EducationLASTNCT07463274
Simulation-Based Team Training for Management of Local Anesthetic Systemic Toxicity (LAST) in Non-Anesthesiologist Surgical Residents
A study testing Education in people with Education and Questionnaires, run by Selcuk University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Education, Questionnaires
- What is being tested?
- Education
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 102 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Sep 2025to 28 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Surgical residents (General Surgery, Orthopedics, Obstetrics \& Gynecology, Dentistry) on active rotation at Selçuk University Faculty of Medicine.
- Voluntary participation with written informed consent.
- No prior comprehensive LAST training in the last 12 months.
Who cannot join
- Prior comprehensive LAST training or instructor experience in the last 12 months.
- Anesthesiology residents or specialists.
- Unable to complete follow-up due to rotation change or leave.
- Declining or withdrawing consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Selcuk Universitesi, School of Medicine, Anesthesiology
Konya, 42250
About this study
Official title: Evaluation of the Effectiveness of a Local Anesthetic Systemic Toxicity (LAST) Knowledge Training Program for Non-Anesthesiologist Surgical Residents
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Guided by Kirkpatrick's evaluation model, the study investigates improvements in knowledge, technical and non-technical skills, and the retention of these competencies one month after training
Read the detailed description
Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication of regional anesthesia. Advances in ultrasound-guided blocks have reduced its incidence, yet LAST remains a major concern due to severe cardiovascular and neurological risks. The American Society of Regional Anesthesia and Pain Medicine (ASRA) recommends early lipid emulsion therapy and emphasizes proper training. Simulation-based multidisciplinary training provides a dynamic and immersive experience, improving both technical and behavioral skills. This trial applies Kirkpatrick's four-level model (reaction, learning, behavior, results) to assess the training program. Primary endpoint: improvement in knowledge test scores. Secondary endpoints: OSCE performance, satisfaction, and key performance indicators related to simulated LAST management.
- Conditions
- Education, Questionnaires
- Being tested
- Education
- Keywords
- Local anesthetic, Questionnaires, Regional anesthesia, Team
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
EducationBehavioural
Local Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training
| Study group | Role | What they receive |
|---|---|---|
| Structured Training Group | Experimental | Experimental: Structured Training Group - Local Anesthetic Systemic Toxicity (LAST) pretest application, then Kirkpatrick-based program (2-3 hours; theoretical + simulation/OSCE). Includes theoretical (pathophysiology, risk factors, prevention, lipid therapy algorithm) and practical modules (simulation scenario, OSCE checklist, structured feedback). Local Anesthetic Systemic Toxicity (LAST) lasttest application It is assumed that a higher test score indicates a higher level of knowledge on the topic. Receives: Behavioral: Education |
| Control | Experimental | Control: Standard Training Group (Wait-list Control) - Routine anesthesia training during standard rotation. Structured training provided after study completion. Receives: Behavioral: Education |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knowledge improvement (Learning outcome)
Local Anesthetic Systemic Toxicity (LAST) Knowledge Level and Awareness Test Change in 25-item multiple-choice test score (Δ = post-test - pre-test) Scoring: 0-25. It is accepted that as the score obtained for the test increases, the level of knowledge about the subject increases.
Measured: Baseline (Day 0) to immediately post-training.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Mar 2026
- Study start15 Sep 2025
- Primary completion28 Feb 2026 (estimated)
- Study completion28 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for EducationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Randomized, Parallel Assignment, Prospective, Assessor-blinded
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 102 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Selcuk University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Faruk Cicekci, Selcuk University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07463274
- Sponsor's protocol ID
- farukcicekci9
- Acronym
- LAST
- Status last verified
- Mar 2026
- First submitted
- 22 Sep 2025
- Last updated
- 11 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data will be made available from the corresponding author upon reasonable request after publication of the article.
Study at a glance
From the registry record, last updated by the sponsor on 11 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effectiveness of a Local Anesthetic Systemic Toxicity (LAST) Knowledge Training Program for Non-Anesthesiologist Surgical Residents
- ClinicalTrials.gov ID
- NCT07463274
- Acronym / sponsor ID
- LAST / farukcicekci9
- Conditions
- Education, Questionnaires
- Keywords
- Local anesthetic, Questionnaires, Regional anesthesia, Team
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 102 participants (estimated)
- Lead sponsor
- Selcuk UniversityUniversity, hospital or other
- Study start
- 15 Sep 2025 (actual)
- Primary completion
- 28 Feb 2026 (estimated)
- Study completion
- 28 Feb 2026 (estimated)
- First posted
- 11 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial evaluates the effectiveness of a simulation-based multidisciplinary team training program on the management of Local Anesthetic Systemic Toxicity (LAST) among non-anesthesiologist surgical residents. Guided by Kirkpatrick's evaluation model, the study investigates improvements in knowledge, technical and non-technical skills, and the retention of these competencies one month after training
Detailed description
Local Anesthetic Systemic Toxicity (LAST) is a rare but potentially life-threatening complication of regional anesthesia. Advances in ultrasound-guided blocks have reduced its incidence, yet LAST remains a major concern due to severe cardiovascular and neurological risks. The American Society of Regional Anesthesia and Pain Medicine (ASRA) recommends early lipid emulsion therapy and emphasizes proper training. Simulation-based multidisciplinary training provides a dynamic and immersive experience, improving both technical and behavioral skills. This trial applies Kirkpatrick's four-level model (reaction, learning, behavior, results) to assess the training program. Primary endpoint: improvement in knowledge test scores. Secondary endpoints: OSCE performance, satisfaction, and key performance indicators related to simulated LAST management.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Randomized, Parallel Assignment, Prospective, Assessor-blinded
| Arm | Type | Receives |
|---|---|---|
| Structured Training Group | Experimental | Behavioral: EducationExperimental: Structured Training Group - Local Anesthetic Systemic Toxicity (LAST) pretest application, then Kirkpatrick-based program (2-3 hours; theoretical + simulation/OSCE). Includes theoretical (pathophysiology, risk factors, prevention, lipid therapy algorithm) and practical modules (simulation scenario, OSCE checklist, structured feedback). Local Anesthetic Systemic Toxicity (LAST) lasttest application It is assumed that a higher test score indicates a higher level of knowledge on the topic. |
| Control | Experimental | Behavioral: EducationControl: Standard Training Group (Wait-list Control) - Routine anesthesia training during standard rotation. Structured training provided after study completion. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Surgical residents (General Surgery, Orthopedics, Obstetrics \& Gynecology, Dentistry) on active rotation at Selçuk University Faculty of Medicine.
- Voluntary participation with written informed consent.
- No prior comprehensive LAST training in the last 12 months.
Key exclusion criteria (4 listed)
- Prior comprehensive LAST training or instructor experience in the last 12 months.
- Anesthesiology residents or specialists.
- Unable to complete follow-up due to rotation change or leave.
- Declining or withdrawing consent.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| EducationLocal Anesthetic Systemic Toxicity (LAST); Simulation-based Education; Perioperative Training | Behavioural | Control, Structured Training Group |
Primary outcome
Knowledge improvement (Learning outcome)
Time frame: Baseline (Day 0) to immediately post-training.
Local Anesthetic Systemic Toxicity (LAST) Knowledge Level and Awareness Test Change in 25-item multiple-choice test score (Δ = post-test - pre-test) Scoring: 0-25. It is accepted that as the score obtained for the test increases, the level of knowledge about the subject increases.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Mar 2026.
- Individual participant dataSharing planned: Yes. De-identified individual participant data will be made available from the corresponding author upon reasonable request after publication of the article.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Education in people with Education and Questionnaires, run by Selcuk University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 11 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knowledge improvement (Learning outcome) (time frame: Baseline (Day 0) to immediately post-training.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Mar 2026.