Medial Proximal Tibial AngleNCT07493733
MPTA on Full Standing and Rosenberg Views in Patients Undergoing High Tibial Osteotomy
An observational study of Medial Proximal Tibial Angle, run by Assiut University.
Trial summary
-Comparison of MPTA on both Full-leg Standing and Rosenberg Radiographs . Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Medial Proximal Tibial Angle
- What is being tested?
- X-ray
- Type of treatment
- Medical device
- How many people
- 49 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2026to 1 Oct 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: Outpatient clinics and inpatient ward of Orthopedics \& Trauma Surgery Department , Asyut University Hospitals , Faculty of Medicine
Who may be able to join
- All patients were screened for medial compartment OA of either the left or right knee joint.
- Availability of preoperative full-length standing radiograph and Rosenberg view.
- Completeness of patient records .
- Patient consent
Who cannot join
- Insufficient patient records .
- Previous ligamentous surgery or osteotomies .
- Known neuromuscular or metabolic disorder .
- Absence of a radiographic reference ball.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparing Medial Proximal Tibial Angle Measurements on Full-leg Standing Radiographs and The Rosenberg View in Patients Undergoing High Tibial Osteotomy
-Comparison of MPTA on both Full-leg Standing and Rosenberg Radiographs .
Read the detailed description
The medial open wedge high tibial osteotomy (MOW-HTO) is awidely and successfully performed treatment for medial compartment osteoarthritis (OA) of the knee joint .
The primary goal of MOW-HTO is to alleviate mechanical stress onthe medial compartment of the knee joint by shifting the weight-bearing line (WBL) toward the lateral compartment .
Correct alignment is essential for achieving long-term success and favorable outcomes, making accurate preoperative planning crucial.
Accepted gold standard for preoperative coronal plane assessment of lower limb alignment are full-leg standing radiographs (FLSR) .
Measurement variables in the coronal plane include the mechanical lateral proximal femoral angle (mLPFA), mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle and mechanical lateral distal tibial angle.
However, alignment measurements are influenced by factors such as knee flexion, rotation, and loading conditions .
Identifying these factors prior to surgery is crucial to minimizing the risk of surgical error.
Posteroanterior weight-bearing radiographs taken with the knee in 45 degrees of flexion, commonly referred to as the Rosenberg view (RB), are routinely used preoperatively . This imaging technique not only facilitates the assessment of the severity of knee OA but also aids in evaluating the degree of soft tissue laxity contributing to varus alignment-a factor increasingly recognized for its clinical significance .
For knowledge, one study has investigated how knee alignment parameters used for planning of HTO differ when measured using the RB .
The invistegator hypothesize that the medial proximal tibial angle (MPTA) does not differ when measured on RB radiographs compared with FLSR. Being a widely accessible and commonly used imaging technique, if confirmed, this finding would suggest that the RB could serve as a com-plementary modality for preoperative planning for MOW-HTO.
- Conditions
- Medial Proximal Tibial Angle
- Being tested
- X-ray
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
X-rayDevice
comparing of MPTA on full standing and rosenberg views
What is being measured
The primary outcome is the main question the study is designed to answer.
Difference in medial proximal tibial angle (MPTA) measurments in both the Rosenberg view and full-leg standing radiographic position
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Mar 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Aug 2028 (estimated)
- Study completion1 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (10)Papers the sponsor has linked to this study.
- Other trials for Medial Proximal Tibial AngleStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 49 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Gad Elkariem Farrag, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07493733
- Sponsor's protocol ID
- Comparison of MPTA in two view
- Status last verified
- Mar 2026
- First submitted
- 17 Mar 2026
- Last updated
- 25 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Ogata K, Yoshii I, Kawamura H, Miura H, Arizono T, Sugioka Y. Standing radiographs cannot determine the correction in high tibial osteotomy. J Bone Joint Surg Br. 1991 Nov;73(6):927-31. doi: 10.1302/0301-620X.73B6.1955438.
PubMed 1955438Deep K, Eachempati KK, Apsingi S. The dynamic nature of alignment and variations in normal knees. Bone Joint J. 2015 Apr;97-B(4):498-502. doi: 10.1302/0301-620X.97B4.33740.
PubMed 25820888Palmer J, Getgood A, Lobenhoffer P, Nakamura R, Monk P. Medial opening wedge high tibial osteotomy for the treatment of medial unicompartmental knee osteoarthritis: A state-of-the-art review. J ISAKOS. 2024 Feb;9(1):39-52. doi: 10.1016/j.jisako.2023.10.004. Epub 2023 Oct 13.
PubMed 37839705Dugdale TW, Noyes FR, Styer D. Preoperative planning for high tibial osteotomy. The effect of lateral tibiofemoral separation and tibiofemoral length. Clin Orthop Relat Res. 1992 Jan;(274):248-64.
PubMed 1729010Yasuda K, Majima T, Tsuchida T, Kaneda K. A ten- to 15-year follow-up observation of high tibial osteotomy in medial compartment osteoarthrosis. Clin Orthop Relat Res. 1992 Sep;(282):186-95.
PubMed 1516311Hernigou P, Medevielle D, Debeyre J, Goutallier D. Proximal tibial osteotomy for osteoarthritis with varus deformity. A ten to thirteen-year follow-up study. J Bone Joint Surg Am. 1987 Mar;69(3):332-54.
PubMed 3818700Coventry MB, Ilstrup DM, Wallrichs SL. Proximal tibial osteotomy. A critical long-term study of eighty-seven cases. J Bone Joint Surg Am. 1993 Feb;75(2):196-201. doi: 10.2106/00004623-199302000-00006.
PubMed 8423180COVENTRY MB. OSTEOTOMY OF THE UPPER PORTION OF THE TIBIA FOR DEGENERATIVE ARTHRITIS OF THE KNEE. A PRELIMINARY REPORT. J Bone Joint Surg Am. 1965 Jul;47:984-90. No abstract available.
PubMed 14318636Ayet CAB, Mancino F, Lim YP, Qian K, Jacob G, Parker DA. Satisfactory 10-year survivorship of medial opening wedge high tibial osteotomy for isolated medial compartment osteoarthritis and varus alignment: An analysis from a high-volume institution. Knee Surg Sports Traumatol Arthrosc. 2025 May;33(5):1804-1814. doi: 10.1002/ksa.12633. Epub 2025 Feb 20.
PubMed 39976154Gkekas NK, Komnos GA, Mylonas T, Chalatsis G, Koutalos AA, Hantes ME. Medial open wedge high tibial osteotomy is a viable option in young patients with advanced arthritis in a long-term follow-up. Knee Surg Sports Traumatol Arthrosc. 2025 Mar;33(3):1025-1032. doi: 10.1002/ksa.12469. Epub 2024 Sep 18.
PubMed 39290201
Study at a glance
From the registry record, last updated by the sponsor on 25 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing Medial Proximal Tibial Angle Measurements on Full-leg Standing Radiographs and The Rosenberg View in Patients Undergoing High Tibial Osteotomy
- ClinicalTrials.gov ID
- NCT07493733
- Acronym / sponsor ID
- Comparison of MPTA in two view
- Conditions
- Medial Proximal Tibial Angle
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 49 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Aug 2028 (estimated)
- Study completion
- 1 Oct 2028 (estimated)
- First posted
- 25 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
-Comparison of MPTA on both Full-leg Standing and Rosenberg Radiographs .
Detailed description
The medial open wedge high tibial osteotomy (MOW-HTO) is awidely and successfully performed treatment for medial compartment osteoarthritis (OA) of the knee joint .
The primary goal of MOW-HTO is to alleviate mechanical stress onthe medial compartment of the knee joint by shifting the weight-bearing line (WBL) toward the lateral compartment .
Correct alignment is essential for achieving long-term success and favorable outcomes, making accurate preoperative planning crucial.
Accepted gold standard for preoperative coronal plane assessment of lower limb alignment are full-leg standing radiographs (FLSR) .
Measurement variables in the coronal plane include the mechanical lateral proximal femoral angle (mLPFA), mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle and mechanical lateral distal tibial angle.
However, alignment measurements are influenced by factors such as knee flexion, rotation, and loading conditions .
Identifying these factors prior to surgery is crucial to minimizing the risk of surgical error.
Posteroanterior weight-bearing radiographs taken with the knee in 45 degrees of flexion, commonly referred to as the Rosenberg view (RB), are routinely used preoperatively . This imaging technique not only facilitates the assessment of the severity of knee OA but also aids in evaluating the degree of soft tissue laxity contributing to varus alignment-a factor increasingly recognized for its clinical significance .
For knowledge, one study has investigated how knee alignment parameters used for planning of HTO differ when measured using the RB .
The invistegator hypothesize that the medial proximal tibial angle (MPTA) does not differ when measured on RB radiographs compared with FLSR. Being a widely accessible and commonly used imaging technique, if confirmed, this finding would suggest that the RB could serve as a com-plementary modality for preoperative planning for MOW-HTO.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- Outpatient clinics and inpatient ward of Orthopedics \& Trauma Surgery Department , Asyut University Hospitals , Faculty of Medicine
Key inclusion criteria (4 listed)
- All patients were screened for medial compartment OA of either the left or right knee joint.
- Availability of preoperative full-length standing radiograph and Rosenberg view.
- Completeness of patient records .
- Patient consent
Key exclusion criteria (4 listed)
- Insufficient patient records .
- Previous ligamentous surgery or osteotomies .
- Known neuromuscular or metabolic disorder .
- Absence of a radiographic reference ball.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| X-raycomparing of MPTA on full standing and rosenberg views | Device | – |
Primary outcome
Difference in medial proximal tibial angle (MPTA) measurments in both the Rosenberg view and full-leg standing radiographic position
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Mar 2026.
- Background: PubMed 1955438Ogata K, Yoshii I, Kawamura H, Miura H, Arizono T, Sugioka Y. Standing radiographs cannot determine the correction in high tibial osteotomy. J Bone Joint Surg Br. 1991 Nov;73(6):927-31. doi: 10.1302/0301-620X.73B6.1955438.
- Background: PubMed 25820888Deep K, Eachempati KK, Apsingi S. The dynamic nature of alignment and variations in normal knees. Bone Joint J. 2015 Apr;97-B(4):498-502. doi: 10.1302/0301-620X.97B4.33740.
- Background: PubMed 37839705Palmer J, Getgood A, Lobenhoffer P, Nakamura R, Monk P. Medial opening wedge high tibial osteotomy for the treatment of medial unicompartmental knee osteoarthritis: A state-of-the-art review. J ISAKOS. 2024 Feb;9(1):39-52. doi: 10.1016/j.jisako.2023.10.004. Epub 2023 Oct 13.
- Background: PubMed 1729010Dugdale TW, Noyes FR, Styer D. Preoperative planning for high tibial osteotomy. The effect of lateral tibiofemoral separation and tibiofemoral length. Clin Orthop Relat Res. 1992 Jan;(274):248-64.
- Background: PubMed 1516311Yasuda K, Majima T, Tsuchida T, Kaneda K. A ten- to 15-year follow-up observation of high tibial osteotomy in medial compartment osteoarthrosis. Clin Orthop Relat Res. 1992 Sep;(282):186-95.
- Background: PubMed 3818700Hernigou P, Medevielle D, Debeyre J, Goutallier D. Proximal tibial osteotomy for osteoarthritis with varus deformity. A ten to thirteen-year follow-up study. J Bone Joint Surg Am. 1987 Mar;69(3):332-54.
- Background: PubMed 8423180Coventry MB, Ilstrup DM, Wallrichs SL. Proximal tibial osteotomy. A critical long-term study of eighty-seven cases. J Bone Joint Surg Am. 1993 Feb;75(2):196-201. doi: 10.2106/00004623-199302000-00006.
- Background: PubMed 14318636COVENTRY MB. OSTEOTOMY OF THE UPPER PORTION OF THE TIBIA FOR DEGENERATIVE ARTHRITIS OF THE KNEE. A PRELIMINARY REPORT. J Bone Joint Surg Am. 1965 Jul;47:984-90. No abstract available.
- Background: PubMed 39976154Ayet CAB, Mancino F, Lim YP, Qian K, Jacob G, Parker DA. Satisfactory 10-year survivorship of medial opening wedge high tibial osteotomy for isolated medial compartment osteoarthritis and varus alignment: An analysis from a high-volume institution. Knee Surg Sports Traumatol Arthrosc. 2025 May;33(5):1804-1814. doi: 10.1002/ksa.12633. Epub 2025 Feb 20.
- Background: PubMed 39290201Gkekas NK, Komnos GA, Mylonas T, Chalatsis G, Koutalos AA, Hantes ME. Medial open wedge high tibial osteotomy is a viable option in young patients with advanced arthritis in a long-term follow-up. Knee Surg Sports Traumatol Arthrosc. 2025 Mar;33(3):1025-1032. doi: 10.1002/ksa.12469. Epub 2024 Sep 18.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Medial Proximal Tibial Angle, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 25 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Gadelkarem Farrag, Resident Doctor (+20 01009372187, agad6126@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Difference in medial proximal tibial angle (MPTA) measurments in both the Rosenberg view and full-leg standing radiographic position (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07493733, which also lists 10 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Mar 2026.