AnaesthesiaPhase 4NCT07517822
Bilateral Erector Spinae Plane Block Versus Bilateral Quadratus Lumborum Plane Block for Postoperative Anaelgesia After Lumbar Spine Surgery
A Phase 4 study testing Ultrasound-guided quadratus lumborum block (QLB) in people with Anaesthesia, run by Ain Shams University at 1 site in Egypt.
Trial summary
The aim of this study is to compare postoperative analgesia and duration for each block performance plus complications after surgery in lumbar spine fixation. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Anaesthesia
- What is being tested?
- Ultrasound-guided quadratus lumborum block (QLB)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2025to 1 Jul 2026
- Phase
- Phase 4
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged between 18 and 65 years.
- American Society of Anesthesiologists (ASA) physical status I to II.
- Body mass index (BMI) less than 35 kg/m2.
Who cannot join
- Revision surgery.
- More than three levels surgery.
- Abnormal state of blood coagulation.
- Chronic opioid consumption.
- Local infection at the injection site).
- Allergy to any involved medications.
- Taking opioids within the past two weeks prior to surgery.
- Time of surgery more than 4 hours.
Trial locations and contacts
1 site in 1 country.
About this study
The aim of this study is to compare postoperative analgesia and duration for each block performance plus complications after surgery in lumbar spine fixation.
- Conditions
- Anaesthesia
- Being tested
- Ultrasound-guided quadratus lumborum block (QLB)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-guided quadratus lumborum block (QLB)Procedure or surgery
And ultrasound guided QLB block with transmuscular approach was performed using 0.5 ml/kg 0.25% bupivacaine to the patients in QLB group
| Study group | Role | What they receive |
|---|---|---|
| Ultrasound-guided quadratus lumborum block | Active comparator | Not described Receives: Procedure: Ultrasound-guided quadratus lumborum block (QLB) |
| Ultrasound Guided Erector Spinae Plane Block (ESPB) | Active comparator | Not described Receives: Procedure: Ultrasound-guided quadratus lumborum block (QLB) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Comparison between postoperative analgesia of QLB and ESPB after lumbar spine surgery via VAS score measurement
The Visual Analog Scale (VAS) is used to assess pain intensity. It consists of a 10 cm line where 0 indicates "no pain" and 10 indicates "the worst possible pain." Higher scores indicate greater pain intensity.
Measured: VAS Score will be used to assess pain or discomfort in postoperative at 2, 4, 6, 12, 24 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start1 Dec 2025
- Primary completion1 Jun 2026 (estimated)
- Study completion1 Jul 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for AnaesthesiaStudies of the same condition, open and under way.
- More trials run by Ain Shams UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Investigator
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07517822
- Sponsor's protocol ID
- MMASU 15/2024
- Status last verified
- Apr 2026
- First submitted
- 2 Apr 2026
- Last updated
- 8 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: To maintain participant confidentiality and because there is no established institutional repository for sharing raw individual participant data for this specific project.
Publications
Mahmoud Fakhry D, ElMoutaz Mahmoud H, Yehia Kassim D, NegmEldeen AbdElAzeem H. Erector Spinae Plane Block versus Quadratus Lumborum Block for Postoperative Analgesia after Laparoscopic Resection of Colorectal Cancer: A Prospective Randomized Study. Anesthesiol Res Pract. 2024 Mar 18;2024:6200915. doi: 10.1155/2024/6200915. eCollection 2024.
PubMed 38529324
Study at a glance
From the registry record, last updated by the sponsor on 8 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Bilateral Erector Spinae Plane Block Versus Bilateral Quadratus Lumborum Plane Block for Postoperative Anaelgesia After Lumbar Spine Surgery
- ClinicalTrials.gov ID
- NCT07517822
- Acronym / sponsor ID
- MMASU 15/2024
- Conditions
- Anaesthesia
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 1 Dec 2025 (actual)
- Primary completion
- 1 Jun 2026 (estimated)
- Study completion
- 1 Jul 2026 (estimated)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to compare postoperative analgesia and duration for each block performance plus complications after surgery in lumbar spine fixation.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Ultrasound-guided quadratus lumborum block | Active comparator | Procedure: Ultrasound-guided quadratus lumborum block (QLB) |
| Ultrasound Guided Erector Spinae Plane Block (ESPB) | Active comparator | Procedure: Ultrasound-guided quadratus lumborum block (QLB) |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Aged between 18 and 65 years.
- American Society of Anesthesiologists (ASA) physical status I to II.
- Body mass index (BMI) less than 35 kg/m2.
Key exclusion criteria (8 listed)
- Revision surgery.
- More than three levels surgery.
- Abnormal state of blood coagulation.
- Chronic opioid consumption.
- Local infection at the injection site).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-guided quadratus lumborum block (QLB)And ultrasound guided QLB block with transmuscular approach was performed using 0.5 ml/kg 0.25% bupivacaine to the patients in QLB group | Procedure or surgery | Ultrasound Guided Erector Spinae Plane Block (ESPB), Ultrasound-guided quadratus lumborum block |
Primary outcome
Comparison between postoperative analgesia of QLB and ESPB after lumbar spine surgery via VAS score measurement
Time frame: VAS Score will be used to assess pain or discomfort in postoperative at 2, 4, 6, 12, 24 hours
The Visual Analog Scale (VAS) is used to assess pain intensity. It consists of a 10 cm line where 0 indicates "no pain" and 10 indicates "the worst possible pain." Higher scores indicate greater pain intensity.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Apr 2026.
- Background: PubMed 38529324Mahmoud Fakhry D, ElMoutaz Mahmoud H, Yehia Kassim D, NegmEldeen AbdElAzeem H. Erector Spinae Plane Block versus Quadratus Lumborum Block for Postoperative Analgesia after Laparoscopic Resection of Colorectal Cancer: A Prospective Randomized Study. Anesthesiol Res Pract. 2024 Mar 18;2024:6200915. doi: 10.1155/2024/6200915. eCollection 2024.
- Individual participant dataSharing planned: No. To maintain participant confidentiality and because there is no established institutional repository for sharing raw individual participant data for this specific project.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Ultrasound-guided quadratus lumborum block (QLB) in people with Anaesthesia, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 8 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Comparison between postoperative analgesia of QLB and ESPB after lumbar spine surgery via VAS score measurement (time frame: VAS Score will be used to assess pain or discomfort in postoperative at 2, 4, 6, 12, 24 hours). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07517822, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Apr 2026.