Post-spinal HeadacheNCT07502482
The Effect of Magnesium on Post-spinal Headaches
An observational study of Post-spinal Headache, run by Haseki Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia Read more about this study
- Who is it for?
- Ages 18 to 45 years, women only
- Conditions the study is for
- Post-spinal Headache
- What is being tested?
- Magnesium
- How many people
- 300 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Apr 2026to 5 Nov 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- Women only
- No healthy volunteers
- Adult
Study population: In this study, which is designed as a retrospective cohort study, the records of all patients who underwent caesarean section under spinal anaesthesia at our hospital between 1 January 2025 and 31 December 2025 and who met the inclusion criteria will be reviewed.
Who may be able to join
- • Patients aged 18-45
- Patients who underwent spinal anaesthesia for elective caesarean section
- Patients with an ASA physical status score of I-III
- Patients in whom a 25G or 27G pencil-point needle was used for spinal anaesthesia
- Patients with complete medical records
Who cannot join
- • Patients undergoing emergency surgery
- Patients with a history of chronic headaches
- Patients who have undergone unsuccessful spinal anaesthesia or multiple attempts
- Patients who have undergone combined spinal-epidural anaesthesia
- Patients with a contraindication to magnesium sulphate
- Patients with insufficient medical records
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Haseki Training and Research Hospital
Istanbul, Sultangazi
About this study
Official title: The Effect of Intravenous Magnesium Sulphate on the Development of Post-Spinal Headache Following Caesarean Section Under Spinal Anaesthesia: A Retrospective Cohort Study
This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia
- Conditions
- Post-spinal Headache
- Being tested
- Magnesium
- Medical subject headings
- Post-Dural Puncture Headache
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MagnesiumOther
Post-spinal headache in patients receiving magnesium
| Study group | Role | What they receive |
|---|---|---|
| administered intravenous magnesium | Not described Receives: Other: Magnesium | |
| without intravenous magnesium | Not described Receives: Other: Magnesium |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of post-spinal headache
the number of people who develop a headache following spinal anaesthesia
Measured: 1. day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Mar 2026
- Study start1 Apr 2026
- Primary completion1 Sep 2026
- Study completion5 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Post-spinal HeadacheStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 300 participants (actual)
Sponsor and investigators
- Lead sponsor
- Haseki Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Emine Yilmaz Guler, Haseki Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07502482
- Sponsor's protocol ID
- MG-260326
- Status last verified
- Nov 2026
- First submitted
- 26 Mar 2026
- Last updated
- 5 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Uppal V, Russell R, Sondekoppam R, Ansari J, Baber Z, Chen Y, DelPizzo K, Dirzu DS, Kalagara H, Kissoon NR, Kranz PG, Leffert L, Lim G, Lobo CA, Lucas DN, Moka E, Rodriguez SE, Sehmbi H, Vallejo MC, Volk T, Narouze S. Consensus Practice Guidelines on Postdural Puncture Headache From a Multisociety, International Working Group: A Summary Report. JAMA Netw Open. 2023 Aug 1;6(8):e2325387. doi: 10.1001/jamanetworkopen.2023.25387.
PubMed 37581893Alatni RI, Alsamani R, Alqefari A. Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. Cureus. 2024 Jan 15;16(1):e52330. doi: 10.7759/cureus.52330. eCollection 2024 Jan.
PubMed 38361721
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Intravenous Magnesium Sulphate on the Development of Post-Spinal Headache Following Caesarean Section Under Spinal Anaesthesia: A Retrospective Cohort Study
- ClinicalTrials.gov ID
- NCT07502482
- Acronym / sponsor ID
- MG-260326
- Conditions
- Post-spinal Headache
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 300 participants (actual)
- Lead sponsor
- Haseki Training and Research HospitalUniversity, hospital or other
- Study start
- 1 Apr 2026 (actual)
- Primary completion
- 1 Sep 2026 (actual)
- Study completion
- 5 Nov 2026 (estimated)
- First posted
- 31 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective cohort study aims to assess the effect of the use of magnesium sulphate in routine clinical practice on the development of post-dural puncture headache in patients undergoing spinal anaesthesia
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| administered intravenous magnesium | – | Other: Magnesium |
| without intravenous magnesium | – | Other: Magnesium |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- In this study, which is designed as a retrospective cohort study, the records of all patients who underwent caesarean section under spinal anaesthesia at our hospital between 1 January 2025 and 31 December 2025 and who met the inclusion criteria will be reviewed.
Key inclusion criteria (5 listed)
- • Patients aged 18-45
Key exclusion criteria (6 listed)
- • Patients undergoing emergency surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MagnesiumPost-spinal headache in patients receiving magnesium | Other | administered intravenous magnesium, without intravenous magnesium |
Primary outcome
Incidence of post-spinal headache
Time frame: 1. day
the number of people who develop a headache following spinal anaesthesia
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- Results publication: PubMed 37581893Uppal V, Russell R, Sondekoppam R, Ansari J, Baber Z, Chen Y, DelPizzo K, Dirzu DS, Kalagara H, Kissoon NR, Kranz PG, Leffert L, Lim G, Lobo CA, Lucas DN, Moka E, Rodriguez SE, Sehmbi H, Vallejo MC, Volk T, Narouze S. Consensus Practice Guidelines on Postdural Puncture Headache From a Multisociety, International Working Group: A Summary Report. JAMA Netw Open. 2023 Aug 1;6(8):e2325387. doi: 10.1001/jamanetworkopen.2023.25387.
- Results publication: PubMed 38361721Alatni RI, Alsamani R, Alqefari A. Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. Cureus. 2024 Jan 15;16(1):e52330. doi: 10.7759/cureus.52330. eCollection 2024 Jan.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Post-spinal Headache, run by Haseki Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of post-spinal headache (time frame: 1. day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07502482, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.