Parkinson's Disease (PD)NCT07485621
LFP-based Parameter Prediction in DBS for Parkinson's Disease
An observational study of Parkinson's Disease (PD), run by Loes Laurijssen at 1 site in Belgium.
Trial summary
The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Parkinson's Disease (PD)
- How many people
- 40 participants
- Where
- 1 siteBelgium
- Study dates
- 5 Mar 2026to Mar 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients with Parkinson's disease who are eligible for deep brain stimulation to treat refractory motor symptoms.
Who may be able to join
- Voluntary written informed consent of the participant
- At least 18 years of age at the time of signing the Informed Consent Form (ICF)
- Diagnosis of idiopathic Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society (MDS)
- Eligible for DBS to treat refractory PD motor symptoms, as based on multidisciplinary DBS screening
- Have sufficient understanding of the Dutch and French language to participate in the study
Who cannot join
- /
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Belgium1 site, 1 recruiting
- Recruiting
University Hospitals Leuven
Leuven, Vlaams-Brabant, 3000
Bart Swinnen, MD, PhD, 0031 16343044, bart.swinnen@uzleuven.be
Bart Swinnen, MD, PhD
About this study
Official title: Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study
The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. The main question it aims to answer is:
Aligns stimulation contact selection based on subcortical LFP recordings with clinically optimized contact selection?
Participants will undergo LFP recordings that are part of standard clinical care during their routine hospital visits.
- Conditions
- Parkinson's Disease (PD)
- Keywords
- Deep brain stimulation, Local field potentials, Parkinson's disease
- Medical subject headings
- Parkinson Disease
What is being measured
The primary outcome is the main question the study is designed to answer.
Alignment of contact selection
Alignment between local field potential-based contact selection and the clinically optimized stimulation contact.
Measured: From the first LFP recording to the last LFP recording (6 - 9 months)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Mar 2026
- Study start5 Mar 2026
- Primary completionMar 2029 (estimated)
- Study completionMar 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson's Disease (PD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Loes Laurijssen
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Loes Laurijssen, University Hospital of Leuven Leuven
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07485621
- Sponsor's protocol ID
- S71459
- Status last verified
- Mar 2026
- First submitted
- 16 Mar 2026
- Last updated
- 20 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study
- ClinicalTrials.gov ID
- NCT07485621
- Acronym / sponsor ID
- S71459
- Conditions
- Parkinson's Disease (PD)
- Keywords
- Deep brain stimulation, Local field potentials, Parkinson's disease
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Loes LaurijssenUniversity, hospital or other
- Study start
- 5 Mar 2026 (actual)
- Primary completion
- Mar 2029 (estimated)
- Study completion
- Mar 2029 (estimated)
- First posted
- 20 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. The main question it aims to answer is:
Aligns stimulation contact selection based on subcortical LFP recordings with clinically optimized contact selection?
Participants will undergo LFP recordings that are part of standard clinical care during their routine hospital visits.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients with Parkinson's disease who are eligible for deep brain stimulation to treat refractory motor symptoms.
Key inclusion criteria (5 listed)
- Voluntary written informed consent of the participant
- At least 18 years of age at the time of signing the Informed Consent Form (ICF)
- Diagnosis of idiopathic Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society (MDS)
- Eligible for DBS to treat refractory PD motor symptoms, as based on multidisciplinary DBS screening
- Have sufficient understanding of the Dutch and French language to participate in the study
Key exclusion criteria (1 listed)
- /
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Alignment of contact selection
Time frame: From the first LFP recording to the last LFP recording (6 - 9 months)
Alignment between local field potential-based contact selection and the clinically optimized stimulation contact.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Parkinson's Disease (PD), run by Loes Laurijssen at 1 site in Belgium.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Belgium. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Bart Swinnen, MD, PhD (0032 16343044, bart.swinnen@uzleuven.be), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Alignment of contact selection (time frame: From the first LFP recording to the last LFP recording (6 - 9 months)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Mar 2026.