Temporomandibular Disorders (TMD)NCT07507734
Occlusal Splint and Exercise Therapy for Temporomandibular Disorders
A study testing Occlusal Splint and Exercise in people with Temporomandibular Disorders (TMD), run by Acibadem University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to learn if an exercise protocol can improve temporomandibular pain, jaw function and muscle mechanical properties in individuals with Temporomandibular Disorders (TMD). This study focuses on patients who are already receiving occlusal splint therapy. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Temporomandibular Disorders (TMD)
- What is being tested?
- Occlusal Splint and Exercise
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 10 Jul 2025to 10 Jul 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Clinical and radiological diagnosis of TMD
- Being between 18-65 years of age
- Presence of Temporomandibular Joint (TMJ) pain for the last 3 months.
Who cannot join
- Intra-articular or degenerative joint disorders and subluxation requiring immediate treatment,
- A history of TMJ or cervical region surgery in the last 3 months,
- A history of treatment from related regions,
- The presence of rheumatic diseases, including TMJ diseases,
- TMJ instability or fracture,
- The presence of perception-cognition disorder,
- The presence of chronic pain, such as trigeminal neuralgia.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Sema Savcı, Professor contact
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Okan University- Dental Hospital
Istanbul, Tuzla, 34947
Gül Merve Yalçın Ülker, DDS, PhD, +90 533 257 71 70, merve.yalcin@okan.edu.tr
About this study
Official title: The Effects of Occlusal Splint and Exercise in Individuals With Temporomandibular Disorders
The goal of this clinical trial is to learn if an exercise protocol can improve temporomandibular pain, jaw function and muscle mechanical properties in individuals with Temporomandibular Disorders (TMD). This study focuses on patients who are already receiving occlusal splint therapy.
The main question it aims to answer is:
Read more
How does the addition of an exercise protocol to occlusal splint therapy affect temporomandibular pain, jaw function and muscle mechanical properties of the masticatory and neck muscles? Researchers will compare the group receiving both occlusal splint therapy and the exercise protocol to a group only occlusal splint therapy to see if the combined approach is more effective.
Participants will:
- Undergo an initial assessment of the Jaw Functional Limitation Scale-20 (JLFS-20), Craniofacial Pain and Disability Inventory (CF-PDI), Graded Chronic Pain Scale Version 2.0 (GCPS-2.0), jaw range of motion, pain pressure threshold and muscle mechanical properties.
- Receive occlusal splint therapy as a part of their treatment.
- Perform a structured exercise protocol (only 1 group)
- Attend follow up sessions at the 4th week to monitor changes in all initial assessment parameters.
Read the detailed description
This research will be conducted as a randomized controlled, two-arm, prospective clinical trial. The study will evaluate the effects of occlusal splint application combined with the Rocabado exercise protocol in individuals with TMD. The intervention period will last for 4 weeks, with assessments conducted at baseline and at the end of the 4 weeks period.
Literature indicates that occlusal splint therapy and specialized exercise protocols are beneficial in improving symptoms in individuals with temporomandibular disorders (TMD). Studies have demonstrated that these interventions can enhance functionality and alleviate pain. However, there is a lack of research specifically comparing the combination of an occlusal splint and an exercise protocol against splint therapy alone, particularly regarding their effects on pain, functionality, and the mechanical properties of the masticatory and neck muscles.
Participants diagnosed with TMD will be recruited from two clinics in Turkey. To prevent potential imbalances, participants will be divided into two groups using stratification (age, gender, and occupation) and block randomization:
- Splint Group (S Group): Will receive nightly occlusal splint therapy only.
- Exercise and Splint Group (ES Group): Will receive the Rocabado 6x6 exercise protocol in addition to nightly occlusal splint therapy.
In the ES group, the occlusal splint and Rocabado exercises (6 times daily, 6 repetitions each) will be performed 7 days a week for 4 weeks. The control (S) group will utilize only the occlusal splint for the same duration.
Evaluations will be performed at baseline and at the 4th week. Clinical assessments will include the Jaw Functional Limitation Scale-20 (JFLS-20), Craniofacial Pain and Disability Inventory (CF-PDI), and Graded Chronic Pain Scale (GCPS) 2.0. Additionally, temporomandibular joint range of motion (ROM), pressure pain threshold (PPT), and mechanical muscle properties (MyotonPRO) will be assessed.
Inclusion criteria
- Clinical and radiological diagnosis of TMD
- Being between 18-65 years of age,
- Presence of temporomansibular joint (TMJ) pain for the last 3 months. Exclusion criteria
- İntra-articular or degenerative joint disorders and subluxation requiring immediate treatment,
- A history of TMJ or cervical region surgery in the last 3 months,
- A history of treatment from related regions,
- The presence of rheumatic diseases, including TMJ diseases,
- TMJ instability or fracture,
- The presence of perception-cognition disorder,
- The presence of chronic pain, such as trigeminal neuralgia.
- Conditions
- Temporomandibular Disorders (TMD)
- Being tested
- Occlusal Splint, Exercise
- Keywords
- temporomandibular disorders, exercise therapy, occlusal splint, muscle mechanical properties, pain, jaw function
- Medical subject headings
- Temporomandibular Joint Disorders, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Occlusal SplintDevice
Participants will be provided with custom-made hard acrylic occlusal splints. They will be instructed to wear the appliance every night during sleep for a period of four consecutive weeks. A licensed dentist will manage the delivery and occlusal adjustment of the splints to ensure they were correctly seated and well-tolerated by the subjects. Both groups will receive a occlusal splint to be worn every night.
ExerciseBehavioural
Also called Rocabado Exercises
Participants will perform the Rocabado 6x6 exercise protocol, which consists of six specific movements designed to restore proper tongue position, improve jaw mobility, and stabilize the craniomandibular relationship. Each exercise will be performed 6 times per session, 6 times a day. The protocol includes: Rest position of the tongue, shoulder posture, stabilized head flexion, axial extension of the neck, control of TMJ rotation and rhythmic stabilization technique. The program consists of performing 6 specific exercises, 6 times per day with 6 repetitions each, for 4 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Splint Group (S Group) | Active comparator | S Group will receive nightly occlusal splint therapy only. Receives: Device: Occlusal Splint |
| Exercise and Splint Group (ES Group) | Experimental | ES Group will receive the Rocabado exercise protocol in addition to nightly occlusal splint therapy. Receives: Device: Occlusal Splint; Behavioral: Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Jaw Range of Motion
Pain-free opening, maximum unassisted opening, maximum assisted opening, lateral and protrusive movements will be mesured by a ruler. All measurements will be noted in milimeters between the incisal edges of upper and lower central incisors. The average of the 3 repetitions will be taken.
Measured: Baseline and 4 weeks after start of treatment
Pain Pressure Threshold
PPT will be evaluated using a digital algometer. After positioning the algometer's rubbet tip pressure will be applied gradually. Measurements will be taken from the belly of the muscles (bilaterally for the masseter, temporalis, sternocleidomastoid and trapezius). The measurements will be made in three repetitions and the average will be noted in kg/cm2.
Measured: Baseline and 4 weeks after start of treatment
Muscle Mechanical Properties
Muscle mechanical properties will be evaluated by the MyotonPRO (Myoton AS, Tallinn, Estonia) device. Device will perform 5 measurements by 15-seconds intervals and the mean values will be recorded. Measurements will be taken from the belly of the muscles (bilaterally masseter, temporalis, sternocleidomastoid and trapezius).
Measured: Baseline and 4 weeks after start of treatment
Secondary outcomes (3)
Jaw functional limitation scale - 20
JLFS-20 will be used to evaluate functional limitations of the jaw. It consists of 20-items and each item scored between 0 (no limitation) to 10 (severe limitaiton) score.
Measured: Baseline and 4 weeks after start of treatment
Craniofacial Pain and Disability Inventory
Craniofacial pain and disability inventory will be used to evaluate TMD-related pain, neck pain, headache and ear pain. It consist of 21 items and each scored on a 4-point Likert-scale ranging from 0 ('no problem') to 3 ('maximum problem') score.
Measured: Baseline and 4 weeks after start of treatment
Graded chronic pain scale version 2.0
Graded chronic pain scale version 2.0 will be used to evaluate pain intensity and pain-related disability over the last 30 days. Chronic pain is graded from grade 1 (indicating low intensity pain-low disability) to grade 4 (indicating high disability-severly limiting).
Measured: Baseline and 4 weeks after start of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start10 Jul 2025
- Primary completion10 Jul 2026 (estimated)
- Study completion10 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Temporomandibular Disorders (TMD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Acibadem University
- Sponsor type
- University, hospital or other
- Collaborators
- Okan University Hospital
- Responsible party
- Principal investigator, Helin Yavuz, Acibadem University
- Investigators
- Helin Yavuz, Physiotherapist, Principal investigator, Acibadem University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07507734
- Sponsor's protocol ID
- AcibademU/2026-01/56
- Status last verified
- Mar 2026
- First submitted
- 27 Mar 2026
- Last updated
- 2 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Olivo SA, Fuentes J, Major PW, Warren S, Thie NM, Magee DJ. The association between neck disability and jaw disability. J Oral Rehabil. 2010 Sep;37(9):670-9. doi: 10.1111/j.1365-2842.2010.02098.x. Epub 2010 May 27.
PubMed 20524969Shimada A, Ishigaki S, Matsuka Y, Komiyama O, Torisu T, Oono Y, Sato H, Naganawa T, Mine A, Yamazaki Y, Okura K, Sakuma Y, Sasaki K. Effects of exercise therapy on painful temporomandibular disorders. J Oral Rehabil. 2019 May;46(5):475-481. doi: 10.1111/joor.12770. Epub 2019 Feb 19.
PubMed 30664815Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF; International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger. J Oral Facial Pain Headache. 2014 Winter;28(1):6-27. doi: 10.11607/jop.1151.
PubMed 24482784Mulet M, Decker KL, Look JO, Lenton PA, Schiffman EL. A randomized clinical trial assessing the efficacy of adding 6 x 6 exercises to self-care for the treatment of masticatory myofascial pain. J Orofac Pain. 2007 Fall;21(4):318-28.
PubMed 18018993Idanez-Robles AM, Obrero-Gaitan E, Lomas-Vega R, Osuna-Perez MC, Cortes-Perez I, Zagalaz-Anula N. Exercise therapy improves pain and mouth opening in temporomandibular disorders: A systematic review with meta-analysis. Clin Rehabil. 2023 Apr;37(4):443-461. doi: 10.1177/02692155221133523. Epub 2022 Oct 20.
PubMed 36263523
Study at a glance
From the registry record, last updated by the sponsor on 2 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Occlusal Splint and Exercise in Individuals With Temporomandibular Disorders
- ClinicalTrials.gov ID
- NCT07507734
- Acronym / sponsor ID
- AcibademU/2026-01/56
- Conditions
- Temporomandibular Disorders (TMD)
- Keywords
- temporomandibular disorders, exercise therapy, occlusal splint, muscle mechanical properties, pain, jaw function
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- Acibadem UniversityUniversity, hospital or other
- Collaborators
- Okan University Hospital
- Study start
- 10 Jul 2025 (actual)
- Primary completion
- 10 Jul 2026 (estimated)
- Study completion
- 10 Jul 2026 (estimated)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if an exercise protocol can improve temporomandibular pain, jaw function and muscle mechanical properties in individuals with Temporomandibular Disorders (TMD). This study focuses on patients who are already receiving occlusal splint therapy.
The main question it aims to answer is:
How does the addition of an exercise protocol to occlusal splint therapy affect temporomandibular pain, jaw function and muscle mechanical properties of the masticatory and neck muscles? Researchers will compare the group receiving both occlusal splint therapy and the exercise protocol to a group only occlusal splint therapy to see if the combined approach is more effective.
Participants will:
- Undergo an initial assessment of the Jaw Functional Limitation Scale-20 (JLFS-20), Craniofacial Pain and Disability Inventory (CF-PDI), Graded Chronic Pain Scale Version 2.0 (GCPS-2.0), jaw range of motion, pain pressure threshold and muscle mechanical properties.
- Receive occlusal splint therapy as a part of their treatment.
- Perform a structured exercise protocol (only 1 group)
- Attend follow up sessions at the 4th week to monitor changes in all initial assessment parameters.
Detailed description
This research will be conducted as a randomized controlled, two-arm, prospective clinical trial. The study will evaluate the effects of occlusal splint application combined with the Rocabado exercise protocol in individuals with TMD. The intervention period will last for 4 weeks, with assessments conducted at baseline and at the end of the 4 weeks period.
Literature indicates that occlusal splint therapy and specialized exercise protocols are beneficial in improving symptoms in individuals with temporomandibular disorders (TMD). Studies have demonstrated that these interventions can enhance functionality and alleviate pain. However, there is a lack of research specifically comparing the combination of an occlusal splint and an exercise protocol against splint therapy alone, particularly regarding their effects on pain, functionality, and the mechanical properties of the masticatory and neck muscles.
Participants diagnosed with TMD will be recruited from two clinics in Turkey. To prevent potential imbalances, participants will be divided into two groups using stratification (age, gender, and occupation) and block randomization:
- Splint Group (S Group): Will receive nightly occlusal splint therapy only.
- Exercise and Splint Group (ES Group): Will receive the Rocabado 6x6 exercise protocol in addition to nightly occlusal splint therapy.
In the ES group, the occlusal splint and Rocabado exercises (6 times daily, 6 repetitions each) will be performed 7 days a week for 4 weeks. The control (S) group will utilize only the occlusal splint for the same duration.
Evaluations will be performed at baseline and at the 4th week. Clinical assessments will include the Jaw Functional Limitation Scale-20 (JFLS-20), Craniofacial Pain and Disability Inventory (CF-PDI), and Graded Chronic Pain Scale (GCPS) 2.0. Additionally, temporomandibular joint range of motion (ROM), pressure pain threshold (PPT), and mechanical muscle properties (MyotonPRO) will be assessed.
Inclusion criteria
- Clinical and radiological diagnosis of TMD
- Being between 18-65 years of age,
- Presence of temporomansibular joint (TMJ) pain for the last 3 months. Exclusion criteria
- İntra-articular or degenerative joint disorders and subluxation requiring immediate treatment,
- A history of TMJ or cervical region surgery in the last 3 months,
- A history of treatment from related regions,
- The presence of rheumatic diseases, including TMJ diseases,
- TMJ instability or fracture,
- The presence of perception-cognition disorder,
- The presence of chronic pain, such as trigeminal neuralgia.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Splint Group (S Group) | Active comparator | Device: Occlusal SplintS Group will receive nightly occlusal splint therapy only. |
| Exercise and Splint Group (ES Group) | Experimental | Device: Occlusal Splint, Behavioral: ExerciseES Group will receive the Rocabado exercise protocol in addition to nightly occlusal splint therapy. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Clinical and radiological diagnosis of TMD
- Being between 18-65 years of age
- Presence of Temporomandibular Joint (TMJ) pain for the last 3 months.
Key exclusion criteria (7 listed)
- Intra-articular or degenerative joint disorders and subluxation requiring immediate treatment,
- A history of TMJ or cervical region surgery in the last 3 months,
- A history of treatment from related regions,
- The presence of rheumatic diseases, including TMJ diseases,
- TMJ instability or fracture,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Occlusal SplintParticipants will be provided with custom-made hard acrylic occlusal splints. They will be instructed to wear the appliance every night during sleep for a period of four consecutive weeks. A licensed dentist will manage the delivery and occlusal adjustment of the splints to ensure they were correctly seated and well-tolerated by the subjects. Both groups will receive a occlusal splint to be worn every night. | Device | Exercise and Splint Group (ES Group), Splint Group (S Group) |
| ExerciseAlso: Rocabado ExercisesParticipants will perform the Rocabado 6x6 exercise protocol, which consists of six specific movements designed to restore proper tongue position, improve jaw mobility, and stabilize the craniomandibular relationship. Each exercise will be performed 6 times per session, 6 times a day. The protocol includes: Rest position of the tongue, shoulder posture, stabilized head flexion, axial extension of the neck, control of TMJ rotation and rhythmic stabilization technique. The program consists of performing 6 specific exercises, 6 times per day with 6 repetitions each, for 4 weeks. | Behavioural | Exercise and Splint Group (ES Group) |
Primary outcome
Jaw Range of Motion
Time frame: Baseline and 4 weeks after start of treatment
Pain-free opening, maximum unassisted opening, maximum assisted opening, lateral and protrusive movements will be mesured by a ruler. All measurements will be noted in milimeters between the incisal edges of upper and lower central incisors. The average of the 3 repetitions will be taken.
Pain Pressure Threshold
Time frame: Baseline and 4 weeks after start of treatment
PPT will be evaluated using a digital algometer. After positioning the algometer's rubbet tip pressure will be applied gradually. Measurements will be taken from the belly of the muscles (bilaterally for the masseter, temporalis, sternocleidomastoid and trapezius). The measurements will be made in three repetitions and the average will be noted in kg/cm2.
Muscle Mechanical Properties
Time frame: Baseline and 4 weeks after start of treatment
Muscle mechanical properties will be evaluated by the MyotonPRO (Myoton AS, Tallinn, Estonia) device. Device will perform 5 measurements by 15-seconds intervals and the mean values will be recorded. Measurements will be taken from the belly of the muscles (bilaterally masseter, temporalis, sternocleidomastoid and trapezius).
3 secondary outcomes
Jaw functional limitation scale - 20
Time frame: Baseline and 4 weeks after start of treatment
Craniofacial Pain and Disability Inventory
Time frame: Baseline and 4 weeks after start of treatment
Graded chronic pain scale version 2.0
Time frame: Baseline and 4 weeks after start of treatment
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Apr 2026.
- Results publication: PubMed 20524969Olivo SA, Fuentes J, Major PW, Warren S, Thie NM, Magee DJ. The association between neck disability and jaw disability. J Oral Rehabil. 2010 Sep;37(9):670-9. doi: 10.1111/j.1365-2842.2010.02098.x. Epub 2010 May 27.
- Results publication: PubMed 30664815Shimada A, Ishigaki S, Matsuka Y, Komiyama O, Torisu T, Oono Y, Sato H, Naganawa T, Mine A, Yamazaki Y, Okura K, Sakuma Y, Sasaki K. Effects of exercise therapy on painful temporomandibular disorders. J Oral Rehabil. 2019 May;46(5):475-481. doi: 10.1111/joor.12770. Epub 2019 Feb 19.
- Results publication: PubMed 24482784Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, List T, Svensson P, Gonzalez Y, Lobbezoo F, Michelotti A, Brooks SL, Ceusters W, Drangsholt M, Ettlin D, Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF; International RDC/TMD Consortium Network, International association for Dental Research; Orofacial Pain Special Interest Group, International Association for the Study of Pain. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger. J Oral Facial Pain Headache. 2014 Winter;28(1):6-27. doi: 10.11607/jop.1151.
- Results publication: PubMed 18018993Mulet M, Decker KL, Look JO, Lenton PA, Schiffman EL. A randomized clinical trial assessing the efficacy of adding 6 x 6 exercises to self-care for the treatment of masticatory myofascial pain. J Orofac Pain. 2007 Fall;21(4):318-28.
- Results publication: PubMed 36263523Idanez-Robles AM, Obrero-Gaitan E, Lomas-Vega R, Osuna-Perez MC, Cortes-Perez I, Zagalaz-Anula N. Exercise therapy improves pain and mouth opening in temporomandibular disorders: A systematic review with meta-analysis. Clin Rehabil. 2023 Apr;37(4):443-461. doi: 10.1177/02692155221133523. Epub 2022 Oct 20.
- Individual participant dataSharing planned: Undecided
Related trials for Temporomandibular Disorders (TMD)
Recruiting
R01_Pilot Jaw Muscle Phenotypes
Chronic TMD Pain, Temporomandibular Disorder
Recruiting
Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome
Myofacial Pain, Myofacial Pain Syndrome
Recruiting
Clinical and Electromyographic Assessment of Occlusal Splint Therapy
Temporomandibular Joint Disorders
Recruiting
An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders
Temporomandibular Disorder, Orofacial Pain
Recruiting
Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders
Temporomandibular Disorders (TMD), TMJ Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Sema Savcı, Professor contact
Helin Yavuz, Physiotherapist principal investigator
Acibadem University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Occlusal Splint and Exercise in people with Temporomandibular Disorders (TMD), run by Acibadem University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 2 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Helin Yavuz, Physiotherapist (+905312281673, Helin.Yavuz1@live.acibadem.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Jaw Range of Motion (time frame: Baseline and 4 weeks after start of treatment). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07507734, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Apr 2026.