Nausea and Vomiting Chemotherapy-InducedNCT07456982
The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting
A study testing Relaxation breathing exercise in people with Nausea and Vomiting Chemotherapy-Induced and Hematological Malignancies, run by Marmara University at 1 site in Turkey (Türkiye).
Trial summary
The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting in Patients With Hematological Malignancies ABSTRACT Background: Chemotherapy is widely used in the treatment of hematological malignancies despite it has important and difficult side effects in patients. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Nausea and Vomiting Chemotherapy-Induced, Hematological Malignancies
- What is being tested?
- Relaxation breathing exercise
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 68 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 30 Jan 2024to Mar 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 years or over with hematological malignancies
- Undergoing chemotherapy
- Not having any communication problems (able to read, write and speak Turkish.
Who cannot join
- Having psychiatric and mental problems
- Receiving radiotherapy concurrent with chemotherapy, 3) Having respiratory distress
- Having central nervous system involvement
- Having Grade 3 or Grade 4 nausea and vomiting.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Marmara University, Mehmet Genç Complex
Istanbul, Kartal, 34000
About this study
Official title: The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting in Patients With Hematological Malignancies
The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting in Patients With Hematological Malignancies ABSTRACT
Background:
Read more
Chemotherapy is widely used in the treatment of hematological malignancies despite it has important and difficult side effects in patients. Chemotherapy induced nausea and vomiting are among the most common side effects in patients and antiemetic drugs may not be always curative.
Purpose:
This research aimed to determine the effectiveness of relaxation breathing exercise on managing chemotherapy induced nausea and vomiting in patients with hematological malignancies undergoing chemotherapy.
Method:
A randomized controlled trial design was conducted with a total of selected sixty eight patients with hematological malignancies (34 intervention and 34 control participants) undergoing chemotherapy hospitalized in the hematology clinic of a Training and Research Hospital. The intervention group implemented relaxation breathing exercise three times a day with a standard treatment protocol and the control group only received routine drug treatment for chemotherapy induced nausea and vomiting. Nausea and vomiting were assessed by filling Rhodes Index of Nausea Vomiting and Retching (RINVR) for the first six days after the start of the chemotherapy.
Results:
Data collection process ended. Data analysis process is in progress.
Conclusion:
In this study the effectiveness of relaxation breathing exercise on chemotherapy related nausea and vomiting will be examined in patients with hematological malignancies.
Keywords: Relaxation breathing exercise; Hematological malignancies; Chemotherapy; Nausea and vomiting
Read the detailed description
The research was conducted in the hematology clinics of a university training and research hospital in Istanbul, Turkey. Hospitalized patients with hematological malignancies who underwent chemotherapy were included in the research. Hematology patients apply to the hematology polyclinics in the hospital and then patients who are diagnosed with hematological malignancies such as leukemia, lymphoma or multiple myelome and will receive chemotherapy are hospitalized. The researcher planned to help patients to cope with nausea and vomiting while they were receiving chemotherapy in this study. Before the chemotherapy had been started, the relaxation breathing exercise training was provided to the hospitalized patients in their rooms who agreed to participate in the study. After training a guidebook about relaxation breathing exercise was given to the patients so that they would not forget how to implement the intervention
- Being tested
- Relaxation breathing exercise, Control group
- Keywords
- Relaxation breathing exercise, Chemotherapy, Nausea and vomiting
- Medical subject headings
- Nausea, Hematologic Neoplasms, Vomiting
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Relaxation breathing exerciseBehavioural
Relaxation breathing exercise:
- Preliminary exercise: Participants lie comfortably on their backs in the bed and focus on the lower abdomen. They place their left ankles over their right knees and then place their right ankles over their left knees. They draw both knees toward their abdomens.
- Relaxation breathing: Participants relax while breathing deeply through their noses and letting them out through their mouths slowly. They count to four and breathe in deeply, they hold their breathe while counting to four, and breathe out while counting to eight.
- Ending exercise:
Participants stretch their arms and legs and then loosen them. They relax the muscles concerned with their faces, shoulders and eyebrows by keeping their mind clear.
Control groupBehavioural
Control group does not perform relaxation breathing exercise. They only receive standard treatment.
| Study group | Role | What they receive |
|---|---|---|
| Relaxation breathing exercise intervention group | Experimental | Not described Receives: Behavioral: Relaxation breathing exercise |
| Control group | Experimental | Not described Receives: Behavioral: Control group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change from the start of the chemotherapy in the frequency and severity of nasea, vomiting and retching at 6 days.
Zero is equivalent to no nausea, no vomiting and no retching and 4 indicates the worst and unbearable nausea, vomiting and retching
Measured: From enrollment to the end of intervention at 6 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Mar 2026
- Study start30 Jan 2024
- Primary completion30 Sep 2025
- Study completionMar 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nausea and Vomiting Chemotherapy-InducedStudies of the same condition, open and under way.
- More trials run by Marmara UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Relaxation breathing exercise: 1.Preliminary exercise Participants lie comfortably on their backs in the bed and focus on the lower abdomen. They place their left ankles over their right knees and then place their right ankles over their left knees. They draw both knees toward their abdomens. 2. Relaxation breathing Participants relax while breathing deeply through their noses and letting them out through their mouths slowly. They count to four and breathe in deeply, they hold their breathe while counting to four, and breathe out while counting to eight. 3. Ending exercise Participants stretch their arms and legs and then loosen them. They relax the muscles concerned with their faces, shoulders and eyebrows by keeping their mind clear.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- Marmara University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Pınar Eksi, Marmara University
- Investigators
- Sıdıka Oğuz, Prof.Dr., Study director, Marmara University, Faculty of Health Sciences, Department of Medical Nursing
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07456982
- Sponsor's protocol ID
- Protocol No:09.2020.1036
- Status last verified
- Feb 2026
- First submitted
- 26 Feb 2026
- Last updated
- 9 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: IPD used in the results
Study at a glance
From the registry record, last updated by the sponsor on 9 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting in Patients With Hematological Malignancies
- ClinicalTrials.gov ID
- NCT07456982
- Acronym / sponsor ID
- Protocol No:09.2020.1036
- Keywords
- Relaxation breathing exercise, Chemotherapy, Nausea and vomiting
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 68 participants (actual)
- Lead sponsor
- Marmara UniversityUniversity, hospital or other
- Study start
- 30 Jan 2024 (actual)
- Primary completion
- 30 Sep 2025 (actual)
- Study completion
- Mar 2026 (estimated)
- First posted
- 9 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Effect of Relaxation Breathing Exercise on Chemotherapy Induced Nausea and Vomiting in Patients With Hematological Malignancies ABSTRACT
Background:
Chemotherapy is widely used in the treatment of hematological malignancies despite it has important and difficult side effects in patients. Chemotherapy induced nausea and vomiting are among the most common side effects in patients and antiemetic drugs may not be always curative.
Purpose:
This research aimed to determine the effectiveness of relaxation breathing exercise on managing chemotherapy induced nausea and vomiting in patients with hematological malignancies undergoing chemotherapy.
Method:
A randomized controlled trial design was conducted with a total of selected sixty eight patients with hematological malignancies (34 intervention and 34 control participants) undergoing chemotherapy hospitalized in the hematology clinic of a Training and Research Hospital. The intervention group implemented relaxation breathing exercise three times a day with a standard treatment protocol and the control group only received routine drug treatment for chemotherapy induced nausea and vomiting. Nausea and vomiting were assessed by filling Rhodes Index of Nausea Vomiting and Retching (RINVR) for the first six days after the start of the chemotherapy.
Results:
Data collection process ended. Data analysis process is in progress.
Conclusion:
In this study the effectiveness of relaxation breathing exercise on chemotherapy related nausea and vomiting will be examined in patients with hematological malignancies.
Keywords: Relaxation breathing exercise; Hematological malignancies; Chemotherapy; Nausea and vomiting
Detailed description
The research was conducted in the hematology clinics of a university training and research hospital in Istanbul, Turkey. Hospitalized patients with hematological malignancies who underwent chemotherapy were included in the research. Hematology patients apply to the hematology polyclinics in the hospital and then patients who are diagnosed with hematological malignancies such as leukemia, lymphoma or multiple myelome and will receive chemotherapy are hospitalized. The researcher planned to help patients to cope with nausea and vomiting while they were receiving chemotherapy in this study. Before the chemotherapy had been started, the relaxation breathing exercise training was provided to the hospitalized patients in their rooms who agreed to participate in the study. After training a guidebook about relaxation breathing exercise was given to the patients so that they would not forget how to implement the intervention
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Relaxation breathing exercise: 1.Preliminary exercise Participants lie comfortably on their backs in the bed and focus on the lower abdomen. They place their left ankles over their right knees and then place their right ankles over their left knees. They draw both knees toward their abdomens. 2. Relaxation breathing Participants relax while breathing deeply through their noses and letting them out through their mouths slowly. They count to four and breathe in deeply, they hold their breathe while counting to four, and breathe out while counting to eight. 3. Ending exercise Participants stretch their arms and legs and then loosen them. They relax the muscles concerned with their faces, shoulders and eyebrows by keeping their mind clear.
| Arm | Type | Receives |
|---|---|---|
| Relaxation breathing exercise intervention group | Experimental | Behavioral: Relaxation breathing exercise |
| Control group | Experimental | Behavioral: Control group |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Aged 18 years or over with hematological malignancies
- Undergoing chemotherapy
- Not having any communication problems (able to read, write and speak Turkish.
Key exclusion criteria (4 listed)
- Having psychiatric and mental problems
- Receiving radiotherapy concurrent with chemotherapy, 3) Having respiratory distress
- Having central nervous system involvement
- Having Grade 3 or Grade 4 nausea and vomiting.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Relaxation breathing exerciseRelaxation breathing exercise: 1. Preliminary exercise: Participants lie comfortably on their backs in the bed and focus on the lower abdomen. They place their left ankles over their right knees and then place their right ankles over their left knees. They draw both knees toward their abdomens. 2. Relaxation breathing: Participants relax while breathing deeply through their noses and letting them out through their mouths slowly. They count to four and breathe in deeply, they hold their breathe while counting to four, and breathe out while counting to eight. 3. Ending exercise: Participants stretch their arms and legs and then loosen them. They relax the muscles concerned with their faces, shoulders and eyebrows by keeping their mind clear. | Behavioural | Relaxation breathing exercise intervention group |
| Control groupControl group does not perform relaxation breathing exercise. They only receive standard treatment. | Behavioural | Control group |
Primary outcome
Change from the start of the chemotherapy in the frequency and severity of nasea, vomiting and retching at 6 days.
Time frame: From enrollment to the end of intervention at 6 days
Zero is equivalent to no nausea, no vomiting and no retching and 4 indicates the worst and unbearable nausea, vomiting and retching
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Mar 2026.
- International journal of clinical trialsLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. IPD used in the results
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sıdıka Oğuz, Prof.Dr. study director
Marmara University, Faculty of Health Sciences, Department of Medical Nursing
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Relaxation breathing exercise in people with Nausea and Vomiting Chemotherapy-Induced and Hematological Malignancies, run by Marmara University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 9 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change from the start of the chemotherapy in the frequency and severity of nasea, vomiting and retching at 6 days. (time frame: From enrollment to the end of intervention at 6 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Mar 2026.