CABGNCT07467941
Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After CABG
An observational study of CABG and Visceral Adipose Tissue, run by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital.
Trial summary
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- CABG, Visceral Adipose Tissue, Atrial Fibrillation (AF)
- What is being tested?
- Postoperative AF Group and Non-AF Group
- Type of treatment
- Injection or infusion
- How many people
- 300 participants
- Where
- No sites listed yet
- Study dates
- 1 Apr 2026to 22 Jan 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients (≥18 years) scheduled for coronary artery bypass graft surgery.
Who may be able to join
- Elective isolated coronary artery bypass graft surgery (on-pump)
- Age ≥18 years, planned prospectively in 300 patients
Who cannot join
- Patients requiring urgent or emergency surgery
- Off-pump coronary artery bypass graft surgery
- Surgeries other than isolated coronary artery bypass graft
- Patients in whom abdominal ultrasound measurement cannot be performed (e.g., due to severe deformity, wounds, edema)
- Active malignancy
- eGFR <30 mL/min
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- Advanced-stage chronic obstructive pulmonary disease (COPD)
- Preoperative atrial fibrillation or atrial flutter
- Patients who do not provide written informed consent for the study
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as heart failure and coronary artery disease. Body mass index (BMI) is calculated by dividing body weight in kilograms by the square of height in meters and is widely used as an indicator of obesity. However, BMI does not quantitatively reflect body fat distribution and fails to account for components such as skeletal muscle and bone mass. Therefore, interest in assessing body fat distribution has increased, and in recent years, studies evaluating the correlation between anthropometric, biochemical, and anatomical measurements and clinical outcomes have become more frequent. In particular, it is acknowledged that abdominal obesity cannot be accurately represented by BMI alone and is primarily associated with visceral adipose tissue (VAT). The aim of this study is to evaluate the association between preoperative visceral and subcutaneous adipose tissue measurements (VAT and SAT), assessed by ultrasonography in patients scheduled for open-heart surgery, and the development of postoperative atrial fibrillation.
- Conditions
- CABG, Visceral Adipose Tissue, Atrial Fibrillation (AF)
- Being tested
- Postoperative AF Group, Non-AF Group
- Keywords
- Atrial Fibrillation (AF), Visceral Adipose Tissue, CABG
- Medical subject headings
- Atrial Fibrillation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Postoperative AF GroupOther
In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.
Non-AF GroupOther
In patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not.
| Study group | Role | What they receive |
|---|---|---|
| Group 1: Postoperative AF Group | Visceral and subcutaneous adipose tissue thickness in patients who develop postoperative atrial fibrillation after coronary artery bypass graft surgery. Receives: Other: Postoperative AF Group | |
| Group 2: Non-AF Group | Visceral and subcutaneous adipose tissue thickness in patients who do not develop postoperative atrial fibrillation after coronary artery bypass graft surgery. Receives: Other: Non-AF Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effect of visceral adipose tissue thickness on postoperative atrial fibrillation
Preoperative ultrasound-guided measurement of visceral adipose tissue thickness will be performed. The association between visceral fat thickness and the development of postoperative atrial fibrillation will be evaluated.
Measured: Within 7 days after coronary artery bypass graft surgery or until hospital discharge
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2026
- Study start1 Apr 2026 (estimated)
- Primary completion22 Dec 2026 (estimated)
- Study completion22 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CABGStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, ÖZGE PEKŞEN KIZILIŞIK, Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07467941
- Sponsor's protocol ID
- 2025/23/1318
- Status last verified
- Mar 2026
- First submitted
- 8 Mar 2026
- Last updated
- 12 Mar 2026
- Results posted
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 12 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study
- ClinicalTrials.gov ID
- NCT07467941
- Acronym / sponsor ID
- 2025/23/1318
- Conditions
- CABG, Visceral Adipose Tissue, Atrial Fibrillation (AF)
- Keywords
- Atrial Fibrillation (AF), Visceral Adipose Tissue, CABG
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research HospitalOther government
- Study start
- 1 Apr 2026 (estimated)
- Primary completion
- 22 Dec 2026 (estimated)
- Study completion
- 22 Jan 2027 (estimated)
- First posted
- 12 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as heart failure and coronary artery disease. Body mass index (BMI) is calculated by dividing body weight in kilograms by the square of height in meters and is widely used as an indicator of obesity. However, BMI does not quantitatively reflect body fat distribution and fails to account for components such as skeletal muscle and bone mass. Therefore, interest in assessing body fat distribution has increased, and in recent years, studies evaluating the correlation between anthropometric, biochemical, and anatomical measurements and clinical outcomes have become more frequent. In particular, it is acknowledged that abdominal obesity cannot be accurately represented by BMI alone and is primarily associated with visceral adipose tissue (VAT). The aim of this study is to evaluate the association between preoperative visceral and subcutaneous adipose tissue measurements (VAT and SAT), assessed by ultrasonography in patients scheduled for open-heart surgery, and the development of postoperative atrial fibrillation.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1: Postoperative AF Group | – | Other: Postoperative AF GroupVisceral and subcutaneous adipose tissue thickness in patients who develop postoperative atrial fibrillation after coronary artery bypass graft surgery. |
| Group 2: Non-AF Group | – | Other: Non-AF GroupVisceral and subcutaneous adipose tissue thickness in patients who do not develop postoperative atrial fibrillation after coronary artery bypass graft surgery. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients (≥18 years) scheduled for coronary artery bypass graft surgery.
Key inclusion criteria (2 listed)
- Elective isolated coronary artery bypass graft surgery (on-pump)
- Age ≥18 years, planned prospectively in 300 patients
Key exclusion criteria (9 listed)
- Patients requiring urgent or emergency surgery
- Off-pump coronary artery bypass graft surgery
- Surgeries other than isolated coronary artery bypass graft
- Patients in whom abdominal ultrasound measurement cannot be performed (e.g., due to severe deformity, wounds, edema)
- Active malignancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Postoperative AF GroupIn patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not. | Other | Group 1: Postoperative AF Group |
| Non-AF GroupIn patients undergoing coronary artery bypass graft surgery, ultrasound-guided measurements of visceral and subcutaneous adipose tissue will be performed preoperatively. The relationship between adipose tissue thickness and the development of postoperative atrial fibrillation will be evaluated by comparing patients who develop AF with those who do not. | Other | Group 2: Non-AF Group |
Primary outcome
Effect of visceral adipose tissue thickness on postoperative atrial fibrillation
Time frame: Within 7 days after coronary artery bypass graft surgery or until hospital discharge
Preoperative ultrasound-guided measurement of visceral adipose tissue thickness will be performed. The association between visceral fat thickness and the development of postoperative atrial fibrillation will be evaluated.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Mar 2026.
- Individual participant dataSharing planned: Undecided
Related trials for CABG
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Coronary Artery Bypass Graft (CABG)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of CABG and Visceral Adipose Tissue, run by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 12 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact OZGE PEKSEN KIZILISIK (+905439406027, ozgepeksen55@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effect of visceral adipose tissue thickness on postoperative atrial fibrillation (time frame: Within 7 days after coronary artery bypass graft surgery or until hospital discharge). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Mar 2026.