Chronic PainpatientPREFNCT07453524
Assessing Chronic Pain Patient Preferences
A study testing Patient questionnaire in people with Chronic Pain, run by Université Catholique de Louvain at 1 site in Belgium.
Trial summary
The goal of this study is to ask chronic pain patients their preferences regarding which side effects of pain medications are least acceptable in relation to their pain relief benefits. This information may help in the selection of improved treatment options in the future. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Pain
- What is being tested?
- Patient questionnaire
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteBelgium
- Study dates
- 15 Mar 2026to 31 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged over 18 years.
- Being treated with pain medication.
- (Chronic-)Pain for at least 3 months.
- Capacity to understand and provide an informed consent form.
Who cannot join
- Insufficient French or English language skills.
- Epilepsy treated by an anti-epileptic.
- Alzheimer's disease.
- Parkinson's disease
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Belgium1 site, 1 recruiting
- Recruiting
UCLouvain/IONS
Brussels, 1200
André Mouraux, 0032 2 436 19 15, andre.mouraux@uclouvain.be
About this study
Official title: Assessing Chronic Pain Patient Preferences Regarding the Analgesic Effect Relative to the Side Effects of Analgesic Drugs
The goal of this study is to ask chronic pain patients their preferences regarding which side effects of pain medications are least acceptable in relation to their pain relief benefits. This information may help in the selection of improved treatment options in the future.
- Conditions
- Chronic Pain
- Being tested
- Patient questionnaire
- Medical subject headings
- Chronic Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Patient questionnaireOther
Online patient questionnaire that assesses multiple aspects such as current analgesic use, side effect burden, treatment satisfaction and patient preferences.
| Study group | Role | What they receive |
|---|---|---|
| Chronic pain patients | Other | Not described Receives: Other: Patient questionnaire |
What is being measured
The primary outcome is the main question the study is designed to answer.
Chronic pain patient preferences of pain medications regarding pain relief relative to the side effects using numeric rating scales (adaptation of the outcome prioritization tool).
Using numeric rating scales from 0 to 10 (adaptation of the outcome prioritization tool) to assess patient perceived importance of analgesic effect relative to not having the following side effects: fatigue, drowsiness (sleepiness), dizziness, difficulty concentrating, nausea, constipation (difficulty passing stools), dry mouth, unintentional weight gain, addiction (medication craving). Higher scores mean the specific outcome is a higher priority for the participant.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Secondary outcomes (11)
Analgesic side effect burden measured by numeric rating scales (NRS)
Using numeric rating scales, from 0 to 10, to assess current burden of the following analgesic side effects: fatigue, drowsiness (sleepiness), dizziness, difficulty concentrating, nausea, constipation (difficulty passing stools), dry mouth, unintentional weight gain, addiction (medication craving). Higher scores mean being more affected by the side effects.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Patient pain levels in the last 24 hours and pain body location and its impact on functioning measured by the Brief Pain Inventory short form (BPI-SF).
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Overall pain levels in the past 7 days measured by a numeric rating scale.
Numeric rating scale from 0 to 10, with higher scores meaning higher pain levels.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Overall sleep quality in the past 7 days measured by a numeric rating scale.
Numeric rating scale from 0 to 10, with higher scores meaning better sleep.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Satisfaction of pain treatment will be assessed by select items from the PTSS
Patient treatment satisfaction will be assessed using 6 selected items from the Pain Treatment Satisfaction Scale (PTSS). The 6 items using 5-point Likert scales assess satisfaction of the time that it takes their pain medication to work, level or amount of pain relief, duration of pain relief, overall satisfaction, and to what extend the level of pain relief meet their expectations.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Evaluating Patient characteristics
Patient characteristics including demographics and which pain type/diagnosis and medications and dose are used including alternative/supplementary treatments.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
MacArthur Scale of Subjective Social Status assessing subjective social status
Single-item measure, on a scale from 1 to 10, that assesses a person's perceived rank relative to others with a higher score meaning a higher rank.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Single Item Global Quality of Life Scale (SIG-QoL)
Assessing global quality of life through a Numerical Rating Scale on a scale from 0 to 100 that includes 11 descriptive markers where a higher scores means a better QOL.
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Patient Health Questionnaire-4 (PHQ-4) is used to measure anxiety and depression
The PHQ-4 uses a 4-point Likert scale (Not at all, Several days, More than half the days, Nearly every day).
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Current Opioid Misuse Measure - 9 items (COMM-9) is used to identify current aberrant opioid-related behavior in chronic pain patients on long-term opioid therapy
The COMM-9 uses a 5-point Likert scale (Never, Seldom, Sometimes, Often, Very often).
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
PROMIS Item Bank v2.0 - Cognitive Function- Short Form 4a assesses patient-perceived cognitive deficits.
The PROMIS Item Bank v2.0 - Cognitive Function- Short Form 4a uses a 5-point Likert scale (Never, Rarely (Once), Sometimes (Two or three times), Often (About once a day), Very often (Several times a day)).
Measured: Single measure at a time selected by the participant within the study period (up to 15 months).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2026
- Study start15 Mar 2026
- Primary completion31 Jul 2027 (estimated)
- Study completion31 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic PainStudies of the same condition, open and under way.
- More trials run by Université Catholique de LouvainThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Université Catholique de Louvain
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07453524
- Sponsor's protocol ID
- QSPainRelief-PatientPref
- Acronym
- patientPREF
- Status last verified
- Mar 2026
- First submitted
- 18 Aug 2025
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing Chronic Pain Patient Preferences Regarding the Analgesic Effect Relative to the Side Effects of Analgesic Drugs
- ClinicalTrials.gov ID
- NCT07453524
- Acronym / sponsor ID
- patientPREF / QSPainRelief-PatientPref
- Conditions
- Chronic Pain
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Université Catholique de LouvainUniversity, hospital or other
- Study start
- 15 Mar 2026 (actual)
- Primary completion
- 31 Jul 2027 (estimated)
- Study completion
- 31 Dec 2027 (estimated)
- First posted
- 6 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to ask chronic pain patients their preferences regarding which side effects of pain medications are least acceptable in relation to their pain relief benefits. This information may help in the selection of improved treatment options in the future.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Chronic pain patients | Other | Other: Patient questionnaire |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Aged over 18 years.
- Being treated with pain medication.
- (Chronic-)Pain for at least 3 months.
- Capacity to understand and provide an informed consent form.
Key exclusion criteria (4 listed)
- Insufficient French or English language skills.
- Epilepsy treated by an anti-epileptic.
- Alzheimer's disease.
- Parkinson's disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Patient questionnaireOnline patient questionnaire that assesses multiple aspects such as current analgesic use, side effect burden, treatment satisfaction and patient preferences. | Other | Chronic pain patients |
Primary outcome
Chronic pain patient preferences of pain medications regarding pain relief relative to the side effects using numeric rating scales (adaptation of the outcome prioritization tool).
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Using numeric rating scales from 0 to 10 (adaptation of the outcome prioritization tool) to assess patient perceived importance of analgesic effect relative to not having the following side effects: fatigue, drowsiness (sleepiness), dizziness, difficulty concentrating, nausea, constipation (difficulty passing stools), dry mouth, unintentional weight gain, addiction (medication craving). Higher scores mean the specific outcome is a higher priority for the participant.
11 secondary outcomes
Analgesic side effect burden measured by numeric rating scales (NRS)
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Patient pain levels in the last 24 hours and pain body location and its impact on functioning measured by the Brief Pain Inventory short form (BPI-SF).
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Overall pain levels in the past 7 days measured by a numeric rating scale.
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Overall sleep quality in the past 7 days measured by a numeric rating scale.
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Satisfaction of pain treatment will be assessed by select items from the PTSS
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Evaluating Patient characteristics
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
MacArthur Scale of Subjective Social Status assessing subjective social status
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Single Item Global Quality of Life Scale (SIG-QoL)
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Patient Health Questionnaire-4 (PHQ-4) is used to measure anxiety and depression
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Current Opioid Misuse Measure - 9 items (COMM-9) is used to identify current aberrant opioid-related behavior in chronic pain patients on long-term opioid therapy
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
PROMIS Item Bank v2.0 - Cognitive Function- Short Form 4a assesses patient-perceived cognitive deficits.
Time frame: Single measure at a time selected by the participant within the study period (up to 15 months).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2026.
- Individual participant dataSharing planned: No
Related trials for Chronic Pain
RecruitingObservational study
Quality of Life and Pain After Appendectomy in Children
Chronic Pain, Postoperative, Quality of Life
Recruiting
SENECA - Smart Therapies for Chronic Pain
Chronic Low Back Pain (CLBP)
RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Osteoarthritis, Knee, Chronic Pain
Not yet recruiting
Effects of Expectancy and Mindfulness Instructions on Chronic Pain
Chronic Pain
RecruitingPhase 2
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
Chronic Pain, Low Back Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Patient questionnaire in people with Chronic Pain, run by Université Catholique de Louvain at 1 site in Belgium.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Chronic pain patient preferences of pain medications regarding pain relief relative to the side effects using numeric rating scales (adaptation of the outcome prioritization tool). (time frame: Single measure at a time selected by the participant within the study period (up to 15 months).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2026.