DehydrationNCT07468539
Post-exercise Rehydration: A Randomised Cross-over Trial Comparing a 100% Fruit Beverage, a Glucose-based Sports Drink, and Water
A study testing Water, Glucose-based sports drink and Fruit beverage in people with Dehydration, run by Nottingham Trent University at 1 site in United Kingdom.
Trial summary
It is well-established that exercise has many health benefits. During exercise in temperate/hot conditions, sweating is necessary to dissipate heat. This sweating typically results in dehydration, which may impair physical and mental performance. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Dehydration
- What is being tested?
- Water, Glucose-based sports drink and Fruit beverage
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 17 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 8 Nov 2024to 22 May 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Training/performing > 1 hrs a week
Who cannot join
- Smoker.
- Pregnant, attempting to become pregnant, or breastfeeding.
- Diabetic.
- You have adverse events/reactions in response to fingertip capillary blood sampling which includes, but is not limited to; fainting and/or serious bruising.
- History of heat-related illness.
- History of heart failure, pulmonary hypertension, embolism, or other pulmonary heart disease.
Show all 13Show fewer
- Previously diagnosed with COPD, emphysema, bronchitis or similar respiratory illness.
- Have a history of severe allergic reactions.
- History of kidney issues.
- Regular use of non-steroidal anti-inflammatory medications.
- Any other medical conditions / medications that may interfere with an individuals ability to safely perform exercise in the heat and experience dehydration.
- Allergies/intolerances to any of the following ingredients: Glucose Syrup, Acid (Citric Acid), Acidity Regulator (Sodium Citrate), Extract of Black Carrot, Watermelon, pomegranate, lime, Preservatives (Potassium Sorbate, Dimethyl Dicarbonate), Stabilisers (Acacia Gum), Sweeteners (Aspartame, Acesulfame K), Antioxidant (Ascorbic Acid), Flavourings, Niacin (Vitamin B3).
- Elite athlete subject to doping tests
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
Nottingham Trent University, Clifton Campus
Nottingham, NG11 8NS
About this study
Official title: Comparing The Rehydration Properties Of Two Sports / Hydration Drinks And Water, Following Exercise In The Heat
It is well-established that exercise has many health benefits. During exercise in temperate/hot conditions, sweating is necessary to dissipate heat. This sweating typically results in dehydration, which may impair physical and mental performance. Therefore, following exercise, effective rehydration is important to restore an optimal hydration state and therefore physical and mental performance. If an individual only rehydrates with water, though, it is unlikely that they will fully rehydrate as plain water is not very well-retained by the body, due to its lack of carbohydrate and electrolytes. For this reason, sports/ hydration drinks are likely to aid in better rehydration, due to their carbohydrate and electrolyte content. This project aims to compare the rehydration effectiveness and glucose responses to two sports / hydration drinks and water (with different carbohydrate and electrolyte contents).
- Conditions
- Dehydration
- Being tested
- Water, Glucose-based sports drink, Fruit beverage
- Medical subject headings
- Dehydration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
WaterOther
Consumption of a water volume (from water) equal to 150% of body mass loses from exercise-induced hypohydration
Glucose-based sports drinkOther
Consumption of a water volume (from a glucose-based sports drink) equal to 150% of body mass loses from exercise-induced hypohydration
Fruit beverageOther
Consumption of a water volume (from a fruit beverage) equal to 150% of body mass loses from exercise-induced hypohydration
| Study group | Role | What they receive |
|---|---|---|
| Water | Experimental | Consumption of a water volume (from water) equal to 150% of body mass loses from exercise-induced hypohydration Receives: Other: Water |
| Glucose-based sports drink | Experimental | Consumption of a water volume (from a glucose-based sports drink) equal to 150% of body mass loses from exercise-induced hypohydration Receives: Other: Glucose-based sports drink |
| Fruit beverage | Experimental | Consumption of a water volume (from a fruit beverage) equal to 150% of body mass loses from exercise-induced hypohydration Receives: Other: Fruit beverage |
What is being measured
The primary outcome is the main question the study is designed to answer.
Net water Balance
([post-exercise body mass (kg) - Pre-exercise body mass (kg)] x 1000) + water volume consumed (g) - cumulative urine output during rehydration period (g)
Measured: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Cumulative urine volume
Measured: 0, 1, 2, 3, and 4 h post-rehydration
Total urine volume
Total urine volume produced during the rehydration period
Measured: Sum of urine produced at 0, 1, 2, 3, and 4 h post-rehydration
Water retention
([water volume consumed (g) - total urine volume produced during the rehydration period (g)] / water volume consumed (g)) x 100
Measured: 4 h post-rehydration
Secondary outcomes (15)
Blood glucose concentration
Measured: Baseline (pre-exercise), post-exercise, and 0, 0.25, 0.5, 0.75, 1, 1.5, and 2 h post-rehydration
Blood glucose area under the curve
Measured: The 2h period following rehydration
Hyperglycaemia incidence
Number of participants that experience blood glucose > 7.8 mmol/L
Measured: The 2 h period following rehydration
Hypoglycaemia incidence
The number of participants that experience blood glucose < 3.9 mmol/L
Measured: The 2 h period following rehydration
Urine osmolality
A measure of urine concentration.
Measured: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Body mass
Body mass in kilograms at baseline compared across trials. Body mass loss (both in grams and as a percentage) from pre-exercise to post-exercise compared across trials.
Measured: Baseline (pre-exercise) and post-exercise (approximately 2 h post-baseline, depending on sweat losses during cycling in the heat)
Thirst
Participants asked to rate their thirst on a scale of 0-10 (0 = no symptom, 10 = maximum symptom)
Measured: Baseline (pre-exercise), towards the end of each 10 minute block of exercise (cycling in the heat), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Gastrointestinal comfort
Participants asked to rate their gastrointestinal comfort on a scale of 0-10 (0 = no symptom, 10 = maximum symptom)
Measured: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Rating of perceived exertion (RPE)
Participants asked to rate their RPE on a scale of 6-20. This is a measure of exercise intensity. Average taken for dehydration period. Average compared across trials.
Measured: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Thermal sensation
Participants asked to rate their thermal sensation on a scale of -10 (unbearably cold) to 10 (unbearably hot). Average taken for dehydration period. Average compared across trials.
Measured: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Time in environmental chamber
The time in minutes that the participant spent in the environmental chamber at 35 degrees Celsius, doing repeated blocks of 10 minutes of cycling followed by 5 minutes of rest, until they reached approximately 1.5% body mass loss. Time compared across trials.
Measured: Up to 120 minutes, depending on body mass losses during cycling in the heat
Laboratory temperature
Temperature (degrees Celsius) of the laboratory measured across the day and averaged. Averages compared across trials.
Measured: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Environmental chamber temperature
Environmental chamber temperature (degrees Celsius) measured and averaged for the cycling in the heat period of each participant. Averages compared across trials.
Measured: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Laboratory humidity
Humidity (relative humidity) of the laboratory measured across the day and averaged. Averages compared across trials.
Measured: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Environmental chamber humidity
Environmental chamber humidity (relative humidity) measured and averaged for the cycling in the heat period of each participant. Averages compared across trials.
Measured: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted12 Mar 2026
- Study start8 Nov 2024
- Primary completion22 May 2025
- Study completion22 May 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DehydrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 17 participants (actual)
Sponsor and investigators
- Lead sponsor
- Nottingham Trent University
- Sponsor type
- University, hospital or other
- Collaborators
- Innate-Essence Limited
- Responsible party
- Principal investigator, Loris Juett, Nottingham Trent University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07468539
- Sponsor's protocol ID
- 1911625
- Status last verified
- Mar 2026
- First submitted
- 3 Mar 2026
- Last updated
- 12 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing The Rehydration Properties Of Two Sports / Hydration Drinks And Water, Following Exercise In The Heat
- ClinicalTrials.gov ID
- NCT07468539
- Acronym / sponsor ID
- 1911625
- Conditions
- Dehydration
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 17 participants (actual)
- Lead sponsor
- Nottingham Trent UniversityUniversity, hospital or other
- Collaborators
- Innate-Essence Limited
- Study start
- 8 Nov 2024 (actual)
- Primary completion
- 22 May 2025 (actual)
- Study completion
- 22 May 2025 (actual)
- First posted
- 12 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
It is well-established that exercise has many health benefits. During exercise in temperate/hot conditions, sweating is necessary to dissipate heat. This sweating typically results in dehydration, which may impair physical and mental performance. Therefore, following exercise, effective rehydration is important to restore an optimal hydration state and therefore physical and mental performance. If an individual only rehydrates with water, though, it is unlikely that they will fully rehydrate as plain water is not very well-retained by the body, due to its lack of carbohydrate and electrolytes. For this reason, sports/ hydration drinks are likely to aid in better rehydration, due to their carbohydrate and electrolyte content. This project aims to compare the rehydration effectiveness and glucose responses to two sports / hydration drinks and water (with different carbohydrate and electrolyte contents).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Water | Experimental | Other: WaterConsumption of a water volume (from water) equal to 150% of body mass loses from exercise-induced hypohydration |
| Glucose-based sports drink | Experimental | Other: Glucose-based sports drinkConsumption of a water volume (from a glucose-based sports drink) equal to 150% of body mass loses from exercise-induced hypohydration |
| Fruit beverage | Experimental | Other: Fruit beverageConsumption of a water volume (from a fruit beverage) equal to 150% of body mass loses from exercise-induced hypohydration |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Training/performing > 1 hrs a week
Key exclusion criteria (13 listed)
- Smoker.
- Pregnant, attempting to become pregnant, or breastfeeding.
- Diabetic.
- You have adverse events/reactions in response to fingertip capillary blood sampling which includes, but is not limited to; fainting and/or serious bruising.
- History of heat-related illness.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| WaterConsumption of a water volume (from water) equal to 150% of body mass loses from exercise-induced hypohydration | Other | Water |
| Glucose-based sports drinkConsumption of a water volume (from a glucose-based sports drink) equal to 150% of body mass loses from exercise-induced hypohydration | Other | Glucose-based sports drink |
| Fruit beverageConsumption of a water volume (from a fruit beverage) equal to 150% of body mass loses from exercise-induced hypohydration | Other | Fruit beverage |
Primary outcome
Net water Balance
Time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
([post-exercise body mass (kg) - Pre-exercise body mass (kg)] x 1000) + water volume consumed (g) - cumulative urine output during rehydration period (g)
Cumulative urine volume
Time frame: 0, 1, 2, 3, and 4 h post-rehydration
Total urine volume
Time frame: Sum of urine produced at 0, 1, 2, 3, and 4 h post-rehydration
Total urine volume produced during the rehydration period
Water retention
Time frame: 4 h post-rehydration
([water volume consumed (g) - total urine volume produced during the rehydration period (g)] / water volume consumed (g)) x 100
15 secondary outcomes
Blood glucose concentration
Time frame: Baseline (pre-exercise), post-exercise, and 0, 0.25, 0.5, 0.75, 1, 1.5, and 2 h post-rehydration
Blood glucose area under the curve
Time frame: The 2h period following rehydration
Hyperglycaemia incidence
Time frame: The 2 h period following rehydration
Hypoglycaemia incidence
Time frame: The 2 h period following rehydration
Urine osmolality
Time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Body mass
Time frame: Baseline (pre-exercise) and post-exercise (approximately 2 h post-baseline, depending on sweat losses during cycling in the heat)
Thirst
Time frame: Baseline (pre-exercise), towards the end of each 10 minute block of exercise (cycling in the heat), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Gastrointestinal comfort
Time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Rating of perceived exertion (RPE)
Time frame: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Thermal sensation
Time frame: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Time in environmental chamber
Time frame: Up to 120 minutes, depending on body mass losses during cycling in the heat
Laboratory temperature
Time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Environmental chamber temperature
Time frame: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Laboratory humidity
Time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration
Environmental chamber humidity
Time frame: Measured towards the end of each 10 minute block of exercise (cycling in the heat). Up to 8 blocks lasting a total of 120 minutes (10 minutes of cycling, followed by 5 minutes of rest), depending on body mass loss.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Mar 2026.
- Individual participant dataSharing planned: No
Related trials for Dehydration
Not yet recruiting
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Enrolling by invitation
Hypernatremia Fluid Therapy in Childhood Diarrhoea
Hypernatremia, Acute Watery Diarrhea
Not yet recruitingPhase 2
Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera
Cholera (Disorder)
Recruiting
Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy
Obesity & Overweight, Type 2 Diabetes
Recruiting
Hydration & Female Life Stages
Dehydration, Menstruation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Water, Glucose-based sports drink and Fruit beverage in people with Dehydration, run by Nottingham Trent University at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Net water Balance (time frame: Baseline (pre-exercise), post-exercise, and 0, 1, 2, 3, and 4 h post-rehydration). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Mar 2026.