HealhtyNCT07491432
Effects of Lower Extremity Neural Mobilization on Gait Biomechanics and Spinal Alignment
A study testing Lower Extremity Neural Slider Exercise and Lower Extremity Neural Tensioner Exercise in people with Healhty and Sedanter, run by Izmir Democracy University at 1 site in Turkey (Türkiye).
Trial summary
This randomized single-blinded trial aimed to compare the immediate effects of lower extremity neural slider and neural tensioner exercises on gait parameters and spinal alignment in sedentary young adults. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- What is being tested?
- Lower Extremity Neural Slider Exercise and Lower Extremity Neural Tensioner Exercise
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Feb 2024to 24 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age between 18 and 30 years
- Sedentary lifestyle (no regular structured exercise within the past 6 months)
- No history of lower extremity or spinal surgery
- No diagnosed neurological disorder
- No diagnosed musculoskeletal disorder
- No current lower extremity pain or functional limitation
- Willingness to participate and provide written informed consent
Who cannot join
- History of hamstring injury
- Current low back, hip, or knee pain
- Known peripheral nerve injury or neurological condition
- Any condition limiting safe participation in neural mobilization exercises
- Inability to complete the intervention protocol
- Withdrawal from the study before post-intervention assessment
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Izmir Democracy University
Izmir, Konak, 35290
About this study
Official title: Acute Effects of Lower Extremity Neural Mobilization on Gait Biomechanics and Spinal Alignment: A Comparison of Neural Slider and Neural Tensioner Techniques
This randomized single-blinded trial aimed to compare the immediate effects of lower extremity neural slider and neural tensioner exercises on gait parameters and spinal alignment in sedentary young adults. Sixty healthy sedentary individuals aged 18-30 years were randomly assigned to receive either a neural slider or neural tensioner intervention. Spatiotemporal gait parameters were assessed using a validated smartphone-based gait analysis application, and spinal alignment angles were measured with a bubble inclinometer before and immediately after a single exercise session. The primary outcome was the acute change in gait-related parameters, and secondary outcomes included changes in spinal alignment and pelvic inclination angles.
Read the detailed description
This randomized, single-blinded experimental study was conducted between February and April 2024 to investigate the acute effects of lower extremity neural mobilization techniques on gait biomechanics and spinal alignment in sedentary individuals.
Sixty healthy sedentary participants (30 females, 30 males) aged 18-30 years were enrolled. Participants were randomly allocated to either a neural slider group or a neural tensioner group using a sealed-envelope randomization method. Allocation concealment was ensured by an independent researcher, and all outcome assessments were performed by a blinded physiotherapist.
Each participant underwent baseline (pre-test) assessments followed by a single session of neural mobilization exercise (3 minutes total, 3 sets of 30 repetitions). Post-intervention measurements were performed five minutes after completion of the exercise.
The primary outcome was the immediate change in spatiotemporal gait parameters, including gait speed, cadence, step length, step length asymmetry, base of support, single and double support times, and gait score. Gait was assessed using the OneStep smartphone application, which has demonstrated high validity compared to laboratory-based gait analysis systems.
Secondary outcomes included changes in spinal alignment and pelvic inclination angles, measured using a bubble inclinometer. Cervical lordosis, thoracic kyphosis, lumbar lordosis, total spinal mobility, and pelvic tilt angles were evaluated in a neutral standing position.
No adverse events were reported during or after the interventions.
- Being tested
- Lower Extremity Neural Slider Exercise, Lower Extremity Neural Tensioner Exercise
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Lower Extremity Neural Slider ExerciseOther
A lower extremity neural slider technique applied in supine position. The movement sequence involved alternating cervical extension with simultaneous knee extension and ankle dorsiflexion, followed by cervical flexion combined with knee flexion and ankle plantarflexion. The intervention was performed for a total of 3 minutes, consisting of 3 sets of 30 repetitions (90 repetitions total). Each repetition included a 1-second hold at end range. The technique was administered by a physiotherapist under standardized conditions.
Lower Extremity Neural Tensioner ExerciseOther
A lower extremity neural tensioner technique applied in supine position. The movement sequence involved simultaneous cervical flexion with knee extension and ankle dorsiflexion to increase neural tension, followed by return to neutral position with cervical extension and knee flexion. The intervention lasted 3 minutes and consisted of 3 sets of 30 repetitions (90 repetitions total), with a 1-second hold at end range. The technique was administered by a physiotherapist under standardized conditions.
| Study group | Role | What they receive |
|---|---|---|
| Neural Slider Group | Experimental | Lower Extremity Neural Slider Exercise Receives: Other: Lower Extremity Neural Slider Exercise |
| Neural Tensioner Group | Experimental | Lower Extremity Neural Tensioner Exercise Receives: Other: Lower Extremity Neural Tensioner Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gait Speed
Gait speed expressed in meters per second (m/s), calculated as total walking distance divided by time during a 1-minute walk on a straight, level surface. Measurements were obtained using the OneStep smartphone application, with the smartphone securely attached to the lateral aspect of the thigh to capture inertial motion data. Speed was derived from step detection and stride timing algorithms. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minutes after the intervention
Gait Cadence
Cadence expressed in steps per minute (steps/min), calculated as the total number of detected steps divided by walking time. Step events were identified through thigh-mounted inertial sensor data captured by the OneStep application during a 1-minute walking trial. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minutes after the interventio
Step Length
Step length expressed in centimeters (cm), defined as the linear distance between the initial contact of one foot and the subsequent initial contact of the contralateral foot. Step length was estimated using validated gait algorithms based on stride time and thigh kinematics recorded by the OneStep application. The outcome represents the change from baseline to post-intervention.
Measured: baseline and 5 minutes after the intervention
Stride Length
Stride length expressed in centimeters (cm), defined as the linear distance between two successive initial contacts of the same foot. Stride length was derived from inertial sensor data captured from the thigh during standardized walking. The outcome represents the change between pre- and post-intervention.
Measured: baseline and 5 minute after interventions.
Step Length Asymmetry
ep length asymmetry expressed as a percentage (%), calculated as the normalized difference between right and left step lengths during walking. Values were automatically derived from spatiotemporal gait data recorded by the thigh-mounted smartphone. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minute later interventions
Step Width
step width expressed in centimeters (cm), defined as the mediolateral distance between the center points of the heels during consecutive foot contacts. This parameter was estimated using validated spatial gait algorithms within the OneStep application. The outcome represents the change from baseline to post-intervention.
Measured: baseline and 5 minutes later interventions
Single Support Time
Right single support time expressed as a percentage of the gait cycle (%), defined as the duration during which only the investigated limb is in contact with the ground. Gait cycle phases were automatically detected using thigh-based inertial motion data. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minutes after interventions
Double Support Time
Double support time expressed as a percentage of the gait cycle (%), defined as the duration during which both feet are simultaneously in contact with the ground. This parameter was calculated using gait phase detection algorithms from inertial sensor data recorded during walking. The outcome represents the change between pre- and post-intervention assessments.
Measured: baseline and 5 minutes after interventions
Secondary outcomes (4)
Pelvic Inclination Angle
Pelvic inclination angle expressed in degrees (°), measured in standing position using a bubble inclinometer placed between the anterior superior iliac spine (ASIS) and posterior superior iliac spine (PSIS). The angle represents the sagittal plane tilt of the pelvis. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minutes after interventions
Cervical Lordosis Angle
Cervical lordosis angle expressed in degrees (°), measured in neutral standing posture using a bubble inclinometer positioned between the spinous processes of C1 and C7. The angle represents sagittal curvature of the cervical spine. The outcome represents the change from baseline to post-intervention.
Measured: baseline and 5 minutes later interventions
Thoracic Kyphosis Angle
Thoracic kyphosis angle expressed in degrees (°), measured using a bubble inclinometer placed between T1 and T12 spinous processes in standing posture. The outcome represents the change between pre- and post-intervention measurements.
Measured: baseline and 5 minutes after interventions
Lumbar Lordosis Angle
Lumbar lordosis angle expressed in degrees (°), measured using a bubble inclinometer placed between L1 and L5 spinous processes in standing posture. The outcome represents the change from pre- to post-intervention.
Measured: baseline and 5 minutes after interventions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Mar 2026
- Study start1 Feb 2024
- Primary completion23 Aug 2026
- Study completion24 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HealhtyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study used a parallel-group randomized design. Participants were randomly assigned to either the neural slider group or the neural tensioner group using a sealed-envelope method. Each participant received a single session of the allocated neural mobilization technique. Outcome assessments were performed before and immediately after the intervention. The two groups were compared in terms of acute changes in gait parameters and spinal alignment.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Izmir Democracy University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ezgi Ünüvar Yüksel, Izmir Democracy University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07491432
- Sponsor's protocol ID
- neuralmobilization
- Status last verified
- Mar 2026
- First submitted
- 18 Mar 2026
- Last updated
- 6 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Lower Extremity Neural Mobilization on Gait Biomechanics and Spinal Alignment: A Comparison of Neural Slider and Neural Tensioner Techniques
- ClinicalTrials.gov ID
- NCT07491432
- Acronym / sponsor ID
- neuralmobilization
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Izmir Democracy UniversityUniversity, hospital or other
- Study start
- 1 Feb 2024 (actual)
- Primary completion
- 23 Aug 2026 (actual)
- Study completion
- 24 Aug 2026 (actual)
- First posted
- 24 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized single-blinded trial aimed to compare the immediate effects of lower extremity neural slider and neural tensioner exercises on gait parameters and spinal alignment in sedentary young adults. Sixty healthy sedentary individuals aged 18-30 years were randomly assigned to receive either a neural slider or neural tensioner intervention. Spatiotemporal gait parameters were assessed using a validated smartphone-based gait analysis application, and spinal alignment angles were measured with a bubble inclinometer before and immediately after a single exercise session. The primary outcome was the acute change in gait-related parameters, and secondary outcomes included changes in spinal alignment and pelvic inclination angles.
Detailed description
This randomized, single-blinded experimental study was conducted between February and April 2024 to investigate the acute effects of lower extremity neural mobilization techniques on gait biomechanics and spinal alignment in sedentary individuals.
Sixty healthy sedentary participants (30 females, 30 males) aged 18-30 years were enrolled. Participants were randomly allocated to either a neural slider group or a neural tensioner group using a sealed-envelope randomization method. Allocation concealment was ensured by an independent researcher, and all outcome assessments were performed by a blinded physiotherapist.
Each participant underwent baseline (pre-test) assessments followed by a single session of neural mobilization exercise (3 minutes total, 3 sets of 30 repetitions). Post-intervention measurements were performed five minutes after completion of the exercise.
The primary outcome was the immediate change in spatiotemporal gait parameters, including gait speed, cadence, step length, step length asymmetry, base of support, single and double support times, and gait score. Gait was assessed using the OneStep smartphone application, which has demonstrated high validity compared to laboratory-based gait analysis systems.
Secondary outcomes included changes in spinal alignment and pelvic inclination angles, measured using a bubble inclinometer. Cervical lordosis, thoracic kyphosis, lumbar lordosis, total spinal mobility, and pelvic tilt angles were evaluated in a neutral standing position.
No adverse events were reported during or after the interventions.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- This study used a parallel-group randomized design. Participants were randomly assigned to either the neural slider group or the neural tensioner group using a sealed-envelope method. Each participant received a single session of the allocated neural mobilization technique. Outcome assessments were performed before and immediately after the intervention. The two groups were compared in terms of acute changes in gait parameters and spinal alignment.
| Arm | Type | Receives |
|---|---|---|
| Neural Slider Group | Experimental | Other: Lower Extremity Neural Slider ExerciseLower Extremity Neural Slider Exercise |
| Neural Tensioner Group | Experimental | Other: Lower Extremity Neural Tensioner ExerciseLower Extremity Neural Tensioner Exercise |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Age between 18 and 30 years
- Sedentary lifestyle (no regular structured exercise within the past 6 months)
- No history of lower extremity or spinal surgery
- No diagnosed neurological disorder
- No diagnosed musculoskeletal disorder
Key exclusion criteria (6 listed)
- History of hamstring injury
- Current low back, hip, or knee pain
- Known peripheral nerve injury or neurological condition
- Any condition limiting safe participation in neural mobilization exercises
- Inability to complete the intervention protocol
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Lower Extremity Neural Slider ExerciseA lower extremity neural slider technique applied in supine position. The movement sequence involved alternating cervical extension with simultaneous knee extension and ankle dorsiflexion, followed by cervical flexion combined with knee flexion and ankle plantarflexion. The intervention was performed for a total of 3 minutes, consisting of 3 sets of 30 repetitions (90 repetitions total). Each repetition included a 1-second hold at end range. The technique was administered by a physiotherapist under standardized conditions. | Other | Neural Slider Group |
| Lower Extremity Neural Tensioner ExerciseA lower extremity neural tensioner technique applied in supine position. The movement sequence involved simultaneous cervical flexion with knee extension and ankle dorsiflexion to increase neural tension, followed by return to neutral position with cervical extension and knee flexion. The intervention lasted 3 minutes and consisted of 3 sets of 30 repetitions (90 repetitions total), with a 1-second hold at end range. The technique was administered by a physiotherapist under standardized conditions. | Other | Neural Tensioner Group |
Primary outcome
Gait Speed
Time frame: baseline and 5 minutes after the intervention
Gait speed expressed in meters per second (m/s), calculated as total walking distance divided by time during a 1-minute walk on a straight, level surface. Measurements were obtained using the OneStep smartphone application, with the smartphone securely attached to the lateral aspect of the thigh to capture inertial motion data. Speed was derived from step detection and stride timing algorithms. The outcome represents the change from pre- to post-intervention.
Gait Cadence
Time frame: baseline and 5 minutes after the interventio
Cadence expressed in steps per minute (steps/min), calculated as the total number of detected steps divided by walking time. Step events were identified through thigh-mounted inertial sensor data captured by the OneStep application during a 1-minute walking trial. The outcome represents the change from pre- to post-intervention.
Step Length
Time frame: baseline and 5 minutes after the intervention
Step length expressed in centimeters (cm), defined as the linear distance between the initial contact of one foot and the subsequent initial contact of the contralateral foot. Step length was estimated using validated gait algorithms based on stride time and thigh kinematics recorded by the OneStep application. The outcome represents the change from baseline to post-intervention.
Stride Length
Time frame: baseline and 5 minute after interventions.
Stride length expressed in centimeters (cm), defined as the linear distance between two successive initial contacts of the same foot. Stride length was derived from inertial sensor data captured from the thigh during standardized walking. The outcome represents the change between pre- and post-intervention.
Step Length Asymmetry
Time frame: baseline and 5 minute later interventions
ep length asymmetry expressed as a percentage (%), calculated as the normalized difference between right and left step lengths during walking. Values were automatically derived from spatiotemporal gait data recorded by the thigh-mounted smartphone. The outcome represents the change from pre- to post-intervention.
Step Width
Time frame: baseline and 5 minutes later interventions
step width expressed in centimeters (cm), defined as the mediolateral distance between the center points of the heels during consecutive foot contacts. This parameter was estimated using validated spatial gait algorithms within the OneStep application. The outcome represents the change from baseline to post-intervention.
Single Support Time
Time frame: baseline and 5 minutes after interventions
Right single support time expressed as a percentage of the gait cycle (%), defined as the duration during which only the investigated limb is in contact with the ground. Gait cycle phases were automatically detected using thigh-based inertial motion data. The outcome represents the change from pre- to post-intervention.
Double Support Time
Time frame: baseline and 5 minutes after interventions
Double support time expressed as a percentage of the gait cycle (%), defined as the duration during which both feet are simultaneously in contact with the ground. This parameter was calculated using gait phase detection algorithms from inertial sensor data recorded during walking. The outcome represents the change between pre- and post-intervention assessments.
4 secondary outcomes
Pelvic Inclination Angle
Time frame: baseline and 5 minutes after interventions
Cervical Lordosis Angle
Time frame: baseline and 5 minutes later interventions
Thoracic Kyphosis Angle
Time frame: baseline and 5 minutes after interventions
Lumbar Lordosis Angle
Time frame: baseline and 5 minutes after interventions
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Lower Extremity Neural Slider Exercise and Lower Extremity Neural Tensioner Exercise in people with Healhty and Sedanter, run by Izmir Democracy University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gait Speed (time frame: baseline and 5 minutes after the intervention). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Nov 2026.