Skin RejuvenationNCT07467954
Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation
A study testing Fractional CO₂ laser and Long-pulsed 1064-nm Nd:YAG laser in people with Skin Rejuvenation and Laser, run by Universitas Padjadjaran at 1 site in Indonesia.
Trial summary
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin… Read more about this study
- Who is it for?
- Ages 30 to 59 yearsHealthy volunteers can take part
- Conditions the study is for
- Skin Rejuvenation, Laser
- What is being tested?
- Fractional CO₂ laser and Long-pulsed 1064-nm Nd:YAG laser
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 15 participants
- Where
- 1 siteIndonesia
- Study dates
- 14 Oct 2025to 16 Apr 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 59 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male and female patients with skin aging classified as Glogau scale II-III
- Age 30-59 years.
Who cannot join
- Pregnant or breastfeeding women.
- Active smokers.
- Individuals with high levels of sun exposure.
- History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months.
- Use of oral isotretinoin within the past six months.
- Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks.
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- Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month.
- Presence of active facial skin inflammation.
- History of keloid formation.
- History of allergy to topical lidocaine anesthesia.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Indonesia1 site, 1 recruiting
- Recruiting
Hasan Sadikin General Hospital
Bandung, West Java, 40161
About this study
Official title: A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.
- Conditions
- Skin Rejuvenation, Laser
- Being tested
- Fractional CO₂ laser, Long-pulsed 1064-nm Nd:YAG laser
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Fractional CO₂ laserProcedure or surgery
Fractional CO₂ laser was applied to one randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers fractional ablative microthermal zones to stimulate dermal remodeling and collagen production. Treatment parameters were adjusted according to skin type and clinical indication.
Long-pulsed 1064-nm Nd:YAG laserProcedure or surgery
Long-pulsed 1064-nm Nd:YAG laser was applied to the contralateral randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers non-ablative dermal heating to stimulate collagen remodeling and improve skin texture and elasticity.
| Study group | Role | What they receive |
|---|---|---|
| Arm 1 | Experimental | In this split-face study, each participant received fractional CO₂ laser treatment on one side of the face. The treated side was randomly assigned. The procedure was performed three times at one-month intervals. Receives: Procedure: Fractional CO₂ laser |
| Arm 2 | Active comparator | In the same participants, the contralateral side of the face received long-pulsed 1064-nm Nd:YAG laser treatment. The side allocation was randomized. The procedure was performed three times at one-month intervals. Receives: Procedure: Long-pulsed 1064-nm Nd:YAG laser |
What is being measured
The primary outcome is the main question the study is designed to answer.
Dermal Thickness
Dermal thickness was assessed based on the two-dimensional area of the hyperechoic band that appears brighter than the epidermis on ultrasonography assessment.
Measured: From enrollment to the end of treatment at 20 weeks
Skin Elasticity
Skin elasticity was defined as the ability of the skin to return to its original shape after deformation caused by mechanical traction. It was measured using a skin elasticity meter, and the R (recovery) value was assessed at 8 evaluation points on the face.
Measured: From enrollment to the end of treatment at 20 weeks
Wrinkles
Lines or folds formed on the skin surface as a result of mechanical stress, skin dehydration, or repetitive muscular activity, and were evaluated using a facial skin analyzer
Measured: From enrollment to the end of treatment at 20 weeks
Global Aesthetic Improvement Scale Scores
A 5-point rating scale (1-5) used to measure the degree of aesthetic improvement in patients following a procedure.
Measured: From enrollment to the end of treatment at 20 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2026
- Study start14 Oct 2025
- Primary completion10 Mar 2026 (estimated)
- Study completion16 Apr 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Skin RejuvenationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 15 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Universitas Padjadjaran
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Kartika Ruchiatan, M.D., Principal investigator, Faculty of Medicine Universitas Padjadjaran Bandung
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07467954
- Sponsor's protocol ID
- DV-202603.01
- Status last verified
- Mar 2026
- First submitted
- 8 Mar 2026
- Last updated
- 12 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores
- ClinicalTrials.gov ID
- NCT07467954
- Acronym / sponsor ID
- DV-202603.01
- Conditions
- Skin Rejuvenation, Laser
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 15 participants (estimated)
- Lead sponsor
- Universitas PadjadjaranUniversity, hospital or other
- Study start
- 14 Oct 2025 (actual)
- Primary completion
- 10 Mar 2026 (estimated)
- Study completion
- 16 Apr 2026 (estimated)
- First posted
- 12 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm 1 | Experimental | Procedure: Fractional CO₂ laserIn this split-face study, each participant received fractional CO₂ laser treatment on one side of the face. The treated side was randomly assigned. The procedure was performed three times at one-month intervals. |
| Arm 2 | Active comparator | Procedure: Long-pulsed 1064-nm Nd:YAG laserIn the same participants, the contralateral side of the face received long-pulsed 1064-nm Nd:YAG laser treatment. The side allocation was randomized. The procedure was performed three times at one-month intervals. |
Who may qualify
- Ages
- 30 to 59 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Male and female patients with skin aging classified as Glogau scale II-III
- Age 30-59 years.
Key exclusion criteria (10 listed)
- Pregnant or breastfeeding women.
- Active smokers.
- Individuals with high levels of sun exposure.
- History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months.
- Use of oral isotretinoin within the past six months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Fractional CO₂ laserFractional CO₂ laser was applied to one randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers fractional ablative microthermal zones to stimulate dermal remodeling and collagen production. Treatment parameters were adjusted according to skin type and clinical indication. | Procedure or surgery | Arm 1 |
| Long-pulsed 1064-nm Nd:YAG laserLong-pulsed 1064-nm Nd:YAG laser was applied to the contralateral randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers non-ablative dermal heating to stimulate collagen remodeling and improve skin texture and elasticity. | Procedure or surgery | Arm 2 |
Primary outcome
Dermal Thickness
Time frame: From enrollment to the end of treatment at 20 weeks
Dermal thickness was assessed based on the two-dimensional area of the hyperechoic band that appears brighter than the epidermis on ultrasonography assessment.
Skin Elasticity
Time frame: From enrollment to the end of treatment at 20 weeks
Skin elasticity was defined as the ability of the skin to return to its original shape after deformation caused by mechanical traction. It was measured using a skin elasticity meter, and the R (recovery) value was assessed at 8 evaluation points on the face.
Wrinkles
Time frame: From enrollment to the end of treatment at 20 weeks
Lines or folds formed on the skin surface as a result of mechanical stress, skin dehydration, or repetitive muscular activity, and were evaluated using a facial skin analyzer
Global Aesthetic Improvement Scale Scores
Time frame: From enrollment to the end of treatment at 20 weeks
A 5-point rating scale (1-5) used to measure the degree of aesthetic improvement in patients following a procedure.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Kartika Ruchiatan, M.D. principal investigator
Faculty of Medicine Universitas Padjadjaran Bandung
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Fractional CO₂ laser and Long-pulsed 1064-nm Nd:YAG laser in people with Skin Rejuvenation and Laser, run by Universitas Padjadjaran at 1 site in Indonesia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 12 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Indonesia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmad R Ganiem, M.D., Ph.D (+62 878 2288 3773, rizalbdg@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Dermal Thickness (time frame: From enrollment to the end of treatment at 20 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Mar 2026.