Systemic InflammationWACNCT07456683
The Effect of Water With Anti-Inflammatory Capabilities on the Inflammatory Response to Heavy Resistance Exercise
A study testing We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks. in people with Systemic Inflammation and Hydration, run by University of Arkansas, Fayetteville at 1 site in United States.
Trial summary
The purpose of this research is to assess the anti-inflammatory effects of berry-flavored water in response to an acute bout of exercise. This investigation is part of a larger collaborative project between the Exercise Science Research Center, the Center for Human Nutrition, and the University of Arkansas Sensory… Read more about this study
- Who is it for?
- Ages 18 to 39 yearsHealthy volunteers can take part
- Conditions the study is for
- Systemic Inflammation, Hydration, Resting Metabolism
- What is being tested?
- We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 17 May 2021to 10 Feb 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 39 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Sedentary to moderately active, as defined by the International Physical Activity Questionnaire (IPAQ)
Who cannot join
- Kidney, liver, cardiac, or immune conditions that may compromise their health Not used to lifting weights more than 1 time per month. Participants identified as being 'high fruit/vegetable consumers' will also be excluded from the study because they habitually consume polyphenols and antioxidants already exhibiting anti-inflammatory effects that would compromise our findings.
- A history of fainting from routine blood draws.
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Arkansas Exercise Science Research Center
Fayetteville, Arkansas, 72701
About this study
The purpose of this research is to assess the anti-inflammatory effects of berry-flavored water in response to an acute bout of exercise. This investigation is part of a larger collaborative project between the Exercise Science Research Center, the Center for Human Nutrition, and the University of Arkansas Sensory Science Center, which seeks to examine the potential of waters infused with naturally occurring bioactive anti-inflammatory volatile compounds to improve overall health. We expect that this water infused with natural bioactive berry volatile compounds will demonstrate preventive physiological benefits in relation to systemic inflammation, including a decreased level of baseline (resting) inflammation and attenuated post-exercise inflammation.
Read the detailed description
Participants will be asked to refrain from eating berries for 48 hours, drinking alcohol for 24 hours and consuming caffeine for 12 hours prior to reporting for their baseline test, and all subsequent visits to the lab. This will be confirmed via self-report form. All visits to the lab will be completed between the hours of 0700 and 0900 in order to ensure each participant arrives fasted. For baseline testing, occurring on Day 0, participants will determine their 1 repetition maximum (1RM) back squat using standardized protocols set forth by the National Strength and Conditioning Association. Following their 1RM determination, participants will receive a dual energy X-ray absorption scan to determine body composition. On Day 6, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 7, participants will report to the lab and offer a blood sample from an antecubital vein. They will then undergo a standardized warm up, which will consist of 5 minutes at a self-selected pace on a treadmill, followed by two sets of 10 body weight squats, 10 glute bridges, and 10 lunges on each leg. Following the warmup, participants will complete an acute heavy resistance exercise protocol (AHREP), which will consist of 6x10 repetition maximum (10RM) back squat, with two minutes rest between sets. This protocol was chosen due to its effectiveness in eliciting a large inflammatory response in other studies. Working set load will be estimated by taking 75% the 1RM weight, which estimates 10RM. Following each set, participants will be asked to rate their effort on a scale of 6-20. Immediately following completion of the exercise, participants will provide another blood sample, before a standardized cool down where they will be asked to walk at a comfortable pace on a treadmill. On Day 8, approximately 24 hours after completion of AHREP1, participants will return to the lab for another blood draw and complete a muscle soreness questionnaire and a self-reported muscle function questionnaire. Prior to leaving the lab, they will be given 42 bottles containing 16.9ozs of berry-infused water, or plain water, which they will be instructed to drink 2 times per day, starting after they leave the lab. On Day 9, approximately 48 hours after completion of AHREP1, the participants return to the lab for another blood draw and another muscle soreness questionnaire. On Day 27, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 28 of the study, participants will return to the lab as a compliance check. They will receive another 42 drinks, (berry-infused water or plain water) as well as offer a blood sample. They will fill out a Pittsburg Sleep Quality Index form and a Profile of Mood States form. On Day 41, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 42 of the study, participants return to the lab and offer a blood sample. They will then undergo a standardized warm up. Following the warmup, participants will complete a second AHREP. Immediately following completion of the exercise, participants will provide another blood sample, before a standardized cool down where they will be asked to walk at a comfortable pace on a treadmill. On Day 43, approximately 24 hours after completion of AHREP2, participants will return to the lab for another blood draw and complete a muscle soreness questionnaire and a self-perceived function questionnaire. On Day 44, approximately 48 hours after completion of AHREP2, the participants return to the lab for another blood draw and another muscle soreness questionnaire and self-perceived function questionnaire. At this point the participation in the study will be concluded and participants compensated for their efforts.
- Conditions
- Systemic Inflammation, Hydration, Resting Metabolism
- Being tested
- We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks.Other
Participants consumed 1L of special water every day for 6 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Consuming WAC beverage for 6 weeks | Experimental | Not described Receives: Other: We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Inflammation
Innflammatory biomarkers
Measured: Baseline, Post-lifting, day 1 post, day 2 post, 3-week post, baseline 2, post-lifting 2, day1 (2), day 2 (2). All over a 6-wk period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Mar 2026
- Study start17 May 2021
- Primary completion10 Feb 2024
- Study completion10 Feb 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Systemic InflammationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Arkansas, Fayetteville
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Brendon P. McDermott, University of Arkansas, Fayetteville
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07456683
- Sponsor's protocol ID
- 2102314312
- Acronym
- WAC
- Status last verified
- Mar 2026
- First submitted
- 2 Mar 2026
- Last updated
- 6 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Water With Anti-Inflammatory Capabilities on the Inflammatory Response to Heavy Resistance Exercise
- ClinicalTrials.gov ID
- NCT07456683
- Acronym / sponsor ID
- WAC / 2102314312
- Conditions
- Systemic Inflammation, Hydration, Resting Metabolism
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- University of Arkansas, FayettevilleUniversity, hospital or other
- Study start
- 17 May 2021 (actual)
- Primary completion
- 10 Feb 2024 (actual)
- Study completion
- 10 Feb 2024 (actual)
- First posted
- 6 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this research is to assess the anti-inflammatory effects of berry-flavored water in response to an acute bout of exercise. This investigation is part of a larger collaborative project between the Exercise Science Research Center, the Center for Human Nutrition, and the University of Arkansas Sensory Science Center, which seeks to examine the potential of waters infused with naturally occurring bioactive anti-inflammatory volatile compounds to improve overall health. We expect that this water infused with natural bioactive berry volatile compounds will demonstrate preventive physiological benefits in relation to systemic inflammation, including a decreased level of baseline (resting) inflammation and attenuated post-exercise inflammation.
Detailed description
Participants will be asked to refrain from eating berries for 48 hours, drinking alcohol for 24 hours and consuming caffeine for 12 hours prior to reporting for their baseline test, and all subsequent visits to the lab. This will be confirmed via self-report form. All visits to the lab will be completed between the hours of 0700 and 0900 in order to ensure each participant arrives fasted. For baseline testing, occurring on Day 0, participants will determine their 1 repetition maximum (1RM) back squat using standardized protocols set forth by the National Strength and Conditioning Association. Following their 1RM determination, participants will receive a dual energy X-ray absorption scan to determine body composition. On Day 6, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 7, participants will report to the lab and offer a blood sample from an antecubital vein. They will then undergo a standardized warm up, which will consist of 5 minutes at a self-selected pace on a treadmill, followed by two sets of 10 body weight squats, 10 glute bridges, and 10 lunges on each leg. Following the warmup, participants will complete an acute heavy resistance exercise protocol (AHREP), which will consist of 6x10 repetition maximum (10RM) back squat, with two minutes rest between sets. This protocol was chosen due to its effectiveness in eliciting a large inflammatory response in other studies. Working set load will be estimated by taking 75% the 1RM weight, which estimates 10RM. Following each set, participants will be asked to rate their effort on a scale of 6-20. Immediately following completion of the exercise, participants will provide another blood sample, before a standardized cool down where they will be asked to walk at a comfortable pace on a treadmill. On Day 8, approximately 24 hours after completion of AHREP1, participants will return to the lab for another blood draw and complete a muscle soreness questionnaire and a self-reported muscle function questionnaire. Prior to leaving the lab, they will be given 42 bottles containing 16.9ozs of berry-infused water, or plain water, which they will be instructed to drink 2 times per day, starting after they leave the lab. On Day 9, approximately 48 hours after completion of AHREP1, the participants return to the lab for another blood draw and another muscle soreness questionnaire. On Day 27, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 28 of the study, participants will return to the lab as a compliance check. They will receive another 42 drinks, (berry-infused water or plain water) as well as offer a blood sample. They will fill out a Pittsburg Sleep Quality Index form and a Profile of Mood States form. On Day 41, 24 hours leading into the next visit, participants will be asked to record food and fluid intake via a standard diet log and collect urine output in a urine collection jug for 24 hours. This visit will require participants to come to the lab to pick up a diet log and urine collection jug. On Day 42 of the study, participants return to the lab and offer a blood sample. They will then undergo a standardized warm up. Following the warmup, participants will complete a second AHREP. Immediately following completion of the exercise, participants will provide another blood sample, before a standardized cool down where they will be asked to walk at a comfortable pace on a treadmill. On Day 43, approximately 24 hours after completion of AHREP2, participants will return to the lab for another blood draw and complete a muscle soreness questionnaire and a self-perceived function questionnaire. On Day 44, approximately 48 hours after completion of AHREP2, the participants return to the lab for another blood draw and another muscle soreness questionnaire and self-perceived function questionnaire. At this point the participation in the study will be concluded and participants compensated for their efforts.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Consuming WAC beverage for 6 weeks | Experimental | Other: We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks. |
Who may qualify
- Ages
- 18 to 39 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Sedentary to moderately active, as defined by the International Physical Activity Questionnaire (IPAQ)
Key exclusion criteria (2 listed)
- Kidney, liver, cardiac, or immune conditions that may compromise their health Not used to lifting weights more than 1 time per month. Participants identified as being 'high fruit/vegetable consumers' will also be excluded from the study because they habitually consume polyphenols and antioxidants already exhibiting anti-inflammatory effects that would compromise our findings.
- A history of fainting from routine blood draws.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks.Participants consumed 1L of special water every day for 6 weeks. | Other | Consuming WAC beverage for 6 weeks |
Primary outcome
Inflammation
Time frame: Baseline, Post-lifting, day 1 post, day 2 post, 3-week post, baseline 2, post-lifting 2, day1 (2), day 2 (2). All over a 6-wk period
Innflammatory biomarkers
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Mar 2026.
Related trials for Systemic Inflammation
Not yet recruitingPhase 2/3
A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial
Streptococcus Agalactiae Infection, Neonatal Sepsis
Active, not recruiting
CT for Personalized Mechanical Ventilation
Ventilator-Induced Lung Injury, Sepsis Syndrome
RecruitingPhase 4
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
Infection, Sepsis
Not yet recruiting
Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)
Acute-on-Chronic Liver Failure (ACLF)
Active, not recruitingPhase 4
Thymosin Alpha 1 and IgM Levels in Sepsis
Sepsis, Septic Shock
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing We made a water with berry essence volatiles (cranberry, blackberry, and blueberry). This was consumed for 6 weeks. in people with Systemic Inflammation and Hydration, run by University of Arkansas, Fayetteville at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Inflammation (time frame: Baseline, Post-lifting, day 1 post, day 2 post, 3-week post, baseline 2, post-lifting 2, day1 (2), day 2 (2). All over a 6-wk period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Mar 2026.