The Impact of Extreme Physical Exertion on HealthNCT07451717
A Comprehensive Interdisciplinary Assessment of the Impact of Ultramarathons on the Health of Middle-aged and Older Amateur Runners - SUPERMARATON 2025 Project
An observational study of The Impact of Extreme Physical Exertion on Health and The Impact of Extreme Physical Exertion on Glucose, run by Medical University of Gdansk at 1 site in Poland.
Trial summary
The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. Read more about this study
- Who is it for?
- Ages 44 years and olderHealthy volunteers can take part
- Conditions the study is for
- The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Glucose, The Impact of Extreme Physical Exertion on Respiratory System
- What is being tested?
- Blood and urine analysis
- How many people
- 52 participants
- Where
- 1 sitePoland
- Study dates
- 14 Aug 2025to 15 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 44 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Amateur ultramarathon runners
Who may be able to join
- Age ≥ 45 years
- Planned completion of a 100 km race during a specific sporting event
- Willingness to participate in all research procedures included in the project
Who cannot join
- Refusal to participate in the project
- Occurrence of serious illnesses that may pose a risk to the athlete
- Detection of significant changes in health status during the initial examination that may be associated with complications during exercise (participants were advised against participating in the race and were not included in the study group)
Trial locations and contacts
1 site in 1 country.
About this study
The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. A multi-module strategy was employed, including assessment of metabolic, circulatory, respiratory, neurological, dental, psychological, and musculoskeletal functions.
- Conditions
- The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Glucose, The Impact of Extreme Physical Exertion on Respiratory System, The Impact of Extreme Physical Exertion on Joints and Muscles, The Impact of Extreme Physical Exertion on Cardiovascular System, The Impact of Extreme Physical Exertion on Kidney Function and Water-electrolytes Balance
- Being tested
- Blood and urine analysis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood and urine analysisDiagnostic test
Blood and urine analysis
| Study group | Role | What they receive |
|---|---|---|
| Amateurs runners age 45+ | Amateurs runners age 45+ who will participate in a 100km ultramarathon Receives: Diagnostic Test: Blood and urine analysis |
What is being measured
The primary outcome is the main question the study is designed to answer.
Changes in blood and urine results
NT-proBNP in pg/ml
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Troponin I
Troponin I in ng/L
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Glucose
Glucose in mg/dl
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Insulin
Insulin in ulU/ml
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Hemoglobin A1c
Hemoglobin A1c in %
Measured: Blood samples were collected one day before the start
Lipid profile
LDL cholesterol, HDL cholesterol, total cholesterol and Triglicerydes in mg/dl
Measured: Blood samples were collected one day before the start
Creatinine kinase
Creatinine kinase in U/l
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Uric acid
Uric acid in mg/dl
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Vitamine D3
Vitamine D3 in ng/ml
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Serum iron
serum iron in ug/dl
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Ferritin
Ferritin in ng/ml
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Creatinine
Creatinine in mg/dl
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Sodium
Sodium in mmol/l
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Potassium
Potassium in mmol/l
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
C-reative protein
C-reractive protein in mg/l
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Liver enzymes
alanine aminotransferase, aspartate aminotransferase in U/L
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Bilirubin
Bilirubin in mg/dl
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Albumin
Albumin in g/l
Measured: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Cortisol in saline
Cortisol in saline in ug/dL
Measured: Saline smaples were taken one day before the race and within one hour after finishing the race
FSH and LH
FSH and LH
Measured: Blood samples were collected one day before the start and within 1 hour after finishing the race
Estradiol
Estradiol in pg/ml
Measured: Blood samples were collected one day before the start and within 1 hour after finishing the race
Testosterone
Testosterone in ng/dl
Measured: Blood samples were collected one day before the start and within 1 hour after finishing the race
SHGB
SHGB in nmol/l
Measured: Blood samples were collected one day before the start and within 1 hour after finishing the race
Cortisole and progestrone
Cortisole and progestrone in ng/ml
Measured: Blood samples were collected one day before the start and within 1 hour after finishing the race
Continuous glucose monitoring
continuous glucose monitoring using FS libre
Measured: Sensor was placed one day before the race and was measuring glucose for 14 days
Weight
Weight in kilograms
Measured: Measurements were taken 1 day before and within 1 hour after finishing the race
Height
Height in cm
Measured: Measurements were taken 1 day before the race
Body composition
Body composition using Tanita BC-545N - parameters in %
Measured: Measurements have been made 1 day before the race and within 1 hour after finishing the race
ECG
ECG measurements
Measured: Measurements have been made 1 day before the race and within 1 hour after finishing the race
Echocardiography
Echocardiography
Measured: Measurements have been made 1 day before the race and within 1 hour after finishing the race
ECG Holter
ECG Holter
Measured: ECG Holter was connected 1 day before the race and was checking heart rate and ecg within following 14 days
Neurological examination
Neurological examination
Measured: Examination was performed 1 day before the race and within 1 hour after finishing the race
Dental examination
Dental examination
Measured: Examination was performed 1 day before the race and within 1 hour after finishing the race
Ortophedic examination
Ortophedic examination
Measured: Examination was performed 1 day before the race and within 1 hour after finishing the race
Spirometry
Spirometry
Measured: Examination was performed 1 day before the race and within 1 hour after finishing the race
Psychological examination
Psychological examination
Measured: Examination was performed 1 day before the race and within 1 hour after finishing the race
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Mar 2026
- Study start14 Aug 2025
- Primary completion26 Aug 2025
- Study completion15 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for The Impact of Extreme Physical Exertion on HealthStudies of the same condition, open and under way.
- More trials run by Medical University of GdanskThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 52 participants (actual)
Sponsor and investigators
- Lead sponsor
- Medical University of Gdansk
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07451717
- Sponsor's protocol ID
- KB/186/2025
- Status last verified
- Feb 2026
- First submitted
- 15 Feb 2026
- Last updated
- 5 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006 Mar 14;174(6):801-9. doi: 10.1503/cmaj.051351.
PubMed 16534088
Study at a glance
From the registry record, last updated by the sponsor on 5 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comprehensive Interdisciplinary Assessment of the Impact of Ultramarathons on the Health of Middle-aged and Older Amateur Runners - SUPERMARATON 2025 Project
- ClinicalTrials.gov ID
- NCT07451717
- Acronym / sponsor ID
- KB/186/2025
- Conditions
- The Impact of Extreme Physical Exertion on Health, The Impact of Extreme Physical Exertion on Glucose, The Impact of Extreme Physical Exertion on Respiratory System, The Impact of Extreme Physical Exertion on Joints and Muscles, The Impact of Extreme Physical Exertion on Cardiovascular System, The Impact of Extreme Physical Exertion on Kidney Function and Water-electrolytes Balance
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 52 participants (actual)
- Lead sponsor
- Medical University of GdanskUniversity, hospital or other
- Study start
- 14 Aug 2025 (actual)
- Primary completion
- 26 Aug 2025 (actual)
- Study completion
- 15 Dec 2025 (actual)
- First posted
- 5 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The "Supermarathon 2025" study was designed as a prospective, interdisciplinary field study to assess the impact of extreme physical exertion, such as a 100-kilometer ultramarathon, on the health of individuals aged ≥ 45 years. A multi-module strategy was employed, including assessment of metabolic, circulatory, respiratory, neurological, dental, psychological, and musculoskeletal functions.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Amateurs runners age 45+ | – | Diagnostic Test: Blood and urine analysisAmateurs runners age 45+ who will participate in a 100km ultramarathon |
Who may qualify
- Ages
- 44 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Amateur ultramarathon runners
Key inclusion criteria (3 listed)
- Age ≥ 45 years
- Planned completion of a 100 km race during a specific sporting event
- Willingness to participate in all research procedures included in the project
Key exclusion criteria (3 listed)
- Refusal to participate in the project
- Occurrence of serious illnesses that may pose a risk to the athlete
- Detection of significant changes in health status during the initial examination that may be associated with complications during exercise (participants were advised against participating in the race and were not included in the study group)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood and urine analysisBlood and urine analysis | Diagnostic test | Amateurs runners age 45+ |
Primary outcome
Changes in blood and urine results
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
NT-proBNP in pg/ml
Troponin I
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Troponin I in ng/L
Glucose
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Glucose in mg/dl
Insulin
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Insulin in ulU/ml
Hemoglobin A1c
Time frame: Blood samples were collected one day before the start
Hemoglobin A1c in %
Lipid profile
Time frame: Blood samples were collected one day before the start
LDL cholesterol, HDL cholesterol, total cholesterol and Triglicerydes in mg/dl
Creatinine kinase
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Creatinine kinase in U/l
Uric acid
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Uric acid in mg/dl
Vitamine D3
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Vitamine D3 in ng/ml
Serum iron
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
serum iron in ug/dl
Ferritin
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Ferritin in ng/ml
Creatinine
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Creatinine in mg/dl
Sodium
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Sodium in mmol/l
Potassium
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Potassium in mmol/l
C-reative protein
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
C-reractive protein in mg/l
Liver enzymes
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
alanine aminotransferase, aspartate aminotransferase in U/L
Bilirubin
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Bilirubin in mg/dl
Albumin
Time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.
Albumin in g/l
Cortisol in saline
Time frame: Saline smaples were taken one day before the race and within one hour after finishing the race
Cortisol in saline in ug/dL
FSH and LH
Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race
FSH and LH
Estradiol
Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race
Estradiol in pg/ml
Testosterone
Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race
Testosterone in ng/dl
SHGB
Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race
SHGB in nmol/l
Cortisole and progestrone
Time frame: Blood samples were collected one day before the start and within 1 hour after finishing the race
Cortisole and progestrone in ng/ml
Continuous glucose monitoring
Time frame: Sensor was placed one day before the race and was measuring glucose for 14 days
continuous glucose monitoring using FS libre
Weight
Time frame: Measurements were taken 1 day before and within 1 hour after finishing the race
Weight in kilograms
Height
Time frame: Measurements were taken 1 day before the race
Height in cm
Body composition
Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race
Body composition using Tanita BC-545N - parameters in %
ECG
Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race
ECG measurements
Echocardiography
Time frame: Measurements have been made 1 day before the race and within 1 hour after finishing the race
Echocardiography
ECG Holter
Time frame: ECG Holter was connected 1 day before the race and was checking heart rate and ecg within following 14 days
ECG Holter
Neurological examination
Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race
Neurological examination
Dental examination
Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race
Dental examination
Ortophedic examination
Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race
Ortophedic examination
Spirometry
Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race
Spirometry
Psychological examination
Time frame: Examination was performed 1 day before the race and within 1 hour after finishing the race
Psychological examination
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Mar 2026.
- Background: PubMed 16534088Warburton DE, Nicol CW, Bredin SS. Health benefits of physical activity: the evidence. CMAJ. 2006 Mar 14;174(6):801-9. doi: 10.1503/cmaj.051351.
- Individual participant dataSharing planned: Undecided
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of The Impact of Extreme Physical Exertion on Health and The Impact of Extreme Physical Exertion on Glucose, run by Medical University of Gdansk at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Changes in blood and urine results (time frame: Blood and urine samples were collected one day before the start and three times after the start - within 1 hour after finishing the race, after 12-15 hours after finishing the race and five days after finishing the race.). The study lists 36 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07451717, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Mar 2026.