Physiological TremorNCT07480200
Effect of Trigger Point Cryostimulation on Exercise-Induced Tremor in Adolescent Swimmers
A study testing Cryostimulation of Myofascial Trigger Points in people with Physiological Tremor and Exercise-Induced Neuromuscular Fatigue, run by Józef Piłsudski University of Physical Education at 1 site in Poland.
Trial summary
This study examines whether local cryostimulation of myofascial trigger points can reduce physiological tremor that occurs after intense physical exercise. Thirty-four adolescent competitive swimmers participate in a randomized crossover study comparing two conditions: local ice stimulation of trigger points and a… Read more about this study
- Who is it for?
- Ages 10 to 16 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Physiological Tremor, Exercise-Induced Neuromuscular Fatigue
- What is being tested?
- Cryostimulation of Myofascial Trigger Points
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 sitePoland
- Study dates
- 1 May 2024to 1 Jul 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 10 to 16 years
- Men only
- Healthy volunteers accepted
- Child
Who may be able to join
- - Competitive adolescent swimmers
- Age between 10 and 16 years
- Regular participation in swimming training (at least 3 training sessions per week)
- No current musculoskeletal injury affecting the lower limbs
- Ability to perform maximal swimming effort
- Written informed consent from participants and their legal guardians
Who cannot join
- - Current lower limb injury or pain
- Neurological disorders affecting motor control
- Contraindications to cold exposure or cryotherapy
- Participation in other interventions that could affect neuromuscular performance
Trial locations and contacts
1 site in 1 country.
Poland1 site
Józef Piłsudski University of Physical Education in Warsaw
Warsaw, Mazovian
About this study
Official title: Targeted Cryostimulation of Myofascial Trigger Points Attenuates Exercise-Induced Tremor in Adolescent Swimmers
This study examines whether local cryostimulation of myofascial trigger points can reduce physiological tremor that occurs after intense physical exercise. Thirty-four adolescent competitive swimmers participate in a randomized crossover study comparing two conditions: local ice stimulation of trigger points and a control condition without intervention. Physiological tremor of the lower limbs is measured using accelerometry before and after a 30-second maximal tethered swimming effort. The study aims to determine whether targeted cryostimulation can attenuate exercise-induced neuromuscular tremor and improve post-exercise motor stability in young athletes.
Read the detailed description
This study investigates whether targeted cryostimulation of myofascial trigger points (MTrPs) can attenuate exercise-induced physiological tremor in adolescent swimmers. The study uses a randomized reversed crossover design in which each participant completes two experimental conditions: local cryostimulation of identified trigger points and a control condition without intervention.
Thirty-four competitive adolescent swimmers participate in the study. Physiological tremor of both lower limbs is measured using triaxial accelerometry under standardized conditions before and after a maximal 30-second tethered swimming effort.
In the cryostimulation condition, cold packs are applied for 60 seconds to identified myofascial trigger points in the quadriceps and hamstring muscle groups. In the control condition, no cryostimulation is applied prior to exercise.
The primary outcome is the change in tremor power in the 2-5 Hz frequency band following exercise. Secondary outcomes include tremor power in the 9-14 Hz frequency band and tremor frequency parameters. Tremor signals are analyzed using frequency-domain analysis based on power spectral density calculations derived from accelerometer data.
The aim of the study is to determine whether localized cryostimulation of myofascial trigger points can modulate neuromuscular responses to fatigue and reduce the magnitude of exercise-induced tremor in adolescent athletes.
- Being tested
- Cryostimulation of Myofascial Trigger Points
- Keywords
- Cryostimulation, Myofascial Trigger Points, Physiological Tremor, Adolescent Athletes, Swimming, Accelerometry
- Medical subject headings
- Essential Tremor
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cryostimulation of Myofascial Trigger PointsProcedure or surgery
Local cryostimulation is applied to identified myofascial trigger points in the quadriceps and hamstring muscles using cold packs for 60 seconds before a 30-second maximal tethered swimming effort.
| Study group | Role | What they receive |
|---|---|---|
| Cryostimulation of Myofascial Trigger Points | Experimental | Participants receive local cryostimulation of identified myofascial trigger points in the quadriceps and hamstring muscles. Cold packs are applied for 60 seconds to the trigger points before performing a 30-second maximal tethered swimming effort. Physiological tremor of the lower limbs is measured before and after exercise using accelerometry. Receives: Procedure: Cryostimulation of Myofascial Trigger Points |
| Control Condition (No Cryostimulation) | No intervention | Participants complete the same experimental protocol without cryostimulation. After baseline tremor assessment, participants perform a 30-second maximal tethered swimming effort. No cooling intervention is applied before exercise. Physiological tremor of the lower limbs is measured before and after exercise using accelerometry under the same conditions as in the experimental arm. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exercise-Induced Physiological Tremor of the Lower Limbs
Physiological tremor of the lower limbs measured using accelerometry before and after a 30-second maximal tethered swimming effort. Tremor amplitude is quantified from accelerometer signals to assess the effect of local cryostimulation of myofascial trigger points.
Measured: Immediately before and immediately after the 30-second maximal tethered swimming effort during the experimental session.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2026
- Study start1 May 2024
- Primary completion1 Jun 2024
- Study completion1 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Physiological TremorStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This study uses a randomized reversed crossover design. Each participant completes two experimental conditions: local cryostimulation of myofascial trigger points and a control condition without intervention. The order of conditions is counterbalanced across participants to minimize potential order and carryover effects. Physiological tremor is measured at baseline and after a standardized exercise protocol in both conditions.
- Masking
- None (open label)
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Józef Piłsudski University of Physical Education
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Szymon Kuliś, Józef Piłsudski University of Physical Education
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07480200
- Sponsor's protocol ID
- CRYO-TREMOR-2024
- Status last verified
- Mar 2026
- First submitted
- 13 Mar 2026
- Last updated
- 24 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Kulis S, Skorulski M, Callegari B, Pietraszewski P. Targeted cryostimulation of myofascial trigger points modulates exercise-induced physiological tremor in adolescent swimmers: a randomized counterbalanced crossover trial. BMC Sports Sci Med Rehabil. 2026 Jun 26. doi: 10.1186/s13102-026-01839-x. Online ahead of print.
PubMed 42363198
Study at a glance
From the registry record, last updated by the sponsor on 24 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Targeted Cryostimulation of Myofascial Trigger Points Attenuates Exercise-Induced Tremor in Adolescent Swimmers
- ClinicalTrials.gov ID
- NCT07480200
- Acronym / sponsor ID
- CRYO-TREMOR-2024
- Keywords
- Cryostimulation, Myofascial Trigger Points, Physiological Tremor, Adolescent Athletes, Swimming, Accelerometry
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Józef Piłsudski University of Physical EducationUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 Jun 2024 (actual)
- Study completion
- 1 Jul 2024 (actual)
- First posted
- 18 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examines whether local cryostimulation of myofascial trigger points can reduce physiological tremor that occurs after intense physical exercise. Thirty-four adolescent competitive swimmers participate in a randomized crossover study comparing two conditions: local ice stimulation of trigger points and a control condition without intervention. Physiological tremor of the lower limbs is measured using accelerometry before and after a 30-second maximal tethered swimming effort. The study aims to determine whether targeted cryostimulation can attenuate exercise-induced neuromuscular tremor and improve post-exercise motor stability in young athletes.
Detailed description
This study investigates whether targeted cryostimulation of myofascial trigger points (MTrPs) can attenuate exercise-induced physiological tremor in adolescent swimmers. The study uses a randomized reversed crossover design in which each participant completes two experimental conditions: local cryostimulation of identified trigger points and a control condition without intervention.
Thirty-four competitive adolescent swimmers participate in the study. Physiological tremor of both lower limbs is measured using triaxial accelerometry under standardized conditions before and after a maximal 30-second tethered swimming effort.
In the cryostimulation condition, cold packs are applied for 60 seconds to identified myofascial trigger points in the quadriceps and hamstring muscle groups. In the control condition, no cryostimulation is applied prior to exercise.
The primary outcome is the change in tremor power in the 2-5 Hz frequency band following exercise. Secondary outcomes include tremor power in the 9-14 Hz frequency band and tremor frequency parameters. Tremor signals are analyzed using frequency-domain analysis based on power spectral density calculations derived from accelerometer data.
The aim of the study is to determine whether localized cryostimulation of myofascial trigger points can modulate neuromuscular responses to fatigue and reduce the magnitude of exercise-induced tremor in adolescent athletes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This study uses a randomized reversed crossover design. Each participant completes two experimental conditions: local cryostimulation of myofascial trigger points and a control condition without intervention. The order of conditions is counterbalanced across participants to minimize potential order and carryover effects. Physiological tremor is measured at baseline and after a standardized exercise protocol in both conditions.
| Arm | Type | Receives |
|---|---|---|
| Cryostimulation of Myofascial Trigger Points | Experimental | Procedure: Cryostimulation of Myofascial Trigger PointsParticipants receive local cryostimulation of identified myofascial trigger points in the quadriceps and hamstring muscles. Cold packs are applied for 60 seconds to the trigger points before performing a 30-second maximal tethered swimming effort. Physiological tremor of the lower limbs is measured before and after exercise using accelerometry. |
| Control Condition (No Cryostimulation) | No intervention | –Participants complete the same experimental protocol without cryostimulation. After baseline tremor assessment, participants perform a 30-second maximal tethered swimming effort. No cooling intervention is applied before exercise. Physiological tremor of the lower limbs is measured before and after exercise using accelerometry under the same conditions as in the experimental arm. |
Who may qualify
- Ages
- 10 to 16 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (6 listed)
- - Competitive adolescent swimmers
- Age between 10 and 16 years
- Regular participation in swimming training (at least 3 training sessions per week)
- No current musculoskeletal injury affecting the lower limbs
- Ability to perform maximal swimming effort
Key exclusion criteria (4 listed)
- - Current lower limb injury or pain
- Neurological disorders affecting motor control
- Contraindications to cold exposure or cryotherapy
- Participation in other interventions that could affect neuromuscular performance
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cryostimulation of Myofascial Trigger PointsLocal cryostimulation is applied to identified myofascial trigger points in the quadriceps and hamstring muscles using cold packs for 60 seconds before a 30-second maximal tethered swimming effort. | Procedure or surgery | Cryostimulation of Myofascial Trigger Points |
Primary outcome
Exercise-Induced Physiological Tremor of the Lower Limbs
Time frame: Immediately before and immediately after the 30-second maximal tethered swimming effort during the experimental session.
Physiological tremor of the lower limbs measured using accelerometry before and after a 30-second maximal tethered swimming effort. Tremor amplitude is quantified from accelerometer signals to assess the effect of local cryostimulation of myofascial trigger points.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Mar 2026.
- Derived from this study: PubMed 42363198Kulis S, Skorulski M, Callegari B, Pietraszewski P. Targeted cryostimulation of myofascial trigger points modulates exercise-induced physiological tremor in adolescent swimmers: a randomized counterbalanced crossover trial. BMC Sports Sci Med Rehabil. 2026 Jun 26. doi: 10.1186/s13102-026-01839-x. Online ahead of print.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cryostimulation of Myofascial Trigger Points in people with Physiological Tremor and Exercise-Induced Neuromuscular Fatigue, run by Józef Piłsudski University of Physical Education at 1 site in Poland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 24 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Poland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exercise-Induced Physiological Tremor of the Lower Limbs (time frame: Immediately before and immediately after the 30-second maximal tethered swimming effort during the experimental session.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07480200, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Mar 2026.