Motor LearningStimNovoLearnNCT07455461
Cortical Excitability During de Novo Motor Learning
A study testing De novo motor learning in people with Motor Learning and Corticospinal Excitability, run by Universite du Littoral Cote d'Opale at 1 site in France.
Trial summary
De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Motor Learning, Corticospinal Excitability
- What is being tested?
- De novo motor learning
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- 25 Feb 2026to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- right-handed
- healthy
- having signed an informed consent form
Who cannot join
- counter-indication to transcranial magnetic stimulation
- pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
Eurasport
Loos, 59120
Pierre D Morel, Doctor, 0033781692692, pierre.morel@univ-littoral.fr
About this study
Official title: Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study
De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Several studies have investigated the plasticity mechanisms underlying motor learning using simple paradigms. The results obtained have been variable, with a major trend toward increased corticospinal excitability, while other results show no increase. We expect to observe a significant increase in excitability and enhanced intracortical reorganization mechanisms within M1 in our subjects during our de novo motor learning sessions.
The primary objective of this study is to measure changes in corticospinal excitability of the motor system across 3 de novo motor learning sessions separated by different time intervals.
The secondary objectives will be: 1) to measure learning across the three practice sessions, 2) to measure changes in inhibition and facilitation across the 3 learning sessions, and 3) to measure correlations between subjects' motor performance and corticospinal and intracortical changes.
- Conditions
- Motor Learning, Corticospinal Excitability
- Being tested
- De novo motor learning
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
De novo motor learningBehavioural
Subjects will follow 3 sessions of de-novo motor learning (days 1, 2, 8)
| Study group | Role | What they receive |
|---|---|---|
| Motor learning | Experimental | Subjects follow a de novo motor learning protocol Receives: Behavioral: De novo motor learning |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Motor Evoked Potential (MEP) Amplitude Input-Output Curve Assessed by Single-Pulse TMS
Motor Evoked Potential amplitude (mV) recorded from the target muscle (Abductor Pollicis Brevis) in response to increasing TMS intensities. The parameters of the sigmoid input-output curve will be calculated using a Boltzmann function fit.
Measured: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Change in Short-Interval Intracortical Inhibition (SICI) Assessed by Paired-Pulse TMS
Conditioned MEP amplitude expressed as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at 80% RMT and inter-stimulus interval of 3 ms.
Measured: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Change in Long-Interval Intracortical Inhibition (LICI) Assessed by Paired-Pulse TMS
Conditioned MEP amplitude as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at suprathreshold intensity and inter-stimulus interval of 100ms.
Measured: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Change in Intracortical Facilitation (ICF) Assessed by Paired-Pulse TMS
Conditioned MEP amplitude as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at 80% RMT and an inter-stimulus interval of 10ms.
Measured: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Secondary outcomes (1)
Change in Motor Learning Performance Assessed by Movement Path Length During a 3D Finger-Cursor Task
Path length (mm) of the cursor trajectory during each trial of the motor learning task. Shorter path length indicates more efficient, learned movement.
Measured: During each motor learning session on Day 1, Day 2, and Day 9
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2026
- Study start25 Feb 2026 (estimated)
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Motor LearningStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universite du Littoral Cote d'Opale
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07455461
- Sponsor's protocol ID
- 2023-A02139-36
- Acronym
- StimNovoLearn
- Status last verified
- Feb 2026
- First submitted
- 19 Feb 2026
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study
- ClinicalTrials.gov ID
- NCT07455461
- Acronym / sponsor ID
- StimNovoLearn / 2023-A02139-36
- Conditions
- Motor Learning, Corticospinal Excitability
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Universite du Littoral Cote d'OpaleUniversity, hospital or other
- Study start
- 25 Feb 2026 (estimated)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 6 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
De novo motor learning is a specific learning paradigm that allows investigation of how a new motor skill is learned from scratch. Motor task learning can induce increased corticospinal excitability and reorganization of connectivity observed within the motor cortex (M1). Several studies have investigated the plasticity mechanisms underlying motor learning using simple paradigms. The results obtained have been variable, with a major trend toward increased corticospinal excitability, while other results show no increase. We expect to observe a significant increase in excitability and enhanced intracortical reorganization mechanisms within M1 in our subjects during our de novo motor learning sessions.
The primary objective of this study is to measure changes in corticospinal excitability of the motor system across 3 de novo motor learning sessions separated by different time intervals.
The secondary objectives will be: 1) to measure learning across the three practice sessions, 2) to measure changes in inhibition and facilitation across the 3 learning sessions, and 3) to measure correlations between subjects' motor performance and corticospinal and intracortical changes.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Motor learning | Experimental | Behavioral: De novo motor learningSubjects follow a de novo motor learning protocol |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- right-handed
- healthy
- having signed an informed consent form
Key exclusion criteria (2 listed)
- counter-indication to transcranial magnetic stimulation
- pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| De novo motor learningSubjects will follow 3 sessions of de-novo motor learning (days 1, 2, 8) | Behavioural | Motor learning |
Primary outcome
Change in Motor Evoked Potential (MEP) Amplitude Input-Output Curve Assessed by Single-Pulse TMS
Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Motor Evoked Potential amplitude (mV) recorded from the target muscle (Abductor Pollicis Brevis) in response to increasing TMS intensities. The parameters of the sigmoid input-output curve will be calculated using a Boltzmann function fit.
Change in Short-Interval Intracortical Inhibition (SICI) Assessed by Paired-Pulse TMS
Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Conditioned MEP amplitude expressed as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at 80% RMT and inter-stimulus interval of 3 ms.
Change in Long-Interval Intracortical Inhibition (LICI) Assessed by Paired-Pulse TMS
Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Conditioned MEP amplitude as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at suprathreshold intensity and inter-stimulus interval of 100ms.
Change in Intracortical Facilitation (ICF) Assessed by Paired-Pulse TMS
Time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9
Conditioned MEP amplitude as a ratio of unconditioned MEP amplitude (%), using a conditioning stimulus at 80% RMT and an inter-stimulus interval of 10ms.
1 secondary outcome
Change in Motor Learning Performance Assessed by Movement Path Length During a 3D Finger-Cursor Task
Time frame: During each motor learning session on Day 1, Day 2, and Day 9
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing De novo motor learning in people with Motor Learning and Corticospinal Excitability, run by Universite du Littoral Cote d'Opale at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Pierre D Morel, Dr (0033781692692, pierre.morel@univ-littoral.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Motor Evoked Potential (MEP) Amplitude Input-Output Curve Assessed by Single-Pulse TMS (time frame: Baseline (Day 1, pre-session), immediately post-session on Day 1, pre-session on Day 2, immediately post-session on Day 2, pre-session on Day 9, and immediately post-session on Day 9). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.