Revascularization of Immature Young Permenant TeethNCT07460869
Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar
A study testing Revascularization/Conservative management in people with Revascularization of Immature Young Permenant Teeth, run by Minia University at 1 site in Egypt.
Trial summary
in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients Read more about this study
- Who is it for?
- Ages 6 to 8 yearsHealthy volunteers can take part
- Conditions the study is for
- Revascularization of Immature Young Permenant Teeth
- What is being tested?
- Revascularization/Conservative management
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 10 Jan 2025to 10 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 8 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- Children with immature necrotic lower fitrst permanent molar.
- No history of repeated pathosis or cellulitis.
- Patients accept the treatment modality.
- Patient-free from systemic, allergic or genetic problems.
Who cannot join
- Tooth mobility.
- Teeth with non-restorable crowns.
- Children with facial cellulitis
- Children with draining fistula
- Children with a history of recurrent preapical pathosis
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Dentistry Minya University
Minya, Minya Governorate, 2422998
About this study
Official title: Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.
in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients
Read the detailed description
children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration
- Being tested
- Revascularization/Conservative management
- Keywords
- CGF and PRF
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Revascularization/Conservative managementBiological
Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine
| Study group | Role | What they receive |
|---|---|---|
| CGF and biodentine arm | Active comparator | (control group) Which CGF and bio-dentine are applied to the immature pulp of the first permanent molar Receives: Biological: Revascularization/Conservative management |
| PRF and biodentine arm | Active comparator | PRF and bio-dentine are applied on immature pulp of first permanent molar Receives: Biological: Revascularization/Conservative management |
What is being measured
The primary outcome is the main question the study is designed to answer.
root growth
change root length
Measured: 18 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start10 Jan 2025
- Primary completion10 Jul 2026 (estimated)
- Study completion10 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Revascularization of Immature Young Permenant TeethStudies of the same condition, open and under way.
- More trials run by Minia UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- parallel randomized controlled study
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Minia University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Bothaina Ahmed, Minia University
- Investigators
- Ahmed elheeny, professor of Pediatric and Com, Principal investigator, unaffilliaed
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07460869
- Sponsor's protocol ID
- Bothaina A. Gado
- Status last verified
- Aug 2025
- First submitted
- 13 Feb 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: CONCENTRATED GROWTH FACTOR VERSUS PLATELETS-RICH FIBRIN IN REVASCULARIZATION OF IMMATURE NECROTIC MANDIBULAR FIRST PERMANENT MOLAR
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.
- ClinicalTrials.gov ID
- NCT07460869
- Acronym / sponsor ID
- Bothaina A. Gado
- Keywords
- CGF and PRF
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Minia UniversityUniversity, hospital or other
- Study start
- 10 Jan 2025 (actual)
- Primary completion
- 10 Jul 2026 (estimated)
- Study completion
- 10 Jul 2027 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients
Detailed description
children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- parallel randomized controlled study
| Arm | Type | Receives |
|---|---|---|
| CGF and biodentine arm | Active comparator | Biological: Revascularization/Conservative management(control group) Which CGF and bio-dentine are applied to the immature pulp of the first permanent molar |
| PRF and biodentine arm | Active comparator | Biological: Revascularization/Conservative managementPRF and bio-dentine are applied on immature pulp of first permanent molar |
Who may qualify
- Ages
- 6 to 8 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (4 listed)
- Children with immature necrotic lower fitrst permanent molar.
- No history of repeated pathosis or cellulitis.
- Patients accept the treatment modality.
- Patient-free from systemic, allergic or genetic problems.
Key exclusion criteria (5 listed)
- Tooth mobility.
- Teeth with non-restorable crowns.
- Children with facial cellulitis
- Children with draining fistula
- Children with a history of recurrent preapical pathosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Revascularization/Conservative managementCompare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine | Biological | CGF and biodentine arm, PRF and biodentine arm |
Primary outcome
root growth
Time frame: 18 months
change root length
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: Yes. CONCENTRATED GROWTH FACTOR VERSUS PLATELETS-RICH FIBRIN IN REVASCULARIZATION OF IMMATURE NECROTIC MANDIBULAR FIRST PERMANENT MOLAR
Related trials for Revascularization of Immature Young Permenant Teeth
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Revascularization of Young Immature Permenant Teeth Using Different Types of Intra Canal Medication
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Active, not recruitingPhase 2
The Present Study Was Conducted to Evaluate Bioceramic Root Repair Material Versus Bio MTA in Revascularization of Immature Young Permenant Teeth.
Revascularization of Immature Young Permenant Teeth
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ahmed elheeny, professor of Pediatric and Com principal investigator
unaffilliaed
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Revascularization/Conservative management in people with Revascularization of Immature Young Permenant Teeth, run by Minia University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
root growth (time frame: 18 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.