Alcohol Use DisorderTIPANCT07468825
Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder
An observational study of Alcohol Use Disorder and Cognition Disorders, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alcohol Use Disorder, Cognition Disorders
- How many people
- 30 participants
- Where
- 1 siteFrance
- Study dates
- 1 Apr 2026to 1 Apr 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients diagnosed with Alcohol Use Disorder (DSM-5) receiving outpatient care in the Psychiatry and Addiction Department
Who may be able to join
- Adults aged 18 years or older
- Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
- No objection to participation in the study
Who cannot join
- Diagnosed neurological disorder
- Patient covered by State Medical Assistance (AME)
- Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
- Individuals deprived of liberty by judicial or administrative decision
- Pregnant or breastfeeding women
- Psychiatric disorders that could compromise proper study participation (excluding Alcohol Use Disorder)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
CHU Bicêtre
Le Kremlin-Bicêtre
Catherine MARTELLI, PhD, 145593372 ext. +33, catherine.martelli@aphp.fr
About this study
Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior.
This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD.
Read more
Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:
- A computerized learning task in which they respond to visual stimuli and receive feedback on their performance
- Standardized questionnaires assessing psychological traits and cognitive functioning
The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics.
This research does not modify participants' medical care and involves no medication or invasive procedures.
By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.
Read the detailed description
Alcohol Use Disorder (AUD) is associated with difficulties in decision-making and behavioral adaptation, particularly in situations involving uncertainty. Individual psychological traits may influence how people with AUD adjust their behavior when facing changing environments, but this relationship remains insufficiently understood.
This monocentric, non-interventional study aims to explore how individual traits influence adaptive processes in adults diagnosed with Alcohol Use Disorder.
Participants receiving usual care at Paul Brousse Hospital will attend a single experimental session lasting approximately 45 minutes. During this session, they will perform a computerized learning task designed to evaluate behavioral adaptation when task rules change unexpectedly. They will also complete standardized questionnaires assessing personality traits and cognitive functioning.
Behavioral performance during the task will be analyzed to measure adaptation to uncertainty and examined in relation to individual psychological characteristics.
The study does not involve medication, medical devices, or any modification of clinical care.
- Conditions
- Alcohol Use Disorder, Cognition Disorders
- Keywords
- Alcohol Use Disorder, Addictive Behaviors, Decision Making, Cognitive Adaptation, Behavioral Flexibility, Uncertainty Processing, Exploration-Exploitation Tradeoff, Neurocognitive Processes, Personality Traits, Psychological Assessment, Computerized Cognitive Task
- Medical subject headings
- Alcoholism, Cognition Disorders, Behavior, Addictive
What is being measured
The primary outcome is the main question the study is designed to answer.
Uncertainty Cost Index During Behavioral Adaptation Task
Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.
Measured: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)
Secondary outcomes (1)
Correlation Between Uncertainty Cost Index and Psychometric Trait Scores
Correlation coefficient between the uncertainty cost index and standardized psychometric test scores assessing personality traits and cognitive characteristics.
Measured: During the single study session (approximately 45 minutes)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Mar 2026
- Study start1 Apr 2026 (estimated)
- Primary completion1 Apr 2026 (estimated)
- Study completion1 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alcohol Use DisorderStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07468825
- Sponsor's protocol ID
- APHP251789
- Other IDs
- 2025-A02680-49
- Acronym
- TIPA
- Status last verified
- Mar 2026
- First submitted
- 9 Mar 2026
- Last updated
- 13 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Individual Traits on Adaptation Processes in Individuals With Alcohol Use Disorder
- ClinicalTrials.gov ID
- NCT07468825
- Acronym / sponsor ID
- TIPA / APHP251789
- Conditions
- Alcohol Use Disorder, Cognition Disorders
- Keywords
- Alcohol Use Disorder, Addictive Behaviors, Decision Making, Cognitive Adaptation, Behavioral Flexibility, Uncertainty Processing, Exploration-Exploitation Tradeoff, Neurocognitive Processes
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Study start
- 1 Apr 2026 (estimated)
- Primary completion
- 1 Apr 2026 (estimated)
- Study completion
- 1 Apr 2027 (estimated)
- First posted
- 13 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Alcohol Use Disorder (AUD) is a chronic condition that affects behavior, decision-making, and the ability to adapt to changing situations. While many studies have examined AUD from medical and social perspectives, less is known about how individual psychological traits influence the way people with AUD respond to uncertainty and adapt their behavior.
This study aims to better understand how personal characteristics such as anxiety, self-esteem, sensitivity to reward and punishment, perfectionism, and cognitive abilities may influence adaptation processes in individuals with AUD.
Participants receiving usual care at Paul Brousse Hospital will be invited to take part in a single experimental session lasting about 45 minutes. During this session, they will complete:
- A computerized learning task in which they respond to visual stimuli and receive feedback on their performance
- Standardized questionnaires assessing psychological traits and cognitive functioning
The learning task is designed to evaluate how participants adjust their behavior when the rules of the task change unexpectedly. Researchers will measure how performance changes in response to uncertainty and examine how these changes relate to individual psychological characteristics.
This research does not modify participants' medical care and involves no medication or invasive procedures.
By improving understanding of the cognitive and behavioral mechanisms involved in Alcohol Use Disorder, the study may help advance scientific knowledge about how individuals adapt to uncertainty and inform future research in addiction and mental health.
Detailed description
Alcohol Use Disorder (AUD) is associated with difficulties in decision-making and behavioral adaptation, particularly in situations involving uncertainty. Individual psychological traits may influence how people with AUD adjust their behavior when facing changing environments, but this relationship remains insufficiently understood.
This monocentric, non-interventional study aims to explore how individual traits influence adaptive processes in adults diagnosed with Alcohol Use Disorder.
Participants receiving usual care at Paul Brousse Hospital will attend a single experimental session lasting approximately 45 minutes. During this session, they will perform a computerized learning task designed to evaluate behavioral adaptation when task rules change unexpectedly. They will also complete standardized questionnaires assessing personality traits and cognitive functioning.
Behavioral performance during the task will be analyzed to measure adaptation to uncertainty and examined in relation to individual psychological characteristics.
The study does not involve medication, medical devices, or any modification of clinical care.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients diagnosed with Alcohol Use Disorder (DSM-5) receiving outpatient care in the Psychiatry and Addiction Department
Key inclusion criteria (3 listed)
- Adults aged 18 years or older
- Patients receiving care for Alcohol Use Disorder at the Psychiatry and Addiction Unit of Paul Brousse Hospital
- No objection to participation in the study
Key exclusion criteria (6 listed)
- Diagnosed neurological disorder
- Patient covered by State Medical Assistance (AME)
- Individuals under legal protection measures (guardianship, curatorship, or legal safeguard)
- Individuals deprived of liberty by judicial or administrative decision
- Pregnant or breastfeeding women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Uncertainty Cost Index During Behavioral Adaptation Task
Time frame: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)
Uncertainty cost index. Exploration-exploitation behaviors are inferred from the percentage of correct responses obtained during the CHEAT phase of the computerized task. For each participant, the difference in accuracy rate between the end of the learning phase and the beginning of the CHEAT phase is calculated. This difference (Δ) defines the uncertainty cost index and reflects exploratory behavioral responses to the introduction of misleading feedback.
1 secondary outcome
Correlation Between Uncertainty Cost Index and Psychometric Trait Scores
Time frame: During the single study session (approximately 45 minutes)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Alcohol Use Disorder and Cognition Disorders, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Catherine MARTELLI, Dr (145593372 ext. +33, catherine.martelli@aphp.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Uncertainty Cost Index During Behavioral Adaptation Task (time frame: At the end of the learning phase and at the beginning of the uncertainty phase during the single study session (approximately 45 minutes)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2026.