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Developmental Language DisorderNCT07510854

Sentence Prediction in Developmental Language Disorder

A study testing Thematic role and Sentence complexity in people with Developmental Language Disorder, run by Father Flanagan's Boys' Home at 1 site in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Millions of children - 7-12% of the school-age population - have developmental language disorder (DLD), a disorder that affects language learning, comprehension, and use. These children have difficulty with sentence production and comprehension at every stage of their development. Read more about this study

Who is it for?
Ages 5 to 7 yearsHealthy volunteers can take part
Conditions the study is for
Developmental Language Disorder
What is being tested?
Thematic role and Sentence complexity
Could I receive a placebo?
No, everyone receives an active treatment
How many people
80 participants
Where
1 siteUnited States
Study dates
16 Feb 2026to Jul 2028
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 5 to 7 years
  • All sexes
  • Healthy volunteers accepted
  • Child

Who may be able to join

  • Pass a hearing screening at 25dB at 0.5, 1, 2, and 4 kHz
  • Have normal or corrected-to-normal vision
  • Have no history of neurological disorders
  • For DLD group, Test of Narrative Language 2 (TNL-2) score less than 92
  • For TD group, TNL-2 score greater than 92, a cut-off that provides excellent sensitivity/specificity (.92/.92).

Who cannot join

  • Scores in the Autism range on the Childhood Autism Rating Scale 2 (CARS-2)
  • Scores below 75 on the Visual Spatial Index of the Wechsler Preschool and Primary Scale of Intelligence 4 (WPPSI-IV)

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Justin Kueser, PhD contact

531-355-5035

justin.kueser@boystown.org

Emma Kate Thome, PhD contact

531-355-5695

emmakate.thome@boystown.org

United States1 site, 1 recruiting
  • Boys Town National Research Hospital

    Omaha, Nebraska, 68131

    Justin Kueser, PhD, 531-355-5035, justin.kueser@boystown.org

    Emma Kate Thome, PhD, 531-355-5695, emmakate.thome@boystown.org

    Recruiting

Other trials in United States

About this study

Millions of children - 7-12% of the school-age population - have developmental language disorder (DLD), a disorder that affects language learning, comprehension, and use. These children have difficulty with sentence production and comprehension at every stage of their development. These difficulties have major implications for the educational attainment of children with DLD compared to children with typical development (TD). Children with TD and adults make rapid predictions of upcoming words following verbs (e.g., predicting the patient in The dog eats the bone or the agent in The bone is eaten by the dog). Extensive work in children and adults indicates that prediction facilitates sentence comprehension by inducing a state of preparedness and contributes to language development by tuning the language system to the input. Children with DLD have a poorer ability to make sentence predictions, which may compound and result in sentence-comprehension deficits. Prior work on prediction deficits in DLD has focused on broad sentence characteristics like typicality or broad participant characteristics like vocabulary test scores. However, studies with typical individuals have identified more specific sentence- and participant-level contributors to sentence prediction. These factors have not been systematically explored in children with DLD. The investigators explore three separate hypotheses concerning factors that affect prediction in DLD. First, sentence- and participant-level properties affect prediction in children with DLD. Second, children with DLD lack robust representations of the underlying linguistic knowledge needed to predict, particularly abstract semantic features. Third, children with DLD have differences in event processing that relate to sentence prediction skill. The investigators investigate these hypotheses in 5-7-year-old school-age children with DLD across three Aims. Aim 1: Measure the effect of sentence- and participant-level properties on sentence prediction. The investigators will measure two participant-level cognitive factors (processing speed, verbal working memory) and their effect on prediction of agents and patients in sentences varying across two properties (syntactic complexity, semantic competition). Aim 2: Measure linguistic knowledge that underlies sentence prediction. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-<round object>). Aim 3: Measure event-processing skills that underlie sentence prediction. The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes. Impact: This project has the promise to be highly impactful. First, it bridges disparate literatures on language processing in adults, children with TD, and children with DLD, providing clarity about predictive processing in DLD. Second, it may influence intervention approaches by identifying areas of strength and need in children with DLD. Third, it sets the stage for larger-scale longitudinal work examining effects of early prediction ability, language knowledge, and event processing on later sentence comprehension.

Being tested
Thematic role, Sentence complexity
Medical subject headings
Language Development Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Thematic roleBehavioural

    The thematic role assessed for some trials will be the agent thematic role (i.e., the actor) and the thematic role assessed for the other trials will be the patient thematic role (i.e., the undergoer).

  • Sentence complexityBehavioural

    In half of the sentences, complexity will be simple (i.e., in simple active or passive sentences with no intervening linguistic material between the verb and the noun-to-be-predicted). In the other half of the sentences, complexity will be complex (i.e., additional linguistic material will intervene between the verb and the noun-to-be-predicted).

Study groups in NCT07510854
Study groupRoleWhat they receive
Measure verb knowledge, sentence processing, and event processingExperimentalThe investigators will measure participant-level cognitive factors and their effect on prediction of agents and patients in sentences varying across syntactic complexity and semantic competition. The investigators will measure knowledge of agent-verb and verb-patient cooccurrences (e.g., dog-bite, eat-apple) and knowledge of verb-specific semantic features (e.g., throw-<round object>). The investigators will measure how children with DLD categorize and attend to agents/patients in visual scenes.
Receives: Behavioral: Thematic role; Behavioral: Sentence complexity

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Behavioral response data

    For verb knowledge tasks, the investigators will measure children's button presses for accuracy.

    Measured: During sessions for verb knowledge tasks

  2. Eye tracking gaze data

    During sentence processing and event processing, the investigators will measure children's looking to one or more images presented on-screen as a sentence is played (Aim 1) or as they point to images (Aim 3). The investigators will analyze how intervention conditions (thematic role and sentence complexity) influences children's looking patterns.

    Measured: During sessions for sentence processing and event processing tasks

Secondary outcomes (1)
  1. Behavioral response data

    For verb knowledge tasks, the investigators will measure children's button presses for latency.

    Measured: During sessions for verb knowledge tasks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Apr 2026
  2. Study start16 Feb 2026
  3. Primary completionJul 2028 (estimated)
  4. Study completionJul 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
80 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07510854
Sponsor's protocol ID
R21DC022371-01
Other IDs
R21DC022371-01A1
Status last verified
Mar 2026
First submitted
24 Feb 2026
Last updated
6 Apr 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study testing Thematic role and Sentence complexity in people with Developmental Language Disorder, run by Father Flanagan's Boys' Home at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 6 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Justin Kueser, PhD (531-355-5035, justin.kueser@boystown.org), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Behavioral response data (time frame: During sessions for verb knowledge tasks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2026.

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