Shock WaveNCT07468734
Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis
A study testing Extracorporeal shock wave therapy and Exercise therapy program in people with Shock Wave and Traditional Physical Therapy, run by German International University at 1 site in Egypt.
Trial summary
This study aims to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus structured therapeutic exercise in patients with chronic knee osteoarthritis (KOA), with respect to pain reduction and improvement of knee function. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Shock Wave, Traditional Physical Therapy, Chronic Knee Osteoarthritis
- What is being tested?
- Extracorporeal shock wave therapy and Exercise therapy program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Mar 2026to 30 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults ≥ 40 years with clinical and radiographic diagnosis of chronic knee osteoarthritis (KOA) (Kellgren-Lawrence grade II-III).
- Both sexes.
- Persistent knee pain ≥ 3 months.
- Ability to provide consent and participate in interventions.
Who cannot join
- Prior knee surgery within last 6 months.
- Intra-articular injections in the last 3 months.
- Systemic inflammatory arthritis or other neurological conditions affecting gait.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
German International University
Cairo, 12613
Magdy M Shabana, MD, 00201006053332, magdy.shabana@giu-uni.de
About this study
Official title: Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis: A Prospective Randomized Controlled Trial
This study aims to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus structured therapeutic exercise in patients with chronic knee osteoarthritis (KOA), with respect to pain reduction and improvement of knee function.
Read the detailed description
Knee osteoarthritis (KOA) is a highly prevalent chronic degenerative joint disease characterized by progressive cartilage loss, chronic pain, stiffness, functional disability, and reduced quality of life in adults, particularly the elderly.
Extracorporeal shock wave therapy (ESWT) has emerged as a non-invasive physical modality that delivers acoustic pressure waves to musculoskeletal tissues, stimulating biological responses such as enhanced microcirculation, anti-inflammatory cytokine modulation, neovascularization, cartilage and bone repair processes, and decreased pain transmission.
- Being tested
- Extracorporeal shock wave therapy, Exercise therapy program
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Extracorporeal shock wave therapyOther
Patients will receive extracorporeal shock wave therapy.
Exercise therapy programOther
Patients will undergo a structured exercise therapy program.
| Study group | Role | What they receive |
|---|---|---|
| ESWT Group | Experimental | Patients will receive extracorporeal shock wave therapy. Receives: Other: Extracorporeal shock wave therapy |
| Exercise Therapy Group | Active comparator | Patients will undergo a structured exercise therapy program. Receives: Other: Exercise therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in pain intensity
Change in pain intensity will be assessed using the Visual Analogue Scale (VAS) which is a 10-cm horizontal line used to measure pain intensity, ranging from (0) "no pain" to (10) "worst imaginable pain".
Measured: 5-week after intervention
Secondary outcomes (4)
Stiffness assessment
Stiffness will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
WOMAC will be recorded at baseline, at the end of the intervention period, and during follow-up. Higher scores indicate greater symptom severity.
Measured: 5-week after intervention
Assessment of physical function
Physical function will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
WOMAC will be recorded at baseline, at the end of the intervention period, and during follow-up. Higher scores indicate greater symptom severity.
Measured: 5-week after intervention
Knee range of motion
Knee range of motion (ROM) will be assessed.
Measured: 5-week after intervention
Incidence of adverse events
Incidence of adverse events will be recorded.
Measured: 5-week after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Mar 2026
- Study start18 Mar 2026
- Primary completion30 Nov 2026 (estimated)
- Study completion30 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Shock WaveStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- German International University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Magdy Mohamed Aly Shabana, German International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07468734
- Sponsor's protocol ID
- DCSR-02026-104
- Status last verified
- Mar 2026
- First submitted
- 9 Mar 2026
- Last updated
- 19 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 19 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07468734
- Acronym / sponsor ID
- DCSR-02026-104
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- German International UniversityUniversity, hospital or other
- Study start
- 18 Mar 2026 (actual)
- Primary completion
- 30 Nov 2026 (estimated)
- Study completion
- 30 Nov 2026 (estimated)
- First posted
- 13 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus structured therapeutic exercise in patients with chronic knee osteoarthritis (KOA), with respect to pain reduction and improvement of knee function.
Detailed description
Knee osteoarthritis (KOA) is a highly prevalent chronic degenerative joint disease characterized by progressive cartilage loss, chronic pain, stiffness, functional disability, and reduced quality of life in adults, particularly the elderly.
Extracorporeal shock wave therapy (ESWT) has emerged as a non-invasive physical modality that delivers acoustic pressure waves to musculoskeletal tissues, stimulating biological responses such as enhanced microcirculation, anti-inflammatory cytokine modulation, neovascularization, cartilage and bone repair processes, and decreased pain transmission.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ESWT Group | Experimental | Other: Extracorporeal shock wave therapyPatients will receive extracorporeal shock wave therapy. |
| Exercise Therapy Group | Active comparator | Other: Exercise therapy programPatients will undergo a structured exercise therapy program. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults ≥ 40 years with clinical and radiographic diagnosis of chronic knee osteoarthritis (KOA) (Kellgren-Lawrence grade II-III).
- Both sexes.
- Persistent knee pain ≥ 3 months.
- Ability to provide consent and participate in interventions.
Key exclusion criteria (3 listed)
- Prior knee surgery within last 6 months.
- Intra-articular injections in the last 3 months.
- Systemic inflammatory arthritis or other neurological conditions affecting gait.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Extracorporeal shock wave therapyPatients will receive extracorporeal shock wave therapy. | Other | ESWT Group |
| Exercise therapy programPatients will undergo a structured exercise therapy program. | Other | Exercise Therapy Group |
Primary outcome
Change in pain intensity
Time frame: 5-week after intervention
Change in pain intensity will be assessed using the Visual Analogue Scale (VAS) which is a 10-cm horizontal line used to measure pain intensity, ranging from (0) "no pain" to (10) "worst imaginable pain".
4 secondary outcomes
Stiffness assessment
Time frame: 5-week after intervention
Assessment of physical function
Time frame: 5-week after intervention
Knee range of motion
Time frame: 5-week after intervention
Incidence of adverse events
Time frame: 5-week after intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Mar 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Extracorporeal shock wave therapy and Exercise therapy program in people with Shock Wave and Traditional Physical Therapy, run by German International University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Magdy M Shabana, MD (00201006053332, magdy.shabana@giu-uni.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in pain intensity (time frame: 5-week after intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Mar 2026.