AphasiaRIAB_GESTONCT07518563
Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning
An observational study of Aphasia and Stroke, run by IRCCS San Camillo, Venezia, Italy at 1 site in Italy.
Trial summary
This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- What is being tested?
- Person with Aphasia
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 7 participants
- Where
- 1 siteItaly
- Study dates
- 1 Jun 2022to 1 Aug 2023
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Person with Aphasia due to left stroke
Who may be able to join
- Age ≥ 18 years Diagnosis of left-sided stroke Clinical diagnosis of aphasia Native language: Italian (L1 Italian)
Who cannot join
- History of psychiatric disorders
Trial locations and contacts
1 site in 1 country.
About this study
This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, neural coupling between the encoder (PWA) and decoder (healthy participant) was analyzed during tasks involving social, affective, and informative gestures with both positive and negative emotional valence.
Read the detailed description
Gestures are essential in non-verbal communication, complementing speech by expressing emotions, intentions, and cognitive states. This study examines neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, we analyzed neural coupling between the encoder (PWA) and decoder (healthy participant) during tasks involving social, affective, and informative gestures with both positive and negative emotional valence. Methods: Seven dyads of participants participated in this study. The research was approved by the Ethical Committee of the IRCCS San CamilloHospital
- Being tested
- Person with Aphasia
- Keywords
- gestures, aphasia, EEG, hyperscanning
- Medical subject headings
- Aphasia, Stroke, Gestures
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Person with AphasiaBehavioural
EEG during gestures production
| Study group | Role | What they receive |
|---|---|---|
| Person with Aphasia | Not described Receives: Behavioral: Person with Aphasia |
What is being measured
The primary outcome is the main question the study is designed to answer.
neural synchronization
Neural synchronization between encoder and decoder
Description: Synchronization of activity in the alpha, beta, delta, and theta EEG bands between the encoder and decoder, assessed during task performance. Metrics will be reported separately for each frequency band.
Time Frame: At EEG recording
Measured: during EEG hyperscanning recording
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Apr 2026
- Study start1 Jun 2022
- Primary completion1 Aug 2023
- Study completion1 Aug 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AphasiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 7 participants (actual)
Sponsor and investigators
- Lead sponsor
- IRCCS San Camillo, Venezia, Italy
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sara Nordio, IRCCS San Camillo, Venezia, Italy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07518563
- Sponsor's protocol ID
- 2021.23
- Other IDs
- Ethical Committee Veneto
- Acronym
- RIAB_GESTO
- Status last verified
- Apr 2026
- First submitted
- 25 Mar 2026
- Last updated
- 22 Apr 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural Synchronization During Gesture Production and Comprehension in Individuals With Aphasia and Healthy Controls: A Study Using EEG Hyperscanning
- ClinicalTrials.gov ID
- NCT07518563
- Acronym / sponsor ID
- RIAB_GESTO / 2021.23
- Keywords
- gestures, aphasia, EEG, hyperscanning
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 7 participants (actual)
- Lead sponsor
- IRCCS San Camillo, Venezia, ItalyUniversity, hospital or other
- Study start
- 1 Jun 2022 (actual)
- Primary completion
- 1 Aug 2023 (actual)
- Study completion
- 1 Aug 2023 (actual)
- First posted
- 8 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study explores the neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, neural coupling between the encoder (PWA) and decoder (healthy participant) was analyzed during tasks involving social, affective, and informative gestures with both positive and negative emotional valence.
Detailed description
Gestures are essential in non-verbal communication, complementing speech by expressing emotions, intentions, and cognitive states. This study examines neural mechanisms of gesture comprehension and production in people with aphasia (PWA) and healthy controls, focusing on brain synchronization during gesture observation and reproduction. Using EEG hyperscanning, we analyzed neural coupling between the encoder (PWA) and decoder (healthy participant) during tasks involving social, affective, and informative gestures with both positive and negative emotional valence. Methods: Seven dyads of participants participated in this study. The research was approved by the Ethical Committee of the IRCCS San CamilloHospital
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Person with Aphasia | – | Behavioral: Person with Aphasia |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Person with Aphasia due to left stroke
Key inclusion criteria (1 listed)
- Age ≥ 18 years Diagnosis of left-sided stroke Clinical diagnosis of aphasia Native language: Italian (L1 Italian)
Key exclusion criteria (1 listed)
- History of psychiatric disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Person with AphasiaEEG during gestures production | Behavioural | Person with Aphasia |
Primary outcome
neural synchronization
Time frame: during EEG hyperscanning recording
Neural synchronization between encoder and decoder Description: Synchronization of activity in the alpha, beta, delta, and theta EEG bands between the encoder and decoder, assessed during task performance. Metrics will be reported separately for each frequency band. Time Frame: At EEG recording
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Apr 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Aphasia and Stroke, run by IRCCS San Camillo, Venezia, Italy at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
neural synchronization (time frame: during EEG hyperscanning recording). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Apr 2026.