Transcranial Magnetic StimulationNCT07512492
Combination Effect of Proprioceptive Training and Transcranial Magnetic Stimulation on Selected Gait Kinematic Parameters in Stroke Patients
A study testing Transcranial Magnetic Stimulation, selected physical therapy program and proprioceptive training in people with Transcranial Magnetic Stimulation and Stroke, run by Cairo University at 1 site in Egypt.
Trial summary
this study was done to investigate the Combination effect of proprioceptive training and transcranial magnetic stimulation on selected gait kinematic parameters in stroke patients. Read more about this study
- Who is it for?
- Ages 50 to 60 years
- Conditions the study is for
- Transcranial Magnetic Stimulation, Stroke, Gait Disorders, Neurologic
- What is being tested?
- Transcranial Magnetic Stimulation, selected physical therapy program and proprioceptive training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2024to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Thirty patients with stroke from both sexes.
- 2) Age will range from 50 to 60 years old.
- 3) Duration of stroke ≥ 6 months.
- 4) Spasticity of the lower limb ranges from 1+ to 2 according to modified ashworth scale
- 5) The patients able to walk with or without assistive device.
- 6) Body mass index is less than 30 kg/m2.
- 7) Patients with sufficient cognitive abilities that enables them to understand and follow instructions (Mini-Mental State Examination scale >24).
Who cannot join
- Previous history of any other neurological disorder
- Recurrent stroke.
- Vestibular deficits.
- Cognitive impairment (a score less than 24 according to mini mental state examination).
- 5- Cardiac pacemaker
- 6- Metallic Implants.
- 7- Aphasia, deafness or blindness
- 7. Deformities or contractures of the lower limbs
Trial locations and contacts
1 site in 1 country.
About this study
this study was done to investigate the Combination effect of proprioceptive training and transcranial magnetic stimulation on selected gait kinematic parameters in stroke patients.
Read the detailed description
After a stroke, mobility is influenced by the central nervous system and peripheral neuromuscular and sensory systems. Effective standing and walking require managing body support against gravity and generating propulsion. Gait deficits in stroke survivors often arise from neural, sensory, muscular issues, and coordination problems, leading to movement disorders like spasticity and ataxia that hinder motor control and gait performance. Typically, stroke patients display reduced gait velocity and abnormal kinematics, marked by asymmetries and decreased weight bearing on the affected limb. Research indicates that combining high-frequency Transcranial magnetic stimulation with task-oriented mirror therapy enhances motor function more effectively than Transcranial magnetic stimulation alone, yielding improvements in hand function and cortical excitability. Similar findings for subacute stroke patients highlight the benefits of integrating action observation with Transcranial magnetic stimulation for better upper limb function.
- Conditions
- Transcranial Magnetic Stimulation, Stroke, Gait Disorders, Neurologic, Proprioceptive Training
- Being tested
- Transcranial Magnetic Stimulation, selected physical therapy program, proprioceptive training
- Medical subject headings
- Stroke, Gait Disorders, Neurologic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Transcranial Magnetic StimulationDevice
Transcranial Magnetic Stimulation (TMS) is a non-invasive method that uses magnetic fields to stimulate brain nerve cells through figure-eight or circular coils with strengths of 1.5 to 3.0 Tesla. The TMS pulses, lasting about 100 microseconds, can be adjusted to induce excitatory or inhibitory responses, with a focus on specific brain regions. Although Transcranial Magnetic Stimulation is safe with mild side effects, its efficacy declines with depth. It is commonly used in treating depression and anxiety, as well as in cognitive neuroscience research, often employing a protocol of high-frequency Transcranial Magnetic Stimulation (≥5 Hertz) for 20 minutes on the lower limb region of the bilateral cerebrum at 90% of the motor threshold.
selected physical therapy programOther
The program provides a set of exercises focused on improving ankle and knee movements, building muscle strength, and increasing the range of motion. It details eight activities: Ankle Movements for controlling foot actions; Active Knee Extension to strengthen the quadriceps; Gluteus maximus Squeezes for gluteal muscle enhancement; Inner Range Quadriceps involving a towel for knee support; Bridging to elevate the pelvis; a Passive Stretching Program for gentle knee stretches; Trunk Rotation to improve mobility; and Ankle Flexion to bend the ankle without foot rotation. The exercises are designed for gradual progression based on patient tolerance.
proprioceptive trainingOther
The program outlines techniques for enhancing patient mobility and balance through various exercises. In modified plantigrade, patients practice stepping forward and backward while weight shifting, facilitated by a therapist's manual contact on the pelvis. Activities with footprint markers encourage active stepping, while resisted stepping involves pushing against elastic resistance. Utilizing a wobble board helps patients maintain balance and perform self-initiated tilts to improve stability. Prerequisite exercises for stair climbing, such as bridging and sit-to-stand transfers, include verbal cues to guide weight shifts and step placements, progressing from low to standard steps with therapist assistance as necessary.
| Study group | Role | What they receive |
|---|---|---|
| Transcranial Magnetic Stimulation and proprioceptive training | Experimental | this group received a transcranial magnetic stimulation session for 20 min ,15 min of strengthening of lower limb and bridging exercises, and passive stretching for lower limb, and adding five exercises of proprioceptive training post Transcranial Magnetic Stimulation session for 15 min. Receives: Device: Transcranial Magnetic Stimulation; Other: selected physical therapy program; Other: proprioceptive training |
| Transcranial Magnetic Stimulation only | Active comparator | this group received only Rtms session for 20 min and 30 min of strengthening of lower limb and bridging exercises and passive stretching for lower limb Receives: Device: Transcranial Magnetic Stimulation; Other: selected physical therapy program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of gait function using Dynamic Gait Index:
For two groups a. Assessment of gait function using Dynamic Gait Index:
Each item is scored on a 4-level ordinal scale.
- Grade 3 = normal performance
- Grade 2 = minimal impairment,
- Grade 1 = moderate impairment,
- Grade 0 = severe impairment. The maximum possible score is 24 points.
The Dynamic gait index can be administered in 10 minutes and requires a box, 2 cones, stairs and twenty-foot walkway.
Measured: At baseline and after 6 weeks
Secondary outcomes (4)
Assessment of ankle range of motion
To measure ankle angle during walking, a digital camera is set 1.5 m away from the subject at shoulder height. The testing involves having subjects maintain a standardized posture while moving naturally between two points, fifteen yards apart. Images and videos captured during this process are analyzed using Kinovea software for angle measurement.
Measured: At baseline and after 6 weeks
Assessment of step length
To measure step length during walking, a digital camera is set 1.5 m away from the subject at shoulder height. The testing involves having subjects maintain a standardized posture while moving naturally between two points, fifteen yards apart. Images and videos captured during this process are analyzed using Kinovea software for angle measurement.
Measured: At baseline and after 6 weeks
Assessment of step duration
To measure step duration during walking, a digital camera is set 1.5 m away from the subject at shoulder height. The testing involves having subjects maintain a standardized posture while moving naturally between two points, fifteen yards apart. Images and videos captured during this process are analyzed using Kinovea software for angle measurement.
Measured: At baseline and after 6 weeks
Assessment of cadence
To measure cadence during walking, a digital camera is set 1.5 m away from the subject at shoulder height. The testing involves having subjects maintain a standardized posture while moving naturally between two points, fifteen yards apart. Images and videos captured during this process are analyzed using Kinovea software for angle measurement.
Measured: At baseline and after 6 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Apr 2026
- Study start1 Dec 2024
- Primary completion1 Aug 2025
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Transcranial Magnetic StimulationStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Alaa Shabaan, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07512492
- Sponsor's protocol ID
- Mahmoud PhD
- Status last verified
- Apr 2026
- First submitted
- 24 Mar 2026
- Last updated
- 6 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Combination Effect of Proprioceptive Training and Transcranial Magnetic Stimulation on Selected Gait Kinematic Parameters in Stroke Patients
- ClinicalTrials.gov ID
- NCT07512492
- Acronym / sponsor ID
- Mahmoud PhD
- Conditions
- Transcranial Magnetic Stimulation, Stroke, Gait Disorders, Neurologic, Proprioceptive Training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Dec 2024 (actual)
- Primary completion
- 1 Aug 2025 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 6 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
this study was done to investigate the Combination effect of proprioceptive training and transcranial magnetic stimulation on selected gait kinematic parameters in stroke patients.
Detailed description
After a stroke, mobility is influenced by the central nervous system and peripheral neuromuscular and sensory systems. Effective standing and walking require managing body support against gravity and generating propulsion. Gait deficits in stroke survivors often arise from neural, sensory, muscular issues, and coordination problems, leading to movement disorders like spasticity and ataxia that hinder motor control and gait performance. Typically, stroke patients display reduced gait velocity and abnormal kinematics, marked by asymmetries and decreased weight bearing on the affected limb. Research indicates that combining high-frequency Transcranial magnetic stimulation with task-oriented mirror therapy enhances motor function more effectively than Transcranial magnetic stimulation alone, yielding improvements in hand function and cortical excitability. Similar findings for subacute stroke patients highlight the benefits of integrating action observation with Transcranial magnetic stimulation for better upper limb function.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Transcranial Magnetic Stimulation and proprioceptive training | Experimental | Device: Transcranial Magnetic Stimulation, Other: selected physical therapy program, Other: proprioceptive trainingthis group received a transcranial magnetic stimulation session for 20 min ,15 min of strengthening of lower limb and bridging exercises, and passive stretching for lower limb, and adding five exercises of proprioceptive training post Transcranial Magnetic Stimulation session for 15 min. |
| Transcranial Magnetic Stimulation only | Active comparator | Device: Transcranial Magnetic Stimulation, Other: selected physical therapy programthis group received only Rtms session for 20 min and 30 min of strengthening of lower limb and bridging exercises and passive stretching for lower limb |
Who may qualify
- Ages
- 50 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (7 listed)
- Thirty patients with stroke from both sexes.
- 2) Age will range from 50 to 60 years old.
- 3) Duration of stroke ≥ 6 months.
- 4) Spasticity of the lower limb ranges from 1+ to 2 according to modified ashworth scale
- 5) The patients able to walk with or without assistive device.
Key exclusion criteria (8 listed)
- Previous history of any other neurological disorder
- Recurrent stroke.
- Vestibular deficits.
- Cognitive impairment (a score less than 24 according to mini mental state examination).
- 5- Cardiac pacemaker
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Transcranial Magnetic StimulationTranscranial Magnetic Stimulation (TMS) is a non-invasive method that uses magnetic fields to stimulate brain nerve cells through figure-eight or circular coils with strengths of 1.5 to 3.0 Tesla. The TMS pulses, lasting about 100 microseconds, can be adjusted to induce excitatory or inhibitory responses, with a focus on specific brain regions. Although Transcranial Magnetic Stimulation is safe with mild side effects, its efficacy declines with depth. It is commonly used in treating depression and anxiety, as well as in cognitive neuroscience research, often employing a protocol of high-frequency Transcranial Magnetic Stimulation (≥5 Hertz) for 20 minutes on the lower limb region of the bilateral cerebrum at 90% of the motor threshold. | Device | Transcranial Magnetic Stimulation and proprioceptive training, Transcranial Magnetic Stimulation only |
| selected physical therapy programThe program provides a set of exercises focused on improving ankle and knee movements, building muscle strength, and increasing the range of motion. It details eight activities: Ankle Movements for controlling foot actions; Active Knee Extension to strengthen the quadriceps; Gluteus maximus Squeezes for gluteal muscle enhancement; Inner Range Quadriceps involving a towel for knee support; Bridging to elevate the pelvis; a Passive Stretching Program for gentle knee stretches; Trunk Rotation to improve mobility; and Ankle Flexion to bend the ankle without foot rotation. The exercises are designed for gradual progression based on patient tolerance. | Other | Transcranial Magnetic Stimulation and proprioceptive training, Transcranial Magnetic Stimulation only |
| proprioceptive trainingThe program outlines techniques for enhancing patient mobility and balance through various exercises. In modified plantigrade, patients practice stepping forward and backward while weight shifting, facilitated by a therapist's manual contact on the pelvis. Activities with footprint markers encourage active stepping, while resisted stepping involves pushing against elastic resistance. Utilizing a wobble board helps patients maintain balance and perform self-initiated tilts to improve stability. Prerequisite exercises for stair climbing, such as bridging and sit-to-stand transfers, include verbal cues to guide weight shifts and step placements, progressing from low to standard steps with therapist assistance as necessary. | Other | Transcranial Magnetic Stimulation and proprioceptive training |
Primary outcome
Assessment of gait function using Dynamic Gait Index:
Time frame: At baseline and after 6 weeks
For two groups a. Assessment of gait function using Dynamic Gait Index: Each item is scored on a 4-level ordinal scale. * Grade 3 = normal performance * Grade 2 = minimal impairment, * Grade 1 = moderate impairment, * Grade 0 = severe impairment. The maximum possible score is 24 points. The Dynamic gait index can be administered in 10 minutes and requires a box, 2 cones, stairs and twenty-foot walkway.
4 secondary outcomes
Assessment of ankle range of motion
Time frame: At baseline and after 6 weeks
Assessment of step length
Time frame: At baseline and after 6 weeks
Assessment of step duration
Time frame: At baseline and after 6 weeks
Assessment of cadence
Time frame: At baseline and after 6 weeks
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Apr 2026.
Related trials for Transcranial Magnetic Stimulation
Recruiting
Adaptive Recruitment Curve Analysis Using Bayesian Modeling
Modeling of Recruitment Curves
Not yet recruitingPhase 1
Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)
Healthy Volunteers
Not yet recruiting
Motor Imagery and Turning Practice to Improve Mobility: Pilot Trial
Mobility Impairment, Community Dwelling Older Adults
Recruiting
Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia
Dystonia Disorder
Recruiting
Treating Insomnia in Mild Cognitive Impairment
Mild Cognitive Impairment (MCI), Insomnia
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Transcranial Magnetic Stimulation, selected physical therapy program and proprioceptive training in people with Transcranial Magnetic Stimulation and Stroke, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of gait function using Dynamic Gait Index: (time frame: At baseline and after 6 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Apr 2026.