End Stage Cronic Kidney DiseaseNCT07507981
Effects of Exercise in Hemodialysis
A study testing Intradialytic aerobic exercise program in people with End Stage Cronic Kidney Disease and Hemodialysis, run by Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran at 1 site in Mexico.
Trial summary
Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- End Stage Cronic Kidney Disease, Hemodialysis
- What is being tested?
- Intradialytic aerobic exercise program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteMexico
- Study dates
- 1 May 2025to 15 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged ≥18 years
- Receiving hemodialysis with a stable prescription for at least 3 months
- At their prescribed dry weight
- Provision of written informed consent
Who cannot join
- Active cardiovascular disease within the past 3 months
- Left ventricular ejection fraction <40%
- Physical and/or cognitive impairment precluding exercise
- Blood pressure >160/110 mmHg
Trial locations and contacts
1 site in 1 country.
Mexico1 site
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, 14080
About this study
Official title: Effects of an Intradialytic Aerobic Exercise Program on Echocardiographic Findings in Patients With End-Stage Chronic Kidney Disease on Hemodialysis
Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis.
Materials and Methods Design: Open-label, single-center, quasi-experimental, single-group study with pre- and post-intervention measurements.
Read more
Study setting: the outpatient hemodialysis unit of the National Institute of Medical Sciences and Nutrition Salvador Zubirán.
Participants: Patients aged ≥18 years with chronic kidney disease on hemodialysis for at least three months, who are at their dry weight.
Procedures: An echocardiogram will be performed post-hemodialysis. Subsequently, patients will undergo a 30-minute intradialytic aerobic exercise program at submaximal intensity during the second hour of dialysis, three times per week for six months. At the end of the six-month period, a post-hemodialysis echocardiogram will be repeated.
- Conditions
- End Stage Cronic Kidney Disease, Hemodialysis
- Being tested
- Intradialytic aerobic exercise program
- Keywords
- Intradialytic Exercise, Hemodialysis, End Stage Cronic Kidney Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Intradialytic aerobic exercise programOther
A six-month intradialytic aerobic exercise program consisting of 30-minute sessions at submaximal intensity, performed during the second hour of hemodialysis three times per week.
| Study group | Role | What they receive |
|---|---|---|
| Patients on hemodialysis who will perform intradialytic aerobic exercise | Experimental | Patients on hemodialysis who will perform intradialytic aerobic exercise for six months Receives: Other: Intradialytic aerobic exercise program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Left ventricular ejection fraction
Left ventricular ejection fraction measured by transthoracic echocardiogram
Measured: From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Apr 2026
- Study start1 May 2025
- Primary completion28 Feb 2026
- Study completion15 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for End Stage Cronic Kidney DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Olynka Vega, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07507981
- Sponsor's protocol ID
- NMM-5123-24-25-1
- Status last verified
- May 2025
- First submitted
- 23 Mar 2026
- Last updated
- 2 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared in order to protect patient privacy and confidentiality and to comply with institutional and ethical regulations.
Study at a glance
From the registry record, last updated by the sponsor on 2 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of an Intradialytic Aerobic Exercise Program on Echocardiographic Findings in Patients With End-Stage Chronic Kidney Disease on Hemodialysis
- ClinicalTrials.gov ID
- NCT07507981
- Acronym / sponsor ID
- NMM-5123-24-25-1
- Conditions
- End Stage Cronic Kidney Disease, Hemodialysis
- Keywords
- Intradialytic Exercise, Hemodialysis, End Stage Cronic Kidney Disease
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 28 Feb 2026 (actual)
- Study completion
- 15 Mar 2026 (actual)
- First posted
- 2 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis.
Materials and Methods Design: Open-label, single-center, quasi-experimental, single-group study with pre- and post-intervention measurements.
Study setting: the outpatient hemodialysis unit of the National Institute of Medical Sciences and Nutrition Salvador Zubirán.
Participants: Patients aged ≥18 years with chronic kidney disease on hemodialysis for at least three months, who are at their dry weight.
Procedures: An echocardiogram will be performed post-hemodialysis. Subsequently, patients will undergo a 30-minute intradialytic aerobic exercise program at submaximal intensity during the second hour of dialysis, three times per week for six months. At the end of the six-month period, a post-hemodialysis echocardiogram will be repeated.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients on hemodialysis who will perform intradialytic aerobic exercise | Experimental | Other: Intradialytic aerobic exercise programPatients on hemodialysis who will perform intradialytic aerobic exercise for six months |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adults aged ≥18 years
- Receiving hemodialysis with a stable prescription for at least 3 months
- At their prescribed dry weight
- Provision of written informed consent
Key exclusion criteria (4 listed)
- Active cardiovascular disease within the past 3 months
- Left ventricular ejection fraction <40%
- Physical and/or cognitive impairment precluding exercise
- Blood pressure >160/110 mmHg
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Intradialytic aerobic exercise programA six-month intradialytic aerobic exercise program consisting of 30-minute sessions at submaximal intensity, performed during the second hour of hemodialysis three times per week. | Other | Patients on hemodialysis who will perform intradialytic aerobic exercise |
Primary outcome
Left ventricular ejection fraction
Time frame: From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter
Left ventricular ejection fraction measured by transthoracic echocardiogram
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Apr 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared in order to protect patient privacy and confidentiality and to comply with institutional and ethical regulations.
Related trials for End Stage Cronic Kidney Disease
RecruitingPhase 1/2
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Kidney Failure, Chronic, Kidney Transplantation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Intradialytic aerobic exercise program in people with End Stage Cronic Kidney Disease and Hemodialysis, run by Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran at 1 site in Mexico.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Mexico. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Left ventricular ejection fraction (time frame: From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Apr 2026.