HydrationNCT07507344
Beverage Hydration Index of Different Solutions
A study testing Hydramin hydration solution, Carbohydrate and Electrolyte hydration solution and Water in people with Hydration, run by University of Memphis at 1 site in United States.
Trial summary
In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Hydration
- What is being tested?
- Hydramin hydration solution, Carbohydrate and Electrolyte hydration solution and Water
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteUnited States
- Study dates
- 23 Feb 2026to 23 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
- Be age 18 years or older
- male or female
- have a body mass index (BMI)between 18.5-35 kg/m2 (not morbidly obese)
- Be engaged in moderate physical activity, defined as ≤5 hours/week of aerobic exercise
- Not have a history or presence of a clinically relevant (that required or requires treatment) cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, biliary, gastrointestinal, pancreatic, or neurologic disorder (reviewed by Nurse practitioner)
- Not have other conditions that are likely to alter fluid balance or be negatively affected by changing electrolyte levels/hydration status (as determined by Nurse practitioner)
- Not be consuming any medication which may alter fluid retention/electrolyte levels such as Selective Serotonin Reuptake Inhibitors, sodium-glucose co-transporter 2 (SGLT2) inhibitor (for type 2 diabetes), laxatives, diuretics, Apremilast, chemotherapy, or lithium. (Medications will be reviewed by Nurse practitioner)
- Not consume nutritional supplements, performance enhancing drugs, and/or non-steroidal anti-inflammatory drugs within 7 days of study visits excluding screening.
- Follow the lifestyle and dietary restrictions before study visits (excluding screening/consenting visit) including before each visit avoiding strenuous activity for 24 hours prior, refrain from caffeine for 12 hours and alcohol for 24 hours, consume the standardized diet and maintain similar activity levels for 24 hours prior, consume 2.5 liters for men or 2.0 liters for women day prior, and fast (water only) of at least 10 hours prior.
- Not have a sensitivity or be allergic to any components of the study interventions (water, calcium chloride, magnesium chloride, potassium bicarbonate, magnesium, sodium, chloride, potassium, vitamin C, dextrose, AminoAbsorb (L-alanine, L-glutamine, glycine).
- Not be a tobacco user
- Not be following a specialized dietary pattern that may alter findings (e.g., low carbohydrate/ketogenic diet, carnivore diet, intermittent fasting etc.)
- Arrive to lab for visits euhydrated (USG 1.005-1.020)
- Have the ability and willingness to fast (consume water/treatments only) for 15 hours (10 hours prior to lab visits not including screening)
- Not be enrolled in another clinical study within 30 days of the first study visit
- Be without active infection or illness of any kind
- Not be pregnant or breastfeeding
- Not have surgery in the previous 4 months
Trial locations and contacts
1 site in 1 country.
United States1 site
Center for Nutraceutical and Dietary Supplement Research
Memphis, Tennessee, 38152
About this study
Official title: Comparison of the Beverage Hydration Index of Different Solutions
In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the Beverage Hydration Index above water alone and perform comparably to the carbohydrate rich solution.
This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.
- Conditions
- Hydration
- Being tested
- Hydramin hydration solution, Carbohydrate and Electrolyte hydration solution, Water
- Keywords
- hydration, electrolytes, Hydramin, Beverage Hydration Index
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hydramin hydration solutionDietary supplement
4 sticks of electrolyte and amino acid powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, AminoAbsorb (L-glutamine, L-Alanine, Glycine)
Carbohydrate and Electrolyte hydration solutionDietary supplement
4 sticks of electrolyte and carbohydrate powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, Dextrose
WaterDietary supplement
1 L Smart Water
| Study group | Role | What they receive |
|---|---|---|
| Hydramin, Electrolyte and Carbohydrate, Water | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Hydramin solution Visit 2: Electrolyte and Carbohydrate Visit 3: Water Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
| Hydramin, Water, Electrolyte and Carbohydrate | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Hydramin solution Visit 2: Water Visit 3: Electrolyte/Carbohydrate Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
| Electrolyte and Carbohydrate, Hydramin, Water | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Electrolyte/Carbohydrate Visit 2: Hydramin solution Visit 3: Water Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
| Electrolyte and Carbohydrate, Water, Hydramin | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Electrolyte/Carbohydrate Visit 2: Water Visit 3: Hydramin solution Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
| Water, Hydramin, Electrolyte and Carbohydrate | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Water Visit 2: Hydramin solution Visit 3: Electrolyte/Carbohydrate Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
| Water, Electrolyte and Carbohydrate, Hydramin | Experimental | At the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours.
Visit 1: Control Visit 2: Electrolyte/Carbohydrate Visit 3: Hydramin solution Receives: Dietary Supplement: Hydramin hydration solution; Dietary Supplement: Carbohydrate and Electrolyte hydration solution; Dietary Supplement: Water |
What is being measured
The primary outcome is the main question the study is designed to answer.
Beverage Hydration Index
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Measured: 0 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Measured: 60 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Measured: 120 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Measured: 180 minutes after beverage consumption
Beverage Hydration Index
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Measured: 240 minutes after beverage consumption
Net Fluid Balance
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Measured: 0 minutes after beverage consumption
Net Fluid Balance
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Measured: 60 minutes after beverage consumption
Net Fluid Balance
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Measured: 120 minutes after beverage consumption
Net Fluid Balance
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Measured: 180 minutes after beverage consumption
Net Fluid Balance
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Measured: 240 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 0 minutes before beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 0 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 60 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 120 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 180 minutes after beverage consumption
Urine Specific Gravity
Urine Specific Gravity measured via refractometry.
Measured: 240 minutes after beverage consumption
Urine Sodium
Urine sodium will be measured in millimoles per kilogram of water
Measured: 0 minutes before beverage consumption
Urine Sodium
Urine sodium will be measured in milliosmoles per kilogram of water
Measured: 0 minutes after beverage consumption
Urine Sodium
Urine sodium will be measured in millimoles per kilogram of water
Measured: 60 minutes after beverage consumption
Urine Sodium
Urine sodium will be measured in milliosmoles per kilogram of water
Measured: 120 minutes after beverage consumption
Urine Sodium
Urine sodium will be measured in millimoles per kilogram of water
Measured: 180 minutes after beverage consumption
Urine Sodium
Urine sodium will be measured in millimoles per kilogram of water
Measured: 240 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 0 minutes before beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 0 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 60 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 120 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 180 minutes after beverage consumption
Urine Potassium
Urine Potassium will be measured in millimoles per kilogram of water
Measured: 240 minutes after beverage consumption
Body mass
Body Mass in kilograms will be measured using a digital scale
Measured: 0 minutes before beverage consumption
Body mass
Body Mass in kilograms will be measured using a digital scale
Measured: 240 minutes after beverage consumption
Body Water
Body water will be determined using a digital bioelectrical impedance analysis scale.
Measured: 0 minutes before beverage consumption
Body Water
Body water will be determined using a digital bioelectrical impedance analysis scale.
Measured: 120 minutes after beverage consumption
Body Water
Body water will be determined using a digital bioelectrical impedance analysis scale.
Measured: 240 minutes after beverage consumption
Secondary outcomes (30)
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.
Measured: 0 minutes before beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.
Measured: 0 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.
Measured: 60 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes being better outcome and higher scores for both negative mood attributes and digestive traits being worse.scale questionnaire with scale 0 (None) to 10 (Extreme)
Measured: 120 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.
Measured: 180 minutes after beverage consumption
Mood and Digestive Questionnaire
Subjects will be asked to self-assess their mood and digestive state via a visual analog scale questionnaire with scale 0 (None) to 10 (Extreme) where higher scores for positive mood attributes indicating a better outcome and higher scores for both negative mood attributes and digestive traits generally indicating a worse outcome.
Measured: 240 minutes after beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 0 minutes before beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 0 minutes after beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 60 minutes after beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 120 minutes after beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 180 minutes after beverage consumption
Diastolic Blood Pressure
Diastolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 240 minutes after beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 0 minutes before beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 0 minutes after beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 60 minutes after beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 120 minutes after beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 180 minutes after beverage consumption
Systolic Blood Pressure
Systolic Blood Pressure will be measured in millimeters mercury using an automated cuff
Measured: 240 minutes after beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 0 minutes before beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 0 minutes after beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 60 minutes after beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 120 minutes after beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 180 minutes after beverage consumption
Heart Rate
Heart rate will be measured in beats per minute using an automated cuff
Measured: 240 minutes after beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 0 minutes before beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 40 minutes after beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 50 minutes after beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 60 minutes after beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 75 minutes after beverage consumption
Blood Glucose
Blood glucose will be measured in milligrams per deciliter using a glucometer
Measured: 90 minutes after beverage consumption
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start23 Feb 2026
- Primary completion20 Jul 2026
- Study completion23 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for HydrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Memphis
- Sponsor type
- University, hospital or other
- Collaborators
- PharmaLinea Ltd.
- Responsible party
- Principal investigator, Richard Bloomer, University of Memphis
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07507344
- Sponsor's protocol ID
- PRO-FY2026-164
- Status last verified
- Aug 2026
- First submitted
- 27 Mar 2026
- Last updated
- 14 Aug 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 14 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Beverage Hydration Index of Different Solutions
- ClinicalTrials.gov ID
- NCT07507344
- Acronym / sponsor ID
- PRO-FY2026-164
- Conditions
- Hydration
- Keywords
- hydration, electrolytes, Hydramin, Beverage Hydration Index
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- University of MemphisUniversity, hospital or other
- Collaborators
- PharmaLinea Ltd.
- Study start
- 23 Feb 2026 (actual)
- Primary completion
- 20 Jul 2026 (actual)
- Study completion
- 23 Jul 2026 (actual)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this study, the impact of two electrolyte hydration stick products (Hydramin containing an electrolyte/amino acid formulation and an identical electrolyte product with the amino-acids replaced with carbohydrate, dextrose) dissolved in 1 liter of water will be assessed and compared to a control (1 liter Smart Water). It is hypothesized that the addition of amino acids and glycine should improve the Beverage Hydration Index above water alone and perform comparably to the carbohydrate rich solution.
This study will focus on general population (not athletes) and follow very similar approaches used in previous studies within the Center for Nutraceutical and Dietary Supplements Research, with the addition of blood glucose testing and body water measurements. Hydration will be assessed via fluid balance (the difference between the amount of water consumed and passed as urine) and calculations of beverage hydration index (the relative amount of urine passed after consumption of a drink compared to water)as well as time in positive fluid balance, and specific gravity, and sodium and potassium in urine. Blood glucose before and following consumption using finger pricks and a glucometer will also be assessed.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Hydramin, Electrolyte and Carbohydrate, Water | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Hydramin solution Visit 2: Electrolyte and Carbohydrate Visit 3: Water |
| Hydramin, Water, Electrolyte and Carbohydrate | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Hydramin solution Visit 2: Water Visit 3: Electrolyte/Carbohydrate |
| Electrolyte and Carbohydrate, Hydramin, Water | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Electrolyte/Carbohydrate Visit 2: Hydramin solution Visit 3: Water |
| Electrolyte and Carbohydrate, Water, Hydramin | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Electrolyte/Carbohydrate Visit 2: Water Visit 3: Hydramin solution |
| Water, Hydramin, Electrolyte and Carbohydrate | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Water Visit 2: Hydramin solution Visit 3: Electrolyte/Carbohydrate |
| Water, Electrolyte and Carbohydrate, Hydramin | Experimental | Dietary Supplement: Hydramin hydration solution, Dietary Supplement: Carbohydrate and Electrolyte hydration solution, Dietary Supplement: WaterAt the beginning of each visit, subjects will arrive hydrated having consumed the standardized meal replacements the day before. Baseline measures will be taken and the subject will then consume one fourth of the randomly assigned condition provided to them every 7.5 minutes (1 liter total volume) over a 30-minute period. After the 1 liter is consumed, subjects will then be monitored for an additional four hours. Visit 1: Control Visit 2: Electrolyte/Carbohydrate Visit 3: Hydramin solution |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hydramin hydration solution4 sticks of electrolyte and amino acid powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, AminoAbsorb (L-glutamine, L-Alanine, Glycine) | Dietary supplement | Electrolyte and Carbohydrate, Hydramin, Water, Electrolyte and Carbohydrate, Water, Hydramin, Hydramin, Electrolyte and Carbohydrate, Water, Hydramin, Water, Electrolyte and Carbohydrate, Water, Electrolyte and Carbohydrate, Hydramin, Water, Hydramin, Electrolyte and Carbohydrate |
| Carbohydrate and Electrolyte hydration solution4 sticks of electrolyte and carbohydrate powder dissolved in 1 L Smart Water. Ingredients: Sodium, Chloride, Potassium, Magnesium, Vitamin C, Dextrose | Dietary supplement | Electrolyte and Carbohydrate, Hydramin, Water, Electrolyte and Carbohydrate, Water, Hydramin, Hydramin, Electrolyte and Carbohydrate, Water, Hydramin, Water, Electrolyte and Carbohydrate, Water, Electrolyte and Carbohydrate, Hydramin, Water, Hydramin, Electrolyte and Carbohydrate |
| Water1 L Smart Water | Dietary supplement | Electrolyte and Carbohydrate, Hydramin, Water, Electrolyte and Carbohydrate, Water, Hydramin, Hydramin, Electrolyte and Carbohydrate, Water, Hydramin, Water, Electrolyte and Carbohydrate, Water, Electrolyte and Carbohydrate, Hydramin, Water, Hydramin, Electrolyte and Carbohydrate |
Primary outcome
Beverage Hydration Index
Time frame: 0 minutes after beverage consumption
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Beverage Hydration Index
Time frame: 60 minutes after beverage consumption
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Beverage Hydration Index
Time frame: 120 minutes after beverage consumption
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Beverage Hydration Index
Time frame: 180 minutes after beverage consumption
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Beverage Hydration Index
Time frame: 240 minutes after beverage consumption
Beverage Hydration Index calculated as mass of urine collected following control (water) divided by the mass of urine collected following treatment
Net Fluid Balance
Time frame: 0 minutes after beverage consumption
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Net Fluid Balance
Time frame: 60 minutes after beverage consumption
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Net Fluid Balance
Time frame: 120 minutes after beverage consumption
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Net Fluid Balance
Time frame: 180 minutes after beverage consumption
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Net Fluid Balance
Time frame: 240 minutes after beverage consumption
Net fluid balance will be calculated subtracting the total urine collected from the total liquid consumed
Urine Specific Gravity
Time frame: 0 minutes before beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Specific Gravity
Time frame: 0 minutes after beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Specific Gravity
Time frame: 60 minutes after beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Specific Gravity
Time frame: 120 minutes after beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Specific Gravity
Time frame: 180 minutes after beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Specific Gravity
Time frame: 240 minutes after beverage consumption
Urine Specific Gravity measured via refractometry.
Urine Sodium
Time frame: 0 minutes before beverage consumption
Urine sodium will be measured in millimoles per kilogram of water
Urine Sodium
Time frame: 0 minutes after beverage consumption
Urine sodium will be measured in milliosmoles per kilogram of water
Urine Sodium
Time frame: 60 minutes after beverage consumption
Urine sodium will be measured in millimoles per kilogram of water
Urine Sodium
Time frame: 120 minutes after beverage consumption
Urine sodium will be measured in milliosmoles per kilogram of water
Urine Sodium
Time frame: 180 minutes after beverage consumption
Urine sodium will be measured in millimoles per kilogram of water
Urine Sodium
Time frame: 240 minutes after beverage consumption
Urine sodium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 0 minutes before beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 0 minutes after beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 60 minutes after beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 120 minutes after beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 180 minutes after beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Urine Potassium
Time frame: 240 minutes after beverage consumption
Urine Potassium will be measured in millimoles per kilogram of water
Body mass
Time frame: 0 minutes before beverage consumption
Body Mass in kilograms will be measured using a digital scale
Body mass
Time frame: 240 minutes after beverage consumption
Body Mass in kilograms will be measured using a digital scale
Body Water
Time frame: 0 minutes before beverage consumption
Body water will be determined using a digital bioelectrical impedance analysis scale.
Body Water
Time frame: 120 minutes after beverage consumption
Body water will be determined using a digital bioelectrical impedance analysis scale.
Body Water
Time frame: 240 minutes after beverage consumption
Body water will be determined using a digital bioelectrical impedance analysis scale.
30 secondary outcomes
Mood and Digestive Questionnaire
Time frame: 0 minutes before beverage consumption
Mood and Digestive Questionnaire
Time frame: 0 minutes after beverage consumption
Mood and Digestive Questionnaire
Time frame: 60 minutes after beverage consumption
Mood and Digestive Questionnaire
Time frame: 120 minutes after beverage consumption
Mood and Digestive Questionnaire
Time frame: 180 minutes after beverage consumption
Mood and Digestive Questionnaire
Time frame: 240 minutes after beverage consumption
Diastolic Blood Pressure
Time frame: 0 minutes before beverage consumption
Diastolic Blood Pressure
Time frame: 0 minutes after beverage consumption
Diastolic Blood Pressure
Time frame: 60 minutes after beverage consumption
Diastolic Blood Pressure
Time frame: 120 minutes after beverage consumption
Diastolic Blood Pressure
Time frame: 180 minutes after beverage consumption
Diastolic Blood Pressure
Time frame: 240 minutes after beverage consumption
Systolic Blood Pressure
Time frame: 0 minutes before beverage consumption
Systolic Blood Pressure
Time frame: 0 minutes after beverage consumption
Systolic Blood Pressure
Time frame: 60 minutes after beverage consumption
Systolic Blood Pressure
Time frame: 120 minutes after beverage consumption
Systolic Blood Pressure
Time frame: 180 minutes after beverage consumption
Systolic Blood Pressure
Time frame: 240 minutes after beverage consumption
Heart Rate
Time frame: 0 minutes before beverage consumption
Heart Rate
Time frame: 0 minutes after beverage consumption
Heart Rate
Time frame: 60 minutes after beverage consumption
Heart Rate
Time frame: 120 minutes after beverage consumption
Heart Rate
Time frame: 180 minutes after beverage consumption
Heart Rate
Time frame: 240 minutes after beverage consumption
Blood Glucose
Time frame: 0 minutes before beverage consumption
Blood Glucose
Time frame: 40 minutes after beverage consumption
Blood Glucose
Time frame: 50 minutes after beverage consumption
Blood Glucose
Time frame: 60 minutes after beverage consumption
Blood Glucose
Time frame: 75 minutes after beverage consumption
Blood Glucose
Time frame: 90 minutes after beverage consumption
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Aug 2026.
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Hydration Status
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Hydramin hydration solution, Carbohydrate and Electrolyte hydration solution and Water in people with Hydration, run by University of Memphis at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 14 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Beverage Hydration Index (time frame: 0 minutes after beverage consumption). The study lists 33 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Aug 2026.