Regional Anesthesia BlockNCT07517809
Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries
A study testing Costoclavicular brachial plexus block and Lateral-sagittal infraclavicular brachial plexus block in people with Regional Anesthesia Block and Brachial Plexus Blocks, run by Ain Shams University at 1 site in Egypt.
Trial summary
The aim of the study is to compare the onset time of the costoclavicular approach of brachial plexus block with that of the lateral-sagittal infraclavicular approach in adults distal upper limb surgeries. Read more about this study
- Who is it for?
- Ages 21 to 65 years
- Conditions the study is for
- Regional Anesthesia Block, Brachial Plexus Blocks
- What is being tested?
- Costoclavicular brachial plexus block and Lateral-sagittal infraclavicular brachial plexus block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 16 Feb 2026to Sep 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- ASA physical status I-III
- Distal upper limb surgery requiring brachial plexus block.
- Patient approval after written and informed consent to participate.
Who cannot join
- Patient refusal.
- Allergy to drugs used.
- Infection at puncture site.
- Coagulopathy or anticoagulant therapy.
- Pre-existing neuropathy or neurological deficit in the affected limb.
- Severe pulmonary disease.
- BMI > 40 kg/m².
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Ain Shams University Hospitals
Cairo
offices of professor D. Vice President, +20226947820, info@ainshams.edu.eg
About this study
Official title: Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries : A Randomized Controlled Trial
The aim of the study is to compare the onset time of the costoclavicular approach of brachial plexus block with that of the lateral-sagittal infraclavicular approach in adults distal upper limb surgeries.
Read the detailed description
Regional anesthesia is commonly used for distal upper limb surgeries as it provides effective surgical anesthesia, reduces opioid consumption, and offers prolonged postoperative analgesia. Ultrasound-guided infraclavicular brachial plexus block is a well-established technique for these procedures. The traditional lateral-sagittal infraclavicular approach (LS-ICB) provides reliable anesthesia but may require multiple needle redirections to achieve adequate spread of local anesthetic around the cords of the brachial plexus. The costoclavicular (CC) approach is a newer ultrasound-guided infraclavicular technique in which the three cords of the brachial plexus are clustered together in the costoclavicular space, potentially allowing easier needle placement and faster spread of local anesthetic.
This prospective randomized controlled trial will include 50 adult patients undergoing distal upper limb surgery under regional anesthesia. Participants will be randomly assigned into two equal groups (25 patients each). Group CC will receive an ultrasound-guided costoclavicular brachial plexus block, while Group ICB will receive an ultrasound-guided lateral-sagittal infraclavicular brachial plexus block.
In both groups, the block will be performed using a mixture of 2% lidocaine and 0.5% bupivacaine in a 1:1 ratio with a total volume of 0.3 mL/kg, administered under real-time ultrasound guidance.
The primary outcome of the study is the time to onset of complete sensory and motor blockade after injection of the local anesthetic solution. Sensory block will be assessed using pinprick testing in the distributions of the median, ulnar, radial, and musculocutaneous nerves.
Secondary outcomes include block performance time, block success rate, incidence of complications (such as vascular puncture, pneumothorax, or local anesthetic systemic toxicity), postoperative pain scores, and total analgesic consumption during the first 24 hours after surgery. The findings of this study may help identify the most effective and safe infraclavicular block technique for distal upper limb surgeries.
- Conditions
- Regional Anesthesia Block, Brachial Plexus Blocks
- Being tested
- Costoclavicular brachial plexus block, Lateral-sagittal infraclavicular brachial plexus block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Costoclavicular brachial plexus blockProcedure or surgery
Ultrasound-guided costoclavicular brachial plexus block performed using a high-frequency linear probe. A mixture of 2% lidocaine and 0.5% bupivacaine (1:1 ratio) with a total volume of 0.3 mL/kg is injected in the costoclavicular space around the cords of the brachial plexus under real-time ultrasound guidance.
Lateral-sagittal infraclavicular brachial plexus blockProcedure or surgery
Ultrasound-guided lateral-sagittal infraclavicular brachial plexus block performed using a high-frequency linear probe. A mixture of 2% lidocaine and 0.5% bupivacaine (1:1 ratio) with a total volume of 0.3 mL/kg is injected around the cords of the brachial plexus under real-time ultrasound guidance.
| Study group | Role | What they receive |
|---|---|---|
| Lateral-sagittal infraclavicular block (LS-ICB) group | Active comparator | Drug : A mixture of 2% lidocaine and 0.5% bupivacaine with volume of 0.3 mL/kg and a ratio of 1:1. Receives: Procedure: Lateral-sagittal infraclavicular brachial plexus block |
| Costoclavicular block brachial plexus (CC) group | Active comparator | Not described Receives: Procedure: Costoclavicular brachial plexus block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to onset of complete sensory and motor block
Time from completion of local anesthetic injection to achievement of complete sensory and motor blockade. Sensory block will be assessed using pinprick testing in the distributions of the median, ulnar, radial, and musculocutaneous nerves. Motor block will be graded using a standardized motor scale. And time will be in minutes and seconds.
Measured: From completion of injection up to 30 minutes after block performance
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start16 Feb 2026
- Primary completionAug 2026 (estimated)
- Study completionSep 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Regional Anesthesia BlockStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07517809
- Sponsor's protocol ID
- FMASU MS 101/2026
- Status last verified
- Apr 2026
- First submitted
- 2 Apr 2026
- Last updated
- 24 Jun 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Between Ultrasound-Guided Costoclavicular and Lateral-Sagittal Infraclavicular Brachial Plexus Blocks in Adult Distal Upper Limb Surgeries : A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07517809
- Acronym / sponsor ID
- FMASU MS 101/2026
- Conditions
- Regional Anesthesia Block, Brachial Plexus Blocks
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 16 Feb 2026 (actual)
- Primary completion
- Aug 2026 (estimated)
- Study completion
- Sep 2026 (estimated)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of the study is to compare the onset time of the costoclavicular approach of brachial plexus block with that of the lateral-sagittal infraclavicular approach in adults distal upper limb surgeries.
Detailed description
Regional anesthesia is commonly used for distal upper limb surgeries as it provides effective surgical anesthesia, reduces opioid consumption, and offers prolonged postoperative analgesia. Ultrasound-guided infraclavicular brachial plexus block is a well-established technique for these procedures. The traditional lateral-sagittal infraclavicular approach (LS-ICB) provides reliable anesthesia but may require multiple needle redirections to achieve adequate spread of local anesthetic around the cords of the brachial plexus. The costoclavicular (CC) approach is a newer ultrasound-guided infraclavicular technique in which the three cords of the brachial plexus are clustered together in the costoclavicular space, potentially allowing easier needle placement and faster spread of local anesthetic.
This prospective randomized controlled trial will include 50 adult patients undergoing distal upper limb surgery under regional anesthesia. Participants will be randomly assigned into two equal groups (25 patients each). Group CC will receive an ultrasound-guided costoclavicular brachial plexus block, while Group ICB will receive an ultrasound-guided lateral-sagittal infraclavicular brachial plexus block.
In both groups, the block will be performed using a mixture of 2% lidocaine and 0.5% bupivacaine in a 1:1 ratio with a total volume of 0.3 mL/kg, administered under real-time ultrasound guidance.
The primary outcome of the study is the time to onset of complete sensory and motor blockade after injection of the local anesthetic solution. Sensory block will be assessed using pinprick testing in the distributions of the median, ulnar, radial, and musculocutaneous nerves.
Secondary outcomes include block performance time, block success rate, incidence of complications (such as vascular puncture, pneumothorax, or local anesthetic systemic toxicity), postoperative pain scores, and total analgesic consumption during the first 24 hours after surgery. The findings of this study may help identify the most effective and safe infraclavicular block technique for distal upper limb surgeries.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Lateral-sagittal infraclavicular block (LS-ICB) group | Active comparator | Procedure: Lateral-sagittal infraclavicular brachial plexus blockDrug : A mixture of 2% lidocaine and 0.5% bupivacaine with volume of 0.3 mL/kg and a ratio of 1:1. |
| Costoclavicular block brachial plexus (CC) group | Active comparator | Procedure: Costoclavicular brachial plexus block |
Who may qualify
- Ages
- 21 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- ASA physical status I-III
- Distal upper limb surgery requiring brachial plexus block.
- Patient approval after written and informed consent to participate.
Key exclusion criteria (7 listed)
- Patient refusal.
- Allergy to drugs used.
- Infection at puncture site.
- Coagulopathy or anticoagulant therapy.
- Pre-existing neuropathy or neurological deficit in the affected limb.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Costoclavicular brachial plexus blockUltrasound-guided costoclavicular brachial plexus block performed using a high-frequency linear probe. A mixture of 2% lidocaine and 0.5% bupivacaine (1:1 ratio) with a total volume of 0.3 mL/kg is injected in the costoclavicular space around the cords of the brachial plexus under real-time ultrasound guidance. | Procedure or surgery | Costoclavicular block brachial plexus (CC) group |
| Lateral-sagittal infraclavicular brachial plexus blockUltrasound-guided lateral-sagittal infraclavicular brachial plexus block performed using a high-frequency linear probe. A mixture of 2% lidocaine and 0.5% bupivacaine (1:1 ratio) with a total volume of 0.3 mL/kg is injected around the cords of the brachial plexus under real-time ultrasound guidance. | Procedure or surgery | Lateral-sagittal infraclavicular block (LS-ICB) group |
Primary outcome
Time to onset of complete sensory and motor block
Time frame: From completion of injection up to 30 minutes after block performance
Time from completion of local anesthetic injection to achievement of complete sensory and motor blockade. Sensory block will be assessed using pinprick testing in the distributions of the median, ulnar, radial, and musculocutaneous nerves. Motor block will be graded using a standardized motor scale. And time will be in minutes and seconds.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Costoclavicular brachial plexus block and Lateral-sagittal infraclavicular brachial plexus block in people with Regional Anesthesia Block and Brachial Plexus Blocks, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Hesham Shahin, M.B.B.CH (+201270857308, 160634@med.asu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to onset of complete sensory and motor block (time frame: From completion of injection up to 30 minutes after block performance). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jun 2026; AzTrials last refreshed its copy on 7 Nov 2026.