PeriodontitisVECTOR-RCTNCT07452640
Vector® System vs Mini-Five Curettes in Non-Surgical Periodontal Therapy
A study testing Vector® Ultrasonic System and Mini-Five Curettes in people with Periodontitis and Chronic Periodontitis, run by Hacettepe University at 1 site in Turkey (Türkiye).
Trial summary
This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy. Patients diagnosed with periodontitis will be randomly assigned to either ultrasonic instrumentation or manual instrumentation. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Periodontitis, Chronic Periodontitis
- What is being tested?
- Vector® Ultrasonic System and Mini-Five Curettes
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 19 Feb 2026to Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18-65 years Willing to participate and provided written informed consent Presence of single-rooted teeth in both maxilla and mandible with vertical bone defects (radiographic intrabony defect ≥2 mm and probing depth ≥5 mm) Diagnosis of Stage III or Stage IV periodontitis Systemically healthy or Systemically healthy patients or American Society of Anesthesiologists (ASA) physical status I-II.
Who cannot join
- Periodontal treatment within the last 6 months Teeth with furcation involvement Smoking more than 10 cigarettes per day Pregnancy Age under 18 years Patients unwilling to attend regular follow-up visits Previously endodontically treated tooth at the treatment site Poor compliance with oral hygiene instructions Single-rooted teeth with horizontal bone loss extending close to the apical third Teeth with mobility grade II or III Previous flap surgery or regenerative periodontal treatment at the study site
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Hacettepe University Facultyof Dentistry
Ankara
Abdullah Cevdet Akman, Prof. Dr., 03123052217, abdullahcevdet.akman@hacettepe.edu.tr
About this study
Official title: A Randomized Single-Blind Clinical Trial Comparing the Clinical and Radiographic Outcomes of the Vector® Ultrasonic System and Minimally Invasive Hand Instrumentation (Mini-Five Curettes) in Non-Surgical Periodontal Therapy
This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy. Patients diagnosed with periodontitis will be randomly assigned to either ultrasonic instrumentation or manual instrumentation. Clinical periodontal parameters and radiographic bone level changes will be evaluated at baseline, 1, 3, 6, and 12 months. The primary objective is to assess differences in clinical attachment level and probing depth reduction between the two treatment modalities.
Read the detailed description
Periodontitis is a chronic inflammatory disease leading to the destruction of supporting periodontal tissues. Non-surgical periodontal therapy is the first-line treatment and includes mechanical debridement using manual or ultrasonic instruments. The Vector®️ ultrasonic system is designed to provide minimally invasive debridement with reduced trauma to root surfaces and surrounding tissues.
This randomized, controlled, single-blind clinical trial will compare the effectiveness of the Vector®️ system and mini-five curettes in patients diagnosed with periodontitis. Participants will be randomly allocated into two groups: the ultrasonic instrumentation group (Vector®️ system) and the manual instrumentation group (mini-five curettes).
Clinical parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) will be recorded at baseline and at 1, 3, 6, and 12 months. Standardized radiographic examinations will be performed at baseline, 6 months, and 12 months to evaluate radiographic bone level changes.
The primary outcome measure is the change in clinical attachment level at 12 months. Secondary outcomes include probing depth reduction, bleeding on probing, and radiographic bone level changes.
The study is conducted at Hacettepe University Faculty of Dentistry, Department of Periodontology. Ethical approval has been obtained from the Hacettepe University Clinical Research Ethics Committee.
- Conditions
- Periodontitis, Chronic Periodontitis
- Being tested
- Vector® Ultrasonic System, Mini-Five Curettes
- Keywords
- Non-Surgical Periodontal Therapy • Vector System • Ultrasonic Instrumentation • Mini-Five Curettes • Clinical Attachment Level • Radiographic Bone Loss
- Medical subject headings
- Periodontitis, Chronic Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vector® Ultrasonic SystemDevice
Minimally invasive ultrasonic instrumentation used for non-surgical periodontal therapy.
Mini-Five CurettesDevice
Manual curette instrumentation used for non-surgical periodontal therapy.
| Study group | Role | What they receive |
|---|---|---|
| Vector System Group | Experimental | Participants receive non-surgical periodontal therapy using the Vector®️ ultrasonic system. Receives: Device: Vector® Ultrasonic System |
| Mini-Five Curettes Group | Active comparator | Participants receive non-surgical periodontal therapy using mini-five curettes. Receives: Device: Mini-Five Curettes |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Probing Depth(PD)
Change in periodontal probing depth (in millimeters) from baseline to follow-up after non-surgical periodontal therapy using Vector®️ ultrasonic system compared with mini-five curettes.
Measured: Baseline,1 month, 3 months, 6 months, and 12 months
Change in Radiographic Vertical Bone Defect Depth
Change in radiographic vertical bone defect depth (mm) assessed on standardized radiographs at baseline, 6 months, and 12 months after treatment.
Measured: Baseline, 6 months, and 12 months
Secondary outcomes (1)
Pain Sensitivity(VAS Score)
Pain sensitivity assessed using a visual analog scale (VAS) during and immediately after the treatment session.
Measured: During treatment and immediately after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Mar 2026
- Study start19 Feb 2026
- Primary completionFeb 2027 (estimated)
- Study completionFeb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned to two parallel groups: ultrasonic instrumentation using the Vector®️ system or manual instrumentation using mini-five curettes.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 36 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hacettepe University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Serife Kosar, Hacettepe University
- Investigators
- Abdullah Cevdet Akman, Principal investigator, Hacettepe University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07452640
- Sponsor's protocol ID
- THD-2026-22611
- Acronym
- VECTOR-RCT
- Status last verified
- Mar 2026
- First submitted
- 1 Mar 2026
- Last updated
- 5 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Single-Blind Clinical Trial Comparing the Clinical and Radiographic Outcomes of the Vector® Ultrasonic System and Minimally Invasive Hand Instrumentation (Mini-Five Curettes) in Non-Surgical Periodontal Therapy
- ClinicalTrials.gov ID
- NCT07452640
- Acronym / sponsor ID
- VECTOR-RCT / THD-2026-22611
- Conditions
- Periodontitis, Chronic Periodontitis
- Keywords
- Non-Surgical Periodontal Therapy • Vector System • Ultrasonic Instrumentation • Mini-Five Curettes • Clinical Attachment Level • Radiographic Bone Loss
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 36 participants (estimated)
- Lead sponsor
- Hacettepe UniversityUniversity, hospital or other
- Study start
- 19 Feb 2026 (actual)
- Primary completion
- Feb 2027 (estimated)
- Study completion
- Feb 2028 (estimated)
- First posted
- 5 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial aims to compare the clinical and radiographic outcomes of the Vector®️ ultrasonic system and mini-five curettes in non-surgical periodontal therapy. Patients diagnosed with periodontitis will be randomly assigned to either ultrasonic instrumentation or manual instrumentation. Clinical periodontal parameters and radiographic bone level changes will be evaluated at baseline, 1, 3, 6, and 12 months. The primary objective is to assess differences in clinical attachment level and probing depth reduction between the two treatment modalities.
Detailed description
Periodontitis is a chronic inflammatory disease leading to the destruction of supporting periodontal tissues. Non-surgical periodontal therapy is the first-line treatment and includes mechanical debridement using manual or ultrasonic instruments. The Vector®️ ultrasonic system is designed to provide minimally invasive debridement with reduced trauma to root surfaces and surrounding tissues.
This randomized, controlled, single-blind clinical trial will compare the effectiveness of the Vector®️ system and mini-five curettes in patients diagnosed with periodontitis. Participants will be randomly allocated into two groups: the ultrasonic instrumentation group (Vector®️ system) and the manual instrumentation group (mini-five curettes).
Clinical parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) will be recorded at baseline and at 1, 3, 6, and 12 months. Standardized radiographic examinations will be performed at baseline, 6 months, and 12 months to evaluate radiographic bone level changes.
The primary outcome measure is the change in clinical attachment level at 12 months. Secondary outcomes include probing depth reduction, bleeding on probing, and radiographic bone level changes.
The study is conducted at Hacettepe University Faculty of Dentistry, Department of Periodontology. Ethical approval has been obtained from the Hacettepe University Clinical Research Ethics Committee.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned to two parallel groups: ultrasonic instrumentation using the Vector®️ system or manual instrumentation using mini-five curettes.
| Arm | Type | Receives |
|---|---|---|
| Vector System Group | Experimental | Device: Vector® Ultrasonic SystemParticipants receive non-surgical periodontal therapy using the Vector®️ ultrasonic system. |
| Mini-Five Curettes Group | Active comparator | Device: Mini-Five CurettesParticipants receive non-surgical periodontal therapy using mini-five curettes. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Adults aged 18-65 years Willing to participate and provided written informed consent Presence of single-rooted teeth in both maxilla and mandible with vertical bone defects (radiographic intrabony defect ≥2 mm and probing depth ≥5 mm) Diagnosis of Stage III or Stage IV periodontitis Systemically healthy or Systemically healthy patients or American Society of Anesthesiologists (ASA) physical status I-II.
Key exclusion criteria (1 listed)
- Periodontal treatment within the last 6 months Teeth with furcation involvement Smoking more than 10 cigarettes per day Pregnancy Age under 18 years Patients unwilling to attend regular follow-up visits Previously endodontically treated tooth at the treatment site Poor compliance with oral hygiene instructions Single-rooted teeth with horizontal bone loss extending close to the apical third Teeth with mobility grade II or III Previous flap surgery or regenerative periodontal treatment at the study site
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vector® Ultrasonic SystemMinimally invasive ultrasonic instrumentation used for non-surgical periodontal therapy. | Device | Vector System Group |
| Mini-Five CurettesManual curette instrumentation used for non-surgical periodontal therapy. | Device | Mini-Five Curettes Group |
Primary outcome
Change in Probing Depth(PD)
Time frame: Baseline,1 month, 3 months, 6 months, and 12 months
Change in periodontal probing depth (in millimeters) from baseline to follow-up after non-surgical periodontal therapy using Vector®️ ultrasonic system compared with mini-five curettes.
Change in Radiographic Vertical Bone Defect Depth
Time frame: Baseline, 6 months, and 12 months
Change in radiographic vertical bone defect depth (mm) assessed on standardized radiographs at baseline, 6 months, and 12 months after treatment.
1 secondary outcome
Pain Sensitivity(VAS Score)
Time frame: During treatment and immediately after treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hacettepe University Facultyof Dentistry
Ankara, Turkey (Türkiye)
Abdullah Cevdet Akman principal investigator
Hacettepe University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vector® Ultrasonic System and Mini-Five Curettes in people with Periodontitis and Chronic Periodontitis, run by Hacettepe University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 5 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Probing Depth(PD) (time frame: Baseline,1 month, 3 months, 6 months, and 12 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Mar 2026.