EmotionsArchi'MotionNCT07507266
Emotions From Salivary Biomarkers in an Architectural Context
An observational study of Emotions, run by Sys2Diag at 1 site in France.
Trial summary
Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Emotions
- What is being tested?
- Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 9 Jun 2026to 14 Jun 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Healthy adult volunteers attending the architectural festival who got exposed and/or got an interaction with an architectural work, with visual, tactile, and/or olfactory stimuli.
Who may be able to join
- Subject over 18 years old
- Subject agreeing to follow the study procedures
- Subject capable of understanding the purpose, nature, and methodology of the study
- Subject affiliated with a French social security scheme or beneficiary of such a scheme.
Who cannot join
- Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme
- Subject deprived of liberty, protected adult, vulnerable person, or minor
- Subject with proven or suspected chronic infectious disease that could pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
- Subject with a deficiency (vision, anosmia) preventing proper interaction with the architectural work
- Subject presenting signs of active oral inflammation, advanced periodontitis, or severe gingivitis
- Subject suffering from Gougerot-Sjögren syndrome (dry syndrome) or mouth cancer
- Pregnant or breastfeeding women.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
Sys2Diag - Umr9005 Cnrs/Alcen
Montpellier, 34184
Franck MOLINA, Phd, +33 (0) 467 047 460, s2d.cpp@sys2diag.cnrs.fr
Wendpouiré A OUEDRAOGO, Msc, +33 (0) 467 047 481, s2d.cpp@sys2diag.cnrs.fr
About this study
Official title: Evaluation of Emotions From Salivary Molecular Biomarkers in an Architectural Context
Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. Recent studies show that emotional states can be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Measuring specific biomarkers through non-invasive biological tests in saliva provides physiological data on an individual's emotional state in response to stimuli, particularly visual or tactile.
Read the detailed description
Architecture influences our well-being, and people's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. For example, noise and lack of vegetation can generate stress and stress associated with the built environment can even negatively impact life expectancy. Moreover, psychology, and more specifically emotional regulation, plays a fundamental role in how individuals perceive and react to their environment. Emotional regulation is closely linked to the attachment style developed during childhood. Studies have shown that insecure attachment is associated with poorer emotional regulation, which can amplify stress reactions in response to an environment perceived as hostile or inadequate. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Its main objective is to create environments that positively influence emotions and well-being, taking into account how our brain perceives and reacts to different elements of space. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. These studies generally use tools such as self-assessment scales (e.g., PANAS for affect), functional magnetic resonance imaging (fMRI), electroencephalogram (EEG), and heart rate measurement. These often subjective or indirect methods require trained and/or medical personnel and heavy equipment. In addition, emotions and their regulation are influenced by several sociodemographic factors, including age and the development of the prefrontal cortex, but also gender, socioeconomic level, education level, and cultural context. These factors modulate exposure to stress, the available regulation strategies, and their effectiveness. Life history, particularly early exposure to traumatic events, is also determining. These elements justify the attention paid to inclusion and exclusion criteria in the study (particularly age, gender, cultural context, etc.) to best control these variables. Recent studies show that emotional states (positive and negative) can also be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Thus, several studies using the Trier Social Stress Test (TSST) have highlighted an increase in the concentration of cortisol, DeHydroEpiAndrosterone (DHEA), and salivary alpha-amylase in response to a state of acute stress and anxiety in tested individuals. Glenk et al. studied 40 adults (21 to 34 years old, allergic or not) using measures such as the State-Trait Anxiety Inventory (STAI-S) (20 self-reported items), the Emotion Regulation Questionnaire (ERQ), a visual analog scale of perceived stress (VAS), salivary cortisol measurements, and plasma oxytocin. Izawa et al. analyzed salivary DHEA levels, blood pressure, and heart rate in 33 students with an average age of 22. Van Stegeren et al. measured salivary cortisol and alpha-amylase in 80 adults (men and women) exposed to TSST. Furthermore, an association between positive emotions and a decrease in salivary cortisol has also been described by Lai et al. in 80 adults via a questionnaire and salivary cortisol analysis. Oxytocin modulates the integration of emotional information and interacts with the reward pathway. It is released during positive social interactions and can downregulate stress and heart rate (study of 163 young adults under 35, high school level, no medication, questionnaires, filmed interviews, blood oxytocin measurement). Finally, Kanen et al. showed that fluctuations in serotonin concentration can generate various emotional phenotypes, highlighting the neurobiological impact on emotional regulation. It is therefore essential that participation in architectural exposure is voluntary, as the perception of control is a key factor in modulating the emotional response. Finally, measuring specific biomarkers (enzymes, hormones) through non-invasive biological tests in saliva provides reliable physiological data on an individual's emotional state). These approaches have already been applied to analyze the effects of olfactory stimuli (study of 170 participants, questionnaires, and salivary biomarkers) or architectural. The objective of the proposed research is therefore to measure, in an immersive context (architecture festival), salivary molecular biomarkers known to be linked to emotions. These measurements are intended to objectively measure the influence of an architectural context on physiological parameters related to emotions, while taking into account the psychological, sociodemographic, and developmental factors identified through a dedicated questionnaire.
- Conditions
- Emotions
- Being tested
- Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions
- Keywords
- Biomarkers, Architecture, Stimuli
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Bio-fluid analysis for the measurement of salivary biomarkers linked to emotionsDiagnostic test
Saliva of participants will be sampled for analysis of biomarkers of interest (DHEA, oxytocin, cortisol, alpha-amylase, serotonin, and dopamine) using enzymatic dosage methods or ELISA-type methods carried out using commercial kits.
| Study group | Role | What they receive |
|---|---|---|
| ARM VT | 30 subjects who will be exposed to an architectural work offering visual and tactile stimulations. Receives: Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions | |
| ARM O | 30 subjects who will be exposed to a second architectural work offering visual, tactile, and olfactory stimulations. Receives: Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work.
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work. This exposure includes a combination of visual, tactile, and/or olfactory stimuli.
Measured: 2 years
Secondary outcomes (4)
Identify a salivary molecular biomarker signature linked to an emotional profile following exposure to an architectural site.
Identify, from measurements of alpha-amylase, cortisol, DHEA, oxytocin, serotonin, and dopamine, one or more profile(s) of biomarker concentration variation, which would differentiate the emotions felt following exposure to an architectural site. These combinations of biomarkers could identify an emotion profile linked to a biomarker signature.
Measured: 2 years
Compare the identified molecular biomarker signatures between the studied architectural sites (different types of visual, tactile, or olfactory stimuli).
Compare the different combinations of biomarker variations identified previously according to the two studied architectural sites. Indeed, since the two sites are architecturally different, the identified signatures could be different depending on the sites.
Measured: 2 years
Establish correlations between the identified biomarker signatures linked to emotional profiles and sociodemographic and developmental data.
Compare the biomarker signatures measured after stimulation and the sociodemographic and developmental data to establish correlations between the stimuli, the emotions felt, and age, gender, etc.
Measured: 2 years
Evaluate the homogeneity of the emotional physiological response following exposure to an architectural site.
Analyze the dispersion of the data obtained for each architectural site according to the day, age, gender, etc.
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start9 Jun 2026 (estimated)
- Primary completion14 Jun 2026 (estimated)
- Study completion14 Jun 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (25)Papers the sponsor has linked to this study.
- Other trials for EmotionsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sys2Diag
- Sponsor type
- Other government
- Collaborators
- Centre National de la Recherche Scientifique, France
- Responsible party
- Principal investigator, Laurence MOLINA, Sys2Diag
- Investigators
- Laurence MOLINA, PhD, Principal investigator, Sys2Diag
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07507266
- Sponsor's protocol ID
- 2025-A00909-40
- Other IDs
- 25.01443.000493#1
- Acronym
- Archi'Motion
- Status last verified
- Apr 2026
- First submitted
- 26 Mar 2026
- Last updated
- 14 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Choo H, Nasar JL, Nikrahei B, Walther DB. Neural codes of seeing architectural styles. Sci Rep. 2017 Jan 10;7:40201. doi: 10.1038/srep40201.
PubMed 28071765Roe JJ, Thompson CW, Aspinall PA, Brewer MJ, Duff EI, Miller D, Mitchell R, Clow A. Green space and stress: evidence from cortisol measures in deprived urban communities. Int J Environ Res Public Health. 2013 Sep 2;10(9):4086-103. doi: 10.3390/ijerph10094086.
PubMed 24002726Giacomello G, Scholten A, Parr MK. Current methods for stress marker detection in saliva. J Pharm Biomed Anal. 2020 Nov 30;191:113604. doi: 10.1016/j.jpba.2020.113604. Epub 2020 Sep 6.
PubMed 32957066Lai JC, Evans PD, Ng SH, Chong AM, Siu OT, Chan CL, Ho SM, Ho RT, Chan P, Chan CC. Optimism, positive affectivity, and salivary cortisol. Br J Health Psychol. 2005 Nov;10(Pt 4):467-84. doi: 10.1348/135910705X26083.
PubMed 16238860Glenk LM, Kothgassner OD, Felnhofer A, Gotovina J, Pranger CL, Jensen AN, Mothes-Luksch N, Goreis A, Palme R, Jensen-Jarolim E. Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety. Stress. 2020 May;23(3):275-283. doi: 10.1080/10253890.2019.1675629. Epub 2019 Oct 24.
PubMed 31578916Santos Schneider F, Molina L, Kahli M, Simphor E, Fournier A, Breau A., Ouedraogo A., Baptiste J., Houot-Cernettig J, Alali M, Dubourg C, Bleuez L, Aguadisch L, Petit V., Molina F, Évaluation objective et en temps réel des émotions induites par un parfum à l'aide d'un test salivaire moléculaire innovant, Cosmétiques, parfums et émotions - L'apport des neurosciences (2nd édition), Chartres, Cosmetic Valley Editions,"Collection Science", 2025, p.195-209.
Molina F, Molina L, Schneider F, M Kahli. Method of emotion identification in human salivary samples. FR2315415 (2023) - (PCT/EP2024/088625)
Chamilothoria K et al. Subjective and physiological responses to facade and sunlight pattern geometry in virtual reality. Building and Environment 2019; 150; 144-155
Küller R et al. Color, Arousal, and Performance - A Comparison of Three Experiments. COLOR research and application 2009; 34(2); 141-152.
Shin Y et al. Modelling Asymmetric Cointegration and Dynamic Multipliers in a Nonlinear ARDL Framework. In: Sickles, R., Horrace, W. (eds) Festschrift in Honor of Peter Schmidt. Springer, New York, NY. 2014
Glass D.C., Singer J.E. Urban Stress. Experiments on Noise and Social Stressors. Academic Press, New York, xiv, 182 pp. 1972
Homolja M et al. The Impact of Moving through the Built Environment on Emotional and Neurophysiological State - A Systematic Literature Review. Victoria University of Wellington Library. 2020.
Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin during the initial stages of romantic attachment: relations to couples' interactive reciprocity. Psychoneuroendocrinology. 2012 Aug;37(8):1277-85. doi: 10.1016/j.psyneuen.2011.12.021. Epub 2012 Jan 26.
PubMed 22281209Izawa S, Sugaya N, Shirotsuki K, Yamada KC, Ogawa N, Ouchi Y, Nagano Y, Suzuki K, Nomura S. Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes. Biol Psychol. 2008 Dec;79(3):294-8. doi: 10.1016/j.biopsycho.2008.07.003. Epub 2008 Jul 25.
PubMed 18706968Matsumoto D, Hwang HS. Culture and emotion: The integration of biological and cultural contributions. Journal of Cross-Cultural Psychology, 2012; 43(1), 91-118.
Study at a glance
From the registry record, last updated by the sponsor on 14 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Emotions From Salivary Molecular Biomarkers in an Architectural Context
- ClinicalTrials.gov ID
- NCT07507266
- Acronym / sponsor ID
- Archi'Motion / 2025-A00909-40
- Conditions
- Emotions
- Keywords
- Biomarkers, Architecture, Stimuli
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Sys2DiagOther government
- Collaborators
- Centre National de la Recherche Scientifique, France
- Study start
- 9 Jun 2026 (estimated)
- Primary completion
- 14 Jun 2026 (estimated)
- Study completion
- 14 Jun 2028 (estimated)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. Recent studies show that emotional states can be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Measuring specific biomarkers through non-invasive biological tests in saliva provides physiological data on an individual's emotional state in response to stimuli, particularly visual or tactile.
Detailed description
Architecture influences our well-being, and people's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. For example, noise and lack of vegetation can generate stress and stress associated with the built environment can even negatively impact life expectancy. Moreover, psychology, and more specifically emotional regulation, plays a fundamental role in how individuals perceive and react to their environment. Emotional regulation is closely linked to the attachment style developed during childhood. Studies have shown that insecure attachment is associated with poorer emotional regulation, which can amplify stress reactions in response to an environment perceived as hostile or inadequate. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Its main objective is to create environments that positively influence emotions and well-being, taking into account how our brain perceives and reacts to different elements of space. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. These studies generally use tools such as self-assessment scales (e.g., PANAS for affect), functional magnetic resonance imaging (fMRI), electroencephalogram (EEG), and heart rate measurement. These often subjective or indirect methods require trained and/or medical personnel and heavy equipment. In addition, emotions and their regulation are influenced by several sociodemographic factors, including age and the development of the prefrontal cortex, but also gender, socioeconomic level, education level, and cultural context. These factors modulate exposure to stress, the available regulation strategies, and their effectiveness. Life history, particularly early exposure to traumatic events, is also determining. These elements justify the attention paid to inclusion and exclusion criteria in the study (particularly age, gender, cultural context, etc.) to best control these variables. Recent studies show that emotional states (positive and negative) can also be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Thus, several studies using the Trier Social Stress Test (TSST) have highlighted an increase in the concentration of cortisol, DeHydroEpiAndrosterone (DHEA), and salivary alpha-amylase in response to a state of acute stress and anxiety in tested individuals. Glenk et al. studied 40 adults (21 to 34 years old, allergic or not) using measures such as the State-Trait Anxiety Inventory (STAI-S) (20 self-reported items), the Emotion Regulation Questionnaire (ERQ), a visual analog scale of perceived stress (VAS), salivary cortisol measurements, and plasma oxytocin. Izawa et al. analyzed salivary DHEA levels, blood pressure, and heart rate in 33 students with an average age of 22. Van Stegeren et al. measured salivary cortisol and alpha-amylase in 80 adults (men and women) exposed to TSST. Furthermore, an association between positive emotions and a decrease in salivary cortisol has also been described by Lai et al. in 80 adults via a questionnaire and salivary cortisol analysis. Oxytocin modulates the integration of emotional information and interacts with the reward pathway. It is released during positive social interactions and can downregulate stress and heart rate (study of 163 young adults under 35, high school level, no medication, questionnaires, filmed interviews, blood oxytocin measurement). Finally, Kanen et al. showed that fluctuations in serotonin concentration can generate various emotional phenotypes, highlighting the neurobiological impact on emotional regulation. It is therefore essential that participation in architectural exposure is voluntary, as the perception of control is a key factor in modulating the emotional response. Finally, measuring specific biomarkers (enzymes, hormones) through non-invasive biological tests in saliva provides reliable physiological data on an individual's emotional state). These approaches have already been applied to analyze the effects of olfactory stimuli (study of 170 participants, questionnaires, and salivary biomarkers) or architectural. The objective of the proposed research is therefore to measure, in an immersive context (architecture festival), salivary molecular biomarkers known to be linked to emotions. These measurements are intended to objectively measure the influence of an architectural context on physiological parameters related to emotions, while taking into account the psychological, sociodemographic, and developmental factors identified through a dedicated questionnaire.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| ARM VT | – | Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions30 subjects who will be exposed to an architectural work offering visual and tactile stimulations. |
| ARM O | – | Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions30 subjects who will be exposed to a second architectural work offering visual, tactile, and olfactory stimulations. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Healthy adult volunteers attending the architectural festival who got exposed and/or got an interaction with an architectural work, with visual, tactile, and/or olfactory stimuli.
Key inclusion criteria (4 listed)
- Subject over 18 years old
- Subject agreeing to follow the study procedures
- Subject capable of understanding the purpose, nature, and methodology of the study
- Subject affiliated with a French social security scheme or beneficiary of such a scheme.
Key exclusion criteria (7 listed)
- Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme
- Subject deprived of liberty, protected adult, vulnerable person, or minor
- Subject with proven or suspected chronic infectious disease that could pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
- Subject with a deficiency (vision, anosmia) preventing proper interaction with the architectural work
- Subject presenting signs of active oral inflammation, advanced periodontitis, or severe gingivitis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Bio-fluid analysis for the measurement of salivary biomarkers linked to emotionsSaliva of participants will be sampled for analysis of biomarkers of interest (DHEA, oxytocin, cortisol, alpha-amylase, serotonin, and dopamine) using enzymatic dosage methods or ELISA-type methods carried out using commercial kits. | Diagnostic test | ARM O, ARM VT |
Primary outcome
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work.
Time frame: 2 years
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work. This exposure includes a combination of visual, tactile, and/or olfactory stimuli.
4 secondary outcomes
Identify a salivary molecular biomarker signature linked to an emotional profile following exposure to an architectural site.
Time frame: 2 years
Compare the identified molecular biomarker signatures between the studied architectural sites (different types of visual, tactile, or olfactory stimuli).
Time frame: 2 years
Establish correlations between the identified biomarker signatures linked to emotional profiles and sociodemographic and developmental data.
Time frame: 2 years
Evaluate the homogeneity of the emotional physiological response following exposure to an architectural site.
Time frame: 2 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Apr 2026.
- Background: PubMed 28071765Choo H, Nasar JL, Nikrahei B, Walther DB. Neural codes of seeing architectural styles. Sci Rep. 2017 Jan 10;7:40201. doi: 10.1038/srep40201.
- Background: PubMed 24002726Roe JJ, Thompson CW, Aspinall PA, Brewer MJ, Duff EI, Miller D, Mitchell R, Clow A. Green space and stress: evidence from cortisol measures in deprived urban communities. Int J Environ Res Public Health. 2013 Sep 2;10(9):4086-103. doi: 10.3390/ijerph10094086.
- Background: PubMed 32957066Giacomello G, Scholten A, Parr MK. Current methods for stress marker detection in saliva. J Pharm Biomed Anal. 2020 Nov 30;191:113604. doi: 10.1016/j.jpba.2020.113604. Epub 2020 Sep 6.
- Background: PubMed 16238860Lai JC, Evans PD, Ng SH, Chong AM, Siu OT, Chan CL, Ho SM, Ho RT, Chan P, Chan CC. Optimism, positive affectivity, and salivary cortisol. Br J Health Psychol. 2005 Nov;10(Pt 4):467-84. doi: 10.1348/135910705X26083.
- Background: PubMed 31578916Glenk LM, Kothgassner OD, Felnhofer A, Gotovina J, Pranger CL, Jensen AN, Mothes-Luksch N, Goreis A, Palme R, Jensen-Jarolim E. Salivary cortisol responses to acute stress vary between allergic and healthy individuals: the role of plasma oxytocin, emotion regulation strategies, reported stress and anxiety. Stress. 2020 May;23(3):275-283. doi: 10.1080/10253890.2019.1675629. Epub 2019 Oct 24.
- BackgroundSantos Schneider F, Molina L, Kahli M, Simphor E, Fournier A, Breau A., Ouedraogo A., Baptiste J., Houot-Cernettig J, Alali M, Dubourg C, Bleuez L, Aguadisch L, Petit V., Molina F, Évaluation objective et en temps réel des émotions induites par un parfum à l'aide d'un test salivaire moléculaire innovant, Cosmétiques, parfums et émotions - L'apport des neurosciences (2nd édition), Chartres, Cosmetic Valley Editions,"Collection Science", 2025, p.195-209.
- BackgroundMolina F, Molina L, Schneider F, M Kahli. Method of emotion identification in human salivary samples. FR2315415 (2023) - (PCT/EP2024/088625)
- BackgroundChamilothoria K et al. Subjective and physiological responses to facade and sunlight pattern geometry in virtual reality. Building and Environment 2019; 150; 144-155
- BackgroundKüller R et al. Color, Arousal, and Performance - A Comparison of Three Experiments. COLOR research and application 2009; 34(2); 141-152.
- BackgroundShin Y et al. Modelling Asymmetric Cointegration and Dynamic Multipliers in a Nonlinear ARDL Framework. In: Sickles, R., Horrace, W. (eds) Festschrift in Honor of Peter Schmidt. Springer, New York, NY. 2014
- BackgroundGlass D.C., Singer J.E. Urban Stress. Experiments on Noise and Social Stressors. Academic Press, New York, xiv, 182 pp. 1972
- BackgroundHomolja M et al. The Impact of Moving through the Built Environment on Emotional and Neurophysiological State - A Systematic Literature Review. Victoria University of Wellington Library. 2020.
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Healthy Adult Participants
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Laurence MOLINA, PhD principal investigator
Sys2Diag
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Emotions, run by Sys2Diag at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Wendpouiré A OUEDRAOGO, Msc (+33 (0) 467 047 481, alimata.ouedraogo@sys2diag.cnrs.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work. (time frame: 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07507266, which also lists 25 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Apr 2026.