Parkinsons Disease (PD)ExergamingNCT07475741
Exergaming for Improving Upper Limb Functions in Parkinson's Disease
A study testing Exergaming and Conventional Physical Therapy in people with Parkinsons Disease (PD), run by University of Health Sciences Lahore at 1 site in Pakistan.
Trial summary
Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living. While digital exergaming has been used to encourage physical activity and improve motor function, it often lacks real-world tactile engagement. Read more about this study
- Who is it for?
- Ages 45 to 85 years
- Conditions the study is for
- Parkinsons Disease (PD)
- What is being tested?
- Exergaming and Conventional Physical Therapy
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 20 Feb 2026to Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Early-stage Parkinson's Disease from I-III of Hoehn and Yahr scale
- Cognitinve Assessment MMSE >= 24 Score
- Able to communicate and understand the commands
- Must be on regular use of Levodopa/carbidopa
Who cannot join
- Advanced stage IV or V
- Patients with severe cognitive deficits.
- History of suffering from other neurological or musculoskeletal conditions affecting hand use for the exercise
- Not taking any medicine for systemic illness
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Punjab institute of Neuroscience Lahore
Lahore, Punjab Province, 54000
Prof. Dr. Mohsin Zaheer, FCPS, +924299268855, info@pins.org.pk
Hafiz Muddassir Riaz, Ph.D Scholar
About this study
Official title: Exergaming With Physical Objects for Upper Limb Rehabilitation in Parkinson's Disease: Effects on Functional Outcome
Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living. While digital exergaming has been used to encourage physical activity and improve motor function, it often lacks real-world tactile engagement. Integrating physical objects into exergaming known as a phygital approach which may enhance sensorimotor learning and functional carryover. However, its impact on upper limb functional outcomes in PD remains underexplored.
Objectives: To assess the effectiveness of exergaming with physical objects on functional outcomes of upper limb rehabilitation in individuals with Parkinson's Disease.
Read more
Methodology: This randomized controlled pilot study will include 30 individuals with early-stage Parkinson's Disease, recruited through convenience sampling and randomly assigned to either a phygital exergaming group or a control group. Both groups will receive sessions over three monthd (3 sessions/week, 30 minutes each). The phygital group will perform task-based exergaming using both physical objects and digital prompts, while the control group will use digital prompts alone. Functional outcomes will be assessed using the Box and Block Test (BBT), at baseline (day 1) and post intervention 12 weeks.
Statistical Analysis: Data will be analyzed using SPSS version 25. Descriptive statistics like gender, stages of diseases etc. will be summarized and described as bar charts and percentages. Within-group differences will be assessed using paired t-tests or Wilcoxon signed-rank tests based on data normality. Between-group comparisons will be conducted using independent t-tests or Mann-Whitney U tests. A p-value of less than 0.05 will be considered statistically significant.
Read the detailed description
Upper limb motor impairments in Parkinson's Disease significantly affect daily functioning and independence . While digital exergaming has emerged as a promising tool in neurorehabilitation, traditional models often rely solely on screen-based interaction and lack real-world physical engagement. Recent studies have highlighted the need to include tactile and sensory feedback to improve functional relevance and user experience. Integrating physical objects into exergames referred to as a "phygital" approach, enhances realism, encourages multisensory stimulation, and may result in better motor learning and functional outcomes.
After the selection of subjects as per the guideline of university ethical review board. Informed consent will be taken from each participant. Participants who meet the inclusion criteria and provide informed consent will be assigned to one of two groups (30 per group) Data collection will occur in private examination rooms to ensure privacy and minimize distractions during assessments. Measures will be taken to maintain participant privacy during assessments and data collection. Data will be collected using Box and Block Test (BBT).
The intervention group (phygital) will receive 36 sessions (three sessions per week over 12 weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop. Control group B will receive the same session frequency and duration, with identical digital prompts, but without the use of physical objects. While conventional Physical Therapy will be given to all the subjects of both groups. All sessions will be conducted under the supervision of a physiotherapist in a controlled clinical environment. Data will be collected at two points: baseline (pre-intervention), immediately after the 6-weeks intervention. Outcome measures will include the Box and Block Test (BBT) for gross manual dexterity.
Data shall be collected through an assessor who will be blinded to the patient group to minimize biases.
Data will be analyzed using IBM SPSS version 25. Descriptive Statistics shall be used to summarize demographics and clinical characteristics (e.g., age, gender, P.D. stage) and shall be presented as means, standard deviations, frequencies, and percentages. Data will be visualized using bar charts and tables. Within group comparisons will be performed to assess pre- and post-intervention changes using the paired t-test for data that meet assumptions of normality. If the data are non-normally distributed, the Wilcoxon signed-rank test will be used as a non-parametric alternative. For between-group comparisons, the independent t-test will be applied to compare outcomes between the intervention and control groups when data are normally distributed, while the Mann-Whitney U test will be used for non-parametric data.
Independent sample t test will be used for comparison of hand motor movements between. A p-value ≤ 0.05 will be considered as significant.
- Conditions
- Parkinsons Disease (PD)
- Being tested
- Exergaming, Conventional Physical Therapy
- Keywords
- Exergaming, Parkinson Disease, Physical Therapy, Upper Limb Rehabilitation
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ExergamingCombination product
Also called Phygital Training
The intervention group (phygital) will receive 36 sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop.
Conventional Physical TherapyProcedure or surgery
Also called Strength Training, Flexibility and Mobility, Balance and Coordination, Gait and Functional Training
Patients will receive routine physiotherapy treatment based on the impairments: Strength Training
Flexibility and Mobility
Balance and Coordination
Gait and Functional Training
Conentional Physical Therapy
| Study group | Role | What they receive |
|---|---|---|
| Control Group (Conventional Physical Therapy Group) | Active comparator | It will act as control group. The participants in this control group will receive the 36 sessions (three sessions per week over 12 weeks), each lasting approximately 30 minutes). Receives: Procedure: Conventional Physical Therapy |
| Phygital Group (Exergamig) | Experimental | The intervention group (phygital) will receive thirty six sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop. Receives: Combination Product: Exergaming |
What is being measured
The primary outcome is the main question the study is designed to answer.
Box and Block Test
The Box and Block Test (BBT) is a 60-second, standardized, unilateral assessment measuring gross manual dexterity in individuals with Parkinson's Condition
Measured: Baseline Measurements at day 1 will be taken prior to the interventions, and late Post-treatment after 12 weeks of intervention, another assessment will be taken. At followup visits, the consistency in the improvement will be assessed.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Mar 2026
- Study start20 Feb 2026
- Primary completionSep 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinsons Disease (PD)Studies of the same condition, open and under way.
- More trials run by University of Health Sciences LahoreThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Health Sciences Lahore
- Sponsor type
- University, hospital or other
- Collaborators
- Punjab Institute of Neurosciences Lahore
- Responsible party
- Principal investigator, Hafiz Muddassir Riaz, University of Health Sciences Lahore
- Investigators
- Dr. Nadia Naseem, Ph.D., Study chair, University of Health Sciences Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07475741
- Sponsor's protocol ID
- UHS/DPS-25/1158
- Acronym
- Exergaming
- Status last verified
- May 2026
- First submitted
- 5 Mar 2026
- Last updated
- 19 May 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exergaming With Physical Objects for Upper Limb Rehabilitation in Parkinson's Disease: Effects on Functional Outcome
- ClinicalTrials.gov ID
- NCT07475741
- Acronym / sponsor ID
- Exergaming / UHS/DPS-25/1158
- Conditions
- Parkinsons Disease (PD)
- Keywords
- Exergaming, Parkinson Disease, Physical Therapy, Upper Limb Rehabilitation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- University of Health Sciences LahoreUniversity, hospital or other
- Collaborators
- Punjab Institute of Neurosciences Lahore
- Study start
- 20 Feb 2026 (actual)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 16 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living. While digital exergaming has been used to encourage physical activity and improve motor function, it often lacks real-world tactile engagement. Integrating physical objects into exergaming known as a phygital approach which may enhance sensorimotor learning and functional carryover. However, its impact on upper limb functional outcomes in PD remains underexplored.
Objectives: To assess the effectiveness of exergaming with physical objects on functional outcomes of upper limb rehabilitation in individuals with Parkinson's Disease.
Methodology: This randomized controlled pilot study will include 30 individuals with early-stage Parkinson's Disease, recruited through convenience sampling and randomly assigned to either a phygital exergaming group or a control group. Both groups will receive sessions over three monthd (3 sessions/week, 30 minutes each). The phygital group will perform task-based exergaming using both physical objects and digital prompts, while the control group will use digital prompts alone. Functional outcomes will be assessed using the Box and Block Test (BBT), at baseline (day 1) and post intervention 12 weeks.
Statistical Analysis: Data will be analyzed using SPSS version 25. Descriptive statistics like gender, stages of diseases etc. will be summarized and described as bar charts and percentages. Within-group differences will be assessed using paired t-tests or Wilcoxon signed-rank tests based on data normality. Between-group comparisons will be conducted using independent t-tests or Mann-Whitney U tests. A p-value of less than 0.05 will be considered statistically significant.
Detailed description
Upper limb motor impairments in Parkinson's Disease significantly affect daily functioning and independence . While digital exergaming has emerged as a promising tool in neurorehabilitation, traditional models often rely solely on screen-based interaction and lack real-world physical engagement. Recent studies have highlighted the need to include tactile and sensory feedback to improve functional relevance and user experience. Integrating physical objects into exergames referred to as a "phygital" approach, enhances realism, encourages multisensory stimulation, and may result in better motor learning and functional outcomes.
After the selection of subjects as per the guideline of university ethical review board. Informed consent will be taken from each participant. Participants who meet the inclusion criteria and provide informed consent will be assigned to one of two groups (30 per group) Data collection will occur in private examination rooms to ensure privacy and minimize distractions during assessments. Measures will be taken to maintain participant privacy during assessments and data collection. Data will be collected using Box and Block Test (BBT).
The intervention group (phygital) will receive 36 sessions (three sessions per week over 12 weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop. Control group B will receive the same session frequency and duration, with identical digital prompts, but without the use of physical objects. While conventional Physical Therapy will be given to all the subjects of both groups. All sessions will be conducted under the supervision of a physiotherapist in a controlled clinical environment. Data will be collected at two points: baseline (pre-intervention), immediately after the 6-weeks intervention. Outcome measures will include the Box and Block Test (BBT) for gross manual dexterity.
Data shall be collected through an assessor who will be blinded to the patient group to minimize biases.
Data will be analyzed using IBM SPSS version 25. Descriptive Statistics shall be used to summarize demographics and clinical characteristics (e.g., age, gender, P.D. stage) and shall be presented as means, standard deviations, frequencies, and percentages. Data will be visualized using bar charts and tables. Within group comparisons will be performed to assess pre- and post-intervention changes using the paired t-test for data that meet assumptions of normality. If the data are non-normally distributed, the Wilcoxon signed-rank test will be used as a non-parametric alternative. For between-group comparisons, the independent t-test will be applied to compare outcomes between the intervention and control groups when data are normally distributed, while the Mann-Whitney U test will be used for non-parametric data.
Independent sample t test will be used for comparison of hand motor movements between. A p-value ≤ 0.05 will be considered as significant.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control Group (Conventional Physical Therapy Group) | Active comparator | Procedure: Conventional Physical TherapyIt will act as control group. The participants in this control group will receive the 36 sessions (three sessions per week over 12 weeks), each lasting approximately 30 minutes). |
| Phygital Group (Exergamig) | Experimental | Combination Product: ExergamingThe intervention group (phygital) will receive thirty six sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop. |
Who may qualify
- Ages
- 45 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Early-stage Parkinson's Disease from I-III of Hoehn and Yahr scale
- Cognitinve Assessment MMSE >= 24 Score
- Able to communicate and understand the commands
- Must be on regular use of Levodopa/carbidopa
Key exclusion criteria (4 listed)
- Advanced stage IV or V
- Patients with severe cognitive deficits.
- History of suffering from other neurological or musculoskeletal conditions affecting hand use for the exercise
- Not taking any medicine for systemic illness
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ExergamingAlso: Phygital TrainingThe intervention group (phygital) will receive 36 sessions (three sessions per week over twelve weeks), each lasting approximately 30 minutes, involving structured exergaming tasks using physical objects (e.g., blocks, spoons, cups) combined with digital prompts on a tablet or laptop. | Combination product | Phygital Group (Exergamig) |
| Conventional Physical TherapyAlso: Strength Training, Flexibility and Mobility, Balance and Coordination, Gait and Functional TrainingPatients will receive routine physiotherapy treatment based on the impairments: Strength Training Flexibility and Mobility Balance and Coordination Gait and Functional Training Conentional Physical Therapy | Procedure or surgery | Control Group (Conventional Physical Therapy Group) |
Primary outcome
Box and Block Test
Time frame: Baseline Measurements at day 1 will be taken prior to the interventions, and late Post-treatment after 12 weeks of intervention, another assessment will be taken. At followup visits, the consistency in the improvement will be assessed.
The Box and Block Test (BBT) is a 60-second, standardized, unilateral assessment measuring gross manual dexterity in individuals with Parkinson's Condition
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Dr. Nadia Naseem, Ph.D. study chair
University of Health Sciences Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exergaming and Conventional Physical Therapy in people with Parkinsons Disease (PD), run by University of Health Sciences Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hafiz Muddassir Riaz, Ph.D Scholar (+92345-6627409, muddassir.riaz@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Box and Block Test (time frame: Baseline Measurements at day 1 will be taken prior to the interventions, and late Post-treatment after 12 weeks of intervention, another assessment will be taken. At followup visits, the consistency in the improvement will be assessed.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 May 2026.