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AgingHCP-S1NCT07517887

Anti-aging Efficacy Study on One Cosmetic Product Containing Mitopure

A study testing Skin care product in people with Aging and Wrinkle Appearance, run by Amazentis SA at 1 site in Germany.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The aim of this study is to investigate the impact of a topical product on skin health and aging Read more about this study

Who is it for?
Ages 45 to 65 yearsHealthy volunteers can take part
Conditions the study is for
Aging, Wrinkle Appearance
What is being tested?
Skin care product
Could I receive a placebo?
No, everyone receives an active treatment
How many people
36 participants
Where
1 siteGermany
Study dates
22 Apr 2026to 19 Jun 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 45 to 65 years
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Written Informed Consent to participate in the study
  • Written Informed Consent for the use of the images for marketing purposes applies to subgroup participants of study 26.0112.
  • Willingness to actively participate in the study and to come to the scheduled visits
  • Female
  • Male, approximately 10 to 15% with little facial hair
  • From 45 to 65 years of age
  • Healthy skin in the test areas
  • Visible wrinkles in the face (grade 3 to 6 according to proderm wrinkle score)

Who cannot join

  • Female participants: Pregnancy or lactation
  • Drug addicts, alcoholics
  • AIDS, HIV-positive or infectious hepatitis
  • Conditions which exclude a participation or might influence the test reaction/evaluation
  • Participation or being in the waiting period after participation in cosmetic and/or pharmaceutical studies pertaining to the test area
  • Active skin disease at the test area
Show all 19Show fewer
  • Documented allergies to face/eye care products or their ingredients
  • Diabetes mellitus
  • Cancer not being diagnosed as cured and requiring chemotherapy, irradiation and/or hormonal treatment within the last 2 years
  • One of the following illnesses with reduced physical capability/fitness: asthma (symptom-free allergic asthma is not an exclusion criterion), hypertension (if not adjusted with medication), cardiovascular diseases
  • Epilepsy
  • Wounds, moles, tattoos, scars, irritated skin, excessive hair growth, freckles, etc. at the test area that could influence the investigation
  • Regular use of tanning beds within the last 6 weeks prior to the start of the study
  • Any topical medication at the test area within the last 3 days prior to the start of the study
  • Systemic therapy with immuno-suppressive drugs (e.g. corticosteroids) and/or antihistamines (e.g. antiallergics) within the last 7 days prior to the start of the study and throughout the entire course of the study that in the opinion of the investigator may affect the outcome of the study
  • Therapy with antibiotics within the last 2 weeks prior to the start of the study and throughout the entire course of the study that in the opinion of the investigator may affect the outcome of the study
  • Cosmetic surgery procedure in the test area (e.g. laser, facelift) within the last 2 years and throughout the entire course of the study
  • Cosmetic surgery treatments in the test area, e.g. IPL (Intensed Pulsed Light), botox, chemical peel, dermabrasion within the last 2 years prior to the start of the study and throughout the entire course of the study
  • Medical treatment for wrinkle reduction (e.g. peeling with vitamin A or fruit acids) on the face within the last 2 weeks prior to the start of the study and throughout the entire course of the study

Trial locations and contacts

1 site in 1 country.

Germany1 site

  • SGS proderm GmbH

    Schenefeld, 22869

Other trials in Germany

About this study

Official title: Anti-aging Efficacy Study on One Cosmetic Product vs Untreated

The aim of this study is to investigate the impact of a topical product on skin health and aging

Being tested
Skin care product

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Skin care productOther

    The cosmetic skin care product will be applied twice daily to half of the face

Study groups in NCT07517887
Study groupRoleWhat they receive
Cosmetic routineExperimentalThe "cosmetic routine" arm will apply the skin care product
Receives: Other: Skin care product
Untreated controlNo interventionThe "Untreated control" arm will not apply the skin care product

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Skin hydration

    Change from baseline in skin hydration (assessed on skin capacitance by Corneometer) after 2 and 8 weeks

    Measured: 8 weeks

Secondary outcomes (8)

  1. Anti-wrinkle efficacy

    Change from baseline in anti-wrinkles efficacy (assessed on three-dimensional structure of the wrinkles in the periorbital regions) after 2 and 8 weeks. Anti-wrinkle efficacy will be assessed using DermaTOP. Parameters measured: Rz and Ra, representing mainly the rough structure (Rz) or the finer skin structure (Ra).

    Measured: 8 weeks

  2. Skin barrier function

    Change from baseline in skin barrier function (assessed onTransepidermal water loss (TEWL) by Tewameter [g/(m²h)]) after 2 and 8 weeks

    Measured: 8 weeks

  3. Skin firmness

    Change from baseline in skin firmness (assessed by R0 (Uf) by Cutometer [mm]) after 2 and 8 weeks

    Measured: 8 weeks

  4. Skin elasticity

    Change from baseline in skin elasticity (assessed by R7 (Ur/Uf) by Cutometer) after 2 and 8 weeks

    Measured: 8 weeks

  5. Clinical skin appearance

    Change from baseline for skin appearance (assessed on VISIA-CR Image analysis) after 2 and 8 weeks

    Measured: 8 weeks

  6. Skin aging hallmarks

    Change from baseline in skin hallmarks of aging (assessed on 22mm D-Squames® tape strips) after 2 and 8 weeks

    Measured: 8 weeks

  7. Product traits

    Subjective evaluation of product traits assessed via questionnaire after 2 and 8 weeks.

    Product traits will be assessed by the subjects with a list of closed questions with the following predefined identical options to tick:

    2 = Fully disagree;

    1 = Rather disagree;

    1. = Rather agree;
    2. = Fully agree

    Measured: 8 weeks

  8. Clinical Before-After Photography

    An additional cohort of 15 participants will apply the test product to their full face. Trained graders will analyze images (assessed on VISIA-CR Image) to visually determine biological skin age after 2 and 8 weeks.

    Measured: 8 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Apr 2026
  2. Study start22 Apr 2026
  3. Primary completion19 Jun 2026
  4. Study completion19 Jun 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Parallel groups
Model description
Split-face design. Subjects will be divided equally in 2 treatment groups (topical product or untreated). Treatments will be randomly and balanced assigned to left and right test area.
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
36 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07517887
Sponsor's protocol ID
26.0076-23 26.0112-23
Acronym
HCP-S1
Status last verified
Jul 2026
First submitted
2 Apr 2026
Last updated
9 Jul 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Skin care product in people with Aging and Wrinkle Appearance, run by Amazentis SA at 1 site in Germany.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 8 inclusion and 19 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 9 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Skin hydration (time frame: 8 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07517887.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Jul 2026.

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