Alveolar Bone LossCGFNCT07520513
Socket Shield Technique With CGF and Xenograft for Immediate Implants
A study testing Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft in people with Alveolar Bone Loss and Socket Shield Technique, run by Cairo University at 1 site in Egypt.
Trial summary
This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Alveolar Bone Loss, Socket Shield Technique, Bone Resorption
- What is being tested?
- Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 7 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Apr 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥18 years old. (Younis, W., \& El-Rashidy, A. 2020).
- Both male and female patients.
- Maxillary, anterior and premolar segments.
Who cannot join
- A medical history that contraindicates oral surgical treatment such as (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous bisphosphonates).
- Presence of active or untreated periodontal disease.
- Vertical root fractures involving the buccal aspect.
- Tooth /teeth with horizontal fractures below bone level.
- Tooth /teeth with external or internal resorption.
- Patients with destructive oral habits such as smoking, chewing tobacco, bruxism, etcetera.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Huda Ayman Alrifai, bachelors contact
Egypt1 site
Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate, 11553
About this study
Official title: Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique
This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.
Read the detailed description
This study is designed as a prospective case series to evaluate the effectiveness of combining concentrated growth factors (CGF) and xenograft with the socket shield technique (SST) during immediate implant placement in the maxillary esthetic region.
Post-extraction alveolar ridge resorption, particularly of the buccal bone plate, represents a significant challenge in achieving optimal esthetic outcomes. The socket shield technique has been introduced to preserve the buccal bone by retaining the labial portion of the root, thereby minimizing post-extraction resorption. However, immediate implant placement is often associated with the presence of a gap between the implant surface and the socket wall, known as the "jumping gap," which may compromise implant stability and osseointegration.
To enhance bone regeneration within this gap, bone grafting materials are commonly utilized. Concentrated growth factors (CGF), an autologous platelet concentrate, have demonstrated the ability to promote angiogenesis, osteogenesis, and soft tissue healing through the sustained release of growth factors. When combined with xenograft, which provides an osteoconductive scaffold, this approach may improve bone regeneration and implant integration.
In this study, eligible patients requiring immediate implant placement in the esthetic zone will undergo partial extraction therapy using the socket shield technique. Implants will be placed immediately after extraction, and CGF will be prepared from the patient's venous blood and mixed with xenograft to form a "sticky bone" graft, which will be applied to fill the jumping gap.
Radiographic evaluation will be performed using cone-beam computed tomography (CBCT) at 2 weeks and 6 months postoperatively to assess crestal bone level changes. Implant stability will be measured using resonance frequency analysis (Osstell device) and expressed as implant stability quotient (ISQ) values.
The findings of this study are expected to provide clinical and radiographic evidence regarding the effectiveness of combining CGF and xenograft with the socket shield technique in enhancing bone regeneration and improving outcomes of immediate implant placement in the esthetic zone.
- Conditions
- Alveolar Bone Loss, Socket Shield Technique, Bone Resorption, Immediate Dental Implant Placement, Concentrated Growth Factors, Xenograft
- Being tested
- Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft
- Keywords
- immediate implants, socket shield technique, Concentrated growth factor, Xenograft
- Medical subject headings
- Alveolar Bone Loss, Bone Resorption
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Socket Shield Technique with Immediate Implant Placement and CGF + XenograftProcedure or surgery
The procedure involves partial extraction therapy using the socket shield technique, where the buccal portion of the root is preserved to maintain the alveolar bone. Immediate implant placement is performed into the extraction socket. Concentrated growth factors (CGF) are prepared from the patient's autologous blood via centrifugation and combined with xenograft to form a "sticky bone" graft. This graft is placed in the jumping gap between the implant and socket wall to enhance bone regeneration and healing. Implant stability will be measured using resonance frequency analysis (Osstell), and radiographic evaluation will be performed using CBCT.
| Study group | Role | What they receive |
|---|---|---|
| Socket Shield Technique with CGF and Xenograft in Immediate Implant Placement | Experimental | Participants will undergo immediate implant placement in the esthetic zone using the socket shield technique. Following partial extraction therapy, implants will be placed immediately, and the jumping gap will be filled using a combination of concentrated growth factors (CGF) and xenograft prepared as "sticky bone." Clinical and radiographic follow-up will be conducted over a 6-month period to evaluate crestal bone levels and implant stability. Receives: Procedure: Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft |
What is being measured
The primary outcome is the main question the study is designed to answer.
crestal bone level
Evaluation of changes in crestal bone level around the dental implant using cone-beam computed tomography (CBCT). Measurements will be taken from a fixed reference point on the implant to the first bone-to-implant contact recorded in millimeters (mm)
Measured: 2 weeks, and 6 months postoperatively
Secondary outcomes (1)
Implant Stability (ISQ Values)
Implant stability will be assessed using resonance frequency analysis with the Osstell device and recorded as Implant Stability Quotient (ISQ). ISQ values range from 1 to 100, where higher values indicate greater implant stability and a better outcome.
Measured: Immediate postoperative, and at 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2026
- Study start5 Apr 2026 (estimated)
- Primary completion1 Sep 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone LossStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 7 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Huda Ayman Alrifai, Cairo University
- Investigators
- Tarek I.A El-Ghareeb, PHD Holder, Study chair, Cairo UniversityAbdelmoez Mohamed EL-Sharkawy, Associate professor, Study director, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07520513
- Sponsor's protocol ID
- OMFS-3-3-20
- Acronym
- CGF
- Status last verified
- Apr 2026
- First submitted
- 3 Apr 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Radiographic Evaluation of Bone Grafting Using Concentrated Growth Factors and Xenograft With Simultaneous Immediate Implant Placement in Socket Shield Technique
- ClinicalTrials.gov ID
- NCT07520513
- Acronym / sponsor ID
- CGF / OMFS-3-3-20
- Conditions
- Alveolar Bone Loss, Socket Shield Technique, Bone Resorption, Immediate Dental Implant Placement, Concentrated Growth Factors, Xenograft
- Keywords
- immediate implants, socket shield technique, Concentrated growth factor, Xenograft
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 7 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 5 Apr 2026 (estimated)
- Primary completion
- 1 Sep 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 9 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective case series aims to evaluate the clinical and radiographic outcomes of immediate implant placement using the socket shield technique combined with concentrated growth factors (CGF) and xenograft in the esthetic zone. The study will assess crestal bone level changes and implant stability over a 6-month follow-up period.
Detailed description
This study is designed as a prospective case series to evaluate the effectiveness of combining concentrated growth factors (CGF) and xenograft with the socket shield technique (SST) during immediate implant placement in the maxillary esthetic region.
Post-extraction alveolar ridge resorption, particularly of the buccal bone plate, represents a significant challenge in achieving optimal esthetic outcomes. The socket shield technique has been introduced to preserve the buccal bone by retaining the labial portion of the root, thereby minimizing post-extraction resorption. However, immediate implant placement is often associated with the presence of a gap between the implant surface and the socket wall, known as the "jumping gap," which may compromise implant stability and osseointegration.
To enhance bone regeneration within this gap, bone grafting materials are commonly utilized. Concentrated growth factors (CGF), an autologous platelet concentrate, have demonstrated the ability to promote angiogenesis, osteogenesis, and soft tissue healing through the sustained release of growth factors. When combined with xenograft, which provides an osteoconductive scaffold, this approach may improve bone regeneration and implant integration.
In this study, eligible patients requiring immediate implant placement in the esthetic zone will undergo partial extraction therapy using the socket shield technique. Implants will be placed immediately after extraction, and CGF will be prepared from the patient's venous blood and mixed with xenograft to form a "sticky bone" graft, which will be applied to fill the jumping gap.
Radiographic evaluation will be performed using cone-beam computed tomography (CBCT) at 2 weeks and 6 months postoperatively to assess crestal bone level changes. Implant stability will be measured using resonance frequency analysis (Osstell device) and expressed as implant stability quotient (ISQ) values.
The findings of this study are expected to provide clinical and radiographic evidence regarding the effectiveness of combining CGF and xenograft with the socket shield technique in enhancing bone regeneration and improving outcomes of immediate implant placement in the esthetic zone.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Socket Shield Technique with CGF and Xenograft in Immediate Implant Placement | Experimental | Procedure: Socket Shield Technique with Immediate Implant Placement and CGF + XenograftParticipants will undergo immediate implant placement in the esthetic zone using the socket shield technique. Following partial extraction therapy, implants will be placed immediately, and the jumping gap will be filled using a combination of concentrated growth factors (CGF) and xenograft prepared as "sticky bone." Clinical and radiographic follow-up will be conducted over a 6-month period to evaluate crestal bone levels and implant stability. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age ≥18 years old. (Younis, W., \& El-Rashidy, A. 2020).
- Both male and female patients.
- Maxillary, anterior and premolar segments.
Key exclusion criteria (6 listed)
- A medical history that contraindicates oral surgical treatment such as (uncontrolled/untreated diabetes mellitus, immuno-compromised status, radio or chemotherapy of the oral and maxillofacial region, treatment with oral and/or intravenous bisphosphonates).
- Presence of active or untreated periodontal disease.
- Vertical root fractures involving the buccal aspect.
- Tooth /teeth with horizontal fractures below bone level.
- Tooth /teeth with external or internal resorption.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Socket Shield Technique with Immediate Implant Placement and CGF + XenograftThe procedure involves partial extraction therapy using the socket shield technique, where the buccal portion of the root is preserved to maintain the alveolar bone. Immediate implant placement is performed into the extraction socket. Concentrated growth factors (CGF) are prepared from the patient's autologous blood via centrifugation and combined with xenograft to form a "sticky bone" graft. This graft is placed in the jumping gap between the implant and socket wall to enhance bone regeneration and healing. Implant stability will be measured using resonance frequency analysis (Osstell), and radiographic evaluation will be performed using CBCT. | Procedure or surgery | Socket Shield Technique with CGF and Xenograft in Immediate Implant Placement |
Primary outcome
crestal bone level
Time frame: 2 weeks, and 6 months postoperatively
Evaluation of changes in crestal bone level around the dental implant using cone-beam computed tomography (CBCT). Measurements will be taken from a fixed reference point on the implant to the first bone-to-implant contact recorded in millimeters (mm)
1 secondary outcome
Implant Stability (ISQ Values)
Time frame: Immediate postoperative, and at 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: No
Related trials for Alveolar Bone Loss
Not yet recruitingObservational study
Diagnostic Accuracy of Large Language Models for Peri-Implant Marginal Bone Loss on Panoramic Radiographs
Peri-implantitis, Alveolar Bone Loss
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Two Bovine Xenografts in Lateral Window Sinus Augmentation With or Without Bone Marrow Blood
Alveolar Bone Loss, Sinus Floor Augmentation
Recruiting
The Application of a Biphasic Calcium Sulfate Graft Material in Sinus Floor Elevation
Alveolar Bone Loss, Edentulism Nos
Enrolling by invitation
Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation
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Recruiting
Effect of Collagen Membrane on Ridge Preservation
Dehiscence, Tooth Extraction
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Huda Ayman Alrifai, bachelors contact
Tarek I.A El-Ghareeb, PHD Holder study chair
Cairo University
Abdelmoez Mohamed EL-Sharkawy, Associate professor study director
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Socket Shield Technique with Immediate Implant Placement and CGF + Xenograft in people with Alveolar Bone Loss and Socket Shield Technique, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Huda Ayman Alrifai, bachelors (+201111373439 ext. +201111373439, hoda.elrefai@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
crestal bone level (time frame: 2 weeks, and 6 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.