Healthy AgeingNCT07460609
Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors
A study testing Blood Flow Restriction Training Exercise and Health Education in people with Healthy Ageing, run by Baylor University at 1 site in United States.
Trial summary
As people age, it can become harder to stay active and independent, especially when dealing with fatigue, joint pain, or other health problems. Heavy weightlifting and high-intensity exercise are effective but may not be comfortable or realistic for many older adults. Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy Ageing
- What is being tested?
- Blood Flow Restriction Training Exercise and Health Education
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Aug 2025to 15 Mar 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Community-dwelling adults aged 60 years or older,
- Able to walk independently ,
- Willing to provide informed consent and participate in exercise and/or health education sessions.
Who cannot join
- Adults with uncontrolled disease (unstable or recent angina, heart failure class III-IV,
- Myocardial infarction within 6 months,
- Uncontrolled hypertension,
- Uncontrolled diabetes,
- Recent deep vain thrombosis,
- Uncontrolled renal disease,
- Those with severe orthopedic or neuromuscular condition that limit safe exercise or walking.
Trial locations and contacts
1 site in 1 country.
About this study
As people age, it can become harder to stay active and independent, especially when dealing with fatigue, joint pain, or other health problems. Heavy weightlifting and high-intensity exercise are effective but may not be comfortable or realistic for many older adults. This study is looking at a gentler type of exercise called blood flow restriction (BFR) training, which uses light weights and slow walking combined with special bands around the arms and legs to gently reduce blood flow during exercise. This method has been shown to help improve strength and fitness using much lighter loads, which may make it a safer and more accessible option for older adults.
In this study, adults age 60 and older will be randomly assign into one of two groups: an exercise group or a health education group. The exercise group will take part in a six-week BFR program that includes supervised light resistance exercises and short walking sessions each week. The health education group will attend three educational sessions over six weeks that focus on healthy aging and ways to manage health and stay active. After the first six weeks, participants will have the chance to switch and take part in the other program, so everyone eventually receives both exercise and education.
Before and after each program, participants will complete simple tests of strength, walking ability, and physical function, along with measurements of heart and blood vessel health, body composition, and blood markers related to aging and overall health. They will also fill out questionnaires about their quality of life, physical activity, and how they feel about their health and aging. The goal of this study is to find out whether BFR exercise and health education can support healthy aging, improve physical function, and help older adults feel more positive and confident about their health. What the study investigators learn may help create better, more accessible programs in the community to keep older adults stronger, healthier, and more independent.
- Conditions
- Healthy Ageing
- Being tested
- Blood Flow Restriction Training Exercise, Health Education
- Keywords
- Healthy Aging, older adults, Low-load Exercise, Health Education, Physical Function, Vascular Health
- Medical subject headings
- Health Education
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood Flow Restriction Training ExerciseBehavioural
Participants will complete a six-week blood flow restriction exercise program consisting of low-load resistance training and short BFR walking sessions performed with standardized cuff pressures under supervision and at home to improve strength and functional capacity.
Health EducationBehavioural
Participants will attend a three health education lectures within six weeks on healthy aging, disease prevention, and lifestyle strategies while maintaining their usual daily activities.
| Study group | Role | What they receive |
|---|---|---|
| Blood Flow Restriction Exercise Intervention | Experimental | Participants in this arm will complete a six-week blood flow restriction (BFR) exercise program. Training includes two weekly supervised sessions using low-load resistance exercises performed with BFR bands, along with two short BFR walking sessions completed at home. This program is designed to improve muscle strength, physical function, and cardiovascular health while using light exercise intensities that are well suited for older adults. Receives: Behavioral: Blood Flow Restriction Training Exercise |
| Health Education Intervention | Other | Participants in this arm will take part in a six-week health education program consisting of three lectures sessions focused on healthy aging, disease prevention, and maintaining physical and mental well-being. Participants will continue their usual daily activities during this period. This arm serves as a comparison condition to evaluate how education alone influences perceptions of aging, health behaviors, and quality of life. Receives: Behavioral: Health Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Functional Exercise Capacity
Measured by the distance in meters covered during a 6-minute walk.
Measured: baseline and 6 weeks.
Grip Strength
Measured with a hand grip dynamometry in kilograms
Measured: Baseline and 6 weeks.
Lower Body Strength and Endurance
Measured with a sit-to-stand test, seconds to complete 5 repetitions of sitting and standing from a chair.
Measured: Baseline and 6 weeks
Body Composition
Adiposity will be measured by Dual energy x-ray absorptiometry as percent of body fat
Measured: Baseline and 6 weeks
Endothelial Function
Measured via brachial artery flow mediated dilation. Percent FMD
Measured: Baseline and 6 weeks
Biomarker of Genetic Aging
Klotho a marker of aging will be quantified through blood samples analysis. Measured with Enzyme-Linked Immunosorbent Assay.
Measured: Baseline and 6 weeks
Metabolic Health
Cholestech LDX analyzer will measure levels of cholesterol HDL mg/dL from a finger prick sample.
Measured: Baseline and 6 weeks
Metabolic Health
Cholestech LDX analyzer will measure levels of cholesterol LDL mg/dL from a finger prick sample.
Measured: baseline and 6 weeks.
Metabolic Health
Cholestech LDX analyzer will measure levels of glucose mg/dL from a finger prick sample.
Measured: Baseline and 6 weeks
Secondary outcomes (2)
Body Mass Index (BMI)
BMI will be determined using weight in kilogram and height in meters squared. kg/m2
Measured: Baseline and 6 week
Blood Pressure
Blood pressure will be measured using an automated oscillometric sphygmomanometer to determine systolic and diastolic blood pressure in mmHg.
Measured: Baseline and 6 weeks.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start1 Aug 2025
- Primary completion15 Mar 2026 (estimated)
- Study completion15 Mar 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy AgeingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Baylor University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07460609
- Sponsor's protocol ID
- 2337478-3
- Status last verified
- Mar 2026
- First submitted
- 12 Dec 2025
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors
- ClinicalTrials.gov ID
- NCT07460609
- Acronym / sponsor ID
- 2337478-3
- Conditions
- Healthy Ageing
- Keywords
- Healthy Aging, older adults, Low-load Exercise, Health Education, Physical Function, Vascular Health
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Baylor UniversityUniversity, hospital or other
- Study start
- 1 Aug 2025 (actual)
- Primary completion
- 15 Mar 2026 (estimated)
- Study completion
- 15 Mar 2026 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
As people age, it can become harder to stay active and independent, especially when dealing with fatigue, joint pain, or other health problems. Heavy weightlifting and high-intensity exercise are effective but may not be comfortable or realistic for many older adults. This study is looking at a gentler type of exercise called blood flow restriction (BFR) training, which uses light weights and slow walking combined with special bands around the arms and legs to gently reduce blood flow during exercise. This method has been shown to help improve strength and fitness using much lighter loads, which may make it a safer and more accessible option for older adults.
In this study, adults age 60 and older will be randomly assign into one of two groups: an exercise group or a health education group. The exercise group will take part in a six-week BFR program that includes supervised light resistance exercises and short walking sessions each week. The health education group will attend three educational sessions over six weeks that focus on healthy aging and ways to manage health and stay active. After the first six weeks, participants will have the chance to switch and take part in the other program, so everyone eventually receives both exercise and education.
Before and after each program, participants will complete simple tests of strength, walking ability, and physical function, along with measurements of heart and blood vessel health, body composition, and blood markers related to aging and overall health. They will also fill out questionnaires about their quality of life, physical activity, and how they feel about their health and aging. The goal of this study is to find out whether BFR exercise and health education can support healthy aging, improve physical function, and help older adults feel more positive and confident about their health. What the study investigators learn may help create better, more accessible programs in the community to keep older adults stronger, healthier, and more independent.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Blood Flow Restriction Exercise Intervention | Experimental | Behavioral: Blood Flow Restriction Training ExerciseParticipants in this arm will complete a six-week blood flow restriction (BFR) exercise program. Training includes two weekly supervised sessions using low-load resistance exercises performed with BFR bands, along with two short BFR walking sessions completed at home. This program is designed to improve muscle strength, physical function, and cardiovascular health while using light exercise intensities that are well suited for older adults. |
| Health Education Intervention | Other | Behavioral: Health EducationParticipants in this arm will take part in a six-week health education program consisting of three lectures sessions focused on healthy aging, disease prevention, and maintaining physical and mental well-being. Participants will continue their usual daily activities during this period. This arm serves as a comparison condition to evaluate how education alone influences perceptions of aging, health behaviors, and quality of life. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Community-dwelling adults aged 60 years or older,
- Able to walk independently ,
- Willing to provide informed consent and participate in exercise and/or health education sessions.
Key exclusion criteria (7 listed)
- Adults with uncontrolled disease (unstable or recent angina, heart failure class III-IV,
- Myocardial infarction within 6 months,
- Uncontrolled hypertension,
- Uncontrolled diabetes,
- Recent deep vain thrombosis,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood Flow Restriction Training ExerciseParticipants will complete a six-week blood flow restriction exercise program consisting of low-load resistance training and short BFR walking sessions performed with standardized cuff pressures under supervision and at home to improve strength and functional capacity. | Behavioural | Blood Flow Restriction Exercise Intervention |
| Health EducationParticipants will attend a three health education lectures within six weeks on healthy aging, disease prevention, and lifestyle strategies while maintaining their usual daily activities. | Behavioural | Health Education Intervention |
Primary outcome
Functional Exercise Capacity
Time frame: baseline and 6 weeks.
Measured by the distance in meters covered during a 6-minute walk.
Grip Strength
Time frame: Baseline and 6 weeks.
Measured with a hand grip dynamometry in kilograms
Lower Body Strength and Endurance
Time frame: Baseline and 6 weeks
Measured with a sit-to-stand test, seconds to complete 5 repetitions of sitting and standing from a chair.
Body Composition
Time frame: Baseline and 6 weeks
Adiposity will be measured by Dual energy x-ray absorptiometry as percent of body fat
Endothelial Function
Time frame: Baseline and 6 weeks
Measured via brachial artery flow mediated dilation. Percent FMD
Biomarker of Genetic Aging
Time frame: Baseline and 6 weeks
Klotho a marker of aging will be quantified through blood samples analysis. Measured with Enzyme-Linked Immunosorbent Assay.
Metabolic Health
Time frame: Baseline and 6 weeks
Cholestech LDX analyzer will measure levels of cholesterol HDL mg/dL from a finger prick sample.
Metabolic Health
Time frame: baseline and 6 weeks.
Cholestech LDX analyzer will measure levels of cholesterol LDL mg/dL from a finger prick sample.
Metabolic Health
Time frame: Baseline and 6 weeks
Cholestech LDX analyzer will measure levels of glucose mg/dL from a finger prick sample.
2 secondary outcomes
Body Mass Index (BMI)
Time frame: Baseline and 6 week
Blood Pressure
Time frame: Baseline and 6 weeks.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Blood Flow Restriction Training Exercise and Health Education in people with Healthy Ageing, run by Baylor University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Functional Exercise Capacity (time frame: baseline and 6 weeks.). The study lists 9 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.