Age-related Changes in Skin Appearance and PhysiologyBCP-SkinNCT07516756

Effect of Collagen Peptides on Skin Health: A Clinical Trial

A study testing Specific Collagen Peptides in people with Age-related Changes in Skin Appearance and Physiology, run by Collagen Research Institute at 1 site in China.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years. Read more about this study

Who is it for?: Ages 35 to 55 years, women onlyHealthy volunteers can take part
Conditions the study is for: Age-related Changes in Skin Appearance and Physiology
What is being tested?: Specific Collagen Peptides
Type of treatment: Pill or oral medicine
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 66 participants
Where: 1 siteChina
Study dates: 8 Aug 2024to 4 Oct 2024
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 35 to 55 years
Women only
Healthy volunteers accepted
Adult

Who may be able to join

Fitzpatrick skin type III-IV
Presence of crow's feet wrinkles graded 2-4
Presence of under-eye fine lines graded 2-5
Generally in good health
Able to comply with study procedures and visit schedule

Who cannot join

Use of systemic or topical anti-inflammatory medication, including corticosteroids, within the 4 weeks prior to baseline
Known hypersensitivity or allergy to any ingredient of the investigational products
Pregnancy, breastfeeding, or intention to become pregnant during the study period
History of relevant dermatological conditions: psoriasis, eczema, atopic dermatitis, or severe acne
Presence of birthmarks, hyperpigmentation, active inflammation, or other visible skin abnormalities in the test areas
Recent aesthetic procedures Use of anti-aging or topical treatments

Show all 13Show fewer

Intake of nutritional supplements
Participation in other clinical studies within the past 2 months
Significant lifestyle or dietary changes during the study period
Excessive UV exposure
Systemic diseases, including heart, immune, vascular, liver, gallbladder, or kidney disorders
Known allergies to foods, cosmetics, skincare products, or topical medications
Any other condition that, in the investigator's opinion, would make the participant ineligible

Trial locations and contacts

1 site in 1 country.

China1 site

Beijing EWISH Testing Technology Co., Ltd
Beijing, Haidan, 100142

Other trials in China

About this study

Official title: Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology: A Randomized, Double-Blind, Placebo-Controlled Trial

Does SCP supplementation increase skin hydration and barrier function? Does SCP improve skin elasticity, firmness, and collagen content? Does SCP reduce the appearance of periorbital wrinkles and improve overall skin appearance? Researchers will compare SCP supplementation to a placebo (a look-alike substance containing no collagen peptides) to see if SCP supports skin structure and appearance over eight weeks.

Participants will:

Consume one sachet of SCP or placebo daily for eight weeks Attend three study visits at baseline, week 4, and week 8 for facial imaging, instrumental skin measurements, and expert assessments Have objective measures taken, including skin hydration, transepidermal water loss, elasticity, firmness, dermal collagen content, and 3D wrinkle morphology Complete subjective skin assessments rated by trained evaluators using a visual analogue scale Report any adverse events or intolerance reactions at each visit This study is designed to provide an integrated evaluation of multiple skin parameters, including barrier function, biomechanical properties, dermal matrix composition, and wrinkle characteristics, in a single trial. By combining objective and subjective measures, the study aims to generate robust and clinically interpretable evidence for the effects of oral collagen peptide supplementation on skin health.

Read the detailed description

This clinical trial investigates whether daily oral supplementation with specific bioactive collagen peptides (SCP) can support healthy skin in adult women. Skin aging is a natural process influenced by genetics, hormones, and lifestyle, leading to wrinkles, reduced elasticity, and changes in skin structure. Collagen is a key protein that helps maintain skin strength and elasticity, and its levels decline with age.

The study will evaluate the effects of an 8-week course of SCP supplementation compared to a placebo in healthy women aged 35-55 years. Researchers aim to determine whether oral collagen peptides can improve skin hydration, elasticity, firmness, and overall appearance. This trial combines multiple objective and subjective measures to provide a comprehensive assessment of skin health, offering insights into non-invasive nutritional strategies to maintain skin structure and appearance over time.

The findings from this study are expected to enhance understanding of how collagen peptides affect skin physiology and contribute to evidence-based recommendations for supporting healthy skin.

Conditions: Age-related Changes in Skin Appearance and Physiology
Being tested: Placebo, Specific Collagen Peptides
Keywords: Bioactive collagen peptides, Oral supplementation, Skin aging, Skin hydration, Skin elasticity, Skin firmness, Wrinkles / periorbital wrinkles, Dermal extracellular matrix, Skin barrier function, Skin physiology, Healthy adult women, Randomized controlled trial (

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

PlaceboDietary supplement
Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.
Specific Collagen PeptidesDietary supplement
Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.

Study groups in NCT07516756
Study group	Role	What they receive
Specific Collagen Peptides	Experimental	Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement. Receives: Dietary Supplement: Specific Collagen Peptides
Maltodextrin	Placebo comparator	Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo. Receives: Dietary Supplement: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

stratum corneum hydration (SCH)
Stratum corneum hydration (SCH) measures the water content in the outermost layer of the skin, reflecting the skin's ability to retain moisture and maintain a healthy barrier. In this study, SCH is the primary efficacy endpoint, used to compare the effect of daily oral supplementation with specific bioactive collagen peptides (SCP) versus placebo over an 8-week period.
SCH is assessed using a Corneometer CM825 at the cheek. Each site is measured six times, and the mean value is used for analysis. Higher SCH values indicate better skin hydration, whereas lower values suggest dryness or impaired barrier function. Changes in SCH over time are compared between the treatment and placebo groups to evaluate the impact of collagen peptide supplementation on skin hydration.
Measured: From enrollment to the end of treatment at 8 weeks

Secondary outcomes (5)

Transepidermal Water Loss (TEWL)
TEWL measures the rate of water loss through the skin, indicating the integrity of the skin barrier. In this study, TEWL is assessed using the Tewameter TM 300 at the cheek in triplicate, with mean values used for analysis. Higher TEWL values suggest impaired barrier function, while lower values indicate better barrier integrity. Changes over the 8-week supplementation period are compared between the collagen peptide and placebo groups.
Measured: From enrollment to the end of treatment at 8 weeks
Skin Elasticity (R2 and R5) and Firmness (F4)
Skin elasticity and firmness are evaluated using the Cutometer MPA580, which applies controlled suction to assess the biomechanical properties of the cheek.
R2 (gross elasticity): overall skin elasticity R5 (net elasticity): elastic recovery relative to total deformation F4 (firmness): resistance to deformation Measurements are performed in triplicate and averaged. These parameters provide insight into the skin's structural resilience and are compared between treatment and placebo groups over 8 weeks.
Measured: From enrollment to the end of treatment at 8 weeks
Dermal collagen content
Dermal collagen content is measured non-invasively using the SIAMETRICS SIAscope V at a 2 mm depth of the cheek. This device quantifies dermal chromophores, including collagen, to assess the integrity and composition of the dermal extracellular matrix. Changes over the 8-week intervention are compared between the SCP and placebo groups.
Measured: From enrollment to the end of treatment at 8 weeks
Wrinkle Morphology
Wrinkle characteristics around the eyes (area, volume, depth) are measured using the Derma TOP 3D imaging system.
Measured: From enrollment to the end of treatment at 8 weeks
Skin Appearance (3D Imaging + VAS)
Full-face 2D images are captured with VISIA-CR for additional objective assessments, including spots, skin tone, hydration, and elasticity.
Subjective evaluations are performed using a Visual Analogue Scale (VAS) by three trained evaluators, assessing:
Smoothness Glossiness Fineness Elasticity Crow's feet and under-eye fine lines VAS scores range from 0 to 10. Higher values indicate better outcomes for attributes such as smoothness, elasticity, and glossiness, while lower values reflect improvement in periorbital wrinkles. Changes over the 8-week supplementation period are compared between treatment and placebo groups.
Measured: From enrollment to the end of treatment at 8 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

8 Aug 20244 Oct 2024

First posted8 Apr 2026
Study start8 Aug 2024
Primary completion4 Oct 2024
Study completion4 Oct 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (36)Papers the sponsor has linked to this study.
Other trials for Age-related Changes in Skin Appearance and PhysiologyStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Prevention
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind
Who is masked: Participant, Care provider, Investigator, Outcomes assessor
Enrolment: 66 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07516756
Sponsor's protocol ID: SECCR2024-97-01
Acronym: BCP-Skin
Status last verified: Apr 2026
First submitted: 1 Apr 2026
Last updated: 8 Apr 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. The data will not be publicly available due to privacy and ethical restrictions.

Publications

Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018 Oct 7;19(10):3059. doi: 10.3390/ijms19103059.
PubMed 30301271
Dahnhardt D, Dahnhardt-Pfeiffer S, Segger D, Poeggeler B, Lemmnitz G. Restoration of the Ultrastructural Integrity of the Dermal Collagen Network by 12-Week Ingestion of Special Collagen Peptides. Dermatol Ther (Heidelb). 2024 Sep;14(9):2509-2521. doi: 10.1007/s13555-024-01251-8. Epub 2024 Aug 16.
PubMed 39150674
Lin P, Alexander RA, Liang CH, Liu C, Lin YH, Lin YH, Chan LP, Kuan CM. Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial. J Cosmet Dermatol. 2021 Jan;20(1):188-194. doi: 10.1111/jocd.13500. Epub 2020 Jun 12.
PubMed 32530124
Inacio PAQ, Chaluppe FA, Aguiar GF, Coelho CF, Vieira RP. Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review. Nutrients. 2024 May 21;16(11):1543. doi: 10.3390/nu16111543.
PubMed 38892477
Dierckx S, Patrizi M, Merino M, Gonzalez S, Mullor JL, Nergiz-Unal R. Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts. Front Med (Lausanne). 2024 May 1;11:1397517. doi: 10.3389/fmed.2024.1397517. eCollection 2024.
PubMed 38751975
Fu Y, Young JF, Rasmussen MK, Dalsgaard TK, Lametsch R, Aluko RE, Therkildsen M. Angiotensin I-converting enzyme-inhibitory peptides from bovine collagen: insights into inhibitory mechanism and transepithelial transport. Food Res Int. 2016 Nov;89(Pt 1):373-381. doi: 10.1016/j.foodres.2016.08.037. Epub 2016 Aug 28.
PubMed 28460927
Feng M, Betti M. Transepithelial transport efficiency of bovine collagen hydrolysates in a human Caco-2 cell line model. Food Chem. 2017 Jun 1;224:242-250. doi: 10.1016/j.foodchem.2016.12.044. Epub 2016 Dec 18.
PubMed 28159262
Osawa Y, Mizushige T, Jinno S, Sugihara F, Inoue N, Tanaka H, Kabuyama Y. Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ. Biomed Res. 2018;39(1):1-11. doi: 10.2220/biomedres.39.1.
PubMed 29467346
Liu Z, Li Y, Song H, He J, Li G, Zheng Y, Li B. Collagen peptides promote photoaging skin cell repair by activating the TGF-beta/Smad pathway and depressing collagen degradation. Food Funct. 2019 Sep 1;10(9):6121-6134. doi: 10.1039/c9fo00610a. Epub 2019 Sep 9.
PubMed 31497829
Wang L, Zhang Y, Zhu Z, Zheng F, Gao R. Food-derived collagen peptides: safety, metabolism, and anti-skin-aging effects. Current Opinion in Food Science. 2023;51:101012. https://doi.org/10.1016/j.cofs.2023.101012.
He X, Gao X, Guo Y, Xie W. Research Progress on Bioactive Factors against Skin Aging. Int J Mol Sci. 2024 Mar 28;25(7):3797. doi: 10.3390/ijms25073797.
PubMed 38612608
Yang Q, Li H, Zhang H, Ma L, Zhang X, Wu J. Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2025 Jul 21;12:1582946. doi: 10.3389/fmed.2025.1582946. eCollection 2025.
PubMed 40761858
Michelotti A, Cestone E, De Ponti I, Pisati M, Sparta E, Tursi F. Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing: a randomized, double-blind, placebo-controlled clinical trial. Eur J Dermatol. 2021 Dec 1;31(6):798-805. doi: 10.1684/ejd.2021.4176.
PubMed 34933842
Morgado-Carrasco D, Gil-Lianes J, Jourdain E, Piquero-Casals J. Oral Supplementation and Systemic Drugs for Skin Aging: A Narrative Review. Actas Dermosifiliogr. 2023 Feb;114(2):114-124. doi: 10.1016/j.ad.2022.09.014. Epub 2022 Oct 4. English, Spanish.
PubMed 36206809
Czajka A, Kania EM, Genovese L, Corbo A, Merone G, Luci C, Sibilla S. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res. 2018 Sep;57:97-108. doi: 10.1016/j.nutres.2018.06.001. Epub 2018 Jun 9.
PubMed 30122200

Study at a glance

From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology: A Randomized, Double-Blind, Placebo-Controlled Trial
ClinicalTrials.gov ID: NCT07516756
Acronym / sponsor ID: BCP-Skin / SECCR2024-97-01
Conditions: Age-related Changes in Skin Appearance and Physiology
Keywords: Bioactive collagen peptides, Oral supplementation, Skin aging, Skin hydration, Skin elasticity, Skin firmness, Wrinkles / periorbital wrinkles, Dermal extracellular matrix
Study type: Interventional
Recruitment status: Completed
Enrolment: 66 participants (actual)
Lead sponsor: Collagen Research InstituteIndustry (pharma, biotech, devices)
Collaborators: GELITA
Study start: 8 Aug 2024 (actual)
Primary completion: 4 Oct 2024 (actual)
Study completion: 4 Oct 2024 (actual)
First posted: 8 Apr 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Participants will:

Detailed description

The findings from this study are expected to enhance understanding of how collagen peptides affect skin physiology and contribute to evidence-based recommendations for supporting healthy skin.

Study design

Primary purpose: Prevention
Allocation: Randomised
Intervention model: Parallel groups
Masking: Quadruple blind (participant, care provider, investigator, outcomes assessor)
Number of arms: 2

Arm	Type	Receives
Specific Collagen Peptides	Experimental	Dietary Supplement: Specific Collagen PeptidesParticipants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.
Maltodextrin	Placebo comparator	Dietary Supplement: PlaceboParticipants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.

Who may qualify

Ages: 35 to 55 years
Sex: Female only
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (5 listed)

Fitzpatrick skin type III-IV
Presence of crow's feet wrinkles graded 2-4
Presence of under-eye fine lines graded 2-5
Generally in good health
Able to comply with study procedures and visit schedule

Key exclusion criteria (13 listed)

Use of systemic or topical anti-inflammatory medication, including corticosteroids, within the 4 weeks prior to baseline
Known hypersensitivity or allergy to any ingredient of the investigational products
Pregnancy, breastfeeding, or intention to become pregnant during the study period
History of relevant dermatological conditions: psoriasis, eczema, atopic dermatitis, or severe acne
Presence of birthmarks, hyperpigmentation, active inflammation, or other visible skin abnormalities in the test areas

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
PlaceboParticipants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.	Dietary supplement	Maltodextrin
Specific Collagen PeptidesParticipants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.	Dietary supplement	Specific Collagen Peptides

Primary outcome

stratum corneum hydration (SCH)
Time frame: From enrollment to the end of treatment at 8 weeks
Stratum corneum hydration (SCH) measures the water content in the outermost layer of the skin, reflecting the skin's ability to retain moisture and maintain a healthy barrier. In this study, SCH is the primary efficacy endpoint, used to compare the effect of daily oral supplementation with specific bioactive collagen peptides (SCP) versus placebo over an 8-week period. SCH is assessed using a Corneometer CM825 at the cheek. Each site is measured six times, and the mean value is used for analysis. Higher SCH values indicate better skin hydration, whereas lower values suggest dryness or impaired barrier function. Changes in SCH over time are compared between the treatment and placebo groups to evaluate the impact of collagen peptide supplementation on skin hydration.

5 secondary outcomes

Transepidermal Water Loss (TEWL)
Time frame: From enrollment to the end of treatment at 8 weeks
Skin Elasticity (R2 and R5) and Firmness (F4)
Time frame: From enrollment to the end of treatment at 8 weeks
Dermal collagen content
Time frame: From enrollment to the end of treatment at 8 weeks
Wrinkle Morphology
Time frame: From enrollment to the end of treatment at 8 weeks
Skin Appearance (3D Imaging + VAS)
Time frame: From enrollment to the end of treatment at 8 weeks

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
Background: PubMed 30301271Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018 Oct 7;19(10):3059. doi: 10.3390/ijms19103059.
Background: PubMed 39150674Dahnhardt D, Dahnhardt-Pfeiffer S, Segger D, Poeggeler B, Lemmnitz G. Restoration of the Ultrastructural Integrity of the Dermal Collagen Network by 12-Week Ingestion of Special Collagen Peptides. Dermatol Ther (Heidelb). 2024 Sep;14(9):2509-2521. doi: 10.1007/s13555-024-01251-8. Epub 2024 Aug 16.
Background: PubMed 32530124Lin P, Alexander RA, Liang CH, Liu C, Lin YH, Lin YH, Chan LP, Kuan CM. Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial. J Cosmet Dermatol. 2021 Jan;20(1):188-194. doi: 10.1111/jocd.13500. Epub 2020 Jun 12.
Background: PubMed 38892477Inacio PAQ, Chaluppe FA, Aguiar GF, Coelho CF, Vieira RP. Effects of Hydrolyzed Collagen as a Dietary Supplement on Fibroblast Activation: A Systematic Review. Nutrients. 2024 May 21;16(11):1543. doi: 10.3390/nu16111543.
Background: PubMed 38751975Dierckx S, Patrizi M, Merino M, Gonzalez S, Mullor JL, Nergiz-Unal R. Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts. Front Med (Lausanne). 2024 May 1;11:1397517. doi: 10.3389/fmed.2024.1397517. eCollection 2024.
Background: PubMed 28460927Fu Y, Young JF, Rasmussen MK, Dalsgaard TK, Lametsch R, Aluko RE, Therkildsen M. Angiotensin I-converting enzyme-inhibitory peptides from bovine collagen: insights into inhibitory mechanism and transepithelial transport. Food Res Int. 2016 Nov;89(Pt 1):373-381. doi: 10.1016/j.foodres.2016.08.037. Epub 2016 Aug 28.
Background: PubMed 28159262Feng M, Betti M. Transepithelial transport efficiency of bovine collagen hydrolysates in a human Caco-2 cell line model. Food Chem. 2017 Jun 1;224:242-250. doi: 10.1016/j.foodchem.2016.12.044. Epub 2016 Dec 18.
Background: PubMed 29467346Osawa Y, Mizushige T, Jinno S, Sugihara F, Inoue N, Tanaka H, Kabuyama Y. Absorption and metabolism of orally administered collagen hydrolysates evaluated by the vascularly perfused rat intestine and liver in situ. Biomed Res. 2018;39(1):1-11. doi: 10.2220/biomedres.39.1.
Background: PubMed 31497829Liu Z, Li Y, Song H, He J, Li G, Zheng Y, Li B. Collagen peptides promote photoaging skin cell repair by activating the TGF-beta/Smad pathway and depressing collagen degradation. Food Funct. 2019 Sep 1;10(9):6121-6134. doi: 10.1039/c9fo00610a. Epub 2019 Sep 9.
BackgroundWang L, Zhang Y, Zhu Z, Zheng F, Gao R. Food-derived collagen peptides: safety, metabolism, and anti-skin-aging effects. Current Opinion in Food Science. 2023;51:101012. https://doi.org/10.1016/j.cofs.2023.101012.
Background: PubMed 38612608He X, Gao X, Guo Y, Xie W. Research Progress on Bioactive Factors against Skin Aging. Int J Mol Sci. 2024 Mar 28;25(7):3797. doi: 10.3390/ijms25073797.
Background: PubMed 40761858Yang Q, Li H, Zhang H, Ma L, Zhang X, Wu J. Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2025 Jul 21;12:1582946. doi: 10.3389/fmed.2025.1582946. eCollection 2025.
Individual participant dataSharing planned: No. The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. The data will not be publicly available due to privacy and ethical restrictions.

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Steffen Oesser, Dr study director

Collagen Research Institute, Schauenburgerstr. 116, D-24118 Kiel

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Specific Collagen Peptides in people with Age-related Changes in Skin Appearance and Physiology, run by Collagen Research Institute at 1 site in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

stratum corneum hydration (SCH) (time frame: From enrollment to the end of treatment at 8 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07516756, which also lists 36 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.