with Polar V800 (Polar Electro, Finland), expressed in ms².
Measured: Baseline to 6 weeks.
Change from baseline in Low-frequency to high-frequency ratio at 6 weeks
Low-frequency to high-frequency ratio measured with Polar V800 (Polar Electro, Finland).
Measured: Baseline to 6 weeks.
Change from baseline in Timed Up and Go Time at 6 weeks
time in seconds to stand from a chair, walk 3 meters, turn, return, and sit down.
Measured: Baseline and 6 weeks.
Change from baseline in 30-second Chair stand repetitions at 6 weeks
number of full stands from a seated position completed in 30seconds.
Measured: Baseline and 6 weeks.
Change from baseline in handgrip strength at 6 weeks
maximum voluntary isometric handgrip strength measured using handheld dynamometer instrutherm DM-90 (Brazil), expressed in kilogram-force (kgf).
Measured: Baseline and 6 weeks.
Change from baseline in isometric knee extensor strength at 6 weeks
Maximum isometric knee extensor strength measured at 90º knee angle using horizontal leg press, expressed in kilogram-force (kgf).
Measured: Baseline and 6 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Mar 2026
- Study start1 Mar 2026
- Primary completion30 Jun 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HypertensionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Raphael Mendes Ritti Dias
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Raphael Mendes Ritti Dias, University of Nove de Julho
- Investigators
- Raphael M Ritti-Dias, PhD, Study chair, University of Nove de Julho
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07448818
- Sponsor's protocol ID
- DYNISO-HT
- Acronym
- Dynamic and Is
- Status last verified
- Apr 2026
- First submitted
- 16 Feb 2026
- Last updated
- 1 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Data will be anonymized and shared after the completion of the study and publication of the main results
Study at a glance
From the registry record, last updated by the sponsor on 1 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Dynamic Strength Training and Isometric Strength Training on Cardiovascular Health Indicators, Mental Health, and Neuromuscular Fitness in Older Adults With Hypertension: A Feasibility Study
- ClinicalTrials.gov ID
- NCT07448818
- Acronym / sponsor ID
- Dynamic and Is / DYNISO-HT
- Conditions
- Hypertension, Elderly (People Aged 65 or More)
- Keywords
- Hypertension, Strength training, Resistance training, Cardiovascular health, blood pressure, old age
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Raphael Mendes Ritti DiasUniversity, hospital or other
- Study start
- 1 Mar 2026 (actual)
- Primary completion
- 30 Jun 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 4 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Participants will be randomly assigned to one of the two training modalities and will complete supervised exercise sessions throughout the intervention period. The study will provide preliminary evidence regarding the safety, acceptability, and potential impact of each training modality on health outcomes in this population.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Dynamic Strength Training | Active comparator | Behavioral: Dynamic Strength TrainingThe subjects randomized to this group will perform two supervised dynamic strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes. |
| Isometric Strength Training | Experimental | Behavioral: Isometric Strength TrainingThe subjects randomized to this group will perform two supervised isometric strength training sessions per week for 6 weeks, each session lasting approximately 30 minutes. |
| Control | Other | Behavioral: No supervised intervention ControlNo supervised training will be provided. Participants in this group will not receive any exercise intervention during the 6-week study period, but they will be stimulated to be active. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Diagnosis of arterial hypertension and currently taking antihypertensive medication
- Age 60 years or older
- Resting blood pressure below 160/95 mmHg
- No high cardiovascular risk according to the American College of Sports Medicine criteria (for participants with type 2 diabetes, glycemic control with fasting glucose <100 mg/dL and postprandial glucose <140 mg/dL)
- Not participating in a structured exercise program for more than three months
Key exclusion criteria (4 listed)
- Presence of acute illnesses, such as influenza, sinusitis, gastroenteritis, urinary tract infection, fever, inflammatory processes, or any clinical condition requiring rest or that may compromise safety during assessments or training.
- Decompensated clinical conditions, including: Blood pressure spikes, Chest pain, Uncontrolled arrhythmias, Shortness of breath at rest, Asthma exacerbations, Decompensated diabetes mellitus, characterized by Persistently elevated blood glucose levels (fasting glucose > 180 mg/dL or postprandial glucose > 250 mg/dL)
- Irregular use of medication
- Any unstable clinical condition or condition that represents additional risk for the practice of physical exercise.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Dynamic Strength TrainingThe experimental group will perform dynamic strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group movements, initially 2 sets of 15 repetitions (Borg 4-6), progressing to 3 sets of 10 repetitions (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for ~30 minutes at moderate intensity. | Behavioural | Dynamic Strength Training |
| Isometric Strength TrainingThe experimental group will perform isometric strength exercises targeting major muscle groups, progressing in intensity and volume over the 6 weeks. Exercises include 8 major muscle group contractions, initially 2 sets of 60 seconds (Borg 4-6), progressing to 3 sets of 40 seconds (Borg 5-7) from week 5. Participants will also be advised to perform non-supervised walking 3-5 times per week for ~30 minutes at moderate intensity. | Behavioural | Isometric Strength Training |
| No supervised intervention ControlThis group serves as a control and will not perform any structured exercise program. | Behavioural | Control |
Primary outcome
Recruitment rate
Time frame: Baseline and 6 weeks
Proportion of enrolled participants relative to the total number of eligible individuals contacted. Reported as a percentage.
Adherence to training sessions
Time frame: During 6 weeks
Percentage of completed training sessions relative to the total number of planned sessions over the 6-week intervention period.
Retention rate
Time frame: During 6 weeks
Proportion of participants who complete the full 6-week intervention
Fidelity to exercise protocol
Time frame: Duiring 6 weeks
Percentage of exercises performed according to the prescribed protocol parameters, including load, repetitions, and time under tension.
Acceptability of the intervention
Time frame: During 6 weeks
Acceptability assessed through a structured satisfaction questionnaire, scored from 0 to 10, administered at the end of the 6-week intervention
Occurrence of adverse events
Time frame: During 6 weeks
Number of intervention-related adverse events, classified as mild, moderate, or severe
17 secondary outcomes
Change from baseline in Clinical resting blood pressure at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Home blood pressure monitoring at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Flow-mediated dilation at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Standard deviation of normal R-R intervals at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Arterial stiffness at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Depressive symptoms at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Anxiety symptoms at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Six-Minute Walk Test distance at 6 weeks
Time frame: Baseline and 6 weeks
Change from baseline in Root mean square of successive differences between R-R intervals at 6 weeks
Time frame: Baseline to 6 weeks
Change from baseline in Proportion of successive R-R intervals differing by more than 50 milliseconds at 6 weeks
Time frame: Baseline to 6 weeks.
Change from baseline in Low-frequency spectral power at 6 weeks
Time frame: Baseline to 6 weeks.
Change from baseline in high-frequency power at 6 weeks
Time frame: Baseline to 6 weeks.
Change from baseline in Low-frequency to high-frequency ratio at 6 weeks
Time frame: Baseline to 6 weeks.
Change from baseline in Timed Up and Go Time at 6 weeks
Time frame: Baseline and 6 weeks.
Change from baseline in 30-second Chair stand repetitions at 6 weeks
Time frame: Baseline and 6 weeks.
Change from baseline in handgrip strength at 6 weeks
Time frame: Baseline and 6 weeks.
Change from baseline in isometric knee extensor strength at 6 weeks
Time frame: Baseline and 6 weeks.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 May 2026.
- Individual participant dataSharing planned: Yes. Data will be anonymized and shared after the completion of the study and publication of the main results
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Raphael M Ritti-Dias, PhD study chair
University of Nove de Julho
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Dynamic Strength Training and Isometric Strength Training in people with Hypertension and Elderly (People Aged 65 or More), run by Raphael Mendes Ritti Dias at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Adão Luis Monte L Monte, Ms (+55 11 94666 5213, adaoluiz8@outlook.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Recruitment rate (time frame: Baseline and 6 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 May 2026.