StrokeNCT07509944
A Functional Near- Infrared Spectroscopy Study on the Brain Activation Characteristics of Stroke Patients During Mirror Movement
An observational study of Stroke and Upper Limb Function, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
Trial summary
After the selected patients are determined, the researchers of this study need to have full communication with the patients. The location is the rehabilitation ward of our hospital and the time is Before joining the group. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Stroke, Upper Limb Function
- What is being tested?
- mirror image and healthy hand movement
- Type of treatment
- Medical device, Lifestyle or therapy programme
- How many people
- 25 participants
- Where
- 1 siteChina
- Study dates
- 1 May 2024to 1 Oct 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The main population of this study consists of individuals aged between 30 and 80 years old who have experienced a stroke for the first time and have residual upper limb dysfunction. There is no limit to the age range.
Who may be able to join
- It meets the diagnostic criteria of the "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China", and is diagnosed as cerebral infarction or cerebral hemorrhage by CT or MRI.
- The first stroke occurred;
- The muscle strength of the flexor and extensor muscles of the affected finger is ≤ grade 1.
- Right-handed player
- Muscle tone improvement: Asworth level 2 or below;
- The disease course is within 6 months and the condition is stable.
- Age: 18 to 75 years old, with normal vision and hearing or corrected to normal.
Who cannot join
- Those with an MMSE score less than 20, severe memory, communication and speech command comprehension disorders, and those who cannot cooperate with examinations and treatments;
- Those with a history of epilepsy;
- Those with a history of stroke, traumatic brain injury or brain tumor in the past;
- Those with peripheral nervous system injuries other than stroke as diagnosed by imaging;
- Those with visual spatial impairments such as visual field defects and unilateral neglect;
- Skull defect or metal bone plates
Show all 9Show fewer
- For those who are not suitable for functional near-infrared examination;
- Those with a history of intracranial surgery.
- Patients with lesion areas in the cerebellum or brainstem.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou
Jiasheng Zhu, 15157177433, zhujiasheng321@sina.com
Yifei Xia, 19816890266, 2523084@zju.edu.cn
About this study
After the selected patients are determined, the researchers of this study need to have full communication with the patients. The location is the rehabilitation ward of our hospital and the time is
Before joining the group. During this process, the patient should be informed of the purpose, procedures and processes of the trial. The informed consent form should be signed by the patient himself/herself. Such as the patient
Illiterate, the informed consent process was witnessed by an independent witness and signed. The subject pressed their fingerprint at the signature. In the study process fully
Listen to and respond to the questions and opinions of the subjects or their representatives.
- Conditions
- Stroke, Upper Limb Function
- Being tested
- mirror image, healthy hand movement
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
mirror imageDevice
Patients will be asked to place the affected hand in the mirror box. While quickly opening and closing the healthy hand, they should observe the reflection of the healthy hand in the mirror and imagine the affected hand doing the same movements.
healthy hand movementBehavioural
Patient will be asked to quickly open and grasp the healthy hand, and keep their eyes on the affected hand.
| Study group | Role | What they receive |
|---|---|---|
| normal hand movement | Not described Receives: Behavioral: healthy hand movement | |
| mirror hand movement | Not described Receives: Device: mirror image |
What is being measured
The primary outcome is the main question the study is designed to answer.
fNIRS measured brain activation
Measured: The measurement of the primary outcome indicators occurred after the patients had received one week of hand function rehabilitation training.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2026
- Study start1 May 2024
- Primary completion1 May 2030 (estimated)
- Study completion1 Oct 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 25 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07509944
- Sponsor's protocol ID
- yan-2025-0018
- Status last verified
- Mar 2026
- First submitted
- 6 May 2025
- Last updated
- 3 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Functional Near- Infrared Spectroscopy Study on the Brain Activation Characteristics of Stroke Patients During Mirror Movement
- ClinicalTrials.gov ID
- NCT07509944
- Acronym / sponsor ID
- yan-2025-0018
- Conditions
- Stroke, Upper Limb Function
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 25 participants (estimated)
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of MedicineUniversity, hospital or other
- Study start
- 1 May 2024 (actual)
- Primary completion
- 1 May 2030 (estimated)
- Study completion
- 1 Oct 2030 (estimated)
- First posted
- 3 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
After the selected patients are determined, the researchers of this study need to have full communication with the patients. The location is the rehabilitation ward of our hospital and the time is
Before joining the group. During this process, the patient should be informed of the purpose, procedures and processes of the trial. The informed consent form should be signed by the patient himself/herself. Such as the patient
Illiterate, the informed consent process was witnessed by an independent witness and signed. The subject pressed their fingerprint at the signature. In the study process fully
Listen to and respond to the questions and opinions of the subjects or their representatives.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| normal hand movement | – | Behavioral: healthy hand movement |
| mirror hand movement | – | Device: mirror image |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The main population of this study consists of individuals aged between 30 and 80 years old who have experienced a stroke for the first time and have residual upper limb dysfunction. There is no limit to the age range.
Key inclusion criteria (7 listed)
- It meets the diagnostic criteria of the "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China", and is diagnosed as cerebral infarction or cerebral hemorrhage by CT or MRI.
- The first stroke occurred;
- The muscle strength of the flexor and extensor muscles of the affected finger is ≤ grade 1.
- Right-handed player
- Muscle tone improvement: Asworth level 2 or below;
Key exclusion criteria (9 listed)
- Those with an MMSE score less than 20, severe memory, communication and speech command comprehension disorders, and those who cannot cooperate with examinations and treatments;
- Those with a history of epilepsy;
- Those with a history of stroke, traumatic brain injury or brain tumor in the past;
- Those with peripheral nervous system injuries other than stroke as diagnosed by imaging;
- Those with visual spatial impairments such as visual field defects and unilateral neglect;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| mirror imagePatients will be asked to place the affected hand in the mirror box. While quickly opening and closing the healthy hand, they should observe the reflection of the healthy hand in the mirror and imagine the affected hand doing the same movements. | Device | mirror hand movement |
| healthy hand movementPatient will be asked to quickly open and grasp the healthy hand, and keep their eyes on the affected hand. | Behavioural | normal hand movement |
Primary outcome
fNIRS measured brain activation
Time frame: The measurement of the primary outcome indicators occurred after the patients had received one week of hand function rehabilitation training.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke and Upper Limb Function, run by Second Affiliated Hospital, Zhejiang University, School of Medicine at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jiasheng Zhu, Bachelor's (+86 15157177433, zhujiasheng321@sina.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
fNIRS measured brain activation (time frame: The measurement of the primary outcome indicators occurred after the patients had received one week of hand function rehabilitation training.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2026.