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Mental Health Well-beingCMR-THAINCT07482839

Feasibility of a Compassionate Mindful Resilience Programme for Thai Secondary School Students

A study testing Four-Week Compassionate Mindful Resilience (CMR) Intervention in people with Mental Health Well-being and Emotional Regulation, run by Queen's University, Belfast at 1 site in United Kingdom.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
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Trial summary

This study is a single-arm feasibility trial designed to evaluate the implementation, acceptability, and preliminary effects of a culturally adapted Compassionate Mindful Resilience (CMR) intervention among adolescents in Thailand. Read more about this study

Who is it for?
Ages 16 to 18 yearsHealthy volunteers can take part
What is being tested?
Four-Week Compassionate Mindful Resilience (CMR) Intervention
Could I receive a placebo?
No, everyone receives an active treatment
How many people
46 participants
Where
1 siteUnited Kingdom
Study dates
11 May 2026to 7 Sep 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 16 to 18 years
  • All sexes
  • Healthy volunteers accepted
  • Child, Adult

Who may be able to join

  • Adolescents between 16 and 18 years of age at the time of enrollment.
  • Current students in Grades 10 to 12 (Mathayom 4-6) at a Thai Secondary School in Northeastern Thailand.
  • Willingness to engage in a mindfulness-based intervention programme.
  • Ability to understand and communicate in the Thai language.
  • Ability to provide informed consent (dual consent from both the student and a parent/legal guardian is required).

Who cannot join

  • Significant mental health conditions that may impede participation, such as schizophrenia, bipolar I disorder, or severe major depression with psychotic features.
  • Cognitive impairments that prevent comprehension of the mindfulness intervention.
  • Concurrent involvement in another psychological intervention that might confound the study results.

Trial locations and contacts

1 site in 1 country.

United Kingdom1 site

  • Queen's University Belfast, School of Nursing and Midwifery

    Belfast, Northern Ireland, BT9 7BL

Other trials in United Kingdom

About this study

Official title: Feasibility Study of a Compassionate Mindful Resilience (CMR) Intervention to Improve Mental Health Well-being Outcomes Among Youth in Thailand

This study is a single-arm feasibility trial designed to evaluate the implementation, acceptability, and preliminary effects of a culturally adapted Compassionate Mindful Resilience (CMR) intervention among adolescents in Thailand. The study is conducted in a secondary school setting and targets students aged 16 to 18 years.

Adolescence is a period of heightened emotional vulnerability and academic pressure. In Thailand, rising levels of stress and anxiety among young people make school-based preventive interventions a public health priority. While mindfulness-based interventions have shown benefits in Western contexts, evidence on compassion-focused programmes culturally adapted for Thai adolescents remains limited.

Read more

All participants enrolled in the study will receive the CMR intervention. The program consists of four weekly group sessions, each lasting approximately 90 minutes, delivered after school hours to minimize disruption to academic activities. Sessions include guided mindfulness practices, group discussions, and practical exercises aimed at increasing present-moment awareness, cultivating self-compassion, improving emotional regulation, and strengthening resilience.

The primary objective of the study is to assess feasibility. Feasibility outcomes include recruitment rate, retention rate, session attendance, intervention fidelity, and participant acceptability. These indicators will inform whether the intervention can be delivered as planned in a Thai school setting and whether progression to a larger-scale trial is justified.

Secondary objectives explore preliminary changes in mental health-related outcomes. These include mindfulness, self-compassion, resilience, and overall well-being, measured using validated Thai-language instruments before and after completion of the intervention. Although the study is not powered to test effectiveness, these data will provide estimates of variability and potential effect sizes to inform the design of a future randomized controlled trial.

Participant safety is addressed through a predefined distress protocol. A school counselor is available during all intervention sessions to provide immediate support if participants experience emotional distress. Ethical approval has been obtained from the relevant institutional ethics committee, and written assent from participants, along with parental or guardian consent, is required prior to enrollment.

Read the detailed description

Detailed Description Study Framework and Theoretical Basis This feasibility study constitutes Phase 3 of a comprehensive research project designed to address the rising rates of stress, anxiety, and substance use risks among Thai adolescents. The intervention utilizes the Compassionate Mindful Resilience (CMR) programme, which integrates secular mindfulness with compassion-based approaches to enhance cognitive resilience and emotional regulation. While MBIs have shown efficacy in adult populations, this study evaluates a culturally adapted version specifically for the Thai secondary school context, where collectivist values and Buddhist traditions may influence implementation.

Trial Design and Procedural Workflow The study employs a single-arm, pre-post feasibility design. This approach is selected to evaluate implementation parameters and participant engagement prior to committing to a full-scale randomized controlled trial (RCT).

  • Intervention Delivery: The CMR programme consists of eight modules delivered over four weekly 90-minute group sessions. Sessions are conducted after school hours (16:00-17:30) to minimize academic disruption and mitigate potential stigma associated with mental health initiatives.
  • Fidelity and Facilitation: The programme is delivered by a PhD candidate trained in CMR under academic supervision from Queen's University Belfast. Delivery fidelity is maintained through adherence checklists, session logs, and standardized recap materials for participants who miss sessions.
  • Stratified Sampling: To ensure developmental diversity, the study utilizes stratified random sampling across Grades 10, 11, and 12, aimed at achieving a balanced representation from the student population.

Technical Application of Participation Models

The research process incorporates established participatory frameworks to assess the depth of stakeholder engagement:

  • Hart's Ladder of Children's Participation: Evaluates whether youth involvement moves beyond tokenism to "Consulted but Informed" and "Adult-Initiated Shared Decisions"
  • Arnstein's Ladder of Participation: Used to track the transition toward "Partnership" and "Delegated Power" during the co-production and evaluation phases.

Statistical Analysis Plan

The analysis focuses on determining the feasibility of the protocol for future larger-scale implementation:

  • Feasibility Metrics: Recruitment rates, consent rates, session attendance, and participant retention will be analyzed using descriptive statistics.
  • Preliminary Effectiveness: Quantitative changes in psychosocial outcomes will be assessed using paired t-tests where distributional assumptions are met, and Wilcoxon signed-rank tests where they are not, following assessment of normality. Effect sizes will be calculated using the metric appropriate to the test applied (Cohen's d for parametric comparisons; r = Z/√N for non-parametric comparisons) to estimate the magnitude of change and inform future power calculations.
  • Exposure Analysis: An exploratory subset analysis will be reported for participants who attend at least 75% of the sessions (three out of four) to investigate dose-response relationships.

Qualitative Process Evaluation To complement quantitative data, a process evaluation will explore the acceptability and contextual relevance of the programme.

  • Thematic Analysis: Post-intervention focus groups and brief exit interviews will be audio-recorded, transcribed verbatim in Thai, and translated into English.
  • Analytical Rigor: Qualitative data will be managed using NVivo software and analyzed via Reflexive Thematic Analysis. A second coder will review a subset of transcripts to ensure credibility and an audit trail will be maintained.

Data Security and Transfer Protocols

  • Pseudonymization: All data are de-identified at the source using study codes; identifiable information remains in Thailand and is not transferred.
  • Electronic Management: Scanned documents and audio transcripts are stored on encrypted, password-protected systems with role-based access.
  • Cross-Border Transfer: Pseudonymized data transferred for analysis utilize encrypted channels in compliance with university governance and data protection legislation.
Being tested
Four-Week Compassionate Mindful Resilience (CMR) Intervention
Keywords
Compassionate Mindful Resilience (CMR), Mindfulness-Based Intervention (MBI), Adolescents, Thailand, Secondary School, Feasibility Study, Co-production, Self-compassion, Youth Mental Health
Medical subject headings
Emotional Regulation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Four-Week Compassionate Mindful Resilience (CMR) InterventionBehavioural

    Also called Adapted CMR-Thai

    A group-based behavioral intervention delivered over four weekly 90-minute sessions (6 hours total contact time). The program integrates mindfulness, self-compassion, and resilience training through eight modules. Technical components include:

    • Mindfulness \& Awareness: Breathing practices, body scans, and "being mode" vs "doing mode".
    • Emotional Intelligence: Application of the RAIN (Recognise, Acknowledge, Investigate, Nurture), HEARTS, and STOP (Stop, Take a breath, Observe, Proceed) models.
    • Resilience Building: Cognitive reappraisal, affectionate breathing, and social connection strategies.
    • Impulse Management: "Urge surfing" meditations and mindful decision-making to support substance-use prevention.
    • Home Practice: Daily 10-minute meditation, journaling, and mindful movement.
Study groups in NCT07482839
Study groupRoleWhat they receive
Compassionate Mindful Resilience (CMR) Experimental GroupExperimental* This single-arm group will receive a culturally adapted, 4-week Compassionate Mindful Resilience (CMR) intervention. * Participants include 46 secondary school students (Aged 16-18) from Grades 10 to 12. * The intervention consists of four weekly 90-minute group sessions delivered after school hours (approximately 16:00-17:30). * Participants engage in mindfulness fundamentals, emotional intelligence training (RAIN and HEARTS models), and resilience strategies. * Home practices include 10-minute daily breathing exercises, journaling, and body scan meditations. * The arm focuses on evaluating recruitment, retention, and the acceptability of the programme in a Thai school context.
Receives: Behavioral: Four-Week Compassionate Mindful Resilience (CMR) Intervention

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Recruitment Rate

    This measure represents the proportion of eligible students who provide informed consent. It is measured as a percentage, calculated as: (Number of Consented Participants / Number of Eligible Students Invited) x 100. The target for success is a recruitment rate of 70% or higher.

    Measured: Week 0 (at the end of recruitment)

  2. Retention Rate

    This measure represents the proportion of enrolled participants who complete the study and provide post-intervention data. It is measured as a percentage, calculated as: (Number of Participants Providing Post-Intervention Data / Number Enrolled) x 100. The target for success is a retention rate of 80% or higher.

    Measured: Week 4 (post-intervention).

  3. Session Attendance

    This measure tracks participant adherence based on the total number of sessions attended. It is calculated as the mean number of sessions attended out of the 4 scheduled sessions. Scores range from 0 to 4 sessions, where a higher number indicates greater attendance.

    Measured: From start to end of the intervention (Week 1 to Week 4).

Secondary outcomes (4)

  1. Change in Mindfulness Scores (Srithanya Sati Scale)

    This outcome assesses the change in dispositional mindfulness using the Srithanya Sati Scale, an 11-item self-report questionnaire. The total score is calculated as the sum of all 11 items. The minimum score is 11 and the maximum score is 44. Higher scores indicate greater levels of mindfulness. The "Change" is calculated by subtracting the Baseline (Week 0) total score from the Post-intervention (Week 4) total score.

    Measured: Baseline (Week 0) and Post-intervention (Week 4).

  2. Change in Self-Compassion Scores (SCS-Y Thai version)

    This outcome assesses the change in how youth treat themselves with kindness during difficult times using a 17-item scale. Each item is rated on a 5-point scale. The total score is calculated as the mean of all 17 items (after reverse-scoring negative items). The minimum score is 1.0 and the maximum score is 5.0. Higher scores indicate higher levels of self-compassion. The "Change" is calculated by subtracting the Baseline (Week 0) mean score from the Post-intervention (Week 4) mean score.

    Measured: Baseline (Week 0) and Post-intervention (Week 4)

  3. Change in Resilience Scores (CD-RISC-10)

    This outcome assesses the change in psychological resilience using a 10-item scale. Each item is rated on a 5-point scale (0-4). The total score is calculated as the sum of all 10 items. The minimum score is 0 and the maximum score is 40. Higher scores represent greater psychological resilience. The "Change" is calculated by subtracting the Baseline (Week 0) total score from the Post-intervention (Week 4) total score.

    Measured: Baseline (Week 0) and Post-intervention (Week 4)

  4. Change in Subjective Well-being (WHO-5 Well-being Index)

    This outcome measures the change in subjective psychological well-being using a 5-item scale. The total score is calculated as the raw sum of the 5 items. The minimum score is 0 and the maximum score is 25. Higher scores indicate better subjective well-being. The "Change" is calculated by subtracting the Baseline (Week 0) raw score from the Post-intervention (Week 4) raw score.

    Measured: Baseline (Week 0) and Post-intervention (Week 4)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted19 Mar 2026
  2. Study start11 May 2026
  3. Primary completion5 Jun 2026
  4. Study completion7 Sep 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Not applicable
Intervention model
Single group
Model description
This feasibility study utilizes a single-arm pre-post design to evaluate the implementation and acceptability of a 4-week CMR intervention. While the ultimate goal is a cluster randomized controlled trial (RCT), this stage focuses on feasibility metrics within a single school setting to inform the design of future larger trials.
Masking
None (open label)
Enrolment
46 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07482839
Sponsor's protocol ID
MHLS 25_106
Acronym
CMR-THAI
Status last verified
Aug 2026
First submitted
12 Feb 2026
Last updated
13 Aug 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be made available to external researchers. Participants are minors aged 16-18 recruited from a single school, and consent was obtained for the publication of pseudonymised findings and quotations and for retention of pseudonymised data within a secure Queen's University Belfast research archive, but not for the release of participant-level datasets to third parties. The Study Protocol (v3.1) and Informed Consent Forms are available via the Queen's Research Portal, and aggregated findings will be published in open-access peer-reviewed journals.

Publications

  • Kabat-Zinn, J. (2003). Mindfulness-Based interventions in context: Past, present, and future. Clinical Psychology: Science and Practice, 10(2), 144-156.

  • Hart, R. A. (1992). Children's participation: From tokenism to citizenship. UNICEF Innocenti Research Centre.

  • Vongsirimas, N., et al. (2017). Evaluating Psychometric Properties of the Connor-Davidson Resilience Scale (10-Item CD-RISC) among University Students in Thailand. Nursing Science Journal of Thailand, 35(3), 25-35.

  • Silpakit O, Silpakit C. A thai version of mindfulness questionnaire: Srithanya Sati scale. East Asian Arch Psychiatry. 2014 Mar;24(1):23-9.

    PubMed 24676484

  • Wilson A, McKeaveney C, Carswell C, Atkinson K, Burton S, McVeigh C, Graham-Wisener L, Jaaskelainen E, Johnston W, O'Rourke D, Reid J, Rej S, Walsh I, Noble H. Experiences of People with Kidney Disease Following the Implementation of the Compassionate Mindful Resilience Programme: Qualitative Findings from the COSMIC Study. Healthcare (Basel). 2023 Nov 8;11(22):2926. doi: 10.3390/healthcare11222926.

    PubMed 37998417

Questions about this trial

What is this clinical trial studying?

A study testing Four-Week Compassionate Mindful Resilience (CMR) Intervention in people with Mental Health Well-being and Emotional Regulation, run by Queen's University, Belfast at 1 site in United Kingdom.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 13 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Recruitment Rate (time frame: Week 0 (at the end of recruitment)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07482839, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Aug 2026.

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