CKDCAG in CKD-ACSNCT07474441
Early Coronary Angiography in Advanced Chronic Kidney Disease With Acute Coronary Syndrome
An observational study of CKD and ACS (Acute Coronary Syndrome), run by Chulalongkorn University.
Trial summary
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- CKD, ACS (Acute Coronary Syndrome), Coronary Angiography (CAG)
- What is being tested?
- coronary angiography
- Type of treatment
- Surgery or procedure
- How many people
- 139 participants
- Where
- No sites listed yet
- Study dates
- 1 Jan 2017to 31 Dec 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: Patients with pre-dialysis CKD stage 4-5 with acute coronary syndrome
Who may be able to join
- Advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m²
- Diagnosis with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital
Who cannot join
- Received maintenance dialysis or kidney transplantation before admission
- Cardiogenic shock or cardiac arrest
- Prior PCI or CABG within 12 months
- Recently diagnosed with ACS within 2 months
- Had a limited life expectancy due to non-cardiovascular disease
- Pregnant.
About this study
Official title: Early Coronary Angiography Associates With Survival Benefit and Longer Time to Initiation of Renal Replacement Therapy in Patients With Advanced Chronic Kidney Disease and Acute Coronary Syndrome: A Survival Analysis
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.
Read the detailed description
Electronic medical records of adult patients admitted with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital, Thailand, were retrospectively reviewed. Eligible patients should have concurrent advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m² calculated by the 2021 CKD-EPI creatinine equation.
- Being tested
- coronary angiography
- Medical subject headings
- Acute Coronary Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
coronary angiographyProcedure or surgery
Also called medication
Standard coronary angiography
| Study group | Role | What they receive |
|---|---|---|
| Early coronary angiography | Recieve coronary angiography within 24 hours of admission Receives: Procedure: coronary angiography | |
| Delayed coronary angiography | Recieve coronary angiography later than 24 hours of admission Receives: Procedure: coronary angiography | |
| Conservative management | Medical management without coronary angiography |
What is being measured
The primary outcome is the main question the study is designed to answer.
Renal replacement therapy initiation
Renal replacement therapy initiation
Measured: Until 31 December 2021
Secondary outcomes (1)
All-cause mortality
All-cause mortality
Measured: Until 31 Dec 2021
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Mar 2026
- Study start1 Jan 2017
- Primary completion31 Dec 2021
- Study completion31 Dec 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for CKDStudies of the same condition, open and under way.
- More trials run by Chulalongkorn UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 139 participants (actual)
Sponsor and investigators
- Lead sponsor
- Chulalongkorn University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Thana Thongsricome, MD, Chulalongkorn University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07474441
- Sponsor's protocol ID
- 046367
- Other IDs
- 0463/67
- Acronym
- CAG in CKD-ACS
- Status last verified
- Mar 2026
- First submitted
- 11 Mar 2026
- Last updated
- 16 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: All data generated or analyzed during this study are included in this article.
Study at a glance
From the registry record, last updated by the sponsor on 16 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early Coronary Angiography Associates With Survival Benefit and Longer Time to Initiation of Renal Replacement Therapy in Patients With Advanced Chronic Kidney Disease and Acute Coronary Syndrome: A Survival Analysis
- ClinicalTrials.gov ID
- NCT07474441
- Acronym / sponsor ID
- CAG in CKD-ACS / 046367
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 139 participants (actual)
- Lead sponsor
- Chulalongkorn UniversityUniversity, hospital or other
- Study start
- 1 Jan 2017 (actual)
- Primary completion
- 31 Dec 2021 (actual)
- Study completion
- 31 Dec 2021 (actual)
- First posted
- 16 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is the retrospective study regarding the association of invasive coronary angiography and time to renal replacement therapy initiation and mortality in patients with chronic kidney disease stage 4-5 who develop acute coronary syndrome.
Detailed description
Electronic medical records of adult patients admitted with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital, Thailand, were retrospectively reviewed. Eligible patients should have concurrent advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m² calculated by the 2021 CKD-EPI creatinine equation.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Early coronary angiography | – | Procedure: coronary angiographyRecieve coronary angiography within 24 hours of admission |
| Delayed coronary angiography | – | Procedure: coronary angiographyRecieve coronary angiography later than 24 hours of admission |
| Conservative management | – | –Medical management without coronary angiography |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Patients with pre-dialysis CKD stage 4-5 with acute coronary syndrome
Key inclusion criteria (2 listed)
- Advanced stage CKD, defined as an eGFR less than 30 mL/min/1.73 m²
- Diagnosis with ACS, by the recorded diagnosis code, between 1 January 2017 and 31 December 2021 at King Chulalongkorn Memorial Hospital
Key exclusion criteria (6 listed)
- Received maintenance dialysis or kidney transplantation before admission
- Cardiogenic shock or cardiac arrest
- Prior PCI or CABG within 12 months
- Recently diagnosed with ACS within 2 months
- Had a limited life expectancy due to non-cardiovascular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| coronary angiographyAlso: medicationStandard coronary angiography | Procedure or surgery | Delayed coronary angiography, Early coronary angiography |
Primary outcome
Renal replacement therapy initiation
Time frame: Until 31 December 2021
Renal replacement therapy initiation
1 secondary outcome
All-cause mortality
Time frame: Until 31 Dec 2021
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Mar 2026.
- Individual participant dataSharing planned: No. All data generated or analyzed during this study are included in this article.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of CKD and ACS (Acute Coronary Syndrome), run by Chulalongkorn University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Renal replacement therapy initiation (time frame: Until 31 December 2021). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Mar 2026.