Anterior Clinoid Process PneumatizationNCT07451080
Impact of Anterior Clinoid Process Pneumatization on Optic Canal and Retinal Nerve Fiber Layer
An observational study of Anterior Clinoid Process Pneumatization and Optic Canal Morphometry, run by Elazıg Fethi Sekin Sehir Hastanesi at 1 site in Turkey (Türkiye).
Trial summary
This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Anterior Clinoid Process Pneumatization, Optic Canal Morphometry, Retinal Nerve Fiber Layer Thickness
- How many people
- 100 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Aug 2025to 1 Feb 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This study population consists of adult patients aged 18 to 65 years who underwent both head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations at Elazığ Fethi Sekin City Hospital between August 2018 and July 2025. Patients will be retrospectively identified through the hospital electronic medical record and PACS archive systems. Participants will be categorized based on the presence or absence of anterior clinoid process (ACP) pneumatization on CT imaging.
Who may be able to join
- Adults aged 18 to 65 years.
- Availability of head and neck computed tomography (CT) imaging in the hospital archive.
- Availability of optical coherence tomography (OCT) examination records in the hospital archive.
- CT and OCT examinations performed between August 2018 and July 2025.
Who cannot join
- Age <18 years or >65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve).
- Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Evaluation of the Effects of Anterior Clinoid Process Pneumatization on Optic Canal Morphometry and Retinal Nerve Fiber Layer Thickness Using Computed Tomography and Optical Coherence Tomography: A Retrospective Cohort Study
This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve.
Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.
- Conditions
- Anterior Clinoid Process Pneumatization, Optic Canal Morphometry, Retinal Nerve Fiber Layer Thickness
- Keywords
- Anterior Clinoid Process, Pneumatization, Optic Canal, Optic Canal Morphometry, Optical Coherence Tomography, Computed Tomography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| ACP Pneumatization Present | Participants with radiologically confirmed anterior clinoid process (ACP) pneumatization identified on computed tomography imaging. | |
| ACP Pneumatization Absent | Participants without radiological evidence of anterior clinoid process (ACP) pneumatization on computed tomography imaging. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Optic Canal Length
Optic canal length measured on computed tomography (CT) images.
Measured: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Optic Canal Mean Diameter
Optic canal mean diameter measured on computed tomography (CT) images.
Measured: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Retinal Nerve Fiber Layer (RNFL) Thickness
Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).
Measured: Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Mar 2026
- Study start1 Aug 2025
- Primary completion25 Jan 2026
- Study completion1 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Anterior Clinoid Process PneumatizationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Elazıg Fethi Sekin Sehir Hastanesi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sinem Keser, Elazıg Fethi Sekin Sehir Hastanesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07451080
- Sponsor's protocol ID
- EFSH-NIEC-2025-13-23
- Status last verified
- Feb 2026
- First submitted
- 20 Feb 2026
- Last updated
- 5 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effects of Anterior Clinoid Process Pneumatization on Optic Canal Morphometry and Retinal Nerve Fiber Layer Thickness Using Computed Tomography and Optical Coherence Tomography: A Retrospective Cohort Study
- ClinicalTrials.gov ID
- NCT07451080
- Acronym / sponsor ID
- EFSH-NIEC-2025-13-23
- Conditions
- Anterior Clinoid Process Pneumatization, Optic Canal Morphometry, Retinal Nerve Fiber Layer Thickness
- Keywords
- Anterior Clinoid Process, Pneumatization, Optic Canal, Optic Canal Morphometry, Optical Coherence Tomography, Computed Tomography
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Elazıg Fethi Sekin Sehir HastanesiUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 25 Jan 2026 (actual)
- Study completion
- 1 Feb 2026 (actual)
- First posted
- 5 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve.
Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ACP Pneumatization Present | – | –Participants with radiologically confirmed anterior clinoid process (ACP) pneumatization identified on computed tomography imaging. |
| ACP Pneumatization Absent | – | –Participants without radiological evidence of anterior clinoid process (ACP) pneumatization on computed tomography imaging. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This study population consists of adult patients aged 18 to 65 years who underwent both head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations at Elazığ Fethi Sekin City Hospital between August 2018 and July 2025. Patients will be retrospectively identified through the hospital electronic medical record and PACS archive systems. Participants will be categorized based on the presence or absence of anterior clinoid process (ACP) pneumatization on CT imaging.
Key inclusion criteria (4 listed)
- Adults aged 18 to 65 years.
- Availability of head and neck computed tomography (CT) imaging in the hospital archive.
- Availability of optical coherence tomography (OCT) examination records in the hospital archive.
- CT and OCT examinations performed between August 2018 and July 2025.
Key exclusion criteria (2 listed)
- Age <18 years or >65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve).
- Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Optic Canal Length
Time frame: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Optic canal length measured on computed tomography (CT) images.
Optic Canal Mean Diameter
Time frame: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)
Optic canal mean diameter measured on computed tomography (CT) images.
Retinal Nerve Fiber Layer (RNFL) Thickness
Time frame: Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)
Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Mar 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Anterior Clinoid Process Pneumatization and Optic Canal Morphometry, run by Elazıg Fethi Sekin Sehir Hastanesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Optic Canal Length (time frame: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Mar 2026.