Post-induction Hypotension (PIH)NCT07509255
Echocardiography-derived Pre-induction Hemodynamic Phenotypes and Post-induction Hypotension: an Exploratory Clustering Analysis
An observational study of Post-induction Hypotension (PIH), run by Avicenna Military Hospital at 1 site in Morocco.
Trial summary
This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes. Read more about this study
- Who is it for?
- Ages 50 years and older
- Conditions the study is for
- Post-induction Hypotension (PIH)
- How many people
- 64 participants
- Where
- 1 siteMorocco
- Study dates
- 1 Feb 2020to 30 Mar 2020
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients aged over 50 years scheduled for elective abdominal surgery under general anesthesia.
Who may be able to join
- Patients scheduled for elective abdominal surgery under genral anesthesia.
Who cannot join
- patients with dyspnoea
- unstable angina,
- severe valvular heart disease
- anticipated or unanticipated difficult airway management
- suspected increased intra-abdominal pressure
- poor echogenicity.
Trial locations and contacts
1 site in 1 country.
Morocco1 site
Cadi Ayyad University . Avicenna Military Hospital
Marrakesh, Marrakech, 10000
About this study
This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes.
Using previously collected clinical and echocardiographic data, the study explored the relationship between pre-induction hemodynamic status and the risk of developing PIH.
The findings may help improve preoperative risk stratification and support more individualized perioperative hemodynamic management.
Read the detailed description
Post-induction hypotension (PIH) was recognized as a common and clinically significant complication associated with adverse perioperative outcomes. This study was conducted as a retrospective analysis of prospectively collected data from adult patients undergoing elective surgery under general anesthesia.
The objective was to evaluate whether pre-induction hemodynamic status, assessed using echocardiographic parameters and routine clinical variables, was associated with the occurrence and timing of PIH. The analysis focused on identifying distinct hemodynamic profiles reflecting underlying cardiovascular physiology.
Unsupervised clustering (k-means) was applied to pre-induction variables to identify phenotypes, and principal component analysis was used to explore variable contributions. Latent profile analysis was performed as a sensitivity analysis. The association between phenotypes and PIH was assessed using time-to-event analysis.
No additional interventions were performed, and patient management was not influenced by the study. All analyses were conducted on anonymized data.
This study aimed to improve the understanding of variability in hemodynamic responses to anesthesia induction and to support future strategies for individualized perioperative care.
- Conditions
- Post-induction Hypotension (PIH)
- Keywords
- General anaesthesia, Transthoracic echocardiography, Post-induction hypotension, Hemodynamic phenotypes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Overall Study Cohort | Adult patients undergoing elective surgery under general anesthesia included in a retrospective analysis of prospectively collected data. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pre-induction hemodynamic phenotype classification
Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.
Measured: pre-induction, before administration of general anesthesia: from admission to the operating to induction of general anesthesia
Pre-induction hemodynamic phenotype classification
Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.
Measured: Baseline (pre-induction, before administration of general anesthesia)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2026
- Study start1 Feb 2020
- Primary completion30 Mar 2020
- Study completion30 Mar 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Post-induction Hypotension (PIH)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 64 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Avicenna Military Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Younes Aissaoui, MD, Avicenna Military Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07509255
- Sponsor's protocol ID
- PIH-Hemo-Phenotypes
- Status last verified
- Apr 2026
- First submitted
- 28 Mar 2026
- Last updated
- 8 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data (including clinical and echocardiographic variables underlying the reported results) will be made available upon reasonable request from qualified healthcare providers or researchers. Data sharing will be subject to approval by the study investigators and compliance with institutional and ethical regulations. Requests must include a methodologically sound proposal and will be evaluated to ensure appropriate use of the data.
Publications
Aissaoui Y, Jozwiak M, Bahi M, Belhadj A, Alaoui H, Qamous Y, Serghini I, Seddiki R. Prediction of post-induction hypotension by point-of-care echocardiography: A prospective observational study. Anaesth Crit Care Pain Med. 2022 Aug;41(4):101090. doi: 10.1016/j.accpm.2022.101090. Epub 2022 May 1.
PubMed 35508291
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Echocardiography-derived Pre-induction Hemodynamic Phenotypes and Post-induction Hypotension: an Exploratory Clustering Analysis
- ClinicalTrials.gov ID
- NCT07509255
- Acronym / sponsor ID
- PIH-Hemo-Phenotypes
- Conditions
- Post-induction Hypotension (PIH)
- Keywords
- General anaesthesia, Transthoracic echocardiography, Post-induction hypotension, Hemodynamic phenotypes
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 64 participants (actual)
- Lead sponsor
- Avicenna Military HospitalUniversity, hospital or other
- Study start
- 1 Feb 2020 (actual)
- Primary completion
- 30 Mar 2020 (actual)
- Study completion
- 30 Mar 2020 (actual)
- First posted
- 3 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated the occurrence of post-induction hypotension (PIH) in patients undergoing elective surgery under general anesthesia. PIH is a common perioperative complication associated with adverse outcomes.
Using previously collected clinical and echocardiographic data, the study explored the relationship between pre-induction hemodynamic status and the risk of developing PIH.
The findings may help improve preoperative risk stratification and support more individualized perioperative hemodynamic management.
Detailed description
Post-induction hypotension (PIH) was recognized as a common and clinically significant complication associated with adverse perioperative outcomes. This study was conducted as a retrospective analysis of prospectively collected data from adult patients undergoing elective surgery under general anesthesia.
The objective was to evaluate whether pre-induction hemodynamic status, assessed using echocardiographic parameters and routine clinical variables, was associated with the occurrence and timing of PIH. The analysis focused on identifying distinct hemodynamic profiles reflecting underlying cardiovascular physiology.
Unsupervised clustering (k-means) was applied to pre-induction variables to identify phenotypes, and principal component analysis was used to explore variable contributions. Latent profile analysis was performed as a sensitivity analysis. The association between phenotypes and PIH was assessed using time-to-event analysis.
No additional interventions were performed, and patient management was not influenced by the study. All analyses were conducted on anonymized data.
This study aimed to improve the understanding of variability in hemodynamic responses to anesthesia induction and to support future strategies for individualized perioperative care.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Overall Study Cohort | – | –Adult patients undergoing elective surgery under general anesthesia included in a retrospective analysis of prospectively collected data. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients aged over 50 years scheduled for elective abdominal surgery under general anesthesia.
Key inclusion criteria (1 listed)
- Patients scheduled for elective abdominal surgery under genral anesthesia.
Key exclusion criteria (6 listed)
- patients with dyspnoea
- unstable angina,
- severe valvular heart disease
- anticipated or unanticipated difficult airway management
- suspected increased intra-abdominal pressure
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Pre-induction hemodynamic phenotype classification
Time frame: pre-induction, before administration of general anesthesia: from admission to the operating to induction of general anesthesia
Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.
Pre-induction hemodynamic phenotype classification
Time frame: Baseline (pre-induction, before administration of general anesthesia)
Pre-induction hemodynamic phenotypes were derived using unsupervised clustering of clinical and echocardiographic variables obtained prior to anesthesia induction.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Results publication: PubMed 35508291Aissaoui Y, Jozwiak M, Bahi M, Belhadj A, Alaoui H, Qamous Y, Serghini I, Seddiki R. Prediction of post-induction hypotension by point-of-care echocardiography: A prospective observational study. Anaesth Crit Care Pain Med. 2022 Aug;41(4):101090. doi: 10.1016/j.accpm.2022.101090. Epub 2022 May 1.
- Individual participant dataSharing planned: Yes. De-identified individual participant data (including clinical and echocardiographic variables underlying the reported results) will be made available upon reasonable request from qualified healthcare providers or researchers. Data sharing will be subject to approval by the study investigators and compliance with institutional and ethical regulations. Requests must include a methodologically sound proposal and will be evaluated to ensure appropriate use of the data.
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Anesthesia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Post-induction Hypotension (PIH), run by Avicenna Military Hospital at 1 site in Morocco.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Morocco. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pre-induction hemodynamic phenotype classification (time frame: pre-induction, before administration of general anesthesia: from admission to the operating to induction of general anesthesia). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07509255, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.