Cardiac Arrest (CA)NCT07520877
Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction
A study testing T-CPR and AED-optimized T-CPR in people with Cardiac Arrest (CA), run by University of Pecs at 1 site in Hungary.
Trial summary
Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR). Early recognition, prompt chest compressions, and rapid defibrillation are critical components of the chain of survival. Read more about this study
- Who is it for?
- Ages 16 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cardiac Arrest (CA)
- What is being tested?
- T-CPR and AED-optimized T-CPR
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteHungary
- Study dates
- 10 Jul 2026to 20 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Adolescents and adults (≥16 years)
- Healthcare professionals or laypersons
- Voluntary participation
Who cannot join
- pregnant women
- people with cardio-pulmonary and musculoskeletal diseases or any other impairment that would risk harm for the volunteer while performing CPR
- physical and/or psychological disabilities
- technical issue during data collection
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction in a Single-rescuer Cardiac Arrest Scenario - a Randomized-controlled Simulation Study
Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR). Early recognition, prompt chest compressions, and rapid defibrillation are critical components of the chain of survival. Telephone-assisted CPR (T-CPR) provided by emergency dispatchers has been shown to significantly increase bystander intervention rates and improve outcomes. While the availability and use of automated external defibrillators (AEDs) further enhance survival, the optimal integration of AED use into dispatcher-guided, single-rescuer scenarios remains insufficiently studied.
This prospective, randomized, controlled simulation study aims to evaluate the effect of modified telephone cardiopulmonary resuscitation (T-CPR) instructions optimized for automated external defibrillator (AED) use on no-flow time and chest compression fraction (CCF) during single-rescuer resuscitation. Participants are randomized to receive either standard T-CPR instructions or enhanced instructions focusing on minimizing interruptions in chest compressions and reducing time to first compression during AED use.
Read the detailed description
Out-of-hospital cardiac arrest (OHCA) is a major public health problem associated with low survival rates despite advances in emergency care systems. Survival is critically dependent on early recognition, immediate initiation of high-quality chest compressions, and timely defibrillation. Bystander intervention plays a pivotal role in this process, and telephone-assisted cardiopulmonary resuscitation (T-CPR) has been demonstrated to substantially increase the likelihood of CPR initiation prior to the arrival of emergency medical services.
The increasing availability of automated external defibrillators (AEDs) in public spaces has further strengthened the chain of survival. Early defibrillation is a key determinant of favorable outcomes, particularly in shockable rhythms. However, the integration of AED use into dispatcher-assisted scenarios - especially when only a single rescuer is present - poses practical challenges. In such situations, the rescuer must balance multiple tasks, including chest compressions, AED retrieval, device preparation, and adherence to voice prompts, all of which may introduce interruptions in compressions and increase no-flow time.
While the benefits of T-CPR and AED use independently are well established, there is limited evidence on how dispatcher instructions can optimally coordinate these interventions in single-rescuer scenarios. In particular, it remains unclear whether modified, AED-optimized T-CPR instructions can reduce no-flow time and improve chest compression fraction (CCF) by minimizing unnecessary interruptions and optimizing task sequencing.
This prospective, randomized, controlled simulation study aims to evaluate the effect of modified telephone cardiopulmonary resuscitation (T-CPR) instructions optimized for automated external defibrillator (AED) use on no-flow time and chest compression fraction (CCF) during single-rescuer resuscitation. Participants are randomized to receive either standard T-CPR instructions or enhanced instructions focusing on minimizing interruptions in chest compressions and reducing time to first compression during AED use.
- Conditions
- Cardiac Arrest (CA)
- Being tested
- T-CPR, AED-optimized T-CPR
- Keywords
- cardiac arrest, automated external defibrillator, dispatcher-assisted cardiopulmonary resuscitation, no-flow time, chest compression fraction
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
T-CPRBehavioural
Participants receive structured telephone CPR instructions reflecting current national practice. AED retrieval is instructed early; however, no additional guidance is provided to optimize timing or minimize interruptions during AED use.
AED-optimized T-CPRBehavioural
Participants receive standard T-CPR instructions supplemented with specific guidance aimed at:
- minimizing interruptions in chest compressions,
- reducing time to first chest compression,
- optimizing AED use workflow.
Key elements include:
- immediate activation of the AED upon retrieval,
- initiation of chest compressions even if AED voice prompts have not yet reached relevant steps,
- continuation of compressions during AED preparation and charging (when appropriate),
- minimization of pauses before and after shock delivery.
| Study group | Role | What they receive |
|---|---|---|
| Standard T-CPR | Experimental | Participants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and the national standard DA-CPR protocol. Receives: Behavioral: T-CPR |
| AED-optimized T-CPR | Active comparator | Participants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and a modified national DA-CPR protocol. Receives: Behavioral: AED-optimized T-CPR |
What is being measured
The primary outcome is the main question the study is designed to answer.
No-flow time
Time without chest compressions measured from entry into the simulation (collapse recognition) until termination of the scenario (giving the third shock).
Measured: During procedure.
Secondary outcomes (4)
Time to first chest compression
The time (in seconds) until the first chest compression (measured from entering the scenario).
Measured: During procedure.
Time to first shock
The time to the first shock by the AED (in seconds, from the time of entering the scenario).
Measured: During procedure
Chest compression fraction
Proportion of time during which chest compressions are performed (until giving the third shock), calculated from the first chest compression until scenario termination.
Measured: During procedure.
Peri-shock pause
The time without chest compression (in seconds) before and after giving the shock.
Measured: During procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2026
- Study start10 Jul 2026
- Primary completion20 Sep 2026
- Study completion20 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Pecs
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. Bálint Bánfai, University of Pecs
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07520877
- Sponsor's protocol ID
- DA-CPR and AED
- Status last verified
- Sep 2026
- First submitted
- 2 Apr 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data underlying the results reported in publications arising from this study may be made available to qualified researchers upon reasonable request. The shared data may include participant-level demographic characteristics and de-identified CPR performance (time-related and quality relatad) and subjective outcome data collected during the study.
Publications
Balassa B, Banfai-Csonka H, Betlehem J, Bottiger BW, Banfai B. Dispatcher-assisted AED use in single-rescuer cardiac arrest: study protocol for a randomized simulation study comparing standard and optimized dispatcher-assisted CPR instructions. Resusc Plus. 2026 Jul 10;30:101412. doi: 10.1016/j.resplu.2026.101412. eCollection 2026 Jul.
PubMed 42541292
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of AED-optimized Telephone-assisted CPR Instructions on No-flow Time and Chest Compression Fraction in a Single-rescuer Cardiac Arrest Scenario - a Randomized-controlled Simulation Study
- ClinicalTrials.gov ID
- NCT07520877
- Acronym / sponsor ID
- DA-CPR and AED
- Conditions
- Cardiac Arrest (CA)
- Keywords
- cardiac arrest, automated external defibrillator, dispatcher-assisted cardiopulmonary resuscitation, no-flow time, chest compression fraction
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- University of PecsUniversity, hospital or other
- Study start
- 10 Jul 2026 (actual)
- Primary completion
- 20 Sep 2026 (actual)
- Study completion
- 20 Sep 2026 (actual)
- First posted
- 9 Apr 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Out-of-hospital cardiac arrest (OHCA) remains a leading cause of mortality worldwide, with survival highly dependent on the immediate initiation of bystander cardiopulmonary resuscitation (CPR). Early recognition, prompt chest compressions, and rapid defibrillation are critical components of the chain of survival. Telephone-assisted CPR (T-CPR) provided by emergency dispatchers has been shown to significantly increase bystander intervention rates and improve outcomes. While the availability and use of automated external defibrillators (AEDs) further enhance survival, the optimal integration of AED use into dispatcher-guided, single-rescuer scenarios remains insufficiently studied.
This prospective, randomized, controlled simulation study aims to evaluate the effect of modified telephone cardiopulmonary resuscitation (T-CPR) instructions optimized for automated external defibrillator (AED) use on no-flow time and chest compression fraction (CCF) during single-rescuer resuscitation. Participants are randomized to receive either standard T-CPR instructions or enhanced instructions focusing on minimizing interruptions in chest compressions and reducing time to first compression during AED use.
Detailed description
Out-of-hospital cardiac arrest (OHCA) is a major public health problem associated with low survival rates despite advances in emergency care systems. Survival is critically dependent on early recognition, immediate initiation of high-quality chest compressions, and timely defibrillation. Bystander intervention plays a pivotal role in this process, and telephone-assisted cardiopulmonary resuscitation (T-CPR) has been demonstrated to substantially increase the likelihood of CPR initiation prior to the arrival of emergency medical services.
The increasing availability of automated external defibrillators (AEDs) in public spaces has further strengthened the chain of survival. Early defibrillation is a key determinant of favorable outcomes, particularly in shockable rhythms. However, the integration of AED use into dispatcher-assisted scenarios - especially when only a single rescuer is present - poses practical challenges. In such situations, the rescuer must balance multiple tasks, including chest compressions, AED retrieval, device preparation, and adherence to voice prompts, all of which may introduce interruptions in compressions and increase no-flow time.
While the benefits of T-CPR and AED use independently are well established, there is limited evidence on how dispatcher instructions can optimally coordinate these interventions in single-rescuer scenarios. In particular, it remains unclear whether modified, AED-optimized T-CPR instructions can reduce no-flow time and improve chest compression fraction (CCF) by minimizing unnecessary interruptions and optimizing task sequencing.
This prospective, randomized, controlled simulation study aims to evaluate the effect of modified telephone cardiopulmonary resuscitation (T-CPR) instructions optimized for automated external defibrillator (AED) use on no-flow time and chest compression fraction (CCF) during single-rescuer resuscitation. Participants are randomized to receive either standard T-CPR instructions or enhanced instructions focusing on minimizing interruptions in chest compressions and reducing time to first compression during AED use.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Standard T-CPR | Experimental | Behavioral: T-CPRParticipants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and the national standard DA-CPR protocol. |
| AED-optimized T-CPR | Active comparator | Behavioral: AED-optimized T-CPRParticipants perform dispatcher-assisted CPR based on the European Resuscitation Council (ERC) 2025 guidelines and a modified national DA-CPR protocol. |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- Adolescents and adults (≥16 years)
- Healthcare professionals or laypersons
- Voluntary participation
Key exclusion criteria (4 listed)
- pregnant women
- people with cardio-pulmonary and musculoskeletal diseases or any other impairment that would risk harm for the volunteer while performing CPR
- physical and/or psychological disabilities
- technical issue during data collection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| T-CPRParticipants receive structured telephone CPR instructions reflecting current national practice. AED retrieval is instructed early; however, no additional guidance is provided to optimize timing or minimize interruptions during AED use. | Behavioural | Standard T-CPR |
| AED-optimized T-CPRParticipants receive standard T-CPR instructions supplemented with specific guidance aimed at: * minimizing interruptions in chest compressions, * reducing time to first chest compression, * optimizing AED use workflow. Key elements include: * immediate activation of the AED upon retrieval, * initiation of chest compressions even if AED voice prompts have not yet reached relevant steps, * continuation of compressions during AED preparation and charging (when appropriate), * minimization of pauses before and after shock delivery. | Behavioural | AED-optimized T-CPR |
Primary outcome
No-flow time
Time frame: During procedure.
Time without chest compressions measured from entry into the simulation (collapse recognition) until termination of the scenario (giving the third shock).
4 secondary outcomes
Time to first chest compression
Time frame: During procedure.
Time to first shock
Time frame: During procedure
Chest compression fraction
Time frame: During procedure.
Peri-shock pause
Time frame: During procedure
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Derived from this study: PubMed 42541292Balassa B, Banfai-Csonka H, Betlehem J, Bottiger BW, Banfai B. Dispatcher-assisted AED use in single-rescuer cardiac arrest: study protocol for a randomized simulation study comparing standard and optimized dispatcher-assisted CPR instructions. Resusc Plus. 2026 Jul 10;30:101412. doi: 10.1016/j.resplu.2026.101412. eCollection 2026 Jul.
- Individual participant dataSharing planned: Yes. De-identified individual participant data underlying the results reported in publications arising from this study may be made available to qualified researchers upon reasonable request. The shared data may include participant-level demographic characteristics and de-identified CPR performance (time-related and quality relatad) and subjective outcome data collected during the study.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing T-CPR and AED-optimized T-CPR in people with Cardiac Arrest (CA), run by University of Pecs at 1 site in Hungary.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hungary. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
No-flow time (time frame: During procedure.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07520877, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.