Hot ClimateNCT07510022
Hot Climate on Bleeding Tendency After Cardiac Surgery in Egyptian Patients
An observational study of Hot Climate and Bleeding Tendency, run by Al-Azhar University at 1 site in Egypt.
Trial summary
This work aimed to assess the effect of regional climatic differences on postoperative bleeding in Egyptian patients undergoing cardiac surgery with cardiopulmonary bypass, by comparing outcomes between patients from hot climate zones (Upper Egypt) and those from moderate climate zones (Lower Egypt). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Hot Climate, Bleeding Tendency, Cardiac Surgery
- What is being tested?
- Open heart surgery
- Type of treatment
- Surgery or procedure
- How many people
- 400 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jun 2023to 1 Jun 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: This retrospective observational study involved 400 Egyptian patients, comprising both sexes, aged≥ 18 years, underwent open-heart surgery with cardiopulmonary bypass. This research took place over a two-year period between June 2023 and June 2025, following approval from the ethical committee of Al-Azhar University Hospitals.
Who may be able to join
- Age ≥18 years.
- Both sexes.
- Egyptian nationality.
- Underwent open-heart surgery with cardiopulmonary bypass.
- Complete medical records and postoperative bleeding data are available.
Who cannot join
- Emergency surgeries
- Pre-existing coagulopathy
- Use of anticoagulants not discontinued prior to surgery
- Re-do surgeries
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of Hot Climate on Bleeding Tendency After Cardiac Surgery in Egyptian Patients
This work aimed to assess the effect of regional climatic differences on postoperative bleeding in Egyptian patients undergoing cardiac surgery with cardiopulmonary bypass, by comparing outcomes between patients from hot climate zones (Upper Egypt) and those from moderate climate zones (Lower Egypt).
Read the detailed description
Egypt experiences extremely high ambient temperatures, especially during the summer months, with daily highs frequently exceeding 40°C. Such climatic extremes can influence physiological homeostasis in surgical patients by altering fluid balance, cardiovascular strain, and hemostatic function.
Seasonal and climatic variations have been linked to changes in cardiovascular surgical outcomes, including mortality, length of stay, and complication rates. Several large observational studies have noted increased bleeding or transfusion requirements in surgeries performed under certain environmental conditions, though findings remain inconsistent.
- Conditions
- Hot Climate, Bleeding Tendency, Cardiac Surgery, Egyptian Patients
- Being tested
- Open heart surgery
- Medical subject headings
- Hemostatic Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Open heart surgeryProcedure or surgery
Patients who underwent open heart surgery with cardiopulmonary bypass.
| Study group | Role | What they receive |
|---|---|---|
| Group A (Hot Climate Group) | Included patients from Upper Egypt. Receives: Procedure: Open heart surgery | |
| Group B (Moderate/Cold Climate Group) | Included patients from Lower Egypt. Receives: Procedure: Open heart surgery |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of mortality
Incidence of mortality was recorded.
Measured: 24 hours postoperatively
Secondary outcomes (2)
Incidence of morbidity
Incidence of morbidity was recorded.
Measured: 24 hours postoperatively
Postoperative bleeding volume
Total postoperative bleeding volume within the first 24 hours after surgery, measured by cumulative chest tube drainage.
Measured: 24 hours postoperatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Apr 2026
- Study start1 Jun 2023
- Primary completion1 Jun 2025
- Study completion1 Jun 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hot ClimateStudies of the same condition, open and under way.
- More trials run by Al-Azhar UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 400 participants (actual)
Sponsor and investigators
- Lead sponsor
- Al-Azhar University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abdallah Sami Mahmoud, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07510022
- Sponsor's protocol ID
- 12/2025
- Status last verified
- Mar 2026
- First submitted
- 28 Mar 2026
- Last updated
- 3 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Hot Climate on Bleeding Tendency After Cardiac Surgery in Egyptian Patients
- ClinicalTrials.gov ID
- NCT07510022
- Acronym / sponsor ID
- 12/2025
- Conditions
- Hot Climate, Bleeding Tendency, Cardiac Surgery, Egyptian Patients
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 400 participants (actual)
- Lead sponsor
- Al-Azhar UniversityUniversity, hospital or other
- Study start
- 1 Jun 2023 (actual)
- Primary completion
- 1 Jun 2025 (actual)
- Study completion
- 1 Jun 2025 (actual)
- First posted
- 3 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This work aimed to assess the effect of regional climatic differences on postoperative bleeding in Egyptian patients undergoing cardiac surgery with cardiopulmonary bypass, by comparing outcomes between patients from hot climate zones (Upper Egypt) and those from moderate climate zones (Lower Egypt).
Detailed description
Egypt experiences extremely high ambient temperatures, especially during the summer months, with daily highs frequently exceeding 40°C. Such climatic extremes can influence physiological homeostasis in surgical patients by altering fluid balance, cardiovascular strain, and hemostatic function.
Seasonal and climatic variations have been linked to changes in cardiovascular surgical outcomes, including mortality, length of stay, and complication rates. Several large observational studies have noted increased bleeding or transfusion requirements in surgeries performed under certain environmental conditions, though findings remain inconsistent.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A (Hot Climate Group) | – | Procedure: Open heart surgeryIncluded patients from Upper Egypt. |
| Group B (Moderate/Cold Climate Group) | – | Procedure: Open heart surgeryIncluded patients from Lower Egypt. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- This retrospective observational study involved 400 Egyptian patients, comprising both sexes, aged≥ 18 years, underwent open-heart surgery with cardiopulmonary bypass. This research took place over a two-year period between June 2023 and June 2025, following approval from the ethical committee of Al-Azhar University Hospitals.
Key inclusion criteria (5 listed)
- Age ≥18 years.
- Both sexes.
- Egyptian nationality.
- Underwent open-heart surgery with cardiopulmonary bypass.
- Complete medical records and postoperative bleeding data are available.
Key exclusion criteria (4 listed)
- Emergency surgeries
- Pre-existing coagulopathy
- Use of anticoagulants not discontinued prior to surgery
- Re-do surgeries
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Open heart surgeryPatients who underwent open heart surgery with cardiopulmonary bypass. | Procedure or surgery | Group A (Hot Climate Group), Group B (Moderate/Cold Climate Group) |
Primary outcome
Incidence of mortality
Time frame: 24 hours postoperatively
Incidence of mortality was recorded.
2 secondary outcomes
Incidence of morbidity
Time frame: 24 hours postoperatively
Postoperative bleeding volume
Time frame: 24 hours postoperatively.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2026.
- Individual participant dataSharing planned: Yes. The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Related trials for Hot Climate
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hot Climate and Bleeding Tendency, run by Al-Azhar University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of mortality (time frame: 24 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2026.