GlaucomaNCT07455786
Modified Trabeculectomy After Failure of Combined Phaco With GATT
A study testing Modified trabeculectomy in people with Glaucoma, run by Assiut University at 1 site in Egypt.
Trial summary
These procedures include deep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule. Read more about this study
- Who is it for?
- Ages 21 to 70 years
- Conditions the study is for
- Glaucoma
- What is being tested?
- Modified trabeculectomy
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Apr 2026to 1 Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- All patients had combined phaco surgery with GATT.
- All patients had phaco with goinopuncture.
Who cannot join
- Healthy patient.
- No history of phaco surgery with GATT or goinopuncture.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Assiut univercity
Asyut, 71111
hassan lotfy fahmy, prof, 01015874517 ext. 002, hassaniron1957@gmail.com
About this study
Official title: Modified Trabeculectomy for Management of Early Failure of Combined Phaco With GATT or With Goinopuncture
These procedures include deep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule.
Read the detailed description
Since the advent of GATT or phacogoinotomy as MIGS, ab-externo canaloplasty and NPDS have become essentially obsolete. The ab-interno techniques to vasodilate Schlemm's canal and goniotomy have largely replaced ab-externo canaloplasty.
. Although the GATT procedure and phacogoinotomy is, minimally invasive methods, yet it needs normal functional collector orifice and not respect physiological function of trabecular meshwork,8 as these procedures depend mainly on incision and damage of trabecular meshwork360 degree in GATT 120 in goniotomy, the main disadvantage of these procedures it is not so suitable for narrow angle glaucoma and have many complications as post operative hyphemia with IOP spike, PAS, corneal injury and create cyclodialysis Moreover trabecular meshwork and Schlemm's canal are vital structures can repair themselves through limbal stem cells or even peripheral iris can cover the incision as the part of repair. The main disadvantage is that the trabeculectomy should not be relied upon when the target IOP is in the low teens. Also, these procedures are expensive and need a long learning curve, hyphemia can prevent completion of the operation.
- Conditions
- Glaucoma
- Being tested
- Modified trabeculectomy
- Keywords
- phaco, glaucoma, trabeculectomy
- Medical subject headings
- Glaucoma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Modified trabeculectomyProcedure or surgery
deep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule
| Study group | Role | What they receive |
|---|---|---|
| Modified Trabeculectomy | Experimental | failure of combined phaco with GATT Receives: Procedure: Modified trabeculectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
IOP
Intraocular pressure measurement
Measured: 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2026
- Study start1 Apr 2026 (estimated)
- Primary completion1 Apr 2027 (estimated)
- Study completion1 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for GlaucomaStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hassan Lotfy Fahmy, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07455786
- Sponsor's protocol ID
- 17203288
- Status last verified
- Mar 2026
- First submitted
- 3 Mar 2026
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Modified Trabeculectomy for Management of Early Failure of Combined Phaco With GATT or With Goinopuncture
- ClinicalTrials.gov ID
- NCT07455786
- Acronym / sponsor ID
- 17203288
- Conditions
- Glaucoma
- Keywords
- phaco, glaucoma, trabeculectomy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Apr 2026 (estimated)
- Primary completion
- 1 Apr 2027 (estimated)
- Study completion
- 1 Apr 2027 (estimated)
- First posted
- 6 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
These procedures include deep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule.
Detailed description
Since the advent of GATT or phacogoinotomy as MIGS, ab-externo canaloplasty and NPDS have become essentially obsolete. The ab-interno techniques to vasodilate Schlemm's canal and goniotomy have largely replaced ab-externo canaloplasty.
. Although the GATT procedure and phacogoinotomy is, minimally invasive methods, yet it needs normal functional collector orifice and not respect physiological function of trabecular meshwork,8 as these procedures depend mainly on incision and damage of trabecular meshwork360 degree in GATT 120 in goniotomy, the main disadvantage of these procedures it is not so suitable for narrow angle glaucoma and have many complications as post operative hyphemia with IOP spike, PAS, corneal injury and create cyclodialysis Moreover trabecular meshwork and Schlemm's canal are vital structures can repair themselves through limbal stem cells or even peripheral iris can cover the incision as the part of repair. The main disadvantage is that the trabeculectomy should not be relied upon when the target IOP is in the low teens. Also, these procedures are expensive and need a long learning curve, hyphemia can prevent completion of the operation.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Modified Trabeculectomy | Experimental | Procedure: Modified trabeculectomyfailure of combined phaco with GATT |
Who may qualify
- Ages
- 21 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- All patients had combined phaco surgery with GATT.
- All patients had phaco with goinopuncture.
Key exclusion criteria (2 listed)
- Healthy patient.
- No history of phaco surgery with GATT or goinopuncture.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Modified trabeculectomydeep non-penetrating sclerectomy, viscocanalostomy, and small incision trabeculectomy, avoiding Tenon's capsule | Procedure or surgery | Modified Trabeculectomy |
Primary outcome
IOP
Time frame: 24 hours
Intraocular pressure measurement
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Modified trabeculectomy in people with Glaucoma, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
IOP (time frame: 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.