MyopiaNCT07512115
The Impact of 'A Miss Is as Good as a Mile': Is Compensation Necessary for Minimal Ocular Deviation in Myopic Laser Surgery?
A study testing Apply compensation to the Kappa angle. and Apply no compensation to the Kappa angle in people with Myopia and Refractive Ametropia, run by Zhongshan Ophthalmic Center, Sun Yat-sen University at 1 site in China.
Trial summary
The goal of this clinical trial is to evaluate the effect of intraoperative kappa-angle compensation on postoperative visual quality in patients undergoing small incision lenticule extraction (SMILE) using the VisuMax 800 platform. The study will enroll patients with myopia and a kappa-angle offset < 0.2 mm. Read more about this study
- Who is it for?
- Ages 18 to 40 years
- Conditions the study is for
- Myopia, Refractive Ametropia
- What is being tested?
- Apply compensation to the Kappa angle. and Apply no compensation to the Kappa angle
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 224 participants
- Where
- 1 siteChina
- Study dates
- 8 Apr 2026to 30 May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 18 to 40 years with myopia or myopic astigmatism and stable refraction for >=1 year, whose refractive errors fall within the treatable range of and meet the indications for SMILE surgery.
- Normal corneal morphology and corneal thickness meeting surgical requirements.
- Preoperative corrected distance visual acuity (CDVA) >= 1.0.
- Preoperative synthetic Kappa angle offset measured >= 0.10 mm and < 0.20 mm.
- Voluntarily agree to undergo SMILE surgery on the VISUMAX 800 platform, understand the randomization scheme, and provide signed informed consent.
Who cannot join
- History of prior ocular surgery, significant ocular trauma, or presence of corneal or ocular diseases that may affect the safety of refractive surgery.
- Severe systemic diseases that may affect ocular healing or surgical safety.
- Females who are pregnant or lactating.
- Inability to cooperate as required to complete the procedure or follow-up visits.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Zhongshan Ophthalmic Center
Guangzhou, Guangdong, 510060
Guofu Huang, +86-20-66686748, huangguofu@gzzoc.com
About this study
Official title: Effect of Centration Compensation on Visual Quality in VisuMax 800 SMILE for Small Kappa Angles: A Randomized Trial
The goal of this clinical trial is to evaluate the effect of intraoperative kappa-angle compensation on postoperative visual quality in patients undergoing small incision lenticule extraction (SMILE) using the VisuMax 800 platform. The study will enroll patients with myopia and a kappa-angle offset < 0.2 mm.
The main questions it aims to answer are:
Read more
Does intraoperative kappa-angle compensation reduce postoperative higher-order aberrations after SMILE? Does kappa-angle compensation improve postoperative visual quality and refractive outcomes compared with no compensation?
Researchers will compare SMILE with intraoperative kappa-angle compensation to SMILE without compensation to determine whether compensation leads to better optical quality and visual performance.
Participants will:
Undergo SMILE surgery with or without intraoperative kappa-angle compensation Complete scheduled postoperative examinations at 1 week, 1 month, 3 months, and 6 months after surgery Receive measurements of visual acuity, refraction, higher-order aberrations, contrast sensitivity, and safety outcomes
Read the detailed description
Angle kappa refers to the offset between the visual axis and the pupil center and may influence the centration of the treatment zone during corneal refractive surgery. Inaccurate centration can lead to decentered ablation and may affect postoperative visual quality, especially higher-order aberrations. With the development of femtosecond laser technology, more precise intraoperative alignment has become possible.
Small incision lenticule extraction (SMILE) is a commonly used corneal refractive procedure with good safety and predictability. The VisuMax 800 system incorporates machine vision-assisted centration guidance, which allows intraoperative adjustment of the treatment center according to the relative position of the corneal vertex and the pupil center. This provides the possibility of performing intraoperative compensation based on the kappa-angle offset.
Previous studies have mainly evaluated centration adjustment in eyes with relatively large kappa-angle offsets and suggested that compensation may improve postoperative optical quality. However, for patients with small offsets, the necessity of intraoperative compensation remains unclear, and prospective randomized clinical trials are limited.
The purpose of this study is to compare the visual outcomes and optical quality after SMILE with or without intraoperative kappa-angle compensation in patients with small kappa-angle offsets.
This study is a single-center, randomized, parallel-group clinical trial. Participants who are suitable for SMILE surgery and have a kappa-angle offset less than 0.2 mm will be enrolled and randomly assigned to receive SMILE with compensation or SMILE without compensation using the VisuMax 800 platform.
All surgeries will be performed by experienced surgeons using standard SMILE procedures. Participants will undergo routine ophthalmic examinations before surgery and will be followed after surgery at scheduled visits.
The main evaluation will assess postoperative visual quality and refractive outcomes. Additional assessments will include visual acuity, refractive accuracy, higher-order aberrations, contrast sensitivity, and safety outcomes.
- Conditions
- Myopia, Refractive Ametropia
- Being tested
- Apply compensation to the Kappa angle., Apply no compensation to the Kappa angle
- Keywords
- myopia, SMILE, Refractive Surgery, Randomized Clinical Trial, Angle Kappa, VisuMax 800
- Medical subject headings
- Myopia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Apply compensation to the Kappa angle.Procedure or surgery
SMILE PRO is an upgraded version/procedural designation of SMILE (Small Incision Lenticule Extraction) performed on the ZEISS VisuMax 800 femtosecond laser platform and remains, in essence, an all-femtosecond corneal refractive procedure. Its basic principle is to use a femtosecond laser to create a lenticule within the corneal stroma together with a small incision, and then remove the lenticule through that incision, thereby reshaping the corneal curvature to correct myopia and astigmatism. In the compensation group, during preoperative parameter input, a fixed intraoperative laser centration compensation of 0.1 mm was uniformly applied to all study eyes meeting the inclusion criteria to achieve a quantitative adjustment of the treatment center toward the visual axis.
Apply no compensation to the Kappa angleProcedure or surgery
SMILE PRO is an upgraded version/procedural designation of SMILE (Small Incision Lenticule Extraction) performed on the ZEISS VisuMax 800 femtosecond laser platform and remains, in essence, an all-femtosecond corneal refractive procedure. Its basic principle is to use a femtosecond laser to create a lenticule within the corneal stroma together with a small incision, and then remove the lenticule through that incision, thereby reshaping the corneal curvature to correct myopia and astigmatism. In the non-compensation group, no kappa-angle-based laser centration compensation was applied intraoperatively, and the treatment center was set according to the system's default centration method.
| Study group | Role | What they receive |
|---|---|---|
| Non-compensation group | Active comparator | Subjects underwent SMILE surgery on the VisuMax 800 platform. Preoperative offset coordinates (x, y) were measured; however, while preserving the directional sign, no kappa-angle-based laser centration compensation was applied intraoperatively, and the treatment center was set according to the system's default centration method. Except for the difference in compensation strategy, all other surgical procedures and postoperative management were identical to those in the compensation group. Receives: Procedure: Apply no compensation to the Kappa angle |
| Compensation group | Experimental | Subjects underwent SMILE surgery on the VisuMax 800 platform. Preoperative offset coordinates (x, y) were measured, and, while preserving the directional sign, a fixed intraoperative laser centration compensation of 0.1 mm was uniformly applied to all eligible study eyes to achieve a quantitative adjustment of the treatment center toward the visual axis. Except for the difference in compensation strategy, all other surgical procedures and postoperative management were identical to those in the non-compensation group. Receives: Procedure: Apply compensation to the Kappa angle. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Coma aberration
Coma aberration measured by wavefront aberrometry to evaluate the effect of intraoperative kappa-angle compensation on postoperative optical quality.
Measured: 3 months after surgery
Secondary outcomes (10)
Higher-order aberrations
Total higher-order aberrations, spherical aberration, and trefoil aberration measured using wavefront aberrometry under standardized conditions to evaluate postoperative optical quality.
Measured: 1 month, 3 months, and 6 months after surgery
Optical zone decentration
Decentration of the optical zone measured using corneal topography by determining the displacement between the optical zone center and the corneal vertex.
Measured: 3 months after surgery
Visual acuity
Binocular uncorrected distance visual acuity and corrected distance visual acuity measured using standardized visual acuity charts to evaluate visual performance and safety.
Measured: 1 month, 3 months, and 6 months after surgery
Manifest refraction
Postoperative sphere, cylinder, and spherical equivalent measured by manifest refraction.
Measured: 1 month, 3 months, and 6 months after surgery
Refractive accuracy
Proportion of eyes within predefined ranges of target refraction to evaluate refractive predictability.
Measured: 1 month, 3 months, and 6 months after surgery
Refractive stability
Refractive stability will be assessed as the change in manifest spherical equivalent refraction between postoperative visits.
Measured: 1 month to 6 months after surgery
Contrast sensitivity
Contrast sensitivity will be measured using a standardized contrast sensitivity testing system (CSV-1000, VectorVision, USA) at multiple spatial frequencies.
Measured: 3 months after surgery
Quality of Vision (QoV) score
Visual symptoms will be assessed using the Quality of Vision (QoV) questionnaire, which evaluates the frequency, severity, and bothersome nature of visual disturbances. Scores are recorded on ordinal scales, with higher scores indicating worse visual quality.
Measured: 3 months after surgery
Patient satisfaction score
Patient satisfaction will be assessed using a 5-point rating scale. Scores range from 1 to 5, with higher scores indicating greater satisfaction.
Measured: 3 months after surgery
Adverse events
Incidence of intraoperative or postoperative complications, including loss of corrected distance visual acuity and other clinically significant events.
Measured: Up to 6 months after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2026
- Study start8 Apr 2026
- Primary completion30 May 2027 (estimated)
- Study completion30 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for MyopiaStudies of the same condition, open and under way.
- More trials run by Zhongshan Ophthalmic Center, Sun Yat-sen UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 224 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07512115
- Sponsor's protocol ID
- IIT2025199
- Status last verified
- Jul 2026
- First submitted
- 21 Mar 2026
- Last updated
- 7 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Doostparast A, Ghandhari M, Rastegar M, Khosronejad AH, Ghandhari M, Eslampoor A. Distribution and inter-device agreement of chord mu/alpha lengths and axes between Pentacam HR, Sirius, and IOLMaster 700. Photodiagnosis Photodyn Ther. 2025 Dec;56:105275. doi: 10.1016/j.pdpdt.2025.105275. Epub 2025 Nov 6.
PubMed 41205666Shao T, Wang Y, Ng ALK, Chan TCY, Hao W, Zhang J, Cheng GPM, Jhanji V. The Effect of Intraoperative Angle Kappa Adjustment on Higher-Order Aberrations Before and After Small Incision Lenticule Extraction. Cornea. 2020 May;39(5):609-614. doi: 10.1097/ICO.0000000000002274.
PubMed 32040010Lai X, Liu X, Zeng T, Huang Y, Yang X. Comparison of visual outcomes and optical aberrations after SMILE with intraoperative Kappa angle adjustments between small and large Kappa angles. Sci Rep. 2024 Jun 24;14(1):14551. doi: 10.1038/s41598-024-65366-w.
PubMed 38914606Deng M, Zhou D, Li M, Shi Y, Sun L, Zou J, Ma X. Evaluation of corneal asymmetry and higher-order aberrations after small incision lenticule extraction for moderate and high myopia. Int Ophthalmol. 2025 Jun 1;45(1):218. doi: 10.1007/s10792-025-03576-5.
PubMed 40451982Vingopoulos F, Zisimopoulos A, Kanellopoulos AJ. Comparison of effective corneal refractive centration to the visual axis: LASIK vs SMILE, a contralateral eye digitized comparison of the postoperative result. J Cataract Refract Surg. 2021 Dec 1;47(12):1511-1518. doi: 10.1097/j.jcrs.0000000000000687.
PubMed 34074993McAlinden C, Pesudovs K, Moore JE. The development of an instrument to measure quality of vision: the Quality of Vision (QoV) questionnaire. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5537-45. doi: 10.1167/iovs.10-5341. Epub 2010 May 26.
PubMed 20505205Chang JS, Law AK, Ng JC, Chan VK. Comparison of refractive and visual outcomes with centration points 80% and 100% from pupil center toward the coaxially sighted corneal light reflex. J Cataract Refract Surg. 2016 Mar;42(3):412-9. doi: 10.1016/j.jcrs.2015.09.030.
PubMed 27063522
Study at a glance
From the registry record, last updated by the sponsor on 7 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Centration Compensation on Visual Quality in VisuMax 800 SMILE for Small Kappa Angles: A Randomized Trial
- ClinicalTrials.gov ID
- NCT07512115
- Acronym / sponsor ID
- IIT2025199
- Conditions
- Myopia, Refractive Ametropia
- Keywords
- myopia, SMILE, Refractive Surgery, Randomized Clinical Trial, Angle Kappa, VisuMax 800
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 224 participants (estimated)
- Lead sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen UniversityUniversity, hospital or other
- Study start
- 8 Apr 2026 (actual)
- Primary completion
- 30 May 2027 (estimated)
- Study completion
- 30 May 2027 (estimated)
- First posted
- 6 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the effect of intraoperative kappa-angle compensation on postoperative visual quality in patients undergoing small incision lenticule extraction (SMILE) using the VisuMax 800 platform. The study will enroll patients with myopia and a kappa-angle offset < 0.2 mm.
The main questions it aims to answer are:
Does intraoperative kappa-angle compensation reduce postoperative higher-order aberrations after SMILE? Does kappa-angle compensation improve postoperative visual quality and refractive outcomes compared with no compensation?
Researchers will compare SMILE with intraoperative kappa-angle compensation to SMILE without compensation to determine whether compensation leads to better optical quality and visual performance.
Participants will:
Undergo SMILE surgery with or without intraoperative kappa-angle compensation Complete scheduled postoperative examinations at 1 week, 1 month, 3 months, and 6 months after surgery Receive measurements of visual acuity, refraction, higher-order aberrations, contrast sensitivity, and safety outcomes
Detailed description
Angle kappa refers to the offset between the visual axis and the pupil center and may influence the centration of the treatment zone during corneal refractive surgery. Inaccurate centration can lead to decentered ablation and may affect postoperative visual quality, especially higher-order aberrations. With the development of femtosecond laser technology, more precise intraoperative alignment has become possible.
Small incision lenticule extraction (SMILE) is a commonly used corneal refractive procedure with good safety and predictability. The VisuMax 800 system incorporates machine vision-assisted centration guidance, which allows intraoperative adjustment of the treatment center according to the relative position of the corneal vertex and the pupil center. This provides the possibility of performing intraoperative compensation based on the kappa-angle offset.
Previous studies have mainly evaluated centration adjustment in eyes with relatively large kappa-angle offsets and suggested that compensation may improve postoperative optical quality. However, for patients with small offsets, the necessity of intraoperative compensation remains unclear, and prospective randomized clinical trials are limited.
The purpose of this study is to compare the visual outcomes and optical quality after SMILE with or without intraoperative kappa-angle compensation in patients with small kappa-angle offsets.
This study is a single-center, randomized, parallel-group clinical trial. Participants who are suitable for SMILE surgery and have a kappa-angle offset less than 0.2 mm will be enrolled and randomly assigned to receive SMILE with compensation or SMILE without compensation using the VisuMax 800 platform.
All surgeries will be performed by experienced surgeons using standard SMILE procedures. Participants will undergo routine ophthalmic examinations before surgery and will be followed after surgery at scheduled visits.
The main evaluation will assess postoperative visual quality and refractive outcomes. Additional assessments will include visual acuity, refractive accuracy, higher-order aberrations, contrast sensitivity, and safety outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Non-compensation group | Active comparator | Procedure: Apply no compensation to the Kappa angleSubjects underwent SMILE surgery on the VisuMax 800 platform. Preoperative offset coordinates (x, y) were measured; however, while preserving the directional sign, no kappa-angle-based laser centration compensation was applied intraoperatively, and the treatment center was set according to the system's default centration method. Except for the difference in compensation strategy, all other surgical procedures and postoperative management were identical to those in the compensation group. |
| Compensation group | Experimental | Procedure: Apply compensation to the Kappa angle.Subjects underwent SMILE surgery on the VisuMax 800 platform. Preoperative offset coordinates (x, y) were measured, and, while preserving the directional sign, a fixed intraoperative laser centration compensation of 0.1 mm was uniformly applied to all eligible study eyes to achieve a quantitative adjustment of the treatment center toward the visual axis. Except for the difference in compensation strategy, all other surgical procedures and postoperative management were identical to those in the non-compensation group. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Patients aged 18 to 40 years with myopia or myopic astigmatism and stable refraction for >=1 year, whose refractive errors fall within the treatable range of and meet the indications for SMILE surgery.
- Normal corneal morphology and corneal thickness meeting surgical requirements.
- Preoperative corrected distance visual acuity (CDVA) >= 1.0.
- Preoperative synthetic Kappa angle offset measured >= 0.10 mm and < 0.20 mm.
- Voluntarily agree to undergo SMILE surgery on the VISUMAX 800 platform, understand the randomization scheme, and provide signed informed consent.
Key exclusion criteria (4 listed)
- History of prior ocular surgery, significant ocular trauma, or presence of corneal or ocular diseases that may affect the safety of refractive surgery.
- Severe systemic diseases that may affect ocular healing or surgical safety.
- Females who are pregnant or lactating.
- Inability to cooperate as required to complete the procedure or follow-up visits.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Apply compensation to the Kappa angle.SMILE PRO is an upgraded version/procedural designation of SMILE (Small Incision Lenticule Extraction) performed on the ZEISS VisuMax 800 femtosecond laser platform and remains, in essence, an all-femtosecond corneal refractive procedure. Its basic principle is to use a femtosecond laser to create a lenticule within the corneal stroma together with a small incision, and then remove the lenticule through that incision, thereby reshaping the corneal curvature to correct myopia and astigmatism. In the compensation group, during preoperative parameter input, a fixed intraoperative laser centration compensation of 0.1 mm was uniformly applied to all study eyes meeting the inclusion criteria to achieve a quantitative adjustment of the treatment center toward the visual axis. | Procedure or surgery | Compensation group |
| Apply no compensation to the Kappa angleSMILE PRO is an upgraded version/procedural designation of SMILE (Small Incision Lenticule Extraction) performed on the ZEISS VisuMax 800 femtosecond laser platform and remains, in essence, an all-femtosecond corneal refractive procedure. Its basic principle is to use a femtosecond laser to create a lenticule within the corneal stroma together with a small incision, and then remove the lenticule through that incision, thereby reshaping the corneal curvature to correct myopia and astigmatism. In the non-compensation group, no kappa-angle-based laser centration compensation was applied intraoperatively, and the treatment center was set according to the system's default centration method. | Procedure or surgery | Non-compensation group |
Primary outcome
Coma aberration
Time frame: 3 months after surgery
Coma aberration measured by wavefront aberrometry to evaluate the effect of intraoperative kappa-angle compensation on postoperative optical quality.
10 secondary outcomes
Higher-order aberrations
Time frame: 1 month, 3 months, and 6 months after surgery
Optical zone decentration
Time frame: 3 months after surgery
Visual acuity
Time frame: 1 month, 3 months, and 6 months after surgery
Manifest refraction
Time frame: 1 month, 3 months, and 6 months after surgery
Refractive accuracy
Time frame: 1 month, 3 months, and 6 months after surgery
Refractive stability
Time frame: 1 month to 6 months after surgery
Contrast sensitivity
Time frame: 3 months after surgery
Quality of Vision (QoV) score
Time frame: 3 months after surgery
Patient satisfaction score
Time frame: 3 months after surgery
Adverse events
Time frame: Up to 6 months after surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Jul 2026.
- Background: PubMed 41205666Doostparast A, Ghandhari M, Rastegar M, Khosronejad AH, Ghandhari M, Eslampoor A. Distribution and inter-device agreement of chord mu/alpha lengths and axes between Pentacam HR, Sirius, and IOLMaster 700. Photodiagnosis Photodyn Ther. 2025 Dec;56:105275. doi: 10.1016/j.pdpdt.2025.105275. Epub 2025 Nov 6.
- Background: PubMed 32040010Shao T, Wang Y, Ng ALK, Chan TCY, Hao W, Zhang J, Cheng GPM, Jhanji V. The Effect of Intraoperative Angle Kappa Adjustment on Higher-Order Aberrations Before and After Small Incision Lenticule Extraction. Cornea. 2020 May;39(5):609-614. doi: 10.1097/ICO.0000000000002274.
- Background: PubMed 38914606Lai X, Liu X, Zeng T, Huang Y, Yang X. Comparison of visual outcomes and optical aberrations after SMILE with intraoperative Kappa angle adjustments between small and large Kappa angles. Sci Rep. 2024 Jun 24;14(1):14551. doi: 10.1038/s41598-024-65366-w.
- Background: PubMed 40451982Deng M, Zhou D, Li M, Shi Y, Sun L, Zou J, Ma X. Evaluation of corneal asymmetry and higher-order aberrations after small incision lenticule extraction for moderate and high myopia. Int Ophthalmol. 2025 Jun 1;45(1):218. doi: 10.1007/s10792-025-03576-5.
- Background: PubMed 34074993Vingopoulos F, Zisimopoulos A, Kanellopoulos AJ. Comparison of effective corneal refractive centration to the visual axis: LASIK vs SMILE, a contralateral eye digitized comparison of the postoperative result. J Cataract Refract Surg. 2021 Dec 1;47(12):1511-1518. doi: 10.1097/j.jcrs.0000000000000687.
- Background: PubMed 20505205McAlinden C, Pesudovs K, Moore JE. The development of an instrument to measure quality of vision: the Quality of Vision (QoV) questionnaire. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5537-45. doi: 10.1167/iovs.10-5341. Epub 2010 May 26.
- Background: PubMed 27063522Chang JS, Law AK, Ng JC, Chan VK. Comparison of refractive and visual outcomes with centration points 80% and 100% from pupil center toward the coaxially sighted corneal light reflex. J Cataract Refract Surg. 2016 Mar;42(3):412-9. doi: 10.1016/j.jcrs.2015.09.030.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Apply compensation to the Kappa angle. and Apply no compensation to the Kappa angle in people with Myopia and Refractive Ametropia, run by Zhongshan Ophthalmic Center, Sun Yat-sen University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Coma aberration (time frame: 3 months after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07512115, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Jul 2026.