Healthy Adult ParticipantsCAP-TINCT07498270
Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
A study testing Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES) and Anterior thalamic stimulation (TI-TES) in people with Healthy Adult Participants and Healthy Participants, run by University of Wisconsin, Madison at 1 site in United States.
Trial summary
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep spindles (brain rhythms in the ~8-16 Hz range). Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Adult Participants, Healthy Participants
- What is being tested?
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES) and Anterior thalamic stimulation (TI-TES)
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 24 participants
- Where
- 1 siteUnited States
- Study dates
- 5 Jun 2026to Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Medically healthy (based on self-report and study team review)
- U.S. citizen or holding permanent resident status
- English-speaking (able to provide consent and complete questionnaires)
Who cannot join
- Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)
- History of inpatient psychiatric hospitalization
- History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions
- Current history of poorly controlled headaches including intractable or poorly controlled migraines
- Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
- History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
Show all 18Show fewer
- Possible pregnancy or plan to become pregnant in the next 6 months (self reported)
- Any metal in the head
- Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)
- Dental implants
- Permanent retainers
- Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions
- Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions
- Any medication that may alter seizure threshold taken during the study i.e., ADHD stimulants (Adderall, amphetamine); Tricyclic/atypical antidepressants (amitriptyline, doxepine, imipramine, maprotiline, nortriptyline, bupropion); SSRIs (Escitalopram, Fluoxetine, Sertraline); Antipsychotics (chlorpromazine, clozapine), Bronchodilators (theophylline, aminophylline); Antibiotics (fluoroquinolones, imipenem, penicillin, cephalosporins, metronidazole, isoniazid); Antivirals (valacyclovir, ritonavir); OTC antihistamines (diphenhydramine, Benadryl)
- Claustrophobia (a fear of small or closed places)
- Back problems that would prevent lying flat for up to two hours
- Regular night-shift work (second or third shift)
- Sleep apnea or other sleep disorder (self-reported)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Wisconsin Institute for Sleep and Consciousness
Madison, Wisconsin, 53719
About this study
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep spindles (brain rhythms in the ~8-16 Hz range). Up to 24 healthy participants in Dane County, Wisconsin will be enrolled for 3 overnight study visits. Participants can expect to be on study for approximately 5 weeks, depending on scheduling availability.
Read the detailed description
This single-site, single-blind, experimental study will test whether thalamic temporal interference transcranial electrical stimulation (TI-TES) delivered during Non-Rapid Eye Movement (NREM) sleep can enhance spindle-frequency activity (SFA) in healthy adults and identify optimal stimulation parameters across frequency and thalamic target location.
After screening/consent, participants will complete a structural MRI for personalized montage optimization, then undergo three overnight High-Density Electroencephalography (hdEEG) and Polysomnography (PSG) sleep sessions (10-12 hours each) in a randomized, counterbalanced crossover design, one session per stimulation location (broad thalamic, anterior thalamic, posterior thalamic). During stable N2 sleep, TI-TES will be delivered in 3-minute epochs separated by 6-minute intervals, for up to 24 epochs per night, under real-time sleep-technician monitoring. The study uses a two-phase frequency plan: Phase 1 (~10 participants) will test 10 Hz, 14 Hz, and matched carrier-only SHAM; contingent on feasibility/sensitivity, Phase 2 (~10 participants) will expand frequencies across 8-16 Hz. Primary outcomes quantify stimulation-related increases in 8-16 Hz spectral power (SFA) and spindle characteristics comparing active TI-TES versus SHAM and across stimulation locations/frequencies.
Primary Objectives:
- Determine whether active thalamic TI-TES increases 8-16 Hz spindle-frequency activity (SFA) relative to carrier-only SHAM (evaluated using STIM-PRE and POST-PRE contrasts).
- Identify the most effective TI-TES stimulation parameters across stimulation frequencies and stimulation locations (broad thalamic, anterior, posterior) by comparing SFA changes across parameter combinations.
- Characterize stimulation-related changes in spindle characteristics (density, amplitude, duration, topography) for slow and fast spindle subtypes. Secondary Objectives:
- Evaluate stimulation-related changes in slow (8-12 Hz) and fast (13-16 Hz) spindle spectral power.
- Evaluate stimulation-related changes in slow wave (0.5-4.0 Hz) spectral power.
- Characterize stimulation-related changes in slow-wave characteristics (density, amplitude, duration).
- Evaluate stimulation-related changes in SO-spindle coupling (phase-amplitude coupling) for slow and fast spindles.
- (Exploratory) Evaluate stimulation-related changes in hdEEG functional connectivity between channels using the phase slope index (PSI).
- Conditions
- Healthy Adult Participants, Healthy Participants
- Being tested
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES), Carrier only SHAM stimulation, Anterior thalamic stimulation (TI-TES), Posterior thalamic stimulation (TI-TES)
- Keywords
- sleep, spindles, non-rapid eye movement, SSD, neurobiology, impairment, brain stimulation, non-invasive stimulation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Magnetic Resonance Imaging (MRI)Other
Also called structural MRI
MRI is to optimize placement of uni- or multipolar TI-TES
Broad thalamic stimulation (TI-TES)Device
Stimulation targeted at the whole thalamus.
Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Carrier only SHAM stimulationDevice
Carrier only SHAM condition.
Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Anterior thalamic stimulation (TI-TES)Device
Stimulation targeted at the anterior thalamus.
Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals
Posterior thalamic stimulation (TI-TES)Device
Stimulation targeted at the posterior thalamus.
Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals.
| Study group | Role | What they receive |
|---|---|---|
| All Participants | Experimental | Participants will complete three overnight stimulation sessions with simultaneous 256-channel hdEEG and PSG, in a randomized, counterbalanced crossover design, with each overnight session using a distinct personalized montage targeting one of three thalamic locations (broad thalamic, anterior thalamic, posterior thalamic), and sessions spaced at least three days apart. Receives: Other: Magnetic Resonance Imaging (MRI); Device: Broad thalamic stimulation (TI-TES); Device: Carrier only SHAM stimulation; Device: Anterior thalamic stimulation (TI-TES); Device: Posterior thalamic stimulation (TI-TES) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Spectral Power (SFA) for Active TI-TES vs SHAM
Comparing active TI-TES vs carrier only SHAM, evaluated using both STIM-PRE and POST-PRE contrasts.
Measured: during each of the 3 overnight visits, 5 weeks
Change in SFA by Location
Changes in 8-16 Hz spectral power across frequency-location combinations (broad thalamic, anterior thalamic, posterior thalamic) for STIM-PRE and POST-PRE to identify the most effective parameters within the tested parameter space.
Measured: during each of the 3 overnight visits, 5 weeks
Spindle Density in slow (8-12 Hz) and fast (13-16 Hz) SFA
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (density) using STIM-PRE and POST-PRE contrasts
Measured: during each of the 3 overnight visits, 5 weeks
Spindle Amplitude in slow (8-12 Hz) and fast (13-16 Hz) SFA
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (amplitude) using STIM-PRE and POST-PRE contrasts
Measured: during each of the 3 overnight visits, 5 weeks
Spindle Duration in slow (8-12 Hz) and fast (13-16 Hz) SFA
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (duration) using STIM-PRE and POST-PRE contrasts
Measured: during each of the 3 overnight visits, 5 weeks
Spindle Topography in slow (8-12 Hz) and fast (13-16 Hz) SFA
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (topography) using STIM-PRE and POST-PRE contrasts
Measured: during each of the 3 overnight visits, 5 weeks
Secondary outcomes (6)
Change in Spectral Power (SFA) for SHAM during slow vs fast conditions
Changes in slow (8-12 Hz) and fast (13-16 Hz) spectral power relative to SHAM
Measured: during each of the 3 overnight visits, 5 weeks
Changes in slow-wave spectral power (0.5-4.0 Hz) relative to SHAM
Changes in slow-wave spectral power (0.5-4.0 Hz) relative to SHAM
Measured: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Density
Changes in slow-wave characteristics (density) in STIM-PRE and POST-PRE contrasts.
Measured: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Amplitude
Changes in slow-wave characteristics (amplitude) in STIM-PRE and POST-PRE contrasts.
Measured: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Duration
Changes in slow-wave characteristics (duration) in STIM-PRE and POST-PRE contrasts.
Measured: during each of the 3 overnight visits, 5 weeks
Changes in Spindle and Slow Oscillation Coupling
Changes in SO-Spindle coupling, quantified via phase-amplitude coupling metrics
Measured: during each of the 3 overnight visits, 5 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Mar 2026
- Study start5 Jun 2026
- Primary completionAug 2027 (estimated)
- Study completionFeb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy Adult ParticipantsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants will complete three overnight stimulation sessions with simultaneous 256-channel hdEEG and PSG, in a randomized, counterbalanced crossover design, with each overnight session using a distinct personalized montage targeting one of three thalamic locations (broad thalamic, anterior thalamic, posterior thalamic), and sessions spaced at least three days apart. Phase 1 will include approximately 10 participants and will test 10 Hz, 14 Hz, and matched carrier-only SHAM across all locations. Contingent on Phase 1 data, Phase 2 will include approximately 10 participants and will expand frequencies across 8-16 Hz or retain only 10 Hz and 14 Hz (plus SHAM) if effect sizes are smaller than anticipated.
- Masking
- None (open label)
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Wisconsin, Madison
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute of Mental Health (NIMH)
- Responsible party
- Sponsor
- Investigators
- Larissa Albantakis, PhD, Principal investigator, University of Wisconsin, Madison
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07498270
- Sponsor's protocol ID
- 2026-0034
- Other IDs
- R21MH141540, SMPH | Psychiatry, Protocol Version 6/1/26
- Acronym
- CAP-TI
- Status last verified
- Jun 2026
- First submitted
- 23 Mar 2026
- Last updated
- 10 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 10 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
- ClinicalTrials.gov ID
- NCT07498270
- Acronym / sponsor ID
- CAP-TI / 2026-0034
- Conditions
- Healthy Adult Participants, Healthy Participants
- Keywords
- sleep, spindles, non-rapid eye movement, SSD, neurobiology, impairment, brain stimulation, non-invasive stimulation
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- University of Wisconsin, MadisonUniversity, hospital or other
- Collaborators
- National Institute of Mental Health (NIMH)
- Study start
- 5 Jun 2026 (actual)
- Primary completion
- Aug 2027 (estimated)
- Study completion
- Feb 2028 (estimated)
- First posted
- 27 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep spindles (brain rhythms in the ~8-16 Hz range). Up to 24 healthy participants in Dane County, Wisconsin will be enrolled for 3 overnight study visits. Participants can expect to be on study for approximately 5 weeks, depending on scheduling availability.
Detailed description
This single-site, single-blind, experimental study will test whether thalamic temporal interference transcranial electrical stimulation (TI-TES) delivered during Non-Rapid Eye Movement (NREM) sleep can enhance spindle-frequency activity (SFA) in healthy adults and identify optimal stimulation parameters across frequency and thalamic target location.
After screening/consent, participants will complete a structural MRI for personalized montage optimization, then undergo three overnight High-Density Electroencephalography (hdEEG) and Polysomnography (PSG) sleep sessions (10-12 hours each) in a randomized, counterbalanced crossover design, one session per stimulation location (broad thalamic, anterior thalamic, posterior thalamic). During stable N2 sleep, TI-TES will be delivered in 3-minute epochs separated by 6-minute intervals, for up to 24 epochs per night, under real-time sleep-technician monitoring. The study uses a two-phase frequency plan: Phase 1 (~10 participants) will test 10 Hz, 14 Hz, and matched carrier-only SHAM; contingent on feasibility/sensitivity, Phase 2 (~10 participants) will expand frequencies across 8-16 Hz. Primary outcomes quantify stimulation-related increases in 8-16 Hz spectral power (SFA) and spindle characteristics comparing active TI-TES versus SHAM and across stimulation locations/frequencies.
Primary Objectives:
- Determine whether active thalamic TI-TES increases 8-16 Hz spindle-frequency activity (SFA) relative to carrier-only SHAM (evaluated using STIM-PRE and POST-PRE contrasts).
- Identify the most effective TI-TES stimulation parameters across stimulation frequencies and stimulation locations (broad thalamic, anterior, posterior) by comparing SFA changes across parameter combinations.
- Characterize stimulation-related changes in spindle characteristics (density, amplitude, duration, topography) for slow and fast spindle subtypes. Secondary Objectives:
- Evaluate stimulation-related changes in slow (8-12 Hz) and fast (13-16 Hz) spindle spectral power.
- Evaluate stimulation-related changes in slow wave (0.5-4.0 Hz) spectral power.
- Characterize stimulation-related changes in slow-wave characteristics (density, amplitude, duration).
- Evaluate stimulation-related changes in SO-spindle coupling (phase-amplitude coupling) for slow and fast spindles.
- (Exploratory) Evaluate stimulation-related changes in hdEEG functional connectivity between channels using the phase slope index (PSI).
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants will complete three overnight stimulation sessions with simultaneous 256-channel hdEEG and PSG, in a randomized, counterbalanced crossover design, with each overnight session using a distinct personalized montage targeting one of three thalamic locations (broad thalamic, anterior thalamic, posterior thalamic), and sessions spaced at least three days apart. Phase 1 will include approximately 10 participants and will test 10 Hz, 14 Hz, and matched carrier-only SHAM across all locations. Contingent on Phase 1 data, Phase 2 will include approximately 10 participants and will expand frequencies across 8-16 Hz or retain only 10 Hz and 14 Hz (plus SHAM) if effect sizes are smaller than anticipated.
| Arm | Type | Receives |
|---|---|---|
| All Participants | Experimental | Other: Magnetic Resonance Imaging (MRI), Device: Broad thalamic stimulation (TI-TES), Device: Carrier only SHAM stimulation, Device: Anterior thalamic stimulation (TI-TES), Device: Posterior thalamic stimulation (TI-TES)Participants will complete three overnight stimulation sessions with simultaneous 256-channel hdEEG and PSG, in a randomized, counterbalanced crossover design, with each overnight session using a distinct personalized montage targeting one of three thalamic locations (broad thalamic, anterior thalamic, posterior thalamic), and sessions spaced at least three days apart. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Medically healthy (based on self-report and study team review)
- U.S. citizen or holding permanent resident status
- English-speaking (able to provide consent and complete questionnaires)
Key exclusion criteria (18 listed)
- Any current or past history of neurological disorders or acquired neurological disease (e.g. stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified in first MRI)
- History of inpatient psychiatric hospitalization
- History of head trauma resulting in prolonged loss of consciousness; or a history of greater than 3 grade I concussions
- Current history of poorly controlled headaches including intractable or poorly controlled migraines
- Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Magnetic Resonance Imaging (MRI)Also: structural MRIMRI is to optimize placement of uni- or multipolar TI-TES | Other | All Participants |
| Broad thalamic stimulation (TI-TES)Stimulation targeted at the whole thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals | Device | All Participants |
| Carrier only SHAM stimulationCarrier only SHAM condition. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals | Device | All Participants |
| Anterior thalamic stimulation (TI-TES)Stimulation targeted at the anterior thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals | Device | All Participants |
| Posterior thalamic stimulation (TI-TES)Stimulation targeted at the posterior thalamus. Within each overnight session, up to 24 stimulation protocols will be administered, randomized across frequencies (including SHAM). Stimulation will be initiated by trained sleep technicians during stable N2 sleep and delivered in 3-minute epochs separated by 6-minute intervals to enable comparison of PRE, STIM, and POST intervals. | Device | All Participants |
Primary outcome
Change in Spectral Power (SFA) for Active TI-TES vs SHAM
Time frame: during each of the 3 overnight visits, 5 weeks
Comparing active TI-TES vs carrier only SHAM, evaluated using both STIM-PRE and POST-PRE contrasts.
Change in SFA by Location
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in 8-16 Hz spectral power across frequency-location combinations (broad thalamic, anterior thalamic, posterior thalamic) for STIM-PRE and POST-PRE to identify the most effective parameters within the tested parameter space.
Spindle Density in slow (8-12 Hz) and fast (13-16 Hz) SFA
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (density) using STIM-PRE and POST-PRE contrasts
Spindle Amplitude in slow (8-12 Hz) and fast (13-16 Hz) SFA
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (amplitude) using STIM-PRE and POST-PRE contrasts
Spindle Duration in slow (8-12 Hz) and fast (13-16 Hz) SFA
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (duration) using STIM-PRE and POST-PRE contrasts
Spindle Topography in slow (8-12 Hz) and fast (13-16 Hz) SFA
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in slow (8-12 Hz) and fast (13-16 Hz) spindle characteristics (topography) using STIM-PRE and POST-PRE contrasts
6 secondary outcomes
Change in Spectral Power (SFA) for SHAM during slow vs fast conditions
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in slow-wave spectral power (0.5-4.0 Hz) relative to SHAM
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Density
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Amplitude
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in Slow-wave Duration
Time frame: during each of the 3 overnight visits, 5 weeks
Changes in Spindle and Slow Oscillation Coupling
Time frame: during each of the 3 overnight visits, 5 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Aug 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Larissa Albantakis, PhD principal investigator
University of Wisconsin, Madison
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES) and Anterior thalamic stimulation (TI-TES) in people with Healthy Adult Participants and Healthy Participants, run by University of Wisconsin, Madison at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 18 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 10 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sean Prahl (608-263-4313, capti@psychiatry.wisc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Spectral Power (SFA) for Active TI-TES vs SHAM (time frame: during each of the 3 overnight visits, 5 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Aug 2026.