Intracranial Pressure MeasurementNCT07465419
IJV Catheterization and Intracranial Pressure Via ONSD
An observational study of Intracranial Pressure Measurement and Measurement of Optic Nerve Sheath Diameter, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to evaluate the effect of internal jugular vein catheterization on intracranial pressure in intubated patients in the intensive care unit using optic nerve sheath diameter Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Intracranial Pressure Measurement, Measurement of Optic Nerve Sheath Diameter
- What is being tested?
- Internal jugular vein catheterization
- Type of treatment
- Surgery or procedure
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Feb 2026to 1 Jun 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Intubated intensive care unit patients who receive internal jugular vein catheterization
Who may be able to join
- The study will include adult patients over 18 years of age who are on mechanical ventilation support and monitored in the intensive care unit.
Who cannot join
- patients with intracranial tumors
- patients with acute traumatic brain injury
- patients diagnosed with acute or chronic eye diseases
- hypercarbic patients
- Patients receiving inotropic support
- patients using medications that affect intraocular pressure
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Sivas Cumhuriyet University
Sivas, Sivas, 58140
About this study
Official title: Evaluation of the Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Using Optic Nerve Sheath Diameter in Intubated Patients in the Intensive Care Unit
The aim of this study is to evaluate the effect of internal jugular vein catheterization on intracranial pressure in intubated patients in the intensive care unit using optic nerve sheath diameter
Read the detailed description
Before central venous catheter insertion, the baseline ONSD value will be determined by measuring the optic nerve sheath diameter in the supine and Trendelenburg positions (15 degrees head down).
Immediately after central venous catheter insertion, the measurement will be taken while the patient is still in the Trendelenburg position. The measurement will be repeated at 5, 15, and 30 minutes after the patient is placed in the supine position.
Transorbital optic nerve sheath diameter measurements will be performed using the linear probe of the ultrasound device routinely used in our clinic. The ultrasound linear probe will be gently placed on the eyelid over the closed eye, ensuring no pressure is applied to the patient's eye. The length of the line representing the optic nerve sheath diameter, which intersects the line drawn 3 mm downwards from the lower edge of the eyeball seen on the ultrasound, will be measured and recorded. The optic nerve sheath diameter will be measured transorbitally vertically once from each eye during the first measurement, and the average will be taken.
- Being tested
- Internal jugular vein catheterization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Internal jugular vein catheterizationProcedure or surgery
Internal jugular vein catheterization
| Study group | Role | What they receive |
|---|---|---|
| IJV catheterization in ICU | Intubated patients in intensive care unit who receive internal jugular vein catheterization Receives: Procedure: Internal jugular vein catheterization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Optic nerve sheath diameter
Optic nerve sheath diameter will be measured via ultrasound prior to IJV catheterization, and after 0, 5, 15, 30 minutes of catheterization
Measured: Prior to IJV catheterization, and after 0, 5, 15, 30 minutes of catheterization
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Mar 2026
- Study start1 Feb 2026
- Primary completion28 May 2026
- Study completion1 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Intracranial Pressure MeasurementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cumhuriyet University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Oguz Gundogdu, Cumhuriyet University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07465419
- Sponsor's protocol ID
- 2025-05/28
- Status last verified
- Jun 2026
- First submitted
- 7 Mar 2026
- Last updated
- 22 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Effect of Internal Jugular Vein Catheterization on Intracranial Pressure Using Optic Nerve Sheath Diameter in Intubated Patients in the Intensive Care Unit
- ClinicalTrials.gov ID
- NCT07465419
- Acronym / sponsor ID
- 2025-05/28
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Cumhuriyet UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 28 May 2026 (actual)
- Study completion
- 1 Jun 2026 (actual)
- First posted
- 11 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to evaluate the effect of internal jugular vein catheterization on intracranial pressure in intubated patients in the intensive care unit using optic nerve sheath diameter
Detailed description
Before central venous catheter insertion, the baseline ONSD value will be determined by measuring the optic nerve sheath diameter in the supine and Trendelenburg positions (15 degrees head down).
Immediately after central venous catheter insertion, the measurement will be taken while the patient is still in the Trendelenburg position. The measurement will be repeated at 5, 15, and 30 minutes after the patient is placed in the supine position.
Transorbital optic nerve sheath diameter measurements will be performed using the linear probe of the ultrasound device routinely used in our clinic. The ultrasound linear probe will be gently placed on the eyelid over the closed eye, ensuring no pressure is applied to the patient's eye. The length of the line representing the optic nerve sheath diameter, which intersects the line drawn 3 mm downwards from the lower edge of the eyeball seen on the ultrasound, will be measured and recorded. The optic nerve sheath diameter will be measured transorbitally vertically once from each eye during the first measurement, and the average will be taken.
Study design
- Observational model
- Case only
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| IJV catheterization in ICU | – | Procedure: Internal jugular vein catheterizationIntubated patients in intensive care unit who receive internal jugular vein catheterization |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Intubated intensive care unit patients who receive internal jugular vein catheterization
Key inclusion criteria (1 listed)
- The study will include adult patients over 18 years of age who are on mechanical ventilation support and monitored in the intensive care unit.
Key exclusion criteria (6 listed)
- patients with intracranial tumors
- patients with acute traumatic brain injury
- patients diagnosed with acute or chronic eye diseases
- hypercarbic patients
- Patients receiving inotropic support
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Internal jugular vein catheterizationInternal jugular vein catheterization | Procedure or surgery | IJV catheterization in ICU |
Primary outcome
Optic nerve sheath diameter
Time frame: Prior to IJV catheterization, and after 0, 5, 15, 30 minutes of catheterization
Optic nerve sheath diameter will be measured via ultrasound prior to IJV catheterization, and after 0, 5, 15, 30 minutes of catheterization
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Jun 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Intracranial Pressure Measurement and Measurement of Optic Nerve Sheath Diameter, run by Cumhuriyet University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Optic nerve sheath diameter (time frame: Prior to IJV catheterization, and after 0, 5, 15, 30 minutes of catheterization). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Jun 2026.