AzTrials
AzTrials

Hip Fracture SurgeriesNCT07522541

ASA or CFS for ICU Prediction in Geriatric Hip Fracture

An observational study of Hip Fracture Surgeries and Geriatric Assessment, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

The aim of this retrospective study is to compare the efficacy of the American Society of Anesthesiologists (ASA) physical status classification and the Clinical Frailty Scale (CFS) in predicting postoperative intensive care unit (ICU) requirements in geriatric patients undergoing hip fracture surgery. Read more about this study

Who is it for?
Ages 65 years and older
What is being tested?
Routine Surgical and Anesthetic Mnagement.
How many people
200 participants
Where
1 siteTurkey (Türkiye)
Study dates
30 Mar 2026to Aug 2026
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 65 years and older
  • All sexes
  • No healthy volunteers
  • Older adult

Study population: The study population consists of approximately 243 geriatric patients aged 65 years and older who underwent surgery for acute traumatic hip fracture (femoral neck, intertrochanteric, or subtrochanteric) at the Department of Anesthesiology and Reanimation, University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, between November 2023 and December 2025. The population includes patients with complete preoperative anesthesia records, ASA physical status scores, and sufficient clinical documentation for retrospective Clinical Frailty Scale (CFS) scoring

Who may be able to join

  • Diagnosis: Patients diagnosed with acute traumatic hip fracture, including femoral neck, intertrochanteric, or subtrochanteric fractures.
  • Surgical Intervention: Patients who have undergone or are scheduled for surgical treatment (e.g., arthroplasty, internal fixation/osteosynthesis) for hip fracture.
  • Data Integrity: Availability of complete electronic health records, including preoperative anesthesia evaluation forms and ASA physical status scores.
  • Functional Assessment: Presence of sufficient clinical and nursing documentation to retrospectively determine the Clinical Frailty Scale (CFS) score based on preoperative functional status.
  • -
  • Exclusion Criteria:Pathological and Periprosthetic Fractures: Fractures resulting from bone metastases or those occurring around an existing prosthesis.
Show all 12Show fewer
  • Multiple Trauma: Patients with concomitant major organ injuries or additional limb fractures that could impact clinical outcomes.
  • Conservative Management: Patients who did not undergo surgical intervention and were managed non-surgically.
  • Incomplete Data: Cases with missing ASA scores, laboratory results, or postoperative clinical follow-up data in the hospital records.
  • Insufficient Functional Documentation: Patients whose clinical or nursing notes are inadequate for retrospective determination of the Clinical Frailty Scale (CFS) score.
  • Patient Transfer: Patients transferred to another healthcare facility preoperatively or in the immediate postoperative period, leading to incomplete data follow-up.
  • -

Who cannot join

None listed.

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site
  • Abdurrahman yurtarslan onkoloji eğitim ve araştırma hastanesi

    Ankara, 06630

Other trials in Turkey (Türkiye)

About this study

Official title: Comparative Analysis of ASA Score and Clinical Frailty Scale in Predicting Postoperative Intensive Care Requirements in Geriatric Hip Fracture Surgery

The aim of this retrospective study is to compare the efficacy of the American Society of Anesthesiologists (ASA) physical status classification and the Clinical Frailty Scale (CFS) in predicting postoperative intensive care unit (ICU) requirements in geriatric patients undergoing hip fracture surgery. The investigators will analyze medical records of patients aged 65 and older. The study will evaluate whether the CFS provides better predictive value for ICU admission compared to the traditional ASA score in this specific surgical population.

Read the detailed description

Study Title Comparative analysis of American Society of Anesthesiologists (ASA) physical status classification and Clinical Frailty Scale (CFS) in predicting postoperative intensive care unit (ICU) admission in geriatric hip fracture surgery Introduction With the rapid increase in the elderly population worldwide, geriatric hip fracture cases have become one of the most critical health issues in anesthesia and surgical practice. This patient group is characterized not only by surgical trauma but also by reduced physiological reserve, multiple chronic diseases, and high frailty levels. Major complications following hip fracture surgery extend hospital stays, increase healthcare costs, and lead to high mortality rates. Therefore, predicting which patients will require intensive care unit (ICU) support in the preoperative period is vital for both patient safety and efficient hospital resource management.

The American Society of Anesthesiologists (ASA) physical status classification, widely used in traditional anesthesia practice, successfully defines a patient's systemic disease burden but does not fully reflect the biological resistance and functional capacity of an elderly individual against surgical stress. It is reported in the literature that patients with the same ASA score can have significantly different clinical outcomes; even with similar chronic disease burdens, patients defined as "frail" face worse postoperative results. The Clinical Frailty Scale (CFS), developed by Kenneth Rockwood, measures "biological aging" based on a patient's mobility level and independence in activities of daily living, revealing the "reserve depletion" that traditional scoring systems overlook.

The primary rationale for this study is to directly compare the success of the ASA score and the CFS in predicting the need for postoperative ICU admission in a geriatric hip fracture population. While both scores are known to have predictive value, their superiority over each other and their combined use in clinical decision-making remain controversial in acute trauma groups like hip fractures. This research will provide a scientific basis for anesthesiologists to use more sensitive tools in preoperative risk assessment and to develop appropriate triage strategies for patients in the "hidden risk" group (low ASA but high CFS scores).

Materials and Methods This study is a retrospective cohort study examining the data of patients aged 65 and older who underwent surgery for a hip fracture (femur neck, intertrochanteric, or subtrochanteric fracture) between November 2023 and December 2025. Approval was obtained from the relevant ethics committee, and the data of 243 patients with complete operative records were evaluated. Cases transferred to another center before surgery, those with inaccessible surgical data, or those followed conservatively were excluded. Demographic information such as age and gender, as well as comorbidities (hypertension, diabetes, coronary artery disease, dementia), preoperative laboratory values (hemoglobin, albumin, creatinine), and echocardiography findings, were obtained through the hospital information management system.

Among the parameters used for risk assessment, ASA scores were recorded directly from preoperative anesthesia forms. Clinical Frailty Scale (CFS) scores were retrospectively calculated based on the Rockwood scale by scoring functional data such as mobility levels, domestic independence, and history of assistive device use found in nursing follow-up notes. Intraoperative variables, including anesthesia technique (general or spinal), surgical duration, and the requirement for vasoactive drugs, were also included. The primary endpoint of the study is the requirement for postoperative ICU admission, while secondary endpoints include total ICU stay, development of delirium in the first 48 hours, myocardial injury after non-cardiac surgery (MINS), acute kidney injury (AKI), and in-hospital mortality.

Inclusion and Exclusion Criteria

Inclusion Criteria

Age: Patients aged 65 years and older.

Diagnosis: Acute traumatic hip fracture (femoral neck, intertrochanteric, or subtrochanteric).

Surgical Intervention: Patients scheduled for and undergoing surgery (arthroplasty, osteosynthesis, etc.) for a hip fracture.

Data Integrity: Complete records of preoperative ASA score, laboratory findings, and postoperative follow-up notes.

Functional Information: Sufficient clinical notes to allow for retrospective CFS scoring.

Exclusion Criteria

Pathological and Periprosthetic Fractures: Fractures due to bone metastasis/tumors or fractures occurring around an existing prosthesis.

Multi-trauma: Presence of other major organ injuries or additional extremity fractures.

Conservative Follow-up: Patients not undergoing surgery due to medical contraindications or preference.

Missing Data: Patients with incomplete records or those transferred to another center immediately post-op.

Being tested
Routine Surgical and Anesthetic Mnagement.
Keywords
Geriatrics, Hip Fractures, Clinical Frailty Scale, Intensive Care Units, Postoperative Complications, Risk Assessment
Medical subject headings
Hip Fractures, Postoperative Complications

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Routine Surgical and Anesthetic Mnagement.Other

    Since this is a retrospective record review, no new intervention is administered. The intervention name represents the standard surgical (arthroplasty or osteosynthesis) and anesthetic (general or spinal) management received by patients for hip fractures according to institutional protocols. The study analyzes the relationship between these routine clinical processes and preoperative ASA and CFS scores

Study groups in NCT07522541
Study groupRoleWhat they receive
Geriatric Hip Fracture CohortThis cohort includes retrospective data from approximately 200 patients aged 65 and older who underwent surgery for hip fractures (femoral neck, intertrochanteric, or subtrochanteric) between November 2023 and November 2025. The study evaluates the requirement for Intensive Care Unit (ICU) admission following routine surgical and anesthesia (general or spinal) interventions. The primary focus is to comparatively analyze the predictive value of preoperative ASA physical status classification and Clinical Frailty Scale (CFS) scores on patients' postoperative ICU needs and clinical outcomes
Receives: Other: Routine Surgical and Anesthetic Mnagement.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Postoperative Intensive Care Unit (ICU) Admission Requirement

    Assessment of whether the patient required immediate postoperative admission to the intensive care unit due to clinical necessity, physiological instability, or the need for advanced monitoring.

    Measured: Within 24 hours postoperatively

Secondary outcomes (4)
  1. Length of Stay in the Intensive Care Unit and Total Hospital Stay

    Calculation of the total duration of stay in the intensive care unit (recorded in days) and the total hospital stay from the date of surgery until hospital discharge.

    Measured: From the day of surgery until hospital discharge, up to 1 year

  2. Postoperative Delirium

    Assessment of clinical signs of delirium (such as acute confusion, disorientation, or agitation) as documented in medical and nursing follow-up notes.

    Measured: Up to 48 hours postoperatively

  3. Major Postoperative Complications

    Frequency of major adverse events based on laboratory results and clinical findings, specifically including myocardial injury after non-cardiac surgery (MINS) and acute kidney injury (AKI).

    Measured: From the end of surgery until hospital discharge, up to 30 days

  4. In-hospital Mortality

    Assessment of the all-cause mortality rate occurring during the patient's hospital stay following the surgical procedure.

    Measured: From the day of surgery until hospital discharge, up to 30 days

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Apr 2026
  2. Study start30 Mar 2026
  3. Primary completionJul 2026 (estimated)
  4. Study completionAug 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Retrospective
Enrolment
200 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07522541
Sponsor's protocol ID
2026-03/69
Status last verified
Apr 2026
First submitted
1 Apr 2026
Last updated
28 May 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: The datasets generated during the current study are not publicly available due to institutional regulations and the sensitive nature of patient medical records but are available from the corresponding author on reasonable request

Publications

  • Saetang M, Kunapaisal T, Chatmongkolchart S, Yongsata D, Sukitpaneenit K. Assessing frailty to predict surgical risk: a comparative study of three tools in older non-cardiac surgery patients. BMC Geriatr. 2025 Nov 21;25(1):941. doi: 10.1186/s12877-025-06683-1.

    PubMed 41272515
  • Becerra-Bolanos A, Hernandez-Aguiar Y, Rodriguez-Perez A. Preoperative frailty and postoperative complications after non-cardiac surgery: a systematic review. J Int Med Res. 2024 Sep;52(9):3000605241274553. doi: 10.1177/03000605241274553.

    PubMed 39268763

Questions about this trial

What is this clinical trial studying?

An observational study of Hip Fracture Surgeries and Geriatric Assessment, run by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 12 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 28 May 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Postoperative Intensive Care Unit (ICU) Admission Requirement (time frame: Within 24 hours postoperatively). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07522541, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2026.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in