Nonfunctioning KidneyNCT07461090
Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis
A study testing open or laparoscopic nephrectomy in people with Nonfunctioning Kidney and Renal Cell Carcinoma (RCC), run by Menoufia University at 1 site in Egypt.
Trial summary
To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy . Read more about this study
- Who is it for?
- Ages 1 year and olderHealthy volunteers can take part
- Conditions the study is for
- Nonfunctioning Kidney, Renal Cell Carcinoma (RCC)
- What is being tested?
- open or laparoscopic nephrectomy
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- Feb 2026to Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- American Society of Anesthesiology score 1-3.
- Indication for :
- Simple total nephrectomy or hemi nephrectomy: benign chronic inflammatory non-functioning kidney
- Partial nephrectomy: localized renal mass ≤7 cm suitable for nephron-sparing surgery.
- Radical nephrectomy or Radical nephrouretrectomy with bladder cuff: localized renal tumor requiring complete nephrectomy without major vascular invasion.
- Patient deemed fit for general anesthesia and surgery.
- Patient provides written informed consent.
Who cannot join
- emergency surgery, dialysis-dependent patients, planned hybrid procedures.
- Patients with incomplete data
- Patients with metastatic disease at presentation.
- Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy.
- Need for concomitant major procedures (eg, large bowel resection) at index operation.
- Locally advanced tumor with obvious major vascular involvement requiring complex vascular reconstruction.
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- Uncorrected coagulopathy.
- Pregnancy or Obese patient (BMI > 40)
- Inability to provide informed consent or comply with follow-up.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Menoufia Faculty of Medicine
Shibīn al Kawm, Shebin Elkom, 32111
Mohamed Ibrahim Abozaid, +20 10 68588750, Mabozaid84@hotmail.com
About this study
To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .
- Conditions
- Nonfunctioning Kidney, Renal Cell Carcinoma (RCC)
- Being tested
- open or laparoscopic nephrectomy
- Keywords
- Clinical effectiveness of laparoscopic nephrectomy, Cost analysis of laparoscopic nephrectomy
- Medical subject headings
- Carcinoma, Renal Cell
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
open or laparoscopic nephrectomyProcedure or surgery
compare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy.
| Study group | Role | What they receive |
|---|---|---|
| open nephrectomy | Active comparator | Length of hospital stay (LOS) , post operative rehabilitation and cost analysis Receives: Procedure: open or laparoscopic nephrectomy |
| laparoscopic nephrectomy | Active comparator | Length of hospital stay (LOS) , post operative rehabilitation and cost analysis Receives: Procedure: open or laparoscopic nephrectomy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Length of hospital stay (LOS).
Number of calendar days from date of index surgery to date of discharge .
Measured: 30 days post operative
Secondary outcomes (1)
clinical effectiveness
Functional recovery was evaluated using a modified World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0).
The questionnaire consists of 10 items scored on a 5-point scale (0-4), with a total score ranging from 0 to 40, where higher scores indicate worse functional outcome and greater disability while Lower scores indicate better functional recovery.
Measured: Post operative 30 days.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study startFeb 2026 (estimated)
- Primary completionJan 2027 (estimated)
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Nonfunctioning KidneyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis between laparoscopic nephrectomy and open nephrectomy . randomized, controlled parallel-group clinical trials comparing peri-operative (pre-, intra-, and postoperative) assessments and cost outcomes of laparoscopic nephrectomy versus open nephrectomy.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Menoufia University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Haitham Badr elnaggar, Menoufia University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07461090
- Sponsor's protocol ID
- laparoscopic nephrectomy
- Status last verified
- Mar 2026
- First submitted
- 19 Feb 2026
- Last updated
- 11 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 11 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Laparoscopic Versus Open Nephrectomy : Clinical Effectivness and Cost Analysis
- ClinicalTrials.gov ID
- NCT07461090
- Acronym / sponsor ID
- laparoscopic nephrectomy
- Conditions
- Nonfunctioning Kidney, Renal Cell Carcinoma (RCC)
- Keywords
- Clinical effectiveness of laparoscopic nephrectomy, Cost analysis of laparoscopic nephrectomy
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Menoufia UniversityUniversity, hospital or other
- Study start
- Feb 2026 (estimated)
- Primary completion
- Jan 2027 (estimated)
- Study completion
- Feb 2027 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis' between laparoscopic nephrectomy and open nephrectomy .
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- To evaluate and compare clinical effectiveness (operative time, blood loss, hospital stay, complications and etc) and cost analysis between laparoscopic nephrectomy and open nephrectomy . randomized, controlled parallel-group clinical trials comparing peri-operative (pre-, intra-, and postoperative) assessments and cost outcomes of laparoscopic nephrectomy versus open nephrectomy.
| Arm | Type | Receives |
|---|---|---|
| open nephrectomy | Active comparator | Procedure: open or laparoscopic nephrectomyLength of hospital stay (LOS) , post operative rehabilitation and cost analysis |
| laparoscopic nephrectomy | Active comparator | Procedure: open or laparoscopic nephrectomyLength of hospital stay (LOS) , post operative rehabilitation and cost analysis |
Who may qualify
- Ages
- 1 year and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (7 listed)
- American Society of Anesthesiology score 1-3.
- Indication for :
- Patient deemed fit for general anesthesia and surgery.
- Patient provides written informed consent.
Key exclusion criteria (9 listed)
- emergency surgery, dialysis-dependent patients, planned hybrid procedures.
- Patients with incomplete data
- Patients with metastatic disease at presentation.
- Prior extensive ipsilateral retroperitoneal surgery or severe adhesions precluding Laparoscopy.
- Need for concomitant major procedures (eg, large bowel resection) at index operation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| open or laparoscopic nephrectomycompare post operative recovery , estimated blood loss and cost analysis between open and laparosopic nephrectomy. | Procedure or surgery | laparoscopic nephrectomy, open nephrectomy |
Primary outcome
Length of hospital stay (LOS).
Time frame: 30 days post operative
Number of calendar days from date of index surgery to date of discharge .
1 secondary outcome
clinical effectiveness
Time frame: Post operative 30 days.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Mar 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing open or laparoscopic nephrectomy in people with Nonfunctioning Kidney and Renal Cell Carcinoma (RCC), run by Menoufia University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Haitham Badr Elnaggar (01003247485 ext. 002, naggarheso@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Length of hospital stay (LOS). (time frame: 30 days post operative). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Mar 2026.