Frailty at Older AdultsTMS MRI TBSNCT07497334
A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
A study testing Theta burst stimulation and Aerobic exercise in people with Frailty at Older Adults and Mild Cognitive Impairment, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
Trial summary
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Read more about this study
- Who is it for?
- Ages 60 to 90 years
- Conditions the study is for
- Frailty at Older Adults, Mild Cognitive Impairment
- What is being tested?
- Theta burst stimulation and Aerobic exercise
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 45 participants
- Where
- 1 siteHong Kong
- Study dates
- 5 Jan 2025to 30 Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- be between 60 and 90 years old;
- scored < 9/12 on the Short Physical Performance Battery;
- scored >18/30 on the Montreal Cognitive Assessment;
- scored >9/42 on the Pictorial Fit-Frail Scale;
- lived in the community;
- be able to ambulate up to four meters with or without assistive devices;
- be able to provide written informed consent on their own behalf;
- can understand verbal and written Cantonese and/or English.
Who cannot join
- have magnetic resonance imaging contraindications;
- have aerobic exercise contraindications;
- have transcranial magnetic stimulation contraindications;
- be diagnosed with neurodegenerative conditions (i.e., dementia, Parkinson's, Alzheimer's disease, Amyotrophic lateral sclerosis, and stroke);
- live in a nursing home or other care facilities/institutions;
- bed taking fixed dose of medication or had been taking medications known to potentially affect cognitive and physical function (e.g., psychotropic medications), as identified through a review of their medication lists recorded in the health software. Medications were categorized by properties (e.g., antipsychotics, antidepressants, etc.) to inform eligibility decisions.
- have a history indicative of carotid sinus sensitivity (i.e., falls due to loss of consciousness);
- cancer and undergo radiation therapy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hong Kong1 site, 1 recruiting
- Recruiting
The Hong Kong Polytechnic University, Department of Rehabilitation Sciences
Hong Kong
Chun Liang HSU, PhD, 852-27666755, chun-liang.hsu@polyu.edu.hk
About this study
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are:
- Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation?
- What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
Read the detailed description
Objectives: To compare the effects of intermittent theta burst stimulation (iTBS) primed with continuous theta burst stimulation (cTBS), nonpriming iTBS, and sham stimulation on top of aerobic exercise in terms of improving cognitive function, mobility, brain structure, and brain function in older adults with cognitive frailty.
Hypothesis to be tested: We hypothesize that iTBS primed with cTBS can maximize the induction of therapeutically beneficial metaplasticity, and that this will be reflected in improved brain structure and brain function, thereby enabling superior cognitive function and mobility improvement in older adults with cognitive frailty.
Design and subjects: A randomized controlled trial involving 60 older adults with cognitive frailty.
Study instruments: Transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI).
Interventions: Participants will be randomly allocated to receive a 39-session intervention with different TBS protocols (i.e., cTBS+iTBS, sham cTBS+iTBS, and sham cTBS+sham iTBS), delivered 3 times per week for 3 months. All participants will receive 60 minutes of aerobic exercise after each stimulation session for 6 months.
Main outcome measures: comprehensive neuropsychological battery covering major executive function (i.e., selective attention/response inhibition, psychomotor speed, set shifting), working memory, and verbal fluency; (2) mobility function evaluated via SPPB, Timed-Up-and-GO (TUG) test, functional gait analysis (i.e., gait speed, gait variability).
Secondary outcomes: underlying neural mechanisms of intervention-induced benefits will be assessed via functional and structural magnetic resonance imaging.
Data analysis: Analysis of variance (ANOVA)
- Conditions
- Frailty at Older Adults, Mild Cognitive Impairment
- Being tested
- Theta burst stimulation, Aerobic exercise
- Keywords
- cognitive frailty, cTBS, iTBS, aerobic exercise, fMRI
- Medical subject headings
- Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Theta burst stimulationDevice
Theta burst stimulation (TBS) will be administered using a figure-of-eight shaped cooling coil (Cool-B65 A/P), which generates auditory "clicks" for sham stimulation that are similar to those produced by active repetitive transcranial magnetic stimulation (rTMS). The placement of the coil will be guided by a navigation system (LOCALITE® TMS Navigator, Germany) using each participant's baseline T1-weighted Magnetic Resonance Imaging (MRI) scans.
TBS is a powerful form of rTMS. Standard 600-pulse intermittent theta burst stimulation (iTBS) can enhance corticomotor excitability, whereas standard 600-pulse continuous theta burst stimulation (cTBS) can suppress it.
Aerobic exerciseBehavioural
The aerobic exercise sessions will include a 10-minute warm-up, followed by 40 minutes of brisk walking and/or stationary exercises without weights, and will conclude with a 10-minute cooldown. The intensity of the aerobic exercise will be monitored using heart rate, starting at 40% of the age-specific heart rate reserve (HRR), which is calculated using the formula: 207 - (0.7 x age). Over the initial 12 weeks, the intensity will be gradually increased until the HRR reaches 65%, and this level will be maintained until the end of the trial.
| Study group | Role | What they receive |
|---|---|---|
| cTBS+iTBS, in addition to aerobic exercise | Experimental | Participants will receive 600-pulse continuous theta burst stimulation (cTBS) at the intensity of 80% resting motor threshold (RMT) as the priming, followed by 600-pulse intermittent theta burst stimulation (iTBS) at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months Receives: Device: Theta burst stimulation; Behavioral: Aerobic exercise |
| Sham cTBS + iTBS, in addition to aerobic exercise | Active comparator | Participants will receive sham 600-pulse cTBS at the intensity of 80% RMT as the priming, followed by 600-pulse iTBS at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months Receives: Device: Theta burst stimulation; Behavioral: Aerobic exercise |
| Sham cTBS + sham iTBS, in addition to aerobic exercise | Sham comparator | Participants will receive sham 600-pulse cTBS at the intensity of 80% RMT as the priming, followed by sham 600-pulse iTBS at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months Receives: Device: Theta burst stimulation; Behavioral: Aerobic exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Montreal Cognitive Assessment
General cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA). The total MoCA score ranges from 0 to 30, with higher scores indicating better cognitive performance
Measured: Baseline, 3 months, and 6 months
Short Physical Performance Battery
Mobility will be assessed using the Short Physical Performance Battery (SPPB). The SPPB evaluates balance, gait speed, and chair stand performance, with total scores ranging from 0 to 12. Higher scores indicate better mobility
Measured: Baseline, 3 months, and 6 months
Pictorial Fit-Frail Scale
Frailty in older adults will be assessed using the Pictorial Fit-Frail Scale (PFFS). The PFFS evaluates 14 health domains, with total scores ranging from 0 to 43. Higher scores indicate a greater severity of frailty.
Measured: Baseline, 3 months, and 6 months
Secondary outcomes (15)
Six Minutes Walking Test
The Six-Minute Walk Test (6MWT) is a practical, self-paced clinical test that measures the total distance an individual can walk on a flat, hard surface in six minutes. A longer distance walked reflects a higher level of functional mobility.
Measured: Baseline, 3 months, and 6 months
Timed-Up-and-Go Test
The Timed Up and Go (TUG) test is a standardized assessment used to evaluate mobility and gait. A longer completion time reflects poorer physical mobility.
Measured: Baseline, 3 months, and 6 months
Task Switch Test
The Task Switching Test is a standardized assessment used to evaluate executive function. A higher accuracy rate and a shorter reaction time reflect superior executive performance
Measured: Baseline, 3 months, and 6 months
Digit Span Test
The Digit Span Test is a standardized neuropsychological assessment used to evaluate attention and working memory. The test comprises two components: Digits Forward and Digits Backward. A higher cumulative score reflects better overall performance. Additionally, a smaller discrepancy score (calculated as the forward span minus the backward span) represents superior cognitive manipulation and updating ability.
Measured: Baseline, 3 months, and 6 months
Digit Symbol Substitution Test
The Digit Symbol Substitution Test (DSST) is a standardized neuropsychological instrument used to evaluate cognitive processing speed and executive function. The total score is determined by the number of correctly completed items within a specified time limit, with higher scores reflecting superior cognitive performance.
Measured: Baseline, 3 months, and 6 months
Stroop Test
The Stroop Test is a standardized neuropsychological assessment used to evaluate executive function, particularly inhibitory control. The completion time for each condition is recorded as the score, with shorter completion times reflecting superior executive performance.
Measured: Baseline, 3 months, and 6 months
Trail Making Test
The Trail Making Test will comprise Part A and Part B. In Part A, participants are instructed to connect numbers in sequential order (e.g., drawing a line from 1 to 2, 2 to 3, 3 to 4, etc.) while being timed. In Part B, participants are instructed to connect, in order, 25 encircled numbers and letters alternately (e.g., 1-A-2-B-3-C) while being timed. A longer time represents worse executive function.
Measured: Baseline, 3 months, and 6 months
30-second sit to stand
Functional mobility and lower-limb functional strength will be measured via the 30-Second Chair Stand Test (30CST). Participants stand up and sit down as rapidly and safely as possible for 30 seconds, where a higher repetition score indicates greater functional mobility.
Measured: Baseline, 3 months, and 6 months
cortical and subcortical volume
Cortical and subcortical volume will be examined in all participants using MRI. Participants will undergo structural MRI on the 3T Siemens scanner at the University Research Facility in Behavioral and Systems Neuroscience. Participants will complete T1 and T2 high resolution anatomical scans.
Measured: Baseline, 3 months, and 6 months
Resting State-Functional Connectivity-Functional MRI
Participants will be instructed to rest with eyes open for approximately 12 minutes. This will allow the investigators to examine activation in the resting state network.
Measured: Baseline, 3 months, and 6 months
Physical Activity Scale for the Elderly
Physical activity will be assessed by Physical Activity Scale for the Elderly (PASE), where a higher score indicates a higher level of physical activity.
Measured: Baseline, 3 months, and 6 months
Geriatric Depression Scale
Depression will be measured by Geriatric Depression Scale (GDS), where a higher score indicates a higher level of depressive symptoms
Measured: Baseline, 3 months, and 6 months
Fatigue Severity Scale
Physical fatigue will be measured by Fatigue Severity Scale (FSS), where a higher score indicates more severe fatigue
Measured: Baseline, 3 months, and 6 months
Functional Comorbidity Index
Total number of comorbid conditions will be assessed through the Functional Comorbidity Index (FCI), where a higher score indicates a greater comorbidity burden.
Measured: Baseline, 3 months, and 6 months
Functional Activities Questionnaire
The difficulties in activities of daily living will be assessed using the Functional Activities Questionnaire (FAQ), with higher scores reflecting severe difficulty in performing daily tasks.
Measured: Baseline, 3 months, and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2026
- Study start5 Jan 2025
- Primary completion30 Jun 2027 (estimated)
- Study completion30 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Frailty at Older AdultsStudies of the same condition, open and under way.
- More trials run by The Hong Kong Polytechnic UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 45 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Hong Kong Polytechnic University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, HSU Chun Liang, The Hong Kong Polytechnic University
- Investigators
- Chun Liang HSU, PhD, Principal investigator, The Hong Kong Polytechnic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07497334
- Sponsor's protocol ID
- HSEARS20240614001
- Other IDs
- P0048639
- Acronym
- TMS MRI TBS
- Status last verified
- Sep 2026
- First submitted
- 23 Mar 2026
- Last updated
- 30 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults
- ClinicalTrials.gov ID
- NCT07497334
- Acronym / sponsor ID
- TMS MRI TBS / HSEARS20240614001
- Conditions
- Frailty at Older Adults, Mild Cognitive Impairment
- Keywords
- cognitive frailty, cTBS, iTBS, aerobic exercise, fMRI
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 45 participants (estimated)
- Lead sponsor
- The Hong Kong Polytechnic UniversityUniversity, hospital or other
- Study start
- 5 Jan 2025 (actual)
- Primary completion
- 30 Jun 2027 (estimated)
- Study completion
- 30 Jun 2027 (estimated)
- First posted
- 27 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are:
- Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation?
- What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
Detailed description
Objectives: To compare the effects of intermittent theta burst stimulation (iTBS) primed with continuous theta burst stimulation (cTBS), nonpriming iTBS, and sham stimulation on top of aerobic exercise in terms of improving cognitive function, mobility, brain structure, and brain function in older adults with cognitive frailty.
Hypothesis to be tested: We hypothesize that iTBS primed with cTBS can maximize the induction of therapeutically beneficial metaplasticity, and that this will be reflected in improved brain structure and brain function, thereby enabling superior cognitive function and mobility improvement in older adults with cognitive frailty.
Design and subjects: A randomized controlled trial involving 60 older adults with cognitive frailty.
Study instruments: Transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI).
Interventions: Participants will be randomly allocated to receive a 39-session intervention with different TBS protocols (i.e., cTBS+iTBS, sham cTBS+iTBS, and sham cTBS+sham iTBS), delivered 3 times per week for 3 months. All participants will receive 60 minutes of aerobic exercise after each stimulation session for 6 months.
Main outcome measures: comprehensive neuropsychological battery covering major executive function (i.e., selective attention/response inhibition, psychomotor speed, set shifting), working memory, and verbal fluency; (2) mobility function evaluated via SPPB, Timed-Up-and-GO (TUG) test, functional gait analysis (i.e., gait speed, gait variability).
Secondary outcomes: underlying neural mechanisms of intervention-induced benefits will be assessed via functional and structural magnetic resonance imaging.
Data analysis: Analysis of variance (ANOVA)
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| cTBS+iTBS, in addition to aerobic exercise | Experimental | Device: Theta burst stimulation, Behavioral: Aerobic exerciseParticipants will receive 600-pulse continuous theta burst stimulation (cTBS) at the intensity of 80% resting motor threshold (RMT) as the priming, followed by 600-pulse intermittent theta burst stimulation (iTBS) at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months |
| Sham cTBS + iTBS, in addition to aerobic exercise | Active comparator | Device: Theta burst stimulation, Behavioral: Aerobic exerciseParticipants will receive sham 600-pulse cTBS at the intensity of 80% RMT as the priming, followed by 600-pulse iTBS at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months |
| Sham cTBS + sham iTBS, in addition to aerobic exercise | Sham comparator | Device: Theta burst stimulation, Behavioral: Aerobic exerciseParticipants will receive sham 600-pulse cTBS at the intensity of 80% RMT as the priming, followed by sham 600-pulse iTBS at the intensity of 80% RMT (i.e., priming iTBS). The stimulation will be delivered 3 sessions per week, lasting for 3 months. Participants will receive a 60-minute aerobic exercise after each stimulation session, lasting for 6 months |
Who may qualify
- Ages
- 60 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- be between 60 and 90 years old;
- scored < 9/12 on the Short Physical Performance Battery;
- scored >18/30 on the Montreal Cognitive Assessment;
- scored >9/42 on the Pictorial Fit-Frail Scale;
- lived in the community;
Key exclusion criteria (8 listed)
- have magnetic resonance imaging contraindications;
- have aerobic exercise contraindications;
- have transcranial magnetic stimulation contraindications;
- be diagnosed with neurodegenerative conditions (i.e., dementia, Parkinson's, Alzheimer's disease, Amyotrophic lateral sclerosis, and stroke);
- live in a nursing home or other care facilities/institutions;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Theta burst stimulationTheta burst stimulation (TBS) will be administered using a figure-of-eight shaped cooling coil (Cool-B65 A/P), which generates auditory "clicks" for sham stimulation that are similar to those produced by active repetitive transcranial magnetic stimulation (rTMS). The placement of the coil will be guided by a navigation system (LOCALITE® TMS Navigator, Germany) using each participant's baseline T1-weighted Magnetic Resonance Imaging (MRI) scans. TBS is a powerful form of rTMS. Standard 600-pulse intermittent theta burst stimulation (iTBS) can enhance corticomotor excitability, whereas standard 600-pulse continuous theta burst stimulation (cTBS) can suppress it. | Device | Sham cTBS + iTBS, in addition to aerobic exercise, Sham cTBS + sham iTBS, in addition to aerobic exercise, cTBS+iTBS, in addition to aerobic exercise |
| Aerobic exerciseThe aerobic exercise sessions will include a 10-minute warm-up, followed by 40 minutes of brisk walking and/or stationary exercises without weights, and will conclude with a 10-minute cooldown. The intensity of the aerobic exercise will be monitored using heart rate, starting at 40% of the age-specific heart rate reserve (HRR), which is calculated using the formula: 207 - (0.7 x age). Over the initial 12 weeks, the intensity will be gradually increased until the HRR reaches 65%, and this level will be maintained until the end of the trial. | Behavioural | Sham cTBS + iTBS, in addition to aerobic exercise, Sham cTBS + sham iTBS, in addition to aerobic exercise, cTBS+iTBS, in addition to aerobic exercise |
Primary outcome
Montreal Cognitive Assessment
Time frame: Baseline, 3 months, and 6 months
General cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA). The total MoCA score ranges from 0 to 30, with higher scores indicating better cognitive performance
Short Physical Performance Battery
Time frame: Baseline, 3 months, and 6 months
Mobility will be assessed using the Short Physical Performance Battery (SPPB). The SPPB evaluates balance, gait speed, and chair stand performance, with total scores ranging from 0 to 12. Higher scores indicate better mobility
Pictorial Fit-Frail Scale
Time frame: Baseline, 3 months, and 6 months
Frailty in older adults will be assessed using the Pictorial Fit-Frail Scale (PFFS). The PFFS evaluates 14 health domains, with total scores ranging from 0 to 43. Higher scores indicate a greater severity of frailty.
15 secondary outcomes
Six Minutes Walking Test
Time frame: Baseline, 3 months, and 6 months
Timed-Up-and-Go Test
Time frame: Baseline, 3 months, and 6 months
Task Switch Test
Time frame: Baseline, 3 months, and 6 months
Digit Span Test
Time frame: Baseline, 3 months, and 6 months
Digit Symbol Substitution Test
Time frame: Baseline, 3 months, and 6 months
Stroop Test
Time frame: Baseline, 3 months, and 6 months
Trail Making Test
Time frame: Baseline, 3 months, and 6 months
30-second sit to stand
Time frame: Baseline, 3 months, and 6 months
cortical and subcortical volume
Time frame: Baseline, 3 months, and 6 months
Resting State-Functional Connectivity-Functional MRI
Time frame: Baseline, 3 months, and 6 months
Physical Activity Scale for the Elderly
Time frame: Baseline, 3 months, and 6 months
Geriatric Depression Scale
Time frame: Baseline, 3 months, and 6 months
Fatigue Severity Scale
Time frame: Baseline, 3 months, and 6 months
Functional Comorbidity Index
Time frame: Baseline, 3 months, and 6 months
Functional Activities Questionnaire
Time frame: Baseline, 3 months, and 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Chun Liang HSU, PhD principal investigator
The Hong Kong Polytechnic University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Theta burst stimulation and Aerobic exercise in people with Frailty at Older Adults and Mild Cognitive Impairment, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact JINGYI WU, MSc (+85260730847, 24144838r@connect.polyu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Montreal Cognitive Assessment (time frame: Baseline, 3 months, and 6 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.