Chronic Musculoskeletal PainDolorAPNCT07461298
Multimodal Intervention for Persistent Musculoskeletal Pain in Primary Care
A study testing Multimodal Pain Management Program and Usual Primary Care in people with Chronic Musculoskeletal Pain, run by Universitat Jaume I at 5 sites in Spain.
Trial summary
This multicenter randomized controlled trial aims to evaluate the effectiveness of a multimodal intervention for the active management of persistent musculoskeletal pain in primary care. Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Chronic Musculoskeletal Pain
- What is being tested?
- Multimodal Pain Management Program and Usual Primary Care
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 146 participants
- Where
- 5 sitesSpain
- Study dates
- Jun 2026to Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged between 18 and 70 years
- Diagnosis of nonspecific persistent musculoskeletal pain lasting at least 6 months
- Receiving care in participating primary care centers
- Ability to understand study procedures and provide written informed consent
- Ability to complete self-administered questionnaires
Who cannot join
- Specific musculoskeletal pathology requiring specialized treatment (e.g., fracture, inflammatory rheumatic disease, malignancy)
- Neurological disorders affecting movement or pain perception
- Severe psychiatric disorders that may interfere with participation
- Participation in another structured pain management program during the study period
- Cognitive impairment preventing questionnaire completion
- Pregnancy (if considered clinically relevant)
Trial locations and contacts
5 sites in 1 country. Contact the study team or a site near you to ask about taking part.
5 sites in 1 country
Spain5 sites
Centro de Salud de Alginet
Alginet, Valencia
Rosa Navarro Catalá, navarro_roscat@gva.es
Centro de Salud de Benifaió
Benifaió, Valencia
Mª José Llácer Bosch, llacer_marbos@gva.es
Centro de Salud Marina Española
Elda, Alicante
Cristina Cuadrado Baca, cuadrado_cri@gva.es
Centro de Salud Integrado de la Vall d'Uixó
Vall d'Uixó, Castellón
Marta Masiá Ramos, masia_marram@gva.es
Centro de Salud de Villena I
Villena, Alicante
Mª Rosario Mondéjar Martín, mondejar_mro@gva.es
About this study
Official title: Effectiveness of a Multimodal Intervention Based on Pain Neuroscience Education, Therapeutic Exercise and Healthy Lifestyle Promotion in Patients With Persistent Musculoskeletal Pain in Primary Care: A Multicenter Randomized Controlled Trial
This multicenter randomized controlled trial aims to evaluate the effectiveness of a multimodal intervention for the active management of persistent musculoskeletal pain in primary care. The intervention combines pain neuroscience education, therapeutic exercise, and the promotion of self-care and healthy lifestyle habits to improve health-related quality of life in adults with persistent nonspecific musculoskeletal pain lasting at least six months.
A total of 146 participants aged 18 to 70 years will be recruited from five primary care centers in the Comunitat Valenciana (Spain) and randomly assigned to either the experimental group or the control group. The primary outcome is health-related quality of life measured using the SF-36 Health Survey. Secondary outcomes include pain intensity, pain catastrophizing, kinesiophobia, central sensitization, emotional symptoms, perceived social support, medication use, and lifestyle-related variables. Assessments will be conducted at baseline, post-intervention, 6 months, and 12 months follow-up.
Read the detailed description
Persistent musculoskeletal pain represents a major public health problem and is one of the most frequent reasons for consultation in primary care. It is associated with reduced quality of life, functional limitations, emotional distress, increased healthcare utilization, and high socioeconomic costs. Contemporary pain science recognizes that persistent pain is a multidimensional experience involving biological, psychological, and social mechanisms, including central sensitization and maladaptive cognitive-emotional processes such as catastrophizing and fear-avoidance behaviors.
Current clinical practice guidelines recommend multimodal and non-pharmacological approaches as first-line management strategies. Pain neuroscience education (PNE) aims to reconceptualize pain by explaining the neurobiological and psychosocial mechanisms involved in persistent pain, thereby reducing perceived threat and maladaptive beliefs. Therapeutic exercise contributes to functional improvement, modulation of central pain mechanisms, and psychological well-being. Additionally, the promotion of self-care strategies and healthy lifestyle habits (including physical activity, sleep hygiene, stress management, and nutritional counseling) may enhance long-term outcomes and patient empowerment.
This study is a multicenter, parallel-group, single-blind randomized controlled trial conducted in five primary care centers in the Comunitat Valenciana (Spain). A total of 146 adults aged 18 to 70 years with nonspecific persistent musculoskeletal pain lasting at least six months will be recruited and randomly allocated to either an experimental group receiving the multimodal intervention or a control group receiving usual care.
The multimodal intervention integrates structured group-based pain neuroscience education sessions, supervised therapeutic exercise, and guidance on self-care and healthy lifestyle habits. The control group will continue to receive standard primary care management.
The primary outcome is health-related quality of life assessed using the SF-36 Health Survey. Secondary outcomes include pain intensity, number of painful areas, pain catastrophizing, kinesiophobia, central sensitization, emotional symptoms, perceived social support, medication consumption, and lifestyle-related variables. Data will be collected at baseline, immediately post-intervention, and at 6- and 12-month follow-ups using the REDCap electronic data capture system.
Statistical analyses will include descriptive statistics and inferential analyses to compare within- and between-group differences over time. The study aims to provide robust evidence regarding the effectiveness of a multimodal, biopsychosocial intervention delivered in primary care for the management of persistent musculoskeletal pain.
- Conditions
- Chronic Musculoskeletal Pain
- Being tested
- Multimodal Pain Management Program, Usual Primary Care
- Keywords
- Physical exercise, Patient Care Group, Primary Health Care, Multimodal Intervention, Health-Related Quality of Life, Self-Management, Pain Neuroscience Education
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multimodal Pain Management ProgramBehavioural
The multimodal program combines pain neuroscience education, therapeutic exercise, and the promotion of self-care and healthy lifestyle habits. Pain neuroscience education focuses on reconceptualizing pain based on contemporary neurophysiological principles. Therapeutic exercise includes supervised physical activity aimed at improving strength, mobility, and functional capacity. The self-care component addresses lifestyle factors such as physical activity, sleep hygiene, stress management, and healthy nutrition.
Usual Primary CareOther
Participants in the control group will continue receiving standard primary care treatment as determined by their healthcare providers. This may include medication, medical advice, or referral to other services according to routine clinical practice.
| Study group | Role | What they receive |
|---|---|---|
| Multimodal Intervention Group | Experimental | Participants assigned to the experimental group will receive a structured multimodal intervention delivered in primary care settings. The intervention integrates group-based pain neuroscience education sessions, supervised therapeutic exercise, and guidance on self-care strategies and healthy lifestyle habits. The program aims to promote active coping, improve functional capacity, and enhance health-related quality of life in individuals with persistent musculoskeletal pain. Receives: Behavioral: Multimodal Pain Management Program |
| Usual Care Group | Active comparator | Participants assigned to the control group will receive usual primary care management for persistent musculoskeletal pain. Usual care may include pharmacological treatment, medical follow-up, and referral to other healthcare services when considered necessary, according to standard clinical practice. Receives: Other: Usual Primary Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Health-Related Quality of Life
Health-related quality of life assessed using the 36-Item Short Form Health Survey (SF-36). The SF-36 measures eight health domains and provides physical and mental component summary scores. Higher scores indicate better health-related quality of life.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Secondary outcomes (10)
Pain Intensity
Pain intensity measured using a numerical rating scale (NRS), where higher scores indicate greater pain intensity.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Number of Painful Body Areas
Number of body areas with reported pain as self-identified by participants.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Pain Catastrophizing
Pain catastrophizing assessed using the Pain Catastrophizing Scale (PCS). Higher scores indicate greater catastrophizing.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Kinesiophobia
Fear of movement assessed using the Tampa Scale of Kinesiophobia (TSK). Higher scores indicate greater fear of movement.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Central Sensitization
Central sensitization symptoms assessed using the Central Sensitization Inventory (CSI). Higher scores indicate greater symptom severity.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Anxiety Symptoms
Anxiety symptoms assessed using the Overall Anxiety Severity and Impairment Scale (OASIS). The OASIS is a 5-item self-report questionnaire measuring the frequency and severity of anxiety symptoms and related functional impairment. Scores range from 0 to 20, with higher scores indicating greater anxiety severity.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Depressive Symptoms
Depressive symptoms assessed using the Overall Depression Severity and Impairment Scale (ODSIS). The ODSIS is a 5-item self-report questionnaire assessing the frequency and severity of depressive symptoms and associated impairment. Scores range from 0 to 20, with higher scores indicating greater depressive symptom severity.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Perceived Social Support
Perceived social support assessed using the Duke-UNC Functional Social Support Questionnaire (DUKE-UNC-11). The questionnaire evaluates perceived emotional and instrumental social support. Scores range from 11 to 55, with higher scores indicating greater perceived social support.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Medication Consumption
Changes in the number and type of medications used for pain management.
Measured: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Participant Satisfaction With the Intervention
Participant satisfaction assessed using the Client Satisfaction Questionnaire-8 (CSQ-8), an 8-item self-report instrument measuring satisfaction with healthcare services. Total scores range from 8 to 32, with higher scores indicating greater satisfaction with the intervention.
Measured: Immediately post-intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study startJun 2026 (estimated)
- Primary completionJan 2028 (estimated)
- Study completionJan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Chronic Musculoskeletal PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomly assigned in a 1:1 ratio to either the experimental group receiving the multimodal intervention or the control group receiving usual primary care. The two groups will be followed in parallel throughout the study period, with outcome assessments conducted at baseline, post-intervention, and at 6- and 12-month follow-ups.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 146 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universitat Jaume I
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07461298
- Sponsor's protocol ID
- UJI-DMP-AP-2026
- Other IDs
- OSF-ptwfy
- Acronym
- DolorAP
- Status last verified
- Mar 2026
- First submitted
- 26 Feb 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data (IPD) underlying the results reported in publications will be made available upon reasonable request. Data will be shared after publication of the primary results and will include variables necessary to reproduce the analyses. All shared data will be fully anonymized in accordance with applicable data protection regulations (including GDPR). Requests must include a methodologically sound research proposal and will require approval by the principal investigator and the corresponding ethics committee where applicable.
Publications
Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J. Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial. JAMA Neurol. 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492.
PubMed 29710099Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH. Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2017 Jan 14;1(1):CD011279. doi: 10.1002/14651858.CD011279.pub2.
PubMed 28087891Louw A, Zimney K, Puentedura EJ, Diener I. The efficacy of pain neuroscience education on musculoskeletal pain: A systematic review of the literature. Physiother Theory Pract. 2016 Jul;32(5):332-55. doi: 10.1080/09593985.2016.1194646. Epub 2016 Jun 28.
PubMed 27351541Qaseem A, Wilt TJ, McLean RM, Forciea MA; Clinical Guidelines Committee of the American College of Physicians; Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP, Humphrey LL, Vijan S. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017 Apr 4;166(7):514-530. doi: 10.7326/M16-2367. Epub 2017 Feb 14.
PubMed 28192789
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of a Multimodal Intervention Based on Pain Neuroscience Education, Therapeutic Exercise and Healthy Lifestyle Promotion in Patients With Persistent Musculoskeletal Pain in Primary Care: A Multicenter Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07461298
- Acronym / sponsor ID
- DolorAP / UJI-DMP-AP-2026
- Conditions
- Chronic Musculoskeletal Pain
- Keywords
- Physical exercise, Patient Care Group, Primary Health Care, Multimodal Intervention, Health-Related Quality of Life, Self-Management, Pain Neuroscience Education
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 146 participants (estimated)
- Lead sponsor
- Universitat Jaume IUniversity, hospital or other
- Study start
- Jun 2026 (estimated)
- Primary completion
- Jan 2028 (estimated)
- Study completion
- Jan 2028 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This multicenter randomized controlled trial aims to evaluate the effectiveness of a multimodal intervention for the active management of persistent musculoskeletal pain in primary care. The intervention combines pain neuroscience education, therapeutic exercise, and the promotion of self-care and healthy lifestyle habits to improve health-related quality of life in adults with persistent nonspecific musculoskeletal pain lasting at least six months.
A total of 146 participants aged 18 to 70 years will be recruited from five primary care centers in the Comunitat Valenciana (Spain) and randomly assigned to either the experimental group or the control group. The primary outcome is health-related quality of life measured using the SF-36 Health Survey. Secondary outcomes include pain intensity, pain catastrophizing, kinesiophobia, central sensitization, emotional symptoms, perceived social support, medication use, and lifestyle-related variables. Assessments will be conducted at baseline, post-intervention, 6 months, and 12 months follow-up.
Detailed description
Persistent musculoskeletal pain represents a major public health problem and is one of the most frequent reasons for consultation in primary care. It is associated with reduced quality of life, functional limitations, emotional distress, increased healthcare utilization, and high socioeconomic costs. Contemporary pain science recognizes that persistent pain is a multidimensional experience involving biological, psychological, and social mechanisms, including central sensitization and maladaptive cognitive-emotional processes such as catastrophizing and fear-avoidance behaviors.
Current clinical practice guidelines recommend multimodal and non-pharmacological approaches as first-line management strategies. Pain neuroscience education (PNE) aims to reconceptualize pain by explaining the neurobiological and psychosocial mechanisms involved in persistent pain, thereby reducing perceived threat and maladaptive beliefs. Therapeutic exercise contributes to functional improvement, modulation of central pain mechanisms, and psychological well-being. Additionally, the promotion of self-care strategies and healthy lifestyle habits (including physical activity, sleep hygiene, stress management, and nutritional counseling) may enhance long-term outcomes and patient empowerment.
This study is a multicenter, parallel-group, single-blind randomized controlled trial conducted in five primary care centers in the Comunitat Valenciana (Spain). A total of 146 adults aged 18 to 70 years with nonspecific persistent musculoskeletal pain lasting at least six months will be recruited and randomly allocated to either an experimental group receiving the multimodal intervention or a control group receiving usual care.
The multimodal intervention integrates structured group-based pain neuroscience education sessions, supervised therapeutic exercise, and guidance on self-care and healthy lifestyle habits. The control group will continue to receive standard primary care management.
The primary outcome is health-related quality of life assessed using the SF-36 Health Survey. Secondary outcomes include pain intensity, number of painful areas, pain catastrophizing, kinesiophobia, central sensitization, emotional symptoms, perceived social support, medication consumption, and lifestyle-related variables. Data will be collected at baseline, immediately post-intervention, and at 6- and 12-month follow-ups using the REDCap electronic data capture system.
Statistical analyses will include descriptive statistics and inferential analyses to compare within- and between-group differences over time. The study aims to provide robust evidence regarding the effectiveness of a multimodal, biopsychosocial intervention delivered in primary care for the management of persistent musculoskeletal pain.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomly assigned in a 1:1 ratio to either the experimental group receiving the multimodal intervention or the control group receiving usual primary care. The two groups will be followed in parallel throughout the study period, with outcome assessments conducted at baseline, post-intervention, and at 6- and 12-month follow-ups.
| Arm | Type | Receives |
|---|---|---|
| Multimodal Intervention Group | Experimental | Behavioral: Multimodal Pain Management ProgramParticipants assigned to the experimental group will receive a structured multimodal intervention delivered in primary care settings. The intervention integrates group-based pain neuroscience education sessions, supervised therapeutic exercise, and guidance on self-care strategies and healthy lifestyle habits. The program aims to promote active coping, improve functional capacity, and enhance health-related quality of life in individuals with persistent musculoskeletal pain. |
| Usual Care Group | Active comparator | Other: Usual Primary CareParticipants assigned to the control group will receive usual primary care management for persistent musculoskeletal pain. Usual care may include pharmacological treatment, medical follow-up, and referral to other healthcare services when considered necessary, according to standard clinical practice. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults aged between 18 and 70 years
- Diagnosis of nonspecific persistent musculoskeletal pain lasting at least 6 months
- Receiving care in participating primary care centers
- Ability to understand study procedures and provide written informed consent
- Ability to complete self-administered questionnaires
Key exclusion criteria (6 listed)
- Specific musculoskeletal pathology requiring specialized treatment (e.g., fracture, inflammatory rheumatic disease, malignancy)
- Neurological disorders affecting movement or pain perception
- Severe psychiatric disorders that may interfere with participation
- Participation in another structured pain management program during the study period
- Cognitive impairment preventing questionnaire completion
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multimodal Pain Management ProgramThe multimodal program combines pain neuroscience education, therapeutic exercise, and the promotion of self-care and healthy lifestyle habits. Pain neuroscience education focuses on reconceptualizing pain based on contemporary neurophysiological principles. Therapeutic exercise includes supervised physical activity aimed at improving strength, mobility, and functional capacity. The self-care component addresses lifestyle factors such as physical activity, sleep hygiene, stress management, and healthy nutrition. | Behavioural | Multimodal Intervention Group |
| Usual Primary CareParticipants in the control group will continue receiving standard primary care treatment as determined by their healthcare providers. This may include medication, medical advice, or referral to other services according to routine clinical practice. | Other | Usual Care Group |
Primary outcome
Health-Related Quality of Life
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Health-related quality of life assessed using the 36-Item Short Form Health Survey (SF-36). The SF-36 measures eight health domains and provides physical and mental component summary scores. Higher scores indicate better health-related quality of life.
10 secondary outcomes
Pain Intensity
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Number of Painful Body Areas
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Pain Catastrophizing
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Kinesiophobia
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Central Sensitization
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Anxiety Symptoms
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Depressive Symptoms
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Perceived Social Support
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Medication Consumption
Time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention
Participant Satisfaction With the Intervention
Time frame: Immediately post-intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Background: PubMed 29710099Malfliet A, Kregel J, Coppieters I, De Pauw R, Meeus M, Roussel N, Cagnie B, Danneels L, Nijs J. Effect of Pain Neuroscience Education Combined With Cognition-Targeted Motor Control Training on Chronic Spinal Pain: A Randomized Clinical Trial. JAMA Neurol. 2018 Jul 1;75(7):808-817. doi: 10.1001/jamaneurol.2018.0492.
- Background: PubMed 28087891Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BH. Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev. 2017 Jan 14;1(1):CD011279. doi: 10.1002/14651858.CD011279.pub2.
- Background: PubMed 27351541Louw A, Zimney K, Puentedura EJ, Diener I. The efficacy of pain neuroscience education on musculoskeletal pain: A systematic review of the literature. Physiother Theory Pract. 2016 Jul;32(5):332-55. doi: 10.1080/09593985.2016.1194646. Epub 2016 Jun 28.
- Background: PubMed 28192789Qaseem A, Wilt TJ, McLean RM, Forciea MA; Clinical Guidelines Committee of the American College of Physicians; Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP, Humphrey LL, Vijan S. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017 Apr 4;166(7):514-530. doi: 10.7326/M16-2367. Epub 2017 Feb 14.
- Individual participant dataSharing planned: Yes. De-identified individual participant data (IPD) underlying the results reported in publications will be made available upon reasonable request. Data will be shared after publication of the primary results and will include variables necessary to reproduce the analyses. All shared data will be fully anonymized in accordance with applicable data protection regulations (including GDPR). Requests must include a methodologically sound research proposal and will require approval by the principal investigator and the corresponding ethics committee where applicable.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
5 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multimodal Pain Management Program and Usual Primary Care in people with Chronic Musculoskeletal Pain, run by Universitat Jaume I at 5 sites in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Victor Ortiz Mallasen (34964387810, ortizv@uji.es), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Health-Related Quality of Life (time frame: Baseline, immediately post-intervention, 6 months, and 12 months after intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07461298, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.