Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate HypertrophyCITNCT07481045
Compensatory Inferior Turbinate Surgery in Septorhinoplasty
A study testing Septorhinoplasty and Inferior Turbinate Surgery in people with Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
Trial summary
Nasal obstruction is a common complaint among patients undergoing septorhinoplasty. In addition to septal deviation, compensatory inferior turbinate hypertrophy may contribute to impaired nasal airflow. For this reason, some surgeons routinely perform inferior turbinate reduction during septorhinoplasty. Read more about this study
- Who is it for?
- Ages 18 to 53 years
- Conditions the study is for
- Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy
- What is being tested?
- Septorhinoplasty and Inferior Turbinate Surgery
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2023to 1 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 53 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients older than 18 years
- Patients presenting with nasal obstruction and aesthetic concerns requiring septorhinoplasty
- Presence of nasal septal deviation confirmed by anterior rhinoscopy, nasal endoscopy, or computed tomography
- Presence of compensatory inferior turbinate hypertrophy in the contralateral nasal cavity
- Patients willing to participate and able to provide informed consent
Who cannot join
- Previous nasal, septal, or turbinate surgery
- Chronic rhinosinusitis with or without nasal polyps
- Bilateral inferior turbinate hypertrophy
- Absence of compensatory inferior turbinate hypertrophy
- Patients requiring additional nasal procedures or grafting techniques beyond the standardized surgical protocol
- Incomplete follow-up
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Concomitant Compensatory Inferior Turbinate Surgery on Functional Outcomes After Septorhinoplasty: A Randomized Controlled Trial
Nasal obstruction is a common complaint among patients undergoing septorhinoplasty. In addition to septal deviation, compensatory inferior turbinate hypertrophy may contribute to impaired nasal airflow. For this reason, some surgeons routinely perform inferior turbinate reduction during septorhinoplasty. However, the necessity and functional benefit of this additional procedure remain controversial.
The aim of this randomized controlled study is to evaluate whether compensatory inferior turbinate surgery provides additional functional benefit when performed simultaneously with septorhinoplasty. Patients undergoing septorhinoplasty will be randomly assigned to either septorhinoplasty alone or septorhinoplasty combined with inferior turbinate surgery.
Read more
Functional outcomes will be assessed using both subjective and objective measures. Subjective nasal obstruction will be evaluated using the Nasal Obstruction Symptom Evaluation (NOSE) scale, and objective nasal airflow will be assessed using peak nasal inspiratory flow (PNIF). Patients will be followed for six months after surgery.
The results of this study are expected to clarify the role of compensatory inferior turbinate surgery in patients undergoing septorhinoplasty and provide evidence regarding whether routine turbinate intervention is necessary in this patient population.
Read the detailed description
Nasal obstruction is a common complaint among patients with nasal septal deviation and is one of the major indications for septorhinoplasty. Although correction of septal deviation often improves nasal airflow, some patients present with compensatory inferior turbinate hypertrophy that may contribute to persistent nasal obstruction. For this reason, inferior turbinate surgery is frequently performed during septorhinoplasty. However, the additional functional benefit of routine turbinate intervention in these patients remains controversial.
This prospective randomized controlled study aims to evaluate the effect of compensatory inferior turbinate surgery on functional outcomes in patients undergoing septorhinoplasty. Patients with nasal obstruction due to septal deviation who are scheduled for septorhinoplasty will be enrolled and randomly assigned to one of two treatment groups: septorhinoplasty alone or septorhinoplasty combined with inferior turbinate surgery.
All surgical procedures will be performed using standard septorhinoplasty techniques. In the intervention group, inferior turbinate reduction will be performed during the same surgical session. Postoperative functional outcomes will be evaluated using both subjective and objective assessment tools. Subjective nasal obstruction will be assessed with the Nasal Obstruction Symptom Evaluation (NOSE) scale, and objective nasal airflow will be measured using peak nasal inspiratory flow (PNIF).
Patients will be followed for six months after surgery. Functional outcomes will be compared between the two groups to determine whether additional inferior turbinate surgery provides clinically meaningful improvement in nasal airway function when performed simultaneously with septorhinoplasty.
- Being tested
- Septorhinoplasty, Inferior Turbinate Surgery
- Keywords
- Septorhinoplasty, Inferior turbinate hypertrophy, Nasal obstruction, Peak nasal inspiratory flowmeter, NOSE score
- Medical subject headings
- Nasal Obstruction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
SeptorhinoplastyProcedure or surgery
Standard open functional septorhinoplasty was performed under general anesthesia, including septoplasty, dorsal profile alignment with transverse and lateral osteotomies, tipplasty, bilateral spreader graft placement, and columellar strut grafting. Silicone nasal splints were placed bilaterally and removed after 72 hours.
Inferior Turbinate SurgeryProcedure or surgery
Inferior turbinate reduction was performed on the non-deviated side using submucosal radiofrequency ablation followed by turbinate lateralization to improve nasal airway patency.
| Study group | Role | What they receive |
|---|---|---|
| SRP | Experimental | Patients undergoing standard open functional septorhinoplasty without inferior turbinate intervention. Receives: Procedure: Septorhinoplasty |
| SRP + CIT Surgery | Experimental | Patients undergoing septorhinoplasty combined with compensatory inferior turbinate surgery. Receives: Procedure: Septorhinoplasty; Procedure: Inferior Turbinate Surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Nasal Obstruction Symptom Evaluation (NOSE) score
The Nasal Obstruction Symptom Evaluation (NOSE) scale is a validated patient-reported questionnaire used to assess the severity of nasal obstruction. Scores range from 0 to 100, with higher scores indicating more severe nasal obstruction.
Measured: Preoperative baseline and 6 months after surgery
Secondary outcomes (1)
Change in Peak Nasal Inspiratory Flow (PNIF)
Peak Nasal Inspiratory Flow (PNIF) is an objective measure of nasal airflow.
Measured: Preoperative baseline and 6 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Mar 2026
- Study start1 Jan 2023
- Primary completion1 Sep 2025
- Study completion1 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate HypertrophyStudies of the same condition, open and under way.
- More trials run by Saglik Bilimleri UniversitesiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants are randomized in a 1:1 ratio to undergo either septorhinoplasty (SRP) alone or septorhinoplasty combined with compensatory inferior turbinate (CIT) surgery. Functional outcomes are compared between the two parallel groups using both subjective and objective measures during the postoperative follow-up period.
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Saglik Bilimleri Universitesi
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zülküf Küçüktağ, Saglik Bilimleri Universitesi
- Investigators
- Zülküf Küçüktağ, M.D., Principal investigator, Saglik Bilimleri Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07481045
- Sponsor's protocol ID
- AEŞH-BADEK1-2025-327
- Acronym
- CIT
- Status last verified
- Mar 2026
- First submitted
- 9 Mar 2026
- Last updated
- 18 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No plan to share individual participant data.
Publications
Kucuktag Z, Ozdogan A, Saygi Uysal G, Altan E. Compensatory Inferior Turbinate RFA and Lateralization in Septorhinoplasty: A Randomized Study. Laryngoscope. 2026 Jul 13. doi: 10.1002/lary.70728. Online ahead of print.
PubMed 42439048
Study at a glance
From the registry record, last updated by the sponsor on 18 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Concomitant Compensatory Inferior Turbinate Surgery on Functional Outcomes After Septorhinoplasty: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07481045
- Acronym / sponsor ID
- CIT / AEŞH-BADEK1-2025-327
- Keywords
- Septorhinoplasty, Inferior turbinate hypertrophy, Nasal obstruction, Peak nasal inspiratory flowmeter, NOSE score
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Saglik Bilimleri UniversitesiUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 1 Sep 2025 (actual)
- Study completion
- 1 Sep 2025 (actual)
- First posted
- 18 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Nasal obstruction is a common complaint among patients undergoing septorhinoplasty. In addition to septal deviation, compensatory inferior turbinate hypertrophy may contribute to impaired nasal airflow. For this reason, some surgeons routinely perform inferior turbinate reduction during septorhinoplasty. However, the necessity and functional benefit of this additional procedure remain controversial.
The aim of this randomized controlled study is to evaluate whether compensatory inferior turbinate surgery provides additional functional benefit when performed simultaneously with septorhinoplasty. Patients undergoing septorhinoplasty will be randomly assigned to either septorhinoplasty alone or septorhinoplasty combined with inferior turbinate surgery.
Functional outcomes will be assessed using both subjective and objective measures. Subjective nasal obstruction will be evaluated using the Nasal Obstruction Symptom Evaluation (NOSE) scale, and objective nasal airflow will be assessed using peak nasal inspiratory flow (PNIF). Patients will be followed for six months after surgery.
The results of this study are expected to clarify the role of compensatory inferior turbinate surgery in patients undergoing septorhinoplasty and provide evidence regarding whether routine turbinate intervention is necessary in this patient population.
Detailed description
Nasal obstruction is a common complaint among patients with nasal septal deviation and is one of the major indications for septorhinoplasty. Although correction of septal deviation often improves nasal airflow, some patients present with compensatory inferior turbinate hypertrophy that may contribute to persistent nasal obstruction. For this reason, inferior turbinate surgery is frequently performed during septorhinoplasty. However, the additional functional benefit of routine turbinate intervention in these patients remains controversial.
This prospective randomized controlled study aims to evaluate the effect of compensatory inferior turbinate surgery on functional outcomes in patients undergoing septorhinoplasty. Patients with nasal obstruction due to septal deviation who are scheduled for septorhinoplasty will be enrolled and randomly assigned to one of two treatment groups: septorhinoplasty alone or septorhinoplasty combined with inferior turbinate surgery.
All surgical procedures will be performed using standard septorhinoplasty techniques. In the intervention group, inferior turbinate reduction will be performed during the same surgical session. Postoperative functional outcomes will be evaluated using both subjective and objective assessment tools. Subjective nasal obstruction will be assessed with the Nasal Obstruction Symptom Evaluation (NOSE) scale, and objective nasal airflow will be measured using peak nasal inspiratory flow (PNIF).
Patients will be followed for six months after surgery. Functional outcomes will be compared between the two groups to determine whether additional inferior turbinate surgery provides clinically meaningful improvement in nasal airway function when performed simultaneously with septorhinoplasty.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants are randomized in a 1:1 ratio to undergo either septorhinoplasty (SRP) alone or septorhinoplasty combined with compensatory inferior turbinate (CIT) surgery. Functional outcomes are compared between the two parallel groups using both subjective and objective measures during the postoperative follow-up period.
| Arm | Type | Receives |
|---|---|---|
| SRP | Experimental | Procedure: SeptorhinoplastyPatients undergoing standard open functional septorhinoplasty without inferior turbinate intervention. |
| SRP + CIT Surgery | Experimental | Procedure: Septorhinoplasty, Procedure: Inferior Turbinate SurgeryPatients undergoing septorhinoplasty combined with compensatory inferior turbinate surgery. |
Who may qualify
- Ages
- 18 to 53 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients older than 18 years
- Patients presenting with nasal obstruction and aesthetic concerns requiring septorhinoplasty
- Presence of nasal septal deviation confirmed by anterior rhinoscopy, nasal endoscopy, or computed tomography
- Presence of compensatory inferior turbinate hypertrophy in the contralateral nasal cavity
- Patients willing to participate and able to provide informed consent
Key exclusion criteria (6 listed)
- Previous nasal, septal, or turbinate surgery
- Chronic rhinosinusitis with or without nasal polyps
- Bilateral inferior turbinate hypertrophy
- Absence of compensatory inferior turbinate hypertrophy
- Patients requiring additional nasal procedures or grafting techniques beyond the standardized surgical protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| SeptorhinoplastyStandard open functional septorhinoplasty was performed under general anesthesia, including septoplasty, dorsal profile alignment with transverse and lateral osteotomies, tipplasty, bilateral spreader graft placement, and columellar strut grafting. Silicone nasal splints were placed bilaterally and removed after 72 hours. | Procedure or surgery | SRP, SRP + CIT Surgery |
| Inferior Turbinate SurgeryInferior turbinate reduction was performed on the non-deviated side using submucosal radiofrequency ablation followed by turbinate lateralization to improve nasal airway patency. | Procedure or surgery | SRP + CIT Surgery |
Primary outcome
Change in Nasal Obstruction Symptom Evaluation (NOSE) score
Time frame: Preoperative baseline and 6 months after surgery
The Nasal Obstruction Symptom Evaluation (NOSE) scale is a validated patient-reported questionnaire used to assess the severity of nasal obstruction. Scores range from 0 to 100, with higher scores indicating more severe nasal obstruction.
1 secondary outcome
Change in Peak Nasal Inspiratory Flow (PNIF)
Time frame: Preoperative baseline and 6 months after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Mar 2026.
- Derived from this study: PubMed 42439048Kucuktag Z, Ozdogan A, Saygi Uysal G, Altan E. Compensatory Inferior Turbinate RFA and Lateralization in Septorhinoplasty: A Randomized Study. Laryngoscope. 2026 Jul 13. doi: 10.1002/lary.70728. Online ahead of print.
- Individual participant dataSharing planned: No. No plan to share individual participant data.
Related trials for Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy
Not yet recruiting
Evaluation of the Outcome of Septoplasty With or Without Inferior Turbinate Reduction
Deviated Nasal Septum, Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Zülküf Küçüktağ, M.D. principal investigator
Saglik Bilimleri Universitesi
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Septorhinoplasty and Inferior Turbinate Surgery in people with Nasal Obstruction Septal Deviation Compensatory Inferior Turbinate Hypertrophy, run by Saglik Bilimleri Universitesi at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Nasal Obstruction Symptom Evaluation (NOSE) score (time frame: Preoperative baseline and 6 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07481045, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Mar 2026.