Menstrual CycleNCT07462286
Menstrual Cycle and Women's Performance
An observational study of Menstrual Cycle and Physical Performance, run by Charles University, Czech Republic at 1 site in Czechia.
Trial summary
This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years. Read more about this study
- Who is it for?
- Ages 18 to 35 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Menstrual Cycle, Physical Performance, Muscle Strength
- What is being tested?
- Menstrual Cycle Tracking, Performance and Strength Testing and Musculoskeletal Assessment
- How many people
- 32 participants
- Where
- 1 siteCzechia
- Study dates
- 1 Apr 2026to 30 Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- Women only
- Healthy volunteers accepted
- Adult
Study population: Premenopausal women aged 18-35 years from the general population with occasional to recreational physical activity, recruited for repeated within-subject assessments across predefined menstrual cycle phases.
Who may be able to join
- Female, age 18-35 years
- Premenopausal
- Occasional to recreational level of physical activity
- Willing and able to track menstrual cycle using a mobile application for approximately 2 months
- Willing and able to attend 3 laboratory visits scheduled to predefined menstrual cycle phases
- Able to provide written informed consent
Who cannot join
- Irregular menstrual cycle (outside protocol-defined regularity)
- Current pregnancy
- Use of hormonal medication for therapeutic purposes (per protocol)
- Current acute illness at time of testing
- Musculoskeletal injury of the lower limb limiting safe performance testing
- Contraindication to body composition assessment methods used in the study (e.g., BIA/DXA, per site protocol)
- Any other condition that, in the investigator's judgment, may interfere with safe participation or data quality
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Czechia1 site
Faculty of Physical Education and Sport, Charles University, José Martího 269/31
Prague, Prague, 16252
Vendula Soukupová, Mgr., +420775976312, vendula.soukupova@ftvs.cuni.cz
About this study
Official title: The Relationship Between the Menstrual Cycle and Physical Performance in Women
This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years.
Participants will track their menstrual cycle using a mobile app for approximately 2 months and attend 3 laboratory visits scheduled to specific cycle phases.
Read more
At each visit, participants will complete non-invasive assessments including lower-limb strength/performance testing, musculoskeletal measurements (muscle and tendon properties), body composition assessment, and symptom-related questionnaires.
The goal is to improve understanding of physiological variability across the menstrual cycle and support evidence-based planning of training, testing, and clinical practice in women.
Read the detailed description
Background and rationale:
Female physiology changes across menstrual cycle phases, which may influence neuromuscular performance, perceived symptoms, and selected tissue/mechanical properties. Current evidence is heterogeneous, partly due to methodological differences in cycle-phase identification and measurement protocols. This study aims to provide standardized data from repeated within-subject assessments across the menstrual cycle.
Objectives:
Primary objective is to evaluate associations between menstrual cycle phase and selected performance-related outcomes in physically active women.
Secondary objectives are to explore phase-related differences in musculoskeletal parameters, body composition outputs, and self-reported symptoms.
Study design:
Prospective, repeated-measures observational study. Each participant is measured repeatedly across predefined menstrual cycle phases.
Participants:
Women from the general population, 18-35 years, with occasional to recreational physical activity level.
Procedures:
Screening and eligibility confirmation according to protocol criteria.
Menstrual cycle tracking via mobile application for approximately 2 months.
Three laboratory visits timed to predefined cycle phases.
At each visit, non-invasive assessments are performed, including:
lower-limb strength/performance testing,
assessment of muscle and tendon mechanical properties,
body composition measurement,
recording of subjectively perceived menstrual-related symptoms.
Outcomes:
Main outcomes include phase-specific differences/associations in selected performance and musculoskeletal variables; additional outcomes include symptom profiles and selected body-composition variables.
Duration and setting:
Individual participation lasts approximately 2 months including cycle tracking and 3 lab visits (approximately 60-90 minutes per visit). Study procedures are conducted at FTVS UK (Prague).
Ethics and data protection:
Participation is voluntary, and participants may withdraw at any time without giving a reason. Data are processed in compliance with applicable data-protection regulations (including GDPR), pseudonymized for analysis, and reported in aggregate/anonymized form. The study is conducted according to institutional ethics approval and the Declaration of Helsinki.
- Conditions
- Menstrual Cycle, Physical Performance, Muscle Strength, Musculoskeletal System, Healthy Volunteers
- Being tested
- Menstrual Cycle Tracking, Performance and Strength Testing, Musculoskeletal Assessment, Body Composition and Symptom Assessment
- Keywords
- menstrual cycle phase, follicular phase, luteal phase, female athletes, physically active women, neuromuscular performance, lower limb strength, muscle mechanical properties, tendon mechanical properties, body composition, symptom tracking, cycle tracking app, repeated measures, observational study, women's health
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Menstrual Cycle TrackingOther
Menstrual cycle monitoring using a mobile application for approximately 2 months to schedule laboratory visits to predefined cycle phases.
Performance and Strength TestingOther
Repeated lower-limb performance/strength assessments during laboratory visits in different menstrual cycle phases.
Musculoskeletal AssessmentOther
Non-invasive assessment of selected muscle and tendon mechanical properties across cycle phases.
Body Composition and Symptom AssessmentOther
Body composition measurement and collection of self-reported menstrual-related symptoms at laboratory visits.
| Study group | Role | What they receive |
|---|---|---|
| Physically Active Women (18-35 years) | Women aged 18-35 years from the general population with occasional to recreational physical activity level. Participants undergo repeated non-invasive assessments across predefined menstrual cycle phases, including performance testing, musculoskeletal measurements, body composition assessment, and symptom tracking. Receives: Other: Menstrual Cycle Tracking; Other: Performance and Strength Testing; Other: Musculoskeletal Assessment; Other: Body Composition and Symptom Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Phase-specific change in lower-limb neuromuscular performance across the menstrual cycle
Within-subject differences in lower-limb performance/strength outcomes measured during three laboratory visits scheduled to predefined menstrual cycle phases.
Measured: Assessed at 3 laboratory visits across approximately 2 months (cycle tracking period)
Secondary outcomes (4)
Phase-specific differences in muscle mechanical properties
Within-subject changes in selected skeletal muscle mechanical properties measured non-invasively across predefined menstrual cycle phases.
Measured: Assessed at 3 laboratory visits across approximately 2 months
Phase-specific differences in tendon mechanical properties
Within-subject changes in selected tendon mechanical properties measured non-invasively across predefined menstrual cycle phases.
Measured: Assessed at 3 laboratory visits across approximately 2 months
Phase-specific differences in body composition variables
Within-subject differences in body composition parameters assessed at laboratory visits scheduled to predefined menstrual cycle phases.
Measured: Assessed at 3 laboratory visits across approximately 2 months
Menstrual-related symptom profile across menstrual cycle phases
Self-reported menstrual-related symptoms recorded via questionnaires/standardized symptom reporting and compared across predefined cycle phases.
Measured: Collected during cycle tracking and at 3 laboratory visits across approximately 2 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Mar 2026
- Study start1 Apr 2026 (estimated)
- Primary completion30 Sep 2026 (estimated)
- Study completion30 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Menstrual CycleStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Charles University, Czech Republic
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07462286
- Sponsor's protocol ID
- EK 008/2026
- Status last verified
- Mar 2026
- First submitted
- 5 Mar 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Relationship Between the Menstrual Cycle and Physical Performance in Women
- ClinicalTrials.gov ID
- NCT07462286
- Acronym / sponsor ID
- EK 008/2026
- Conditions
- Menstrual Cycle, Physical Performance, Muscle Strength, Musculoskeletal System, Healthy Volunteers
- Keywords
- menstrual cycle phase, follicular phase, luteal phase, female athletes, physically active women, neuromuscular performance, lower limb strength, muscle mechanical properties
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- Charles University, Czech RepublicUniversity, hospital or other
- Study start
- 1 Apr 2026 (estimated)
- Primary completion
- 30 Sep 2026 (estimated)
- Study completion
- 30 Mar 2027 (estimated)
- First posted
- 10 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines how different phases of the menstrual cycle are associated with selected performance and musculoskeletal parameters in physically active women aged 18-35 years.
Participants will track their menstrual cycle using a mobile app for approximately 2 months and attend 3 laboratory visits scheduled to specific cycle phases.
At each visit, participants will complete non-invasive assessments including lower-limb strength/performance testing, musculoskeletal measurements (muscle and tendon properties), body composition assessment, and symptom-related questionnaires.
The goal is to improve understanding of physiological variability across the menstrual cycle and support evidence-based planning of training, testing, and clinical practice in women.
Detailed description
Background and rationale:
Female physiology changes across menstrual cycle phases, which may influence neuromuscular performance, perceived symptoms, and selected tissue/mechanical properties. Current evidence is heterogeneous, partly due to methodological differences in cycle-phase identification and measurement protocols. This study aims to provide standardized data from repeated within-subject assessments across the menstrual cycle.
Objectives:
Primary objective is to evaluate associations between menstrual cycle phase and selected performance-related outcomes in physically active women.
Secondary objectives are to explore phase-related differences in musculoskeletal parameters, body composition outputs, and self-reported symptoms.
Study design:
Prospective, repeated-measures observational study. Each participant is measured repeatedly across predefined menstrual cycle phases.
Participants:
Women from the general population, 18-35 years, with occasional to recreational physical activity level.
Procedures:
Screening and eligibility confirmation according to protocol criteria.
Menstrual cycle tracking via mobile application for approximately 2 months.
Three laboratory visits timed to predefined cycle phases.
At each visit, non-invasive assessments are performed, including:
lower-limb strength/performance testing,
assessment of muscle and tendon mechanical properties,
body composition measurement,
recording of subjectively perceived menstrual-related symptoms.
Outcomes:
Main outcomes include phase-specific differences/associations in selected performance and musculoskeletal variables; additional outcomes include symptom profiles and selected body-composition variables.
Duration and setting:
Individual participation lasts approximately 2 months including cycle tracking and 3 lab visits (approximately 60-90 minutes per visit). Study procedures are conducted at FTVS UK (Prague).
Ethics and data protection:
Participation is voluntary, and participants may withdraw at any time without giving a reason. Data are processed in compliance with applicable data-protection regulations (including GDPR), pseudonymized for analysis, and reported in aggregate/anonymized form. The study is conducted according to institutional ethics approval and the Declaration of Helsinki.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Physically Active Women (18-35 years) | – | Other: Menstrual Cycle Tracking, Other: Performance and Strength Testing, Other: Musculoskeletal Assessment, Other: Body Composition and Symptom AssessmentWomen aged 18-35 years from the general population with occasional to recreational physical activity level. Participants undergo repeated non-invasive assessments across predefined menstrual cycle phases, including performance testing, musculoskeletal measurements, body composition assessment, and symptom tracking. |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- Premenopausal women aged 18-35 years from the general population with occasional to recreational physical activity, recruited for repeated within-subject assessments across predefined menstrual cycle phases.
Key inclusion criteria (6 listed)
- Female, age 18-35 years
- Premenopausal
- Occasional to recreational level of physical activity
- Willing and able to track menstrual cycle using a mobile application for approximately 2 months
- Willing and able to attend 3 laboratory visits scheduled to predefined menstrual cycle phases
Key exclusion criteria (7 listed)
- Irregular menstrual cycle (outside protocol-defined regularity)
- Current pregnancy
- Use of hormonal medication for therapeutic purposes (per protocol)
- Current acute illness at time of testing
- Musculoskeletal injury of the lower limb limiting safe performance testing
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Menstrual Cycle TrackingMenstrual cycle monitoring using a mobile application for approximately 2 months to schedule laboratory visits to predefined cycle phases. | Other | Physically Active Women (18-35 years) |
| Performance and Strength TestingRepeated lower-limb performance/strength assessments during laboratory visits in different menstrual cycle phases. | Other | Physically Active Women (18-35 years) |
| Musculoskeletal AssessmentNon-invasive assessment of selected muscle and tendon mechanical properties across cycle phases. | Other | Physically Active Women (18-35 years) |
| Body Composition and Symptom AssessmentBody composition measurement and collection of self-reported menstrual-related symptoms at laboratory visits. | Other | Physically Active Women (18-35 years) |
Primary outcome
Phase-specific change in lower-limb neuromuscular performance across the menstrual cycle
Time frame: Assessed at 3 laboratory visits across approximately 2 months (cycle tracking period)
Within-subject differences in lower-limb performance/strength outcomes measured during three laboratory visits scheduled to predefined menstrual cycle phases.
4 secondary outcomes
Phase-specific differences in muscle mechanical properties
Time frame: Assessed at 3 laboratory visits across approximately 2 months
Phase-specific differences in tendon mechanical properties
Time frame: Assessed at 3 laboratory visits across approximately 2 months
Phase-specific differences in body composition variables
Time frame: Assessed at 3 laboratory visits across approximately 2 months
Menstrual-related symptom profile across menstrual cycle phases
Time frame: Collected during cycle tracking and at 3 laboratory visits across approximately 2 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Menstrual Cycle and Physical Performance, run by Charles University, Czech Republic at 1 site in Czechia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Czechia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Vendula Soukupová, Mgr. (+420775976312, vendula.soukupova@ftvs.cuni.cz), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Phase-specific change in lower-limb neuromuscular performance across the menstrual cycle (time frame: Assessed at 3 laboratory visits across approximately 2 months (cycle tracking period)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.